DE68926882D1 - Plasmidvektor mit pectatlyase-signalsequenz - Google Patents
Plasmidvektor mit pectatlyase-signalsequenzInfo
- Publication number
- DE68926882D1 DE68926882D1 DE68926882T DE68926882T DE68926882D1 DE 68926882 D1 DE68926882 D1 DE 68926882D1 DE 68926882 T DE68926882 T DE 68926882T DE 68926882 T DE68926882 T DE 68926882T DE 68926882 D1 DE68926882 D1 DE 68926882D1
- Authority
- DE
- Germany
- Prior art keywords
- pectatlyase
- signal sequence
- plasmid vector
- vector
- thaumatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C07K14/43—Sweetening agents, e.g. thaumatin, monellin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14203988A | 1988-01-11 | 1988-01-11 | |
| PCT/US1989/000077 WO1989006283A1 (en) | 1988-01-11 | 1989-01-09 | Novel plasmid vector with pectate lyase signal sequence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68926882D1 true DE68926882D1 (de) | 1996-08-29 |
| DE68926882T2 DE68926882T2 (de) | 1997-02-13 |
Family
ID=22498331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68926882T Expired - Lifetime DE68926882T2 (de) | 1988-01-11 | 1989-01-09 | Plasmidvektor mit pectatlyase-signalsequenz |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0396612B1 (de) |
| JP (1) | JP2980626B2 (de) |
| AT (1) | ATE140731T1 (de) |
| CA (1) | CA1338807C (de) |
| DE (1) | DE68926882T2 (de) |
| WO (1) | WO1989006283A1 (de) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5576195A (en) * | 1985-11-01 | 1996-11-19 | Xoma Corporation | Vectors with pectate lyase signal sequence |
| US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| CA1341235C (en) * | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
| ES2080689B1 (es) * | 1994-04-21 | 1996-09-01 | Urquima Sa | Procedimiento de obtencion de un edulcorante natural proteico. |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| EP1048732A1 (de) | 1999-04-26 | 2000-11-02 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von natürlich gefalteten und sekretierten Proteinen |
| EP1077263A1 (de) * | 1999-07-29 | 2001-02-21 | F.Hoffmann-La Roche Ag | Verfahren zur Herstellung von natürlich gefalteten und sekretierten Proteinen durch Co-Sekretion von Chaperonen |
| JP2003524018A (ja) | 2000-02-24 | 2003-08-12 | アイトゲネーシシェ テクニシェ ホッホシューレ チューリッヒ | フィブロネクチンのｅｄ‐ｂドメインに特異的な抗体、前記抗体を含む複合体、および血管形成を検出および治療するためのその使用 |
| US6902734B2 (en) | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
| UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
| US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
| US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
| EP1824980B1 (de) * | 2004-12-07 | 2010-04-28 | Lonza Ag | Rhamnosepromotor-expressionssystem |
| DE102006044841A1 (de) | 2006-09-22 | 2008-04-03 | Wacker Chemie Ag | Signalpeptid zur Produktion von rekombinanten Proteinen |
| KR20110031343A (ko) | 2008-06-20 | 2011-03-25 | 와이어쓰 엘엘씨 | 베타-용혈성 스트렙토코커스 균주로부터 유래된 ｏｒｆ1358을 사용하는 조성물 및 방법 |
| MX2011001409A (es) | 2008-08-14 | 2011-03-29 | Cephalon Australia Pty Ltd | Anticuerpos anti-il-12/il-23. |
| US8921281B2 (en) | 2009-05-20 | 2014-12-30 | Novimmune S.A. | Synthetic polypeptide libraries and methods for generating naturally diversified polypeptide variants |
| MX369173B (es) | 2013-12-24 | 2019-10-30 | Janssen Pharmaceutica Nv | Anticuerpos y fragmentos anti-vista. |
| BR112017027870A2 (pt) | 2015-06-24 | 2018-08-28 | Janssen Pharmaceutica Nv | anticorpos e fragmentos anti-vista |
| BR112018016461A2 (pt) | 2016-02-12 | 2019-10-01 | Janssen Pharmaceutica Nv | anticorpos e fragmentos anti-vista, usos dos mesmos e métodos de identificação dos mesmos |
| US10765724B2 (en) | 2016-03-29 | 2020-09-08 | Janssen Biotech, Inc. | Method of treating psoriasis with increased interval dosing of anti-IL12/23 antibody |
| WO2017175058A1 (en) | 2016-04-07 | 2017-10-12 | Janssen Pharmaceutica Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| AU2017336799B2 (en) | 2016-09-30 | 2023-08-31 | Janssen Biotech, Inc. | Safe and effective method of treating psoriasis with anti-IL23 specific antibody |
| MX2019005661A (es) | 2016-11-16 | 2019-10-07 | Janssen Biotech Inc | Método para tratar la psoriasis con el anticuerpo específico anti-il23. |
| EP3573658A4 (de) | 2017-01-30 | 2021-07-21 | Janssen Biotech, Inc. | Anti-tnf-antikörper, zusammensetzungen und verfahren zur behandlung von aktiver psoriatischer arthritis |
| JP2020506947A (ja) | 2017-02-07 | 2020-03-05 | ヤンセン バイオテツク，インコーポレーテツド | 活動性強直性脊椎炎を治療するための抗ｔｎｆ抗体、組成物、及び方法 |
| TW201922780A (zh) | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | 以抗ｉｌ１２／ｉｌ２３抗體治療狼瘡之安全且有效之方法 |
| WO2019150309A1 (en) | 2018-02-02 | 2019-08-08 | Hammack Scott | Modulators of gpr68 and uses thereof for treating and preventing diseases |
| WO2019171252A1 (en) | 2018-03-05 | 2019-09-12 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
| JP2021530697A (ja) | 2018-07-18 | 2021-11-11 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｉｌ２３特異的抗体で治療した後の持続応答予測因子 |
| CA3113837C (en) | 2018-09-24 | 2022-07-12 | Janssen Biotech, Inc. | Safe and effective method of treating ulcerative colitis with anti-il12/il23 antibody |
| EP3883607A4 (de) | 2018-11-20 | 2022-08-17 | Janssen Biotech, Inc. | Sicheres und effizientes verfahren zur behandlung von psoriasis mit anti-il-23-spezifischem antikörper |
| MA54562A (fr) | 2018-12-18 | 2021-10-27 | Janssen Biotech Inc | Méthode sûre et efficace de traitement du lupus avec un anticorps anti-il12/il23 |
| WO2020148651A1 (en) | 2019-01-15 | 2020-07-23 | Janssen Biotech, Inc. | Anti-tnf antibody compositions and methods for the treatment of juvenile idiopathic arthritis |
| US20220064278A1 (en) | 2019-01-23 | 2022-03-03 | Janssen Biotech, Inc. | Anti-TNF Antibody Compositions for Use in Methods for the Treatment of Psoriatic Arthritis |
| MA55282A (fr) | 2019-03-14 | 2022-01-19 | Janssen Biotech Inc | Procédés de fabrication pour la production de compositions d'anticorps anti-tnf |
| EA202192508A1 (ru) | 2019-03-14 | 2022-03-29 | Янссен Байотек, Инк. | Способы получения композиций антитела к фно |
| KR20210141990A (ko) | 2019-03-14 | 2021-11-23 | 얀센 바이오테크 인코포레이티드 | 항-il12/il23 항체 조성물을 생성하기 위한 제조 방법 |
| EP3938391A1 (de) | 2019-03-14 | 2022-01-19 | Janssen Biotech, Inc. | Verfahren zur herstellung von anti-tnf-antikörperzusammensetzungen |
| MA55383A (fr) | 2019-03-18 | 2022-01-26 | Janssen Biotech Inc | Méthode de traitement du psoriasis chez des sujets pédiatriques avec un anticorps anti-il12/il23 |
| CN113874073A (zh) | 2019-05-23 | 2021-12-31 | 詹森生物科技公司 | 用针对IL-23和TNFα的抗体的联合疗法治疗炎性肠病的方法 |
| EP3976648A1 (de) | 2019-06-03 | 2022-04-06 | Janssen Biotech, Inc. | Anti-tnf-antikörperzusammensetzungen und verfahren zur behandlung von aktiver psoriasis-arthritis |
| JP2022535534A (ja) | 2019-06-03 | 2022-08-09 | ヤンセン バイオテツク，インコーポレーテツド | 活動性強直性脊椎炎を治療するための抗ｔｎｆ抗体、組成物、及び方法 |
| WO2021028752A1 (en) | 2019-08-15 | 2021-02-18 | Janssen Biotech, Inc. | Anti-tfn antibodies for treating type i diabetes |
| CA3212729A1 (en) | 2021-03-12 | 2022-09-15 | Janssen Biotech, Inc. | Safe and effective method of treating psoriatic arthritis with anti-il23 specific antibody |
| JP2024510588A (ja) | 2021-03-12 | 2024-03-08 | ヤンセン バイオテツク，インコーポレーテツド | 抗ｉｌ２３特異的抗体による、ｔｎｆ療法に対する不十分な応答を有する乾癬性関節炎患者を治療する方法 |
| IL309987A (en) | 2021-07-09 | 2024-03-01 | Janssen Biotech Inc | Production methods for the production of anti-IL12/IL23 antibody compositions |
| EP4367137A1 (de) | 2021-07-09 | 2024-05-15 | Janssen Biotech, Inc. | Herstellungsverfahren zur herstellung von anti-tnf-antikörperzusammensetzungen |
| KR20240034218A (ko) | 2021-07-09 | 2024-03-13 | 얀센 바이오테크 인코포레이티드 | 항-tnf 항체 조성물을 생산하기 위한 제조 방법 |
| IL312401A (en) | 2021-10-29 | 2024-06-01 | Janssen Biotech Inc | Methods for treating Crohn's disease with a specific anti-IL23 antibody |
| CA3238377A1 (en) | 2021-11-15 | 2023-05-19 | Janssen Biotech, Inc. | Methods of treating crohn's disease with anti-il23 specific antibody |
| CA3239216A1 (en) | 2021-11-23 | 2023-06-01 | Janssen Biotech, Inc. | Method of treating ulcerative colitis with anti-il23 specific antibody |
| US20230312703A1 (en) | 2022-03-30 | 2023-10-05 | Janssen Biotech, Inc. | Method of Treating Psoriasis with IL-23 Specific Antibody |
| WO2023223265A1 (en) | 2022-05-18 | 2023-11-23 | Janssen Biotech, Inc. | Method for evaluating and treating psoriatic arthritis with il23 antibody |
| US20240199734A1 (en) | 2022-11-22 | 2024-06-20 | Janssen Biotech, Inc. | Method of Treating Ulcerative Colitis with Anti-IL23 Specific Antibody |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6030687A (ja) * | 1983-08-01 | 1985-02-16 | Wakunaga Seiyaku Kk | Ｄνａ遺伝子，その製造法およびそれを含むプラスミド |
| JPS6368087A (ja) * | 1986-09-09 | 1988-03-26 | Oji Paper Co Ltd | 蛋白質の発現と分泌に関与する領域を含むｄｎａ |
| GB8702475D0 (en) * | 1987-02-04 | 1987-03-11 | Ciba Geigy Ag | Expression system |
| CA1341235C (en) * | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
-
1989
- 1989-01-09 DE DE68926882T patent/DE68926882T2/de not_active Expired - Lifetime
- 1989-01-09 AT AT89901763T patent/ATE140731T1/de not_active IP Right Cessation
- 1989-01-09 EP EP89901763A patent/EP0396612B1/de not_active Expired - Lifetime
- 1989-01-09 WO PCT/US1989/000077 patent/WO1989006283A1/en active IP Right Grant
- 1989-01-09 JP JP1501661A patent/JP2980626B2/ja not_active Expired - Lifetime
- 1989-01-10 CA CA000587885A patent/CA1338807C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE140731T1 (de) | 1996-08-15 |
| JP2980626B2 (ja) | 1999-11-22 |
| EP0396612A1 (de) | 1990-11-14 |
| CA1338807C (en) | 1996-12-24 |
| JPH04503151A (ja) | 1992-06-11 |
| WO1989006283A1 (en) | 1989-07-13 |
| EP0396612A4 (en) | 1991-10-02 |
| DE68926882T2 (de) | 1997-02-13 |
| EP0396612B1 (de) | 1996-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: GROSSE, BOCKHORNI, SCHUMACHER, 81476 MUENCHEN |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: GROSSE, SCHUMACHER, KNAUER, VON HIRSCHHAUSEN, 8033 |