ATE94170T1 - Isolierung und strukturbestimmung des zytostatischen linearen depsipeptiden dolastatin 13 und dehydrodolastatin 13. - Google Patents

Isolierung und strukturbestimmung des zytostatischen linearen depsipeptiden dolastatin 13 und dehydrodolastatin 13.

Info

Publication number
ATE94170T1
ATE94170T1 AT90304859T AT90304859T ATE94170T1 AT E94170 T1 ATE94170 T1 AT E94170T1 AT 90304859 T AT90304859 T AT 90304859T AT 90304859 T AT90304859 T AT 90304859T AT E94170 T1 ATE94170 T1 AT E94170T1
Authority
AT
Austria
Prior art keywords
dehydrodolastatin
dolastatin
depsipeptides
depsipeptids
isolation
Prior art date
Application number
AT90304859T
Other languages
English (en)
Inventor
Georges R Pettit
Yoshiaki Dr Kamano
Original Assignee
Univ Arizona State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Arizona State filed Critical Univ Arizona State
Application granted granted Critical
Publication of ATE94170T1 publication Critical patent/ATE94170T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K11/00Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT90304859T 1989-05-18 1990-05-04 Isolierung und strukturbestimmung des zytostatischen linearen depsipeptiden dolastatin 13 und dehydrodolastatin 13. ATE94170T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/353,960 US4986988A (en) 1989-05-18 1989-05-18 Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13

Publications (1)

Publication Number Publication Date
ATE94170T1 true ATE94170T1 (de) 1993-09-15

Family

ID=23391329

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90304859T ATE94170T1 (de) 1989-05-18 1990-05-04 Isolierung und strukturbestimmung des zytostatischen linearen depsipeptiden dolastatin 13 und dehydrodolastatin 13.

Country Status (8)

Country Link
US (1) US4986988A (de)
EP (1) EP0399685B1 (de)
JP (1) JPH02311423A (de)
AT (1) ATE94170T1 (de)
CA (1) CA2013766A1 (de)
DE (1) DE69003168T2 (de)
DK (1) DK0399685T3 (de)
ES (1) ES2060035T3 (de)

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EP0399685A1 (de) 1990-11-28
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ES2060035T3 (es) 1994-11-16
DK0399685T3 (da) 1993-10-25
US4986988A (en) 1991-01-22
DE69003168D1 (de) 1993-10-14
EP0399685B1 (de) 1993-09-08
JPH02311423A (ja) 1990-12-27

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