DE69421173T2 - Neue stickstoff-schwefel-liganden auf der basis eines heterocyclus für die verwendung in werkstoffen für die radiographische bildgebung - Google Patents

Neue stickstoff-schwefel-liganden auf der basis eines heterocyclus für die verwendung in werkstoffen für die radiographische bildgebung

Info

Publication number
DE69421173T2
DE69421173T2 DE69421173T DE69421173T DE69421173T2 DE 69421173 T2 DE69421173 T2 DE 69421173T2 DE 69421173 T DE69421173 T DE 69421173T DE 69421173 T DE69421173 T DE 69421173T DE 69421173 T2 DE69421173 T2 DE 69421173T2
Authority
DE
Germany
Prior art keywords
heterocyclus
materials
radiographic imaging
ligands based
new nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69421173T
Other languages
English (en)
Other versions
DE69421173D1 (de
Inventor
Raghavan Rajagopalan
Ananthachari Srinivasan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of DE69421173D1 publication Critical patent/DE69421173D1/de
Application granted granted Critical
Publication of DE69421173T2 publication Critical patent/DE69421173T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69421173T 1993-03-15 1994-03-10 Neue stickstoff-schwefel-liganden auf der basis eines heterocyclus für die verwendung in werkstoffen für die radiographische bildgebung Expired - Fee Related DE69421173T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3176293A 1993-03-15 1993-03-15
PCT/US1994/002601 WO1994021304A1 (en) 1993-03-15 1994-03-10 Novel heterocycle based nitrogen-sulfur ligands useful in radiographic imaging agents

Publications (2)

Publication Number Publication Date
DE69421173D1 DE69421173D1 (de) 1999-11-18
DE69421173T2 true DE69421173T2 (de) 2000-01-20

Family

ID=21861262

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69421173T Expired - Fee Related DE69421173T2 (de) 1993-03-15 1994-03-10 Neue stickstoff-schwefel-liganden auf der basis eines heterocyclus für die verwendung in werkstoffen für die radiographische bildgebung

Country Status (6)

Country Link
US (1) US5633372A (de)
EP (1) EP0692977B1 (de)
JP (1) JPH08507787A (de)
AU (1) AU6402394A (de)
DE (1) DE69421173T2 (de)
WO (1) WO1994021304A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0008060A (pt) * 1999-12-08 2002-02-05 Pharmacia Corp Composições inibidoras de ciclooxigenase-2 tendo rápido inìcio de eficácia terapêutica

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB950666A (en) * 1960-09-23 1964-02-26 Geigy Ag J R Morpholinones and processes for their production
US3859337A (en) * 1969-06-11 1975-01-07 Stauffer Chemical Co Ethylenediaminetetraacetic acid anhydride derivatives
BE759052A (fr) * 1969-11-18 1971-05-17 May & Baker Ltd Derives d'hydrazinecarbodithioate d'alcoyle
US3758580A (en) * 1971-11-26 1973-09-11 Exxon Research Engineering Co Separation of tertiary chelating polyamines
US4263293A (en) * 1980-05-30 1981-04-21 E. R. Squibb & Sons, Inc. Heterocyclic containing amides as inhibitors of mammalian collagenase
US5071636A (en) * 1987-12-29 1991-12-10 Nihon Medi-Physics Co., Ltd. Chelating compounds and their use
US5011925A (en) * 1989-03-09 1991-04-30 Mallinckrodt, Inc. Morpholinoamido EDTA derivatives
US5376356A (en) * 1989-03-14 1994-12-27 Neorx Corporation Imaging tissue sites of inflammation
US5095111A (en) * 1989-03-17 1992-03-10 The John Hopkins University Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
FR2655339B2 (fr) * 1989-04-19 1992-04-10 Medgenix Group Sa Composes et complexes utiles notamment en imagerie medicale.
JPH04507401A (ja) * 1989-09-05 1992-12-24 マリンクロッド・インコーポレイテッド 新規磁気共鳴造影剤
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5217706A (en) * 1990-11-21 1993-06-08 Mallinckrodt Medical, Inc. Complexes and compositions for magnetic resonance imaging
US5330737A (en) * 1991-12-06 1994-07-19 Mallinckrodt Medical, Inc. Nitrogen-sulfur ligands as opiate receptor drug mimics
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds

Also Published As

Publication number Publication date
EP0692977A4 (de) 1996-04-10
DE69421173D1 (de) 1999-11-18
WO1994021304A1 (en) 1994-09-29
AU6402394A (en) 1994-10-11
EP0692977A1 (de) 1996-01-24
US5633372A (en) 1997-05-27
JPH08507787A (ja) 1996-08-20
EP0692977B1 (de) 1999-10-13

Similar Documents

Publication Publication Date Title
DE69516716D1 (de) Vorrichrung zum ersetzen eines gelenkbandes durch ein transplantat
DE69309064D1 (de) Filtervorrichtung für ein tracheostoma
DE69412268D1 (de) Filter zum filtrieren eines fluids
DE69201671D1 (de) Abdichtaufsätze für Filterelemente.
DE69515492D1 (de) Medium zum fördern einer flüssigkeit in z-richtung
DE69126327D1 (de) Elektrohydraulisches steuergerät für einen antriebsstrang eines fahrzeugs
DE69214942D1 (de) Verfahren für spezifische bindungsassays unter verwendung eines freisetzbaren liganden
DE69904999D1 (de) Belichtungsvorrichtung für ein Werkstück in Form eines Streifens
DE69310736D1 (de) Metallionenreduzierung in antireflexdeckschichten für photoresists
DE69132303T2 (de) Maske für Photolithographie
DE68909281D1 (de) Verstellbare Säule für ein Lastkraftfahrzeug mit verschiebbarer Abdeckung.
DE69125668D1 (de) Filter für computergestütztes Tomographiesystem
DE69112493D1 (de) Gerät zum Lesen eines Fluorenszenzmusters.
DE59105717D1 (de) Lagerung für einen Druckwerkzylinder.
DE69023443D1 (de) Einrichtung mit metallischer Dichtung zur Reparatur eines Futterrohres.
DE69112850D1 (de) Anlegekantensystem für ein Aufzeichnungsbogenkomposit.
DE69101357D1 (de) Verfahren für den Zusammenbau eines Autos.
DE69421173D1 (de) Neue stickstoff-schwefel-liganden auf der basis eines heterocyclus für die verwendung in werkstoffen für die radiographische bildgebung
DE3586509D1 (de) Verfahren zum laminieren eines films auf ein gewebe.
DE59105709D1 (de) Lagerung für einen Druckwerkzylinder.
DE3485339D1 (de) Verfahren zur messung eines biologischen ligands.
DE59103990D1 (de) Verfahren zum Betrieb eines Fahrzeugs.
DE59104498D1 (de) Filterplatte für eine plattenfilterpresse.
DE69423406D1 (de) Einrichtung für den Anschluss eines Schlittens
DE59106646D1 (de) Messverfahren für die Drehlage eines Gleichstrommotors.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee