DE69003168D1 - Isolierung und Strukturbestimmung des zytostatischen linearen depsipeptiden Dolastatin 13 und Dehydrodolastatin 13. - Google Patents

Isolierung und Strukturbestimmung des zytostatischen linearen depsipeptiden Dolastatin 13 und Dehydrodolastatin 13.

Info

Publication number
DE69003168D1
DE69003168D1 DE90304859T DE69003168T DE69003168D1 DE 69003168 D1 DE69003168 D1 DE 69003168D1 DE 90304859 T DE90304859 T DE 90304859T DE 69003168 T DE69003168 T DE 69003168T DE 69003168 D1 DE69003168 D1 DE 69003168D1
Authority
DE
Germany
Prior art keywords
dehydrodolastatin
dolastatin
depsipeptides
isolation
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90304859T
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English (en)
Other versions
DE69003168T2 (de
Inventor
Georges R Pettit
Yoshiaki Dr Kamano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arizona State University ASU
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Arizona State University ASU
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Filing date
Publication date
Application filed by Arizona State University ASU filed Critical Arizona State University ASU
Application granted granted Critical
Publication of DE69003168D1 publication Critical patent/DE69003168D1/de
Publication of DE69003168T2 publication Critical patent/DE69003168T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE90304859T 1989-05-18 1990-05-04 Isolierung und Strukturbestimmung des zytostatischen linearen depsipeptiden Dolastatin 13 und Dehydrodolastatin 13. Expired - Fee Related DE69003168T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/353,960 US4986988A (en) 1989-05-18 1989-05-18 Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13

Publications (2)

Publication Number Publication Date
DE69003168D1 true DE69003168D1 (de) 1993-10-14
DE69003168T2 DE69003168T2 (de) 1994-01-27

Family

ID=23391329

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90304859T Expired - Fee Related DE69003168T2 (de) 1989-05-18 1990-05-04 Isolierung und Strukturbestimmung des zytostatischen linearen depsipeptiden Dolastatin 13 und Dehydrodolastatin 13.

Country Status (8)

Country Link
US (1) US4986988A (de)
EP (1) EP0399685B1 (de)
JP (1) JPH02311423A (de)
AT (1) ATE94170T1 (de)
CA (1) CA2013766A1 (de)
DE (1) DE69003168T2 (de)
DK (1) DK0399685T3 (de)
ES (1) ES2060035T3 (de)

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JPH02311423A (ja) 1990-12-27
US4986988A (en) 1991-01-22
EP0399685A1 (de) 1990-11-28
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DK0399685T3 (da) 1993-10-25
CA2013766A1 (en) 1990-11-18

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