DE68921473T2 - Geschichtete zusammensetzung für die transdermale verabreichung von fentanyl. - Google Patents
Geschichtete zusammensetzung für die transdermale verabreichung von fentanyl.Info
- Publication number
- DE68921473T2 DE68921473T2 DE68921473T DE68921473T DE68921473T2 DE 68921473 T2 DE68921473 T2 DE 68921473T2 DE 68921473 T DE68921473 T DE 68921473T DE 68921473 T DE68921473 T DE 68921473T DE 68921473 T2 DE68921473 T2 DE 68921473T2
- Authority
- DE
- Germany
- Prior art keywords
- fentanyl
- layer
- composite material
- reservoir
- laminated composite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 14
- 229960002428 fentanyl Drugs 0.000 title claims description 76
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 title claims 12
- 239000002131 composite material Substances 0.000 claims abstract description 40
- BHIZVZJETFVJMJ-UHFFFAOYSA-N 2-hydroxypropyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(C)O BHIZVZJETFVJMJ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229940026235 propylene glycol monolaurate Drugs 0.000 claims abstract description 18
- 239000010410 layer Substances 0.000 claims description 69
- -1 polydimethylsiloxane Polymers 0.000 claims description 8
- 150000001412 amines Chemical class 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- 230000004907 flux Effects 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 5
- 239000012790 adhesive layer Substances 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000004753 textile Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 13
- 239000003814 drug Substances 0.000 abstract description 13
- 239000004820 Pressure-sensitive adhesive Substances 0.000 abstract description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract description 6
- 241000761557 Lamina Species 0.000 abstract 1
- 229920001971 elastomer Polymers 0.000 abstract 1
- 239000000806 elastomer Substances 0.000 abstract 1
- 229920001600 hydrophobic polymer Polymers 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 description 67
- 230000001070 adhesive effect Effects 0.000 description 7
- 239000000853 adhesive Substances 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- 230000000202 analgesic effect Effects 0.000 description 5
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 4
- 229920000728 polyester Polymers 0.000 description 4
- 229920006267 polyester film Polymers 0.000 description 4
- 229920002545 silicone oil Polymers 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000036470 plasma concentration Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- BOSAWIQFTJIYIS-UHFFFAOYSA-N 1,1,1-trichloro-2,2,2-trifluoroethane Chemical compound FC(F)(F)C(Cl)(Cl)Cl BOSAWIQFTJIYIS-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000036765 blood level Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- UQDUPQYQJKYHQI-UHFFFAOYSA-N methyl laurate Chemical compound CCCCCCCCCCCC(=O)OC UQDUPQYQJKYHQI-UHFFFAOYSA-N 0.000 description 2
- 229960005181 morphine Drugs 0.000 description 2
- 229940005483 opioid analgesics Drugs 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 206010058019 Cancer Pain Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010038678 Respiratory depression Diseases 0.000 description 1
- 239000002998 adhesive polymer Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000009513 drug distribution Methods 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960004207 fentanyl citrate Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229940127240 opiate Drugs 0.000 description 1
- 229940124636 opioid drug Drugs 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/179,423 US4906463A (en) | 1986-12-22 | 1988-04-08 | Transdermal drug-delivery composition |
| US21137788A | 1988-06-24 | 1988-06-24 | |
| PCT/US1989/001376 WO1989010108A1 (en) | 1988-04-08 | 1989-04-03 | Laminated composite for transdermal administration of fentanyl |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68921473D1 DE68921473D1 (de) | 1995-04-06 |
| DE68921473T2 true DE68921473T2 (de) | 1995-06-22 |
Family
ID=26875305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68921473T Expired - Lifetime DE68921473T2 (de) | 1988-04-08 | 1989-04-03 | Geschichtete zusammensetzung für die transdermale verabreichung von fentanyl. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4906463A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0409910B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH03504977A (cg-RX-API-DMAC7.html) |
| KR (1) | KR950001968B1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE119019T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU633500B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1325381C (cg-RX-API-DMAC7.html) |
| DE (1) | DE68921473T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK175375B1 (cg-RX-API-DMAC7.html) |
| FI (1) | FI904943A0 (cg-RX-API-DMAC7.html) |
| IE (1) | IE891070L (cg-RX-API-DMAC7.html) |
| NO (1) | NO306444B1 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ228637A (cg-RX-API-DMAC7.html) |
| PT (1) | PT90240B (cg-RX-API-DMAC7.html) |
| WO (1) | WO1989010108A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (160)
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|---|---|---|---|---|
| US5241925A (en) * | 1988-12-27 | 1993-09-07 | Dermamed | Apparatus and techniques for administering veterinary medicaments |
| US5332577A (en) * | 1988-12-27 | 1994-07-26 | Dermamed | Transdermal administration to humans and animals |
| US5091186A (en) * | 1989-08-15 | 1992-02-25 | Cygnus Therapeutic Systems | Biphasic transdermal drug delivery device |
| US5124157A (en) * | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| US5324521A (en) * | 1989-12-18 | 1994-06-28 | Dermamed | Systems for transdermal administration of medicaments |
| US5152997A (en) * | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
| US5246706A (en) * | 1991-07-19 | 1993-09-21 | Cygnus Therapeutic Systems | Device for administering bimakalim transdermally |
| US5352456A (en) * | 1991-10-10 | 1994-10-04 | Cygnus Therapeutic Systems | Device for administering drug transdermally which provides an initial pulse of drug |
| US5246705A (en) * | 1992-04-08 | 1993-09-21 | Cygnus Therapeutic System | Occlusive, elastomeric backing materials in transdermal drug delivery systems, and associated methods of manufacture and use |
| US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US6162456A (en) * | 1992-09-24 | 2000-12-19 | Ortho-Mcneil Pharmaceutical, Inc. | Adhesive transdermal drug delivery matrix of a physical blend of hydrophilic and hydrophobic polymers |
| BR9307141A (pt) * | 1992-09-29 | 1999-03-30 | Inhale Therapeutic Syst | Processo para a liberação sistência pulsátil de um fragmento ativo de hormônio de paratiróide (PTH) para um hospedeiro mamífero e para um paciente e composição farmacêutica |
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| US5591767A (en) * | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| CA2114290C (en) * | 1993-01-27 | 2006-01-10 | Nagabushanam Totakura | Post-surgical anti-adhesion device |
| US5635204A (en) * | 1994-03-04 | 1997-06-03 | Montefiore Medical Center | Method for transdermal induction of anesthesia, analgesia or sedation |
| CZ295827B6 (cs) * | 1994-03-07 | 2005-11-16 | Nektar Therapeutics | Způsob aerosolizace dávky inzulinu, inzulinový přípravek a jeho použití |
| US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
| ES2245780T3 (es) * | 1994-05-18 | 2006-01-16 | Nektar Therapeutics | Metodos y composiciones para la formulacion de interferones como un polvo seco. |
| US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| ZA964320B (en) * | 1995-06-05 | 1997-01-13 | Alza Corp | Device for transdermal electrotransport delivery of fentanyl and sufentanil |
| FR2735024B1 (fr) * | 1995-06-08 | 1997-11-28 | Sanofi Sa | Dispositif d'administration cutanee d'un produit medicamenteux ou cosmetique. |
| US5807570A (en) * | 1995-09-29 | 1998-09-15 | Cygnus, Inc. | Transdermal administration of ropinirole and analogs thereof |
| TW411277B (en) * | 1996-05-13 | 2000-11-11 | Hisamitsu Pharmaceutical Co | Percutaneous tape preparation containing fentanyl |
| US5709878A (en) * | 1996-08-02 | 1998-01-20 | Rosenbaum; Jerry | Transdermal delivery of dehydroepiandrosterone |
| US5955097A (en) | 1996-10-18 | 1999-09-21 | Virotex Corporation | Pharmaceutical preparation applicable to mucosal surfaces and body tissues |
| US5800832A (en) * | 1996-10-18 | 1998-09-01 | Virotex Corporation | Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces |
| US5968547A (en) * | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
| US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
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| US20050048102A1 (en) * | 1997-10-16 | 2005-03-03 | Virotex Corporation | Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces |
| US6352722B1 (en) | 1997-12-23 | 2002-03-05 | Quadrant Holdings Cambridge Limited | Derivatized carbohydrates, compositions comprised thereof and methods of use thereof |
| US5869090A (en) * | 1998-01-20 | 1999-02-09 | Rosenbaum; Jerry | Transdermal delivery of dehydroepiandrosterone |
| US6103266A (en) * | 1998-04-22 | 2000-08-15 | Tapolsky; Gilles H. | Pharmaceutical gel preparation applicable to mucosal surfaces and body tissues |
| HK1043317B (en) * | 1999-04-01 | 2006-02-10 | Alza Corporation | Transdermal drug delivery devices comprising a polyurethane drug reservoir |
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| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
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| TWI324518B (en) | 2001-12-19 | 2010-05-11 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
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| US20040086551A1 (en) * | 2002-10-30 | 2004-05-06 | Miller Kenneth J. | Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl |
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-
1988
- 1988-04-08 US US07/179,423 patent/US4906463A/en not_active Expired - Lifetime
-
1989
- 1989-04-03 KR KR1019890702283A patent/KR950001968B1/ko not_active Expired - Lifetime
- 1989-04-03 AU AU38530/89A patent/AU633500B2/en not_active Ceased
- 1989-04-03 EP EP89907942A patent/EP0409910B1/en not_active Expired - Lifetime
- 1989-04-03 AT AT89907942T patent/ATE119019T1/de not_active IP Right Cessation
- 1989-04-03 FI FI904943A patent/FI904943A0/fi not_active Application Discontinuation
- 1989-04-03 DE DE68921473T patent/DE68921473T2/de not_active Expired - Lifetime
- 1989-04-03 WO PCT/US1989/001376 patent/WO1989010108A1/en not_active Ceased
- 1989-04-03 JP JP1507304A patent/JPH03504977A/ja active Granted
- 1989-04-04 IE IE891070A patent/IE891070L/xx unknown
- 1989-04-05 CA CA000595816A patent/CA1325381C/en not_active Expired - Lifetime
- 1989-04-06 NZ NZ228637A patent/NZ228637A/xx unknown
- 1989-04-10 PT PT90240A patent/PT90240B/pt not_active IP Right Cessation
-
1990
- 1990-10-04 NO NO904317A patent/NO306444B1/no unknown
- 1990-10-05 DK DK199002410A patent/DK175375B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE891070L (en) | 1989-10-08 |
| WO1989010108A1 (en) | 1989-11-02 |
| AU633500B2 (en) | 1993-02-04 |
| DE68921473D1 (de) | 1995-04-06 |
| KR900700064A (ko) | 1990-08-11 |
| NZ228637A (en) | 1990-10-26 |
| FI904943A7 (fi) | 1990-10-08 |
| DK241090A (da) | 1990-10-05 |
| EP0409910A4 (en) | 1991-08-21 |
| NO904317D0 (no) | 1990-10-04 |
| KR950001968B1 (ko) | 1995-03-08 |
| NO306444B1 (no) | 1999-11-08 |
| PT90240A (pt) | 1989-11-10 |
| EP0409910A1 (en) | 1991-01-30 |
| US4906463A (en) | 1990-03-06 |
| FI904943A0 (fi) | 1990-10-08 |
| EP0409910B1 (en) | 1995-03-01 |
| JPH03504977A (ja) | 1991-10-31 |
| DK241090D0 (da) | 1990-10-05 |
| ATE119019T1 (de) | 1995-03-15 |
| AU3853089A (en) | 1989-11-24 |
| JPH0575727B2 (cg-RX-API-DMAC7.html) | 1993-10-21 |
| NO904317L (no) | 1990-11-28 |
| PT90240B (pt) | 1994-10-31 |
| CA1325381C (en) | 1993-12-21 |
| DK175375B1 (da) | 2004-09-20 |
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