DE69010745D1 - Verbindungen und Komplexe, besonders verwendbar für ärztliche Darstellung. - Google Patents
Verbindungen und Komplexe, besonders verwendbar für ärztliche Darstellung.Info
- Publication number
- DE69010745D1 DE69010745D1 DE69010745T DE69010745T DE69010745D1 DE 69010745 D1 DE69010745 D1 DE 69010745D1 DE 69010745 T DE69010745 T DE 69010745T DE 69010745 T DE69010745 T DE 69010745T DE 69010745 D1 DE69010745 D1 DE 69010745D1
- Authority
- DE
- Germany
- Prior art keywords
- image
- alkyl
- aryl
- represent
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 239000003446 ligand Substances 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 238000003384 imaging method Methods 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000004696 coordination complex Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 150000002739 metals Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052713 technetium Inorganic materials 0.000 abstract 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8905215A FR2646157B1 (fr) | 1989-04-19 | 1989-04-19 | Ligands et complexes utiles notamment en imagerie medicale |
| FR898915896A FR2655339B2 (fr) | 1989-04-19 | 1989-12-01 | Composes et complexes utiles notamment en imagerie medicale. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69010745D1 true DE69010745D1 (de) | 1994-08-25 |
| DE69010745T2 DE69010745T2 (de) | 1995-03-16 |
Family
ID=26227284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69010745T Expired - Fee Related DE69010745T2 (de) | 1989-04-19 | 1990-04-18 | Verbindungen und Komplexe, besonders verwendbar für ärztliche Darstellung. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5276147A (de) |
| EP (1) | EP0394126B1 (de) |
| JP (1) | JP3046037B2 (de) |
| AT (1) | ATE108773T1 (de) |
| CA (1) | CA2014786A1 (de) |
| DE (1) | DE69010745T2 (de) |
| ES (1) | ES2060093T3 (de) |
| FR (1) | FR2655339B2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994020148A1 (en) * | 1993-03-12 | 1994-09-15 | Mallinckrodt Medical, Inc. | Imidazole based nitrogen-sulfur ligands useful in radiographic imaging agents |
| DE69421173T2 (de) * | 1993-03-15 | 2000-01-20 | Mallinckrodt Inc | Neue stickstoff-schwefel-liganden auf der basis eines heterocyclus für die verwendung in werkstoffen für die radiographische bildgebung |
| US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| DE69526203T2 (de) * | 1994-01-12 | 2002-11-28 | Amersham Plc Little Chalfont | Biologische zielgerichtete mittel |
| JPH11511137A (ja) * | 1995-08-08 | 1999-09-28 | ファイブロゲン，インコーポレーテッド | コラーゲンの過剰生産に関係した疾患を治療するためのｃ−プロテイナーゼ阻害剤 |
| US6534037B1 (en) | 1998-01-21 | 2003-03-18 | Neorx Corporation | Non-steroidal compounds for steroid receptors and uses relating thereto |
| US6231832B1 (en) | 1998-03-23 | 2001-05-15 | Brookhaven Science Associates | Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use |
| CZ299375B6 (cs) | 1998-11-30 | 2008-07-09 | Nihon Nohyaku Co., Ltd. | Ftalamidové deriváty nebo jejich soli, zemedelsko-zahradnický insekticid je obsahující a jeho použití |
| CN1649628A (zh) * | 2002-02-26 | 2005-08-03 | 天藤制药株式会社 | 向脂质体中包封金属络合物的方法 |
| US20090209740A1 (en) * | 2006-03-24 | 2009-08-20 | Fujifilm Ri Pharma Co., Ltd | Composition for preparation of radioactive pharmaceutical for diagnosis of regional cerebral blood flow |
| US7947814B2 (en) * | 2006-04-25 | 2011-05-24 | Air Products And Chemicals, Inc. | Metal complexes of polydentate beta-ketoiminates |
| US9079923B2 (en) | 2010-08-05 | 2015-07-14 | Air Products And Chemicals, Inc. | Multidentate ketoimine ligands for metal complexes |
| US8617305B2 (en) | 2011-01-25 | 2013-12-31 | Air Products And Chemicals, Inc. | Metal complexes for metal-containing film deposition |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5791927A (en) * | 1980-11-27 | 1982-06-08 | Nippon Mejifuijitsukusu Kk | Technetium-99m labelled diagnosticum |
| US4615876A (en) * | 1983-04-25 | 1986-10-07 | Curators Of The University Of Missouri | Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides |
| US4638051A (en) * | 1984-04-30 | 1987-01-20 | The Johns Hopkins University | Brain imaging radiopharmaceuticals |
| US4963688A (en) * | 1984-07-19 | 1990-10-16 | University Of Florida | Compounds for site-enhanced delivery of radionuclides and uses thereof |
| GB8426845D0 (en) * | 1984-10-24 | 1984-11-28 | Amersham Int Plc | Complexes of technetium-99m |
| US4746505A (en) * | 1985-04-26 | 1988-05-24 | President And Fellows Of Harvard College | Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands |
| US4714605A (en) * | 1986-10-14 | 1987-12-22 | E. R. Squibb & Sons, Inc. | Technetium-99m labeled dioxime complexes |
| US5071636A (en) * | 1987-12-29 | 1991-12-10 | Nihon Medi-Physics Co., Ltd. | Chelating compounds and their use |
| US4895960A (en) * | 1989-01-23 | 1990-01-23 | University Of Cincinnati | Cyclo substituted propyleneamine oxime and its use as a brain imaging agent |
-
1989
- 1989-12-01 FR FR898915896A patent/FR2655339B2/fr not_active Expired - Lifetime
-
1990
- 1990-04-18 CA CA002014786A patent/CA2014786A1/fr not_active Abandoned
- 1990-04-18 ES ES90401046T patent/ES2060093T3/es not_active Expired - Lifetime
- 1990-04-18 DE DE69010745T patent/DE69010745T2/de not_active Expired - Fee Related
- 1990-04-18 EP EP90401046A patent/EP0394126B1/de not_active Expired - Lifetime
- 1990-04-18 AT AT90401046T patent/ATE108773T1/de active
- 1990-04-19 US US07/510,958 patent/US5276147A/en not_active Expired - Fee Related
- 1990-04-19 JP JP2104390A patent/JP3046037B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03163055A (ja) | 1991-07-15 |
| EP0394126A1 (de) | 1990-10-24 |
| FR2655339A2 (fr) | 1991-06-07 |
| JP3046037B2 (ja) | 2000-05-29 |
| ES2060093T3 (es) | 1994-11-16 |
| EP0394126B1 (de) | 1994-07-20 |
| FR2655339B2 (fr) | 1992-04-10 |
| CA2014786A1 (fr) | 1990-10-19 |
| ATE108773T1 (de) | 1994-08-15 |
| US5276147A (en) | 1994-01-04 |
| DE69010745T2 (de) | 1995-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: MDS NORDION INC., KANATA, ONTARIO, CA |
|
| 8339 | Ceased/non-payment of the annual fee |