DE68928042T2 - Verwendung von Peptidase-Hemmer zur Herstellung von Medikamenten für die Behandlung von Schlaganfällen - Google Patents
Verwendung von Peptidase-Hemmer zur Herstellung von Medikamenten für die Behandlung von SchlaganfällenInfo
- Publication number
- DE68928042T2 DE68928042T2 DE68928042T DE68928042T DE68928042T2 DE 68928042 T2 DE68928042 T2 DE 68928042T2 DE 68928042 T DE68928042 T DE 68928042T DE 68928042 T DE68928042 T DE 68928042T DE 68928042 T2 DE68928042 T2 DE 68928042T2
- Authority
- DE
- Germany
- Prior art keywords
- alpha
- amino acid
- group
- peptidase
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25476288A | 1988-10-07 | 1988-10-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68928042D1 DE68928042D1 (de) | 1997-06-19 |
DE68928042T2 true DE68928042T2 (de) | 1997-08-28 |
Family
ID=22965502
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68928662T Expired - Fee Related DE68928662T2 (de) | 1988-10-07 | 1989-10-06 | Peptidase-Hemmer |
DE68928042T Expired - Fee Related DE68928042T2 (de) | 1988-10-07 | 1989-10-06 | Verwendung von Peptidase-Hemmer zur Herstellung von Medikamenten für die Behandlung von Schlaganfällen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68928662T Expired - Fee Related DE68928662T2 (de) | 1988-10-07 | 1989-10-06 | Peptidase-Hemmer |
Country Status (18)
Country | Link |
---|---|
EP (2) | EP0363284B1 (de) |
JP (2) | JPH02134398A (de) |
KR (2) | KR900006362A (de) |
CN (2) | CN1041951A (de) |
AT (2) | ATE153029T1 (de) |
AU (1) | AU617875B2 (de) |
CA (2) | CA2000340A1 (de) |
DE (2) | DE68928662T2 (de) |
DK (2) | DK494689A (de) |
ES (2) | ES2118710T3 (de) |
FI (2) | FI894748A (de) |
GR (1) | GR3024158T3 (de) |
HU (2) | HUT54105A (de) |
IL (2) | IL91896A0 (de) |
NO (2) | NO894013L (de) |
NZ (2) | NZ230893A (de) |
PT (2) | PT91926B (de) |
ZA (2) | ZA897514B (de) |
Families Citing this family (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5510531A (en) * | 1989-04-10 | 1996-04-23 | Suntory Limited | Proteinase inhibitor |
US5162500A (en) * | 1989-04-15 | 1992-11-10 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Poststatin and related compounds or salts thereof |
HUT62312A (en) * | 1990-03-05 | 1993-04-28 | Cephalon Inc | Process for producing chymotrypsin-like proteases and their inhibitors |
GB9019558D0 (en) * | 1990-09-07 | 1990-10-24 | Szelke Michael | Enzyme inhibitors |
WO1992012140A1 (en) * | 1990-12-28 | 1992-07-23 | Georgia Tech Research Corporation | Peptides ketoamides, ketoacids, and ketoesters |
US5444042A (en) * | 1990-12-28 | 1995-08-22 | Cortex Pharmaceuticals | Method of treatment of neurodegeneration with calpain inhibitors |
HU217612B (hu) * | 1991-05-23 | 2000-03-28 | Merrel Dow Pharmaceuticals Inc. | Eljárás elasztáz és katepszin G inhibitor hatású peptidek előállítására |
CA2071621C (en) * | 1991-06-19 | 1996-08-06 | Ahihiko Hosoda | Aldehyde derivatives |
US5650508A (en) * | 1991-12-27 | 1997-07-22 | Georgia Tech Research Corporation | Peptide ketoamides |
US6235929B1 (en) | 1991-12-27 | 2001-05-22 | Georgia Tech Research Corporation | Tripeptide α-ketoamides |
US5514694A (en) * | 1992-09-21 | 1996-05-07 | Georgia Tech Research Corp | Peptidyl ketoamides |
DE69414279T2 (de) * | 1993-02-09 | 1999-04-08 | Bayer Ag | Sulfonamidaminomethylenderivate als Immunsuppressiva |
US5672582A (en) * | 1993-04-30 | 1997-09-30 | Merck & Co., Inc. | Thrombin inhibitors |
US6984627B1 (en) | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US5783563A (en) * | 1993-06-03 | 1998-07-21 | Astra Aktiebolag | Method for treatment or prophylaxis of venous thrombosis |
US5541290A (en) * | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
EP0639585A1 (de) * | 1993-08-20 | 1995-02-22 | Banyu Pharmaceutical Co., Ltd. | Elastase Hemmer |
US5977074A (en) * | 1993-10-01 | 1999-11-02 | Merrell Pharmaceuticals, Inc. | Inhibitors of β-amyloid protein production |
IT1270882B (it) * | 1993-10-05 | 1997-05-13 | Isagro Srl | Oligopeptidi ad attivita' fungicida |
US6060462A (en) * | 1993-10-20 | 2000-05-09 | Dupont Pharmaceuticals Company | Electrophilic peptide analogs as inhibitors of trypsin-like enzymes |
US5486623A (en) | 1993-12-08 | 1996-01-23 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
US5693617A (en) * | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
US6660268B1 (en) | 1994-03-18 | 2003-12-09 | The President And Fellows Of Harvard College | Proteasome regulation of NF-KB activity |
DE4421052A1 (de) | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
DE4421884A1 (de) | 1994-06-23 | 1996-01-04 | Hoechst Ag | Verfahren zur Herstellung von Hydroxycarbonsäureaniliden |
US5510369A (en) * | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
DE4427837A1 (de) | 1994-08-05 | 1996-02-08 | Hoechst Ag | Verfahren zur Herstellung von O-Acylglykolsäureaniliden |
US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
SE9404196D0 (sv) * | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
US5872101A (en) * | 1995-01-06 | 1999-02-16 | Sibia Neurosciences, Inc. | Methods of treating neurodegenerative disorders using protease inhibitors |
US5691368A (en) * | 1995-01-11 | 1997-11-25 | Hoechst Marion Roussel, Inc. | Substituted oxazolidine calpain and/or cathepsin B inhibitors |
US5656261A (en) | 1995-01-18 | 1997-08-12 | The Picower Institute For Medical Research | Preventing and reversing advanced glycosylation endproducts |
NO315930B1 (no) * | 1995-01-18 | 2003-11-17 | Picower Inst For Medical Res T | Anvendelse av tiazoliumforbindelser ved fremstilling av farmasöytiske preparater, preparater som inneholder forbindelsene, samt nyetiazoliumforbindelser |
EP0808163B1 (de) * | 1995-01-18 | 2003-07-23 | Alteon, Inc. | Verwendung von thiazoliumverbindungen zum verhindern und umkehren der bildung von endprodukten der fortgeschrittenen glykosylierung |
DE19504225A1 (de) | 1995-02-09 | 1996-08-14 | Hoechst Ag | Verfahren zur Herstellung von O-Acyloxycarbonsäureaniliden |
TR199700803T1 (xx) * | 1995-02-17 | 1998-02-21 | Basf Aktiengesellschaft | Trombin-inhibit�rleri olarak yeni dipeptidik amidinler. |
US5629324A (en) * | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
US5721214A (en) * | 1995-06-07 | 1998-02-24 | Cor Therapeutics, Inc. | Inhibitors of factor Xa |
US6022861A (en) * | 1995-06-07 | 2000-02-08 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
US6046169A (en) * | 1995-06-07 | 2000-04-04 | Cor Therapeutics, Inc. | Inhibitors of factor XA |
US5919765A (en) * | 1995-06-07 | 1999-07-06 | Cor Therapeutics, Inc. | Inhibitors of factor XA |
US6211154B1 (en) | 1995-06-07 | 2001-04-03 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
US6069130A (en) | 1995-06-07 | 2000-05-30 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
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US5723580A (en) * | 1995-09-14 | 1998-03-03 | Cephalon, Inc. | Ketomethylene group-containing aldehyde cysteine and serine protease inhibitors |
US5827877A (en) * | 1995-09-14 | 1998-10-27 | Cephalon, Inc. | Ketomethylene group-containing cysteine and serine protease inhibitors |
US5763576A (en) * | 1995-10-06 | 1998-06-09 | Georgia Tech Research Corp. | Tetrapeptide α-ketoamides |
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SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
US5792761A (en) * | 1996-08-12 | 1998-08-11 | Merck & Co., Inc. | Thrombin inhibitors |
BR9712000A (pt) * | 1996-09-06 | 1999-08-24 | Nippon Kayaku Kk | Derivados de acetamida sais dos mesmos composi-Æo farmac-utica inibidores de protease de quimase de desgranula-Æo de mastÄcitos ou de libera-Æo de histamina de mastÄcitos e de ativa-Æo de eosinÄfilo ou de libera-Æo de oxig-nio ativo de eosinÄfilo e processo para produzir os dervados de acetamida |
ZA979327B (en) * | 1996-10-18 | 1998-05-11 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease. |
SI0932617T1 (en) * | 1996-10-18 | 2002-06-30 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
US5798377A (en) * | 1996-10-21 | 1998-08-25 | Merck & Co., Inc. | Thrombin inhibitors |
DE19648793A1 (de) | 1996-11-26 | 1998-05-28 | Basf Ag | Neue Benzamide und deren Anwendung |
WO1998038990A1 (en) * | 1997-03-07 | 1998-09-11 | Hoechst Marion Roussel, Inc. | Method of treating trauma associated with brain, spinal cord or peripheral nerve injury using carbobenzyloxy n-protected di- and tripeptide phenylalaninals |
AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
DE69836346T2 (de) | 1997-11-26 | 2007-05-24 | Ortho-Mcneil Pharmaceutical, Inc. | Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmer |
US6204384B1 (en) | 1997-11-26 | 2001-03-20 | Corvas International, Inc. | Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (II) |
US6011047A (en) * | 1997-11-26 | 2000-01-04 | Corvas International Inc. | Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors |
SE9704543D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
HUP0100082A3 (en) | 1998-01-26 | 2001-12-28 | Abbott Gmbh & Co Kg | Thrombin inhibitor, peptide derivatives, pharmaceutical compositions comprising thereof and their use |
WO1999038501A2 (en) | 1998-02-02 | 1999-08-05 | Trustees Of Tufts College | Method of regulating glucose metabolism, and reagents related thereto |
BR9911100A (pt) | 1998-06-11 | 2001-02-13 | Dimensional Pharm Inc | Inibidores de pirazinona protease |
SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
TR200102037T2 (tr) | 1999-01-13 | 2001-10-22 | Astrazeneca Ab | Yeni amidinobenzilamin türevleri ve trombin engelleyiciler olarak kullanılmaları. |
AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
MXPA01011956A (es) | 1999-05-27 | 2002-06-21 | Dimensional Pharm Inc | Oxazaheterociclos como inhibidores de proteasas. |
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US6630510B1 (en) * | 1999-10-28 | 2003-10-07 | Merck & Co., Inc. | Substituted succinic acid metallo-β-lactamase inhibitors and their use in treating bacterial infections |
KR20020067937A (ko) * | 2000-01-26 | 2002-08-24 | 오노 야꾸힝 고교 가부시키가이샤 | 벤젠 축합 헤테로환 유도체 및 그 유도체를 유효성분으로서 함유하는 약제 |
SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
WO2001092234A1 (en) | 2000-06-01 | 2001-12-06 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
WO2002006248A2 (en) | 2000-07-17 | 2002-01-24 | 3-Dimensional Pharmaceuticals, Inc. | Cyclic oxyguanidine pyrazinones as protease inhibitors |
AU8063701A (en) * | 2000-07-21 | 2002-02-05 | Schering Corp | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus |
US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
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-
1989
- 1989-10-03 ZA ZA897514A patent/ZA897514B/xx unknown
- 1989-10-03 ZA ZA897515A patent/ZA897515B/xx unknown
- 1989-10-04 NZ NZ230893A patent/NZ230893A/en unknown
- 1989-10-04 AU AU42491/89A patent/AU617875B2/en not_active Ceased
- 1989-10-05 IL IL91896A patent/IL91896A0/xx unknown
- 1989-10-05 IL IL91895A patent/IL91895A0/xx unknown
- 1989-10-05 NZ NZ230916A patent/NZ230916A/en unknown
- 1989-10-06 KR KR1019890014374A patent/KR900006362A/ko not_active Application Discontinuation
- 1989-10-06 AT AT89402762T patent/ATE153029T1/de not_active IP Right Cessation
- 1989-10-06 KR KR1019890014375A patent/KR900006363A/ko not_active Application Discontinuation
- 1989-10-06 PT PT91926A patent/PT91926B/pt not_active IP Right Cessation
- 1989-10-06 JP JP1260361A patent/JPH02134398A/ja active Pending
- 1989-10-06 FI FI894748A patent/FI894748A/fi not_active IP Right Cessation
- 1989-10-06 ES ES89402763T patent/ES2118710T3/es not_active Expired - Lifetime
- 1989-10-06 HU HU895247A patent/HUT54105A/hu unknown
- 1989-10-06 NO NO89894013A patent/NO894013L/no unknown
- 1989-10-06 PT PT91927A patent/PT91927B/pt not_active IP Right Cessation
- 1989-10-06 ES ES89402762T patent/ES2103709T3/es not_active Expired - Lifetime
- 1989-10-06 JP JP26036089A patent/JP3203579B2/ja not_active Expired - Fee Related
- 1989-10-06 DE DE68928662T patent/DE68928662T2/de not_active Expired - Fee Related
- 1989-10-06 NO NO89894014A patent/NO894014L/no unknown
- 1989-10-06 DK DK494689A patent/DK494689A/da not_active Application Discontinuation
- 1989-10-06 AT AT89402763T patent/ATE165835T1/de not_active IP Right Cessation
- 1989-10-06 FI FI894747A patent/FI894747A/fi not_active IP Right Cessation
- 1989-10-06 DE DE68928042T patent/DE68928042T2/de not_active Expired - Fee Related
- 1989-10-06 EP EP89402762A patent/EP0363284B1/de not_active Expired - Lifetime
- 1989-10-06 EP EP89402763A patent/EP0364344B1/de not_active Expired - Lifetime
- 1989-10-06 HU HU895246A patent/HU895246D0/hu unknown
- 1989-10-06 DK DK494789A patent/DK494789A/da not_active Application Discontinuation
- 1989-10-07 CN CN89107700A patent/CN1041951A/zh active Pending
- 1989-10-07 CN CN89107699A patent/CN1041950A/zh active Pending
- 1989-10-10 CA CA002000340A patent/CA2000340A1/en not_active Abandoned
- 1989-10-10 CA CA002000342A patent/CA2000342C/en not_active Expired - Fee Related
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1997
- 1997-07-18 GR GR970401803T patent/GR3024158T3/el unknown
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