DE69106501D1 - Osmotisches dosiersystem zur verabreichung von flüssigen arzneimitteln. - Google Patents

Osmotisches dosiersystem zur verabreichung von flüssigen arzneimitteln.

Info

Publication number
DE69106501D1
DE69106501D1 DE69106501T DE69106501T DE69106501D1 DE 69106501 D1 DE69106501 D1 DE 69106501D1 DE 69106501 T DE69106501 T DE 69106501T DE 69106501 T DE69106501 T DE 69106501T DE 69106501 D1 DE69106501 D1 DE 69106501D1
Authority
DE
Germany
Prior art keywords
administration
dosing system
medicinal products
liquid medicinal
osmotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69106501T
Other languages
English (en)
Other versions
DE69106501T2 (de
Inventor
Patrick Wong
Felix Theeuwes
Brian Barclay
Michael Dealey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DE69106501D1 publication Critical patent/DE69106501D1/de
Publication of DE69106501T2 publication Critical patent/DE69106501T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • External Artificial Organs (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Wrappers (AREA)
  • Materials For Medical Uses (AREA)
  • Paper (AREA)
DE69106501T 1990-04-02 1991-03-28 Osmotisches dosiersystem zur verabreichung von flüssigen arzneimitteln. Expired - Fee Related DE69106501T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/502,705 US5324280A (en) 1990-04-02 1990-04-02 Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
PCT/US1991/002176 WO1991015196A1 (en) 1990-04-02 1991-03-28 Osmotic dosage system for liquid drug delivery

Publications (2)

Publication Number Publication Date
DE69106501D1 true DE69106501D1 (de) 1995-02-16
DE69106501T2 DE69106501T2 (de) 1995-05-11

Family

ID=23999024

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69106501T Expired - Fee Related DE69106501T2 (de) 1990-04-02 1991-03-28 Osmotisches dosiersystem zur verabreichung von flüssigen arzneimitteln.

Country Status (17)

Country Link
US (2) US5324280A (de)
EP (1) EP0523172B1 (de)
JP (1) JP2927956B2 (de)
KR (1) KR0176724B1 (de)
AT (1) ATE116543T1 (de)
AU (1) AU645315B2 (de)
CA (1) CA2039456C (de)
DE (1) DE69106501T2 (de)
DK (1) DK0523172T3 (de)
ES (1) ES2075444T3 (de)
FI (1) FI924419A0 (de)
IE (1) IE62394B1 (de)
NO (1) NO923756L (de)
NZ (1) NZ237642A (de)
PT (1) PT97203B (de)
WO (1) WO1991015196A1 (de)
ZA (1) ZA912380B (de)

Families Citing this family (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2693907B1 (fr) * 1992-07-23 1994-09-02 Rhone Poulenc Rorer Sa Procédé d'administration de solutions de facteur de stimulation des colonies granulocytaires.
US6440457B1 (en) * 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
WO1995010989A1 (en) * 1993-10-19 1995-04-27 Scimed Life Systems, Inc. Intravascular stent pump
US5496360A (en) * 1994-04-12 1996-03-05 Ventritex, Inc. Implantable cardiac electrode with rate controlled drug delivery
ES2183841T3 (es) * 1994-06-13 2003-04-01 Alza Corp Formas de dosificacion para administrar un farmasco en una formulacion lquidid.
US5633011A (en) * 1994-08-04 1997-05-27 Alza Corporation Progesterone replacement therapy
US5718700A (en) * 1994-09-20 1998-02-17 Alza Corporation Exit means in dosage form
US5531734A (en) * 1995-01-13 1996-07-02 Abbott Laboratories Method of altering composition of nutritional product during enteral tube feeding
US6036669A (en) 1995-01-13 2000-03-14 Abbott Laboratories Apparatus for altering composition of nutritional product during enteral tube feeding
US5533973A (en) * 1995-01-13 1996-07-09 Abbott Laboratories Alteration of nutritional product during enteral tube feeding
US6277092B1 (en) 1995-01-13 2001-08-21 Abbott Laboratories Apparatus for altering composition of nutritional product during enteral tube feeding
US5531682A (en) * 1995-01-13 1996-07-02 Abbott Laboratories Apparatus for adding marker dye to nutritional product during enternal tube feeding
US5531681A (en) * 1995-01-13 1996-07-02 Abbott Laboratories Apparatus for altering composition of nutritional product during enteral tube feeding
FR2731154B1 (fr) * 1995-03-03 1997-05-09 Roussel Uclaf Compositions pharmaceutiques comprenant des derives de dinoreburnamenine
US5651979A (en) * 1995-03-30 1997-07-29 Gel Sciences, Inc. Apparatus and method for delivering a biologically active compound into a biological environment
US5800422A (en) * 1995-06-02 1998-09-01 Alza Corporation Osmotic device with delayed activation of drug delivery and complete drug release
US6261584B1 (en) 1996-02-02 2001-07-17 Alza Corporation Sustained delivery of an active agent using an implantable system
US6395292B2 (en) * 1996-02-02 2002-05-28 Alza Corporation Sustained delivery of an active agent using an implantable system
US6156331A (en) * 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
CZ300994B6 (cs) * 1996-02-02 2009-10-07 Alza Corporation Implantabilní zarízení pro dodávání aktivního cinidla
US6919373B1 (en) 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
KR100576583B1 (ko) * 1997-12-22 2006-05-04 알자 코포레이션 서방성 약물 송달 장치용 속도 조절막
US6080132A (en) * 1998-02-27 2000-06-27 Abbott Laboratories Apparatus for altering characteristics of a fluid
US6099859A (en) * 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
CA2331542A1 (en) * 1998-05-14 1999-11-18 Alza Corporation Antidepressant therapy
US6524620B2 (en) 1998-07-20 2003-02-25 Andrx Pharmaceuticals, Inc. Diltiazem controlled release formulation and method of manufacture
US6309373B1 (en) 1998-08-12 2001-10-30 Abbott Laboratories Apparatus for altering the characteristics of a fluid
US6183466B1 (en) 1998-08-21 2001-02-06 Alza Corporation Dosage form comprising a capsule
US6099862A (en) 1998-08-31 2000-08-08 Andrx Corporation Oral dosage form for the controlled release of a biguanide and sulfonylurea
US6551613B1 (en) * 1998-09-08 2003-04-22 Alza Corporation Dosage form comprising therapeutic formulation
CN1227003C (zh) * 1998-09-09 2005-11-16 阿尔萨公司 包括液体制剂的剂型
US6174547B1 (en) * 1999-07-14 2001-01-16 Alza Corporation Dosage form comprising liquid formulation
US20090297602A1 (en) * 1998-11-02 2009-12-03 Devane John G Modified Release Loxoprofen Compositions
US6706282B1 (en) * 1998-11-02 2004-03-16 Evangeline Cruz Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones
GB9824658D0 (en) * 1998-11-11 1999-01-06 Brown Malcolm D A capsule based drug delivery system
IL143691A0 (en) * 1998-12-17 2002-04-21 Alza Corp Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings
EP1140039B1 (de) 1998-12-18 2009-11-04 Alza Corporation Durchsichtige transdermale nicotinabgabevorrichtungen
US6198966B1 (en) 1999-02-26 2001-03-06 Medtronic, Inc. Recirculating implantable drug delivery system
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
JP3061616B1 (ja) * 1999-04-09 2000-07-10 株式会社セラリカ野田 低カロリ―調製ロ―ヤルゼリ―
DE19923817A1 (de) * 1999-05-18 2000-11-23 Roland Bodmeier Kapsel mit kontrollierter Wirkstofffreisetzung
US20040230155A1 (en) * 1999-06-22 2004-11-18 Erblan Surgical Inc. Insufflator and method of use
US20060015075A1 (en) * 1999-06-22 2006-01-19 Erblan Surgical Inc. Guarded infusor needle and infusor locking system
US6251432B1 (en) 1999-07-01 2001-06-26 Abbott Laboratories Sustained release dosage form unit having latex coating and method of making the same
EP1239840B1 (de) 1999-12-09 2005-04-06 Alza Corporation Antivirale arznei
AR026148A1 (es) * 2000-01-21 2003-01-29 Osmotica Argentina S A Dispositivo osmotico con pasaje preformado que aumenta de tamano
CA2399000C (en) 2000-02-04 2009-12-22 Alza Corporation Osmotically-driven fluid dispenser and coating composition
US6464688B1 (en) 2000-02-15 2002-10-15 Microsolutions, Inc. Osmotic pump delivery system with flexible drug compartment
GB2398499B (en) * 2000-02-16 2004-11-24 Bioprogress Technology Ltd Two layer capsules
GB0003424D0 (en) * 2000-02-16 2000-04-05 Bioprogress Tech Int Inc A controlled release capsule
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US6468559B1 (en) 2000-04-28 2002-10-22 Lipocine, Inc. Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods
US20020161387A1 (en) * 2000-06-22 2002-10-31 Blanco Ernesto E. Safety trocar with progressive cutting tip guards and gas jet tissue deflector
US20040230160A1 (en) * 2000-06-22 2004-11-18 Erblan Surgical Inc. Safety trocar including sealing member
US20020198215A1 (en) * 2000-10-23 2002-12-26 Lino Tavares Terazosin transdermal device and methods
US6866866B1 (en) * 2000-11-03 2005-03-15 Andrx Labs, Llc Controlled release metformin compositions
US6790459B1 (en) 2000-11-03 2004-09-14 Andrx Labs, Llc Methods for treating diabetes via administration of controlled release metformin
US20060034922A1 (en) * 2000-11-03 2006-02-16 Andrx Labs, Llc Controlled release metformin compositions
US20020197235A1 (en) * 2000-11-03 2002-12-26 Moran Stanford Mark Method for short-term and long-term drug dosimetry
DE10100689A1 (de) * 2001-01-09 2002-07-18 Henkel Kgaa Wasch- und reinigungsaktive Substanzen enthaltende Mikrokapseln
US6632217B2 (en) * 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump
WO2002100318A2 (en) 2001-06-12 2002-12-19 Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
US7163688B2 (en) * 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
US7083578B2 (en) * 2001-07-12 2006-08-01 Given Imaging Ltd. Device and method for examining a body lumen
US7349733B2 (en) * 2001-11-02 2008-03-25 Ceramatel, Inc. Iontophoretic drug delivery systems
EP1536839B1 (de) * 2001-11-09 2010-09-15 Intarcia Therapeutics, Inc Kombinationstherapie mit omega-interferon zur behandlung von hepatitis c virus oder gelbfieber virus infektionen
CA2471096A1 (en) * 2001-12-19 2003-07-03 Alza Corporation Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
CN1620281A (zh) * 2001-12-19 2005-05-25 阿尔扎公司 用于治疗剂的受控传递的制剂和剂型
US6775570B2 (en) 2002-02-04 2004-08-10 Ceramatec, Inc. Iontophoretic treatment device
US7047069B2 (en) 2002-02-04 2006-05-16 Ceramatec, Inc. Iontophoretic fluid delivery device
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
AU2003241537A1 (en) * 2002-05-23 2003-12-12 Andrx Corporation Biguanide formulations
CN1668279A (zh) * 2002-06-17 2005-09-14 阿尔萨公司 具有包含分散在液体载体中的渗透物质的早期零级推动力动力系统的渗透递送体系
AR039744A1 (es) * 2002-06-26 2005-03-09 Alza Corp Metodos y formas de dosificacion para aumentar la solubilidad de las composiciones de farmacos para la administracion controlada
BR0312429A (pt) * 2002-06-26 2005-04-19 Alza Corp Pistão de deformidade mìnima e de volume eficiente para sistemas de distribuição de drogas por osmose
AR040301A1 (es) * 2002-06-28 2005-03-23 Alza Corp Composicion osmotica expansible y suspension para revestimiento mejoradas
CA2494233A1 (en) * 2002-07-29 2004-02-05 Alza Corporation Formulations and dosage forms for controlled delivery of topiramate
US20050232995A1 (en) * 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
US20040091538A1 (en) * 2002-10-31 2004-05-13 Crystal Pollock-Dove Dosage form providing ascending release of liquid formulation
AR041745A1 (es) * 2002-10-31 2005-05-26 Alza Corp Formulacion y forma de dosificacion que provee mayor biodisponibilidad de los farmacos hidrofobos
US7014636B2 (en) * 2002-11-21 2006-03-21 Alza Corporation Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel
US7491234B2 (en) * 2002-12-03 2009-02-17 Boston Scientific Scimed, Inc. Medical devices for delivery of therapeutic agents
JP2006510655A (ja) * 2002-12-11 2006-03-30 ファイザー・プロダクツ・インク 高脂肪環境への活性物質の制御放出
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
CA2530136C (en) * 2003-06-26 2012-10-16 Control Delivery Systems, Inc. In-situ gelling drug delivery system
CN1842321B (zh) * 2003-06-26 2012-07-04 控制递送系统有限公司 生物蚀解性缓释递药系统
US8815284B2 (en) * 2003-06-26 2014-08-26 Psivida Us, Inc. Bioerodible sustained release drug delivery systems
EP1653922A2 (de) * 2003-08-06 2006-05-10 Alza Corporation Gleichförmige zuführung von topiramat über einen verlängerten zeitraum mit verbesserter dispersionsformulierung
US20050136108A1 (en) * 2003-08-22 2005-06-23 Yam Noymi V. Stepwise delivery of topiramate over prolonged period of time
CA2564227A1 (en) * 2003-09-02 2005-03-10 Alza Corporation Novel drug compositions and dosage forms of topiramate
CA2545834A1 (en) * 2003-11-14 2005-06-02 Alza Corporation Controlled release of topiramate in liquid dosage forms
AU2004308973A1 (en) * 2003-12-23 2005-07-14 Alza Corporation Methods and dosage forms for increasing solubility of drug compositions for controlled delivery
US20050175696A1 (en) * 2003-12-29 2005-08-11 David Edgren Drug granule coatings that impart smear resistance during mechanical compression
AU2004312084A1 (en) * 2003-12-29 2005-07-21 Alza Corporation, Inc. Novel drug compositions and dosage forms of topiramate
MXPA06007509A (es) * 2003-12-29 2007-10-18 Johnson & Johnson Composiciones de farmaco y formas de dosis novedosas.
DK2299275T3 (en) 2004-07-30 2018-05-07 Adeza Biomedical Corp Classification of oncofetal fetronectin level for pregnancy-related indications
US20060045891A1 (en) * 2004-08-24 2006-03-02 Lovalenti Phillip M Density-matched suspension vehicles and pharmaceutical suspensions
ATE413864T1 (de) * 2005-01-27 2008-11-15 Alza Corp Orale osmotische darreichungsform mit membran mit hoher flussdichte
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
EP1874269A2 (de) * 2005-04-19 2008-01-09 Alza Corporation Kombination aus tramadol und substanzen mit gabapentin
JP2008542308A (ja) * 2005-06-02 2008-11-27 タリオン ファーマシューティカルズ インク. ファルネシルジベンゾジアゼピノン製剤
US20090214643A1 (en) * 2005-07-19 2009-08-27 Franklin Amie E Improved pharmacokinetic profile of beta-adrenergic inverse agonists for the treatment of pulmonary airway diseases
AR055099A1 (es) * 2005-07-28 2007-08-08 Alza Corp Formulaciones liquidas para la administracion controlada de derivados de bencisoxazol
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
PL116330U1 (en) * 2005-10-31 2007-04-02 Alza Corp Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
US20070196487A1 (en) * 2006-02-16 2007-08-23 Geerke Johan H Method and apparatus for drilling orifices in osmotic tablets incorporating near-infrared spectroscopy
DE602007009377D1 (de) 2006-05-30 2010-11-04 Intarcia Therapeutics Inc Zweiteiliger flussmodulator mit einem internen kanal für ein osmotisches ausgabesystem
US7682356B2 (en) 2006-08-09 2010-03-23 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies for use therein
US20080177219A1 (en) * 2007-01-23 2008-07-24 Joshi Ashok V Method for Iontophoretic Fluid Delivery
US8524749B2 (en) * 2007-02-09 2013-09-03 Alza Corporation Controlled release compositions of tizanidine
GB0707127D0 (en) * 2007-04-13 2007-05-23 Zysis Ltd Pharmaceutical compositions
JP5351884B2 (ja) 2007-04-23 2013-11-27 インターシア セラピューティクス,インコーポレイティド インスリン分泌促進性ペプチドの懸濁製剤及び使用
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US20090087484A1 (en) * 2007-09-28 2009-04-02 Alza Corporation Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules
US20090110724A1 (en) * 2007-10-31 2009-04-30 Everett Laboratories, Inc. Compositions and methods for treatment of pain
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
CA2726861C (en) 2008-02-13 2014-05-27 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US20090311335A1 (en) * 2008-06-12 2009-12-17 Scott Jenkins Combination of a triptan and an nsaid
US20090312627A1 (en) * 2008-06-16 2009-12-17 Matott Laura A Radio-labeled ingestible capsule
CA2638240C (en) * 2008-08-29 2010-02-02 Alexander Macgregor Method of treating dysglycemia and glucose excursions
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
SG173167A1 (en) 2009-01-29 2011-08-29 Forsight Labs Llc Posterior segment drug delivery
RU2589823C2 (ru) * 2009-04-09 2016-07-10 Алкермес Фарма Айэленд Лимитед Композиция для доставки лекарственных средств
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
CA2979355C (en) * 2009-05-18 2023-02-21 Dose Medical Corporation Drug eluting ocular implant
MX2011013080A (es) 2009-06-16 2012-01-20 Pfizer Formas de dosis de apixaban.
US20130029970A1 (en) 2009-07-10 2013-01-31 Ironwood Pharmaceuticals, Inc CB Receptor Agonists
EP2478919A4 (de) * 2009-09-15 2014-04-30 Team Academy Of Pharmaceutical Science Tablette mit durch eine osmotische pumpe gesteuerter freisetzung und herstellungsverfahren dafür
HUE035862T2 (en) 2009-09-28 2018-05-28 Intarcia Therapeutics Inc Rapid development and / or completion of substantially steady-state drug delivery
US8945010B2 (en) 2009-12-23 2015-02-03 Covidien Lp Method of evaluating constipation using an ingestible capsule
CA2785468A1 (en) * 2009-12-23 2011-06-30 Psivida Us, Inc. Sustained release delivery devices
UY33110A (es) 2009-12-23 2011-07-29 Ironwood Pharmaceuticals Inc Moduladores de CRTH2
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US20130178453A1 (en) 2010-02-09 2013-07-11 Ironwood Pharmaceuticals, Inc. Cannabinoid Agonists
WO2011100324A1 (en) 2010-02-09 2011-08-18 Ironwood Pharmaceuticals Inc. Cannabinoid receptor agonists
WO2011115804A1 (en) 2010-03-17 2011-09-22 Ironwood Pharmaceuticals, Inc. Sgc stimulators
BR112012033341B1 (pt) 2010-06-30 2022-08-23 Cyclerion Therapeutics, Inc Estimulantes de sgc
US20130259830A1 (en) 2010-07-12 2013-10-03 Ironwood Pharmaceuticals, Inc. Crth2 modulators
WO2012009137A1 (en) 2010-07-12 2012-01-19 Ironwood Pharmaceuticals, Inc. Crth2 modulators
AU2011285548B2 (en) 2010-08-05 2014-02-06 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
EP2600930B1 (de) 2010-08-05 2021-02-17 ForSight Vision4, Inc. Injektionsapparat zur verabreichung von medikamenten
JP5907966B2 (ja) 2010-08-05 2016-04-26 フォーサイト・ビジョン フォー・インコーポレーテッド 埋め込み型治療デバイス
SG188317A1 (en) 2010-08-30 2013-04-30 Sinusys Corp Devices for dilating a paranasal sinus opening and for treating sinusitis
US9061030B2 (en) 2010-11-09 2015-06-23 Ironwood Pharmaceuticals, Inc. sGC stimulators
WO2012068549A2 (en) 2010-11-19 2012-05-24 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
EP4249059A3 (de) 2011-06-28 2023-11-29 ForSight Vision4, Inc. Vorrichtung zum sammeln einer flüssigkeitsprobe aus einer reservoirkammer einer therapeutischen vorrichtung für das auge
CA2848385C (en) 2011-09-16 2021-10-26 Forsight Vision4, Inc. Methods and apparatus to exchange a fluid of an implantable device
EP2797915B1 (de) 2011-12-27 2016-07-13 Ironwood Pharmaceuticals, Inc. 2-Benzyl-3-(Oxazol/Thiazol)-5-(Pyrimidin-2-yl)-1(H)-Pyrazol-Derivate als Stimulatoren der löslichen Guanylat-Cyclase (sGC) zur Behandlung von Bluthochdruck und Herzversagen
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
JP2015509786A (ja) 2012-02-29 2015-04-02 サイナシス コーポレーション 副鼻腔開口部を拡張して副鼻腔炎を治療するためのデバイスおよび方法
US20150080381A1 (en) 2012-04-12 2015-03-19 Ironwood Pharmaceuticals, Inc. Methods of treating alopecia and acne
US9309235B2 (en) 2012-09-18 2016-04-12 Ironwood Pharmaceuticals, Inc. SGC stimulators
CA2885645A1 (en) 2012-09-19 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
US9968603B2 (en) 2013-03-14 2018-05-15 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
LT2970243T (lt) 2013-03-15 2020-03-10 Cyclerion Therapeutics, Inc. Sgc stimuliatoriai
EP4302736A3 (de) 2013-03-28 2024-04-03 ForSight Vision4, Inc. Ophthalmisches implantat zur abgabe von therapeutischen substanzen
US9687263B2 (en) 2013-05-30 2017-06-27 SinuSys Corporation Devices and methods for inserting a sinus dilator
JP6486359B2 (ja) * 2013-08-19 2019-03-20 タリス バイオメディカル エルエルシー 多ユニット薬物送達デバイス及び方法
US20160310408A1 (en) * 2013-12-06 2016-10-27 Durect Corporation Compositions Comprising Antioxidant, Fluid Dispensers, and Methods Involving the Same
EP3092231B1 (de) 2013-12-11 2018-06-27 Ironwood Pharmaceuticals, Inc. Sgc-stimulatoren
JP6655610B2 (ja) 2014-05-29 2020-02-26 グローコス コーポレーション 制御された薬物送達機能を備えるインプラント及びそれを使用する方法
KR102416726B1 (ko) 2014-07-15 2022-07-05 포사이트 비젼4, 인크. 안구 이식물 전달 디바이스 및 방법
JP2017524034A (ja) 2014-08-08 2017-08-24 フォーサイト・ビジョン フォー・インコーポレーテッドForsight Vision4, Inc. 受容体型チロシンキナーゼ阻害剤の安定で可溶な製剤およびその調製の方法
US20170291889A1 (en) 2014-09-17 2017-10-12 Ironwood Pharmaceuticals, Inc. Pyrazole derivatives as sgc stimulators
US10844064B2 (en) 2014-09-17 2020-11-24 Cyclerion Therapeutics, Inc. sGC stimulators
WO2016044445A2 (en) 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
AU2015346450B2 (en) 2014-11-10 2020-01-30 Forsight Vision4, Inc. Expandable drug delivery devices and method of use
ES2968262T3 (es) 2015-06-03 2024-05-08 I2O Therapeutics Inc Sistemas de colocación de implantes
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
CA3005238A1 (en) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Porous structures for extended release drug delivery devices
BR112018070383A2 (pt) 2016-04-05 2019-02-05 Forsight Vision4 Inc dispositivos para aplicação de fármaco oculares implantáveis
AU2017252294B2 (en) 2016-04-20 2021-12-02 Dose Medical Corporation Bioresorbable ocular drug delivery device
WO2017200943A1 (en) 2016-05-16 2017-11-23 Intarcia Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
JP7050759B2 (ja) 2016-09-02 2022-04-08 サイクレリオン・セラピューティクス,インコーポレーテッド 縮合二環式sgc刺激剤
US11690828B2 (en) 2016-11-08 2023-07-04 Cyclerion Therapeutics, Inc. Treatment of CNS diseases with sGC stimulators
EP3538520A2 (de) 2016-11-08 2019-09-18 Cyclerion Therapeutics, Inc. Sgc-stimulatoren
CN110225762A (zh) 2017-01-03 2019-09-10 因塔西亚制药公司 包括glp-1受体激动剂的连续施用和药物的共同施用的方法
CA3082891A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3760805A (en) * 1971-01-13 1973-09-25 Alza Corp Osmotic dispenser with collapsible supply container
US3995631A (en) * 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US4138013A (en) * 1976-08-27 1979-02-06 Parke, Davis & Company Enteric capsules
US4180073A (en) * 1977-08-29 1979-12-25 Alza Corporation Device for delivering drug to biological environment
US4203442A (en) * 1977-08-29 1980-05-20 Alza Corporation Device for delivering drug to a fluid environment
US4203440A (en) * 1978-10-23 1980-05-20 Alza Corporation Device having variable volume chamber for dispensing useful agent
US4203441A (en) * 1978-12-18 1980-05-20 Alza Corporation Osmotically triggered device with gas generating means
FR2524311A1 (fr) * 1982-04-05 1983-10-07 Azalbert Gilles Gelule compartimentee aux fins d'ingestions simultanees a effets differes
US4627850A (en) * 1983-11-02 1986-12-09 Alza Corporation Osmotic capsule
AU591171B2 (en) * 1983-11-02 1989-11-30 Alza Corporation Dispenser for delivering thermo-responsive composition
US4781714A (en) * 1983-11-02 1988-11-01 Alza Corporation Dispenser for delivering thermo-responsive composition
US4693886A (en) * 1985-04-22 1987-09-15 Alza Corporation Osmotic device with inert core
US4842867A (en) * 1986-05-09 1989-06-27 Alza Corporation Pulsed drug delivery of doxylamine
US4929233A (en) * 1988-08-26 1990-05-29 Alza Corporation Implantable fluid imbibing pump with improved closure

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JP2927956B2 (ja) 1999-07-28
JPH07502252A (ja) 1995-03-09
US5413572A (en) 1995-05-09
EP0523172B1 (de) 1995-01-04
KR0176724B1 (ko) 1999-03-20
ES2075444T3 (es) 1995-10-01
FI924419A (fi) 1992-10-01
DE69106501T2 (de) 1995-05-11
US5324280A (en) 1994-06-28
IE911040A1 (en) 1991-10-09
ZA912380B (en) 1992-01-29
AU7673791A (en) 1991-10-30
AU645315B2 (en) 1994-01-13
NO923756L (no) 1992-12-02
CA2039456A1 (en) 1991-10-03
PT97203A (pt) 1991-12-31
IE62394B1 (en) 1995-01-25
CA2039456C (en) 2003-11-11
EP0523172A1 (de) 1993-01-20
NZ237642A (en) 1993-07-27
PT97203B (pt) 1999-03-31
ATE116543T1 (de) 1995-01-15
DK0523172T3 (da) 1995-07-10
FI924419A0 (fi) 1992-10-01
WO1991015196A1 (en) 1991-10-17
NO923756D0 (no) 1992-09-28

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