KR900700064A - 펜타닐의 경피 투여용 적층 혼성체 - Google Patents

펜타닐의 경피 투여용 적층 혼성체

Info

Publication number
KR900700064A
KR900700064A KR1019890702283A KR890702283A KR900700064A KR 900700064 A KR900700064 A KR 900700064A KR 1019890702283 A KR1019890702283 A KR 1019890702283A KR 890702283 A KR890702283 A KR 890702283A KR 900700064 A KR900700064 A KR 900700064A
Authority
KR
South Korea
Prior art keywords
fentanyl
hybrid
laminated
layer
weight
Prior art date
Application number
KR1019890702283A
Other languages
English (en)
Other versions
KR950001968B1 (ko
Inventor
더블유. 클레어리 게리
디. 로이 새미어
Original Assignee
게리 더블유.클레어리
시그너스 리서취 코오퍼레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 게리 더블유.클레어리, 시그너스 리서취 코오퍼레이션 filed Critical 게리 더블유.클레어리
Publication of KR900700064A publication Critical patent/KR900700064A/ko
Application granted granted Critical
Publication of KR950001968B1 publication Critical patent/KR950001968B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide

Abstract

내용 없음

Description

펜타닐의 경피 투여용 적층 혼성체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 한 구체예의 단면도이다. 제2도는 본 발명의 제2구체예의 단면도이다.

Claims (8)

  1. 펜타닐의 경피 투여용 고체 상태 적층 혼성체로서, (a) 펜타닐에 대하여 실질적으로 불투과성이며 혼성체의 표면을 규정하는 지지층, (b) 사용중에 혼성체의 기저면을 규정하며, (i) 1내지 5중량%의 펜타닐, (ii) 1내지 10중량%의 프로필렌 글로콜 모노라우레이트(PGML), (iii) 10-8내지 10-11㎠/sec 범위의 펜타닐에 대한 확산률 및 1.5내지 5㎎/㎖범위의 펜타닐에 대한 용해도를 가지는, 85내지 98중량%의 아민 내성 압력민감 점착 중합체로 이루어지는 점착 펜타닐 저장층으로 이루어지며, 상기 혼성체는 약 2내지 약 10mcg/㎠/hr 범위의 정상 상태 펜타닐 피부 유동율을 나타내고, 대략 사용 첫째날 동안에 혼성체 중의 적어도 약 75%가 투여되는 것을 특징으로 하는 적층 혼성체.
  2. 제1항에 있어서, 펜타닐은 저장층의 1.7 내지 3중량%를 구성하고, 프로필렌 글리콜 모노라우레이트는 저장층의 1.5내지 5중량%를 구성하며, 중합체는 저장층의 약 90내지 96중량%를 구성하는 것을 특징으로 하는 적층 혼성체.
  3. 제1항에 있어서, 지지층이 폐쇄성인 것을 특징으로 하는 적층 혼성체.
  4. 제3항에 있어서, 중합체가 폴리디메틸실옥산인 것을 특징으로 하는 적층 혼성체.
  5. 제3항에 있어서, 상기 기저면의 면적이 10내지 40㎠이며, 정상상태 펜타닐 유동율은 2내지 100mcg/㎠/hr 범위이고, 펜타닐의 적어도 약 85%가 대략 사용 첫째날 동안에 투여되는 것을 특징으로 하는 적층 혼성체.
  6. 제3항에 있어서, (c) 지지층과 저장층 사이에 끼워져 있는 다공성 구조층을 포함하는 것을 특징으로 하는 적층 혼성체.
  7. 제6항에 있어서, 다공성 구조층이 부직포로 만들어지는 것을 특징으로 하는 적층 혼성체.
  8. 제6항에 있어서, 다공성 구조층이 상기 아민 내성 압력 민감점착 중합체 조성물 층에 의하여 지지층에 점착되는 것을 특징으로 하는 적층 혼성체.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890702283A 1988-04-08 1989-04-03 펜타닐의 경피투여용 적층 혼성체 KR950001968B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US179,423 1988-04-08
US07/179,423 US4906463A (en) 1986-12-22 1988-04-08 Transdermal drug-delivery composition
US21137788A 1988-06-24 1988-06-24
US211,377 1988-06-24
PCT/US1989/001376 WO1989010108A1 (en) 1988-04-08 1989-04-03 Laminated composite for transdermal administration of fentanyl

Publications (2)

Publication Number Publication Date
KR900700064A true KR900700064A (ko) 1990-08-11
KR950001968B1 KR950001968B1 (ko) 1995-03-08

Family

ID=26875305

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890702283A KR950001968B1 (ko) 1988-04-08 1989-04-03 펜타닐의 경피투여용 적층 혼성체

Country Status (15)

Country Link
US (1) US4906463A (ko)
EP (1) EP0409910B1 (ko)
JP (1) JPH03504977A (ko)
KR (1) KR950001968B1 (ko)
AT (1) ATE119019T1 (ko)
AU (1) AU633500B2 (ko)
CA (1) CA1325381C (ko)
DE (1) DE68921473T2 (ko)
DK (1) DK175375B1 (ko)
FI (1) FI904943A0 (ko)
IE (1) IE891070L (ko)
NO (1) NO306444B1 (ko)
NZ (1) NZ228637A (ko)
PT (1) PT90240B (ko)
WO (1) WO1989010108A1 (ko)

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FI904943A0 (fi) 1990-10-08
DE68921473T2 (de) 1995-06-22
NO306444B1 (no) 1999-11-08
WO1989010108A1 (en) 1989-11-02
EP0409910A4 (en) 1991-08-21
NO904317L (no) 1990-11-28
ATE119019T1 (de) 1995-03-15
DK241090D0 (da) 1990-10-05
IE891070L (en) 1989-10-08
JPH0575727B2 (ko) 1993-10-21
DK175375B1 (da) 2004-09-20
NZ228637A (en) 1990-10-26
PT90240B (pt) 1994-10-31
KR950001968B1 (ko) 1995-03-08
JPH03504977A (ja) 1991-10-31
US4906463A (en) 1990-03-06
EP0409910B1 (en) 1995-03-01
PT90240A (pt) 1989-11-10
AU633500B2 (en) 1993-02-04
CA1325381C (en) 1993-12-21
DK241090A (da) 1990-10-05
NO904317D0 (no) 1990-10-04
EP0409910A1 (en) 1991-01-30
AU3853089A (en) 1989-11-24

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