ES2041238T3 - Matriz de difusion para la administracion de medicamento por via percutanea y dispositivo de administracion de medicamento por via percutanea que los incluye. - Google Patents
Matriz de difusion para la administracion de medicamento por via percutanea y dispositivo de administracion de medicamento por via percutanea que los incluye.Info
- Publication number
- ES2041238T3 ES2041238T3 ES87311308T ES87311308T ES2041238T3 ES 2041238 T3 ES2041238 T3 ES 2041238T3 ES 87311308 T ES87311308 T ES 87311308T ES 87311308 T ES87311308 T ES 87311308T ES 2041238 T3 ES2041238 T3 ES 2041238T3
- Authority
- ES
- Spain
- Prior art keywords
- medicines
- administration
- diffusion matrix
- percutaneous
- percutanea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
Abstract
UN MATERIAL COMPUESTO LAMINADO DE ESTADO SOLIDO, ELASTICO, PARA ADMINISTRAR UN MEDICAMENTO TRANSDERMICAMENTE, CONSTA DE UNA CAPA SUPERIOR DE UN ELASTOMERO ELASTICO, UNA CAPA DE MATRIZ DE DIFUSION MEDIA COMPUESTA DE UN ARMAZON DE ESPUMA MACROPOROSA DE POLIURETANO, EN CUYOS POROS SE HAYAN EMBEBIDOS UNA MEZCLA VISCOELASTICA DE UN ADHESIVO DE POLISILOXANO DE GRADO MEDICO, MEDICAMENTO Y, OPCIONALMENTE, UN MEJORADOR DE ABSORCION PERCUTANEA, Y UNA CAPA SUPERFICIAL BASAL DEL ADHESIVO DE POLISILOXANO DE GRADO MEDICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94538986A | 1986-12-22 | 1986-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2041238T1 ES2041238T1 (es) | 1993-11-16 |
ES2041238T3 true ES2041238T3 (es) | 1994-01-16 |
Family
ID=25483025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87311308T Expired - Lifetime ES2041238T3 (es) | 1986-12-22 | 1987-12-22 | Matriz de difusion para la administracion de medicamento por via percutanea y dispositivo de administracion de medicamento por via percutanea que los incluye. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4911916A (es) |
EP (1) | EP0272918B1 (es) |
JP (1) | JPH07112972B2 (es) |
AT (1) | ATE78183T1 (es) |
AU (1) | AU607172B2 (es) |
CA (1) | CA1308655C (es) |
DE (1) | DE3780432T2 (es) |
ES (1) | ES2041238T3 (es) |
GR (1) | GR3005368T3 (es) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6468316A (en) * | 1987-09-08 | 1989-03-14 | Teikoku Seiyaku Kk | External plaster containing salbutamol |
US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
IE62871B1 (en) * | 1988-03-08 | 1995-03-08 | Warner Lambert Co | Compositions with enhanced penetration |
US5124158A (en) * | 1988-06-30 | 1992-06-23 | The Upjohn Company | Transdermal antisecretory agents for gastrointestinal disease |
FR2635979B1 (fr) * | 1988-09-07 | 1992-05-29 | Lhd Lab Hygiene Dietetique | Dispositif auto-adhesif d'administration d'un principe actif par voie percutanee |
DE3838061A1 (de) * | 1988-11-10 | 1990-05-23 | Holzer Walter | Sterile selbstklebefolie fuer die medizinische eingriffsvorbereitung |
DE3901551A1 (de) * | 1989-01-20 | 1990-07-26 | Lohmann Therapie Syst Lts | Superfizielles therapeutisches system mit einem gehalt an einem antineoplastischen wirkstoff, insbesondere 5-fluoruracil |
US5248295A (en) * | 1989-05-08 | 1993-09-28 | Iomed, Inc. | Bioelectrode seal |
US5124157A (en) * | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
DE3928858A1 (de) * | 1989-08-31 | 1991-03-07 | Beiersdorf Ag | Vernetzte hydrogele und verfahren zu deren herstellung |
US5240711A (en) * | 1989-11-29 | 1993-08-31 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Transdermal therapeutic system comprising as active component buprenorphine |
JP2839164B2 (ja) * | 1989-12-25 | 1998-12-16 | 帝國製薬株式会社 | 消炎鎮痛貼付剤 |
ES2099747T3 (es) * | 1990-06-01 | 1997-06-01 | Population Council Inc | Aplicacion topica terapeuticamente eficaz de la st1435. |
US5455043A (en) * | 1990-06-13 | 1995-10-03 | Fischel-Ghodsian; Fariba | Device for controlled release of vaporous medications through nasal route |
US5071704A (en) * | 1990-06-13 | 1991-12-10 | Fischel Ghodsian Fariba | Device for controlled release of vapors and scents |
US5152997A (en) * | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
GB9102660D0 (en) * | 1991-02-07 | 1991-03-27 | Ultra Lab Ltd | Wound dressing materials |
US5486362A (en) * | 1991-05-07 | 1996-01-23 | Dynagen, Inc. | Controlled, sustained release delivery system for treating drug dependency |
AU2154892A (en) * | 1991-05-07 | 1992-12-21 | Dynagen, Inc. | A controlled, sustained release delivery system for treating drug dependency |
US5403595A (en) * | 1991-05-07 | 1995-04-04 | Dynagen, Inc. | Controlled, sustained release delivery system for smoking cessation |
US5402777A (en) * | 1991-06-28 | 1995-04-04 | Alza Corporation | Methods and devices for facilitated non-invasive oxygen monitoring |
US5705185A (en) * | 1991-09-25 | 1998-01-06 | Beta Pharmaceuticals Co. | Transdermal delivery of estradiol and process for manufacturing said device |
US5518734A (en) * | 1991-09-25 | 1996-05-21 | Beta Pharmaceuticals Co. | Transdermal delivery system for estradiol and process for manufacturing said device |
US5780051A (en) * | 1992-04-02 | 1998-07-14 | Dynagen, Inc. | Methods and articles of manufacture for nicotine cessation and monitoring nicotine use |
GB2273044B (en) * | 1992-12-02 | 1997-04-09 | Pacific Chem Co Ltd | Medicinal patches for percutaneous administration |
DE4308649C2 (de) * | 1993-03-18 | 1995-11-16 | Lohmann Gmbh & Co Kg | Medizinisches Pflastermaterial sowie Verfahren zu seiner Herstellung und dessen Verwendung |
US5762952A (en) * | 1993-04-27 | 1998-06-09 | Hercon Laboratories Corporation | Transdermal delivery of active drugs |
US5503844A (en) * | 1993-05-18 | 1996-04-02 | Mli Acquisition Corp. Ii | Foam laminate transdermal patch |
US5785991A (en) * | 1995-06-07 | 1998-07-28 | Alza Corporation | Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate |
US5716621A (en) * | 1996-07-03 | 1998-02-10 | Pharmadyn, Inc. | Nonocclusive drug delivery device and process for its manufacture |
US6348210B1 (en) | 1998-11-13 | 2002-02-19 | Alza Corporation | Methods for transdermal drug administration |
US7608640B2 (en) * | 1999-03-02 | 2009-10-27 | Jallal Messadek | Glycine betaine and its use |
ES2244422T3 (es) * | 1999-04-01 | 2005-12-16 | Alza Corporation | Dispositivos para la administracion transdermica de farmacos que comprenden un deposito de poliuretano para farmacos. |
US6277401B1 (en) * | 1999-05-07 | 2001-08-21 | U.S. Dermatologics, Inc. | Drug delivery device |
US6495229B1 (en) * | 1999-09-17 | 2002-12-17 | Avery Dennison Corporation | Pattern coated adhesive article |
GB2355014A (en) * | 1999-10-05 | 2001-04-11 | Procter & Gamble | Foams and compositions containing these foams |
DE10007859A1 (de) * | 2000-02-21 | 2001-08-23 | Bayer Ag | Langzeitstabile wasser- und ölabweisende Oberfläche |
KR100382373B1 (ko) * | 2000-08-28 | 2003-05-01 | 주식회사 동성화학 | 약제의 역확산 억제능이 우수한 패취제 제조용 폴리우레탄 지지체 및 이의 제조방법 |
US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
FR2814949B1 (fr) * | 2000-10-11 | 2004-03-05 | Epitact | Bille d'orteil pour la prevention ou le soin des effets de l'hyperhydrose plantaire |
JP5354763B2 (ja) * | 2001-03-16 | 2013-11-27 | アルザ・コーポレーシヨン | フェンタニルを投与するための経皮的張り付け剤 |
US20050208117A1 (en) * | 2001-03-16 | 2005-09-22 | Venkatraman Subramanian S | Transdermal administration of fentanyl and analogs thereof |
JP4489356B2 (ja) * | 2001-05-11 | 2010-06-23 | メリオン リサーチ スリー リミテッド | 浸透促進剤 |
DE10141650C1 (de) * | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
DE10159745A1 (de) | 2001-12-05 | 2003-07-03 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit verbessertem Langzeittragekomfort |
BE1015608A6 (fr) * | 2003-07-15 | 2005-06-07 | Messadek Jallal | Traitement des arterites. |
DE602004003577T2 (de) * | 2003-04-17 | 2007-09-20 | Jallal Messadek | Flottierende orale Formulierungen mit kontrollierter Freisetzung von Betain |
US20070259014A1 (en) * | 2003-06-20 | 2007-11-08 | Vgx Pharmaceuticals, Inc. | Compositions for and Methods for Treating Hiv |
US20080131493A1 (en) * | 2004-01-02 | 2008-06-05 | Haitham Matloub | Method and Multilayered Device for Controlled Topical Delivery of Therapeutic Agents to the Skin |
US8591940B2 (en) * | 2004-01-02 | 2013-11-26 | New Medical Technology Inc. | Method of treating scar tissue |
GB2410748A (en) * | 2004-02-03 | 2005-08-10 | Johnson & Johnson Medical Ltd | Medicated polyurethane foams |
US8219168B2 (en) | 2004-04-13 | 2012-07-10 | Abbott Diabetes Care Inc. | Article and method for applying a coupling agent for a non-invasive optical probe |
JP4557596B2 (ja) * | 2004-04-28 | 2010-10-06 | 積水化成品工業株式会社 | 外用貼付剤およびその製造方法、並びにその使用方法 |
BE1016128A6 (fr) * | 2004-07-22 | 2006-03-07 | Messadek Jallal | Combinaisons therapeutiques |
WO2006050581A2 (en) * | 2004-11-10 | 2006-05-18 | Jallal Messadek | Betaine as agent against arthropod - or mosquito -borne diseases |
US20060188558A1 (en) * | 2005-02-18 | 2006-08-24 | Mylan Technologies, Inc. | Transdermal systems having control delivery system |
US7833979B2 (en) * | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
ATE540690T1 (de) * | 2005-04-27 | 2012-01-15 | Jallal Messadek | Insulinkombinationen |
US7469437B2 (en) | 2005-06-24 | 2008-12-30 | Tempur-Pedic Management, Inc. | Reticulated material body support and method |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
CN1994290B (zh) * | 2006-01-04 | 2011-03-16 | 上海医药工业研究院 | 卡巴拉汀透皮贴剂及其制备方法 |
DE102006028987A1 (de) * | 2006-06-24 | 2007-12-27 | Lts Lohmann Therapie-Systeme Ag | Ultraschallverstärktes transdermales therapeutisches System |
JP5241714B2 (ja) * | 2006-07-07 | 2013-07-17 | プロテウス デジタル ヘルス, インコーポレイテッド | スマートな非経口送達システム |
US7825093B2 (en) | 2006-10-25 | 2010-11-02 | Amgen Inc. | Methods of using OSK1 peptide analogs |
CL2008000512A1 (es) | 2007-02-22 | 2008-08-29 | Bayer Cropscience Sa | Compuestos derivados de n-(3-fenilpropil)carboxamida; procedimiento de preparacion de dichos compuestos; composicion fungicida; y metodo para combatir de forma preventiva o curativa los hongos fitopatogenos de cultivos. |
MX2009012609A (es) | 2007-05-22 | 2009-12-07 | Amgen Inc | Composiciones y metodos para producir proteinas de fusion bioactivas. |
KR101583680B1 (ko) * | 2007-10-15 | 2016-01-08 | 알자 코퍼레이션 | 펜타닐의 1일-1회 교체 경피 투여 |
WO2009055733A1 (en) * | 2007-10-25 | 2009-04-30 | Proteus Biomedical, Inc. | Fluid transfer port information system |
US8419638B2 (en) * | 2007-11-19 | 2013-04-16 | Proteus Digital Health, Inc. | Body-associated fluid transport structure evaluation devices |
WO2009065193A1 (en) * | 2007-11-21 | 2009-05-28 | Jallal Messadek | Treatment of aspirin resistance with betaine and/or betaine enriched molasses |
US20100100060A1 (en) * | 2008-10-17 | 2010-04-22 | Novartis Ag | Applicator for pharmaceutical product and method of using same |
WO2011034323A2 (en) * | 2009-09-16 | 2011-03-24 | Samyang Corporation | Transdermal delivery system, method for manufacturing the same, and transdermal delivery method using the system |
CA2788336C (en) | 2010-02-01 | 2018-05-01 | Proteus Digital Health, Inc. | Data gathering system |
JP5330609B2 (ja) | 2010-02-01 | 2013-10-30 | プロテウス デジタル ヘルス, インコーポレイテッド | 2つの手首におけるデータ収集システム |
DK2557924T3 (da) | 2010-04-13 | 2019-09-23 | Relmada Therapeutics Inc | Dermale farmaceutiske sammensætninger af 1-methyl-2',6'-pipecoloxylidid og fremgangsmåde til deres anvendelse |
BR112013023674A2 (pt) | 2011-03-16 | 2016-12-13 | Amgen Inc | inibidores potentes e seletivos de nav1.3 e nav1.7 |
WO2014165277A2 (en) | 2013-03-12 | 2014-10-09 | Amgen Inc. | POTENT AND SELECTIVE INHIBITORS OF Nav1.7 |
US20200268681A1 (en) * | 2016-12-29 | 2020-08-27 | International Bioceutical Co. LLC | Modular transdermal delivery system and associated methods of manufacture and use |
US11318190B2 (en) | 2017-05-05 | 2022-05-03 | United States Government As Represented By The Department Of Veterans Affairs | Methods and compositions for treating liver disease |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3426754A (en) * | 1964-06-12 | 1969-02-11 | Celanese Corp | Breathable medical dressing |
US3486968A (en) * | 1967-10-12 | 1969-12-30 | Reeves Bros Inc | Microporous polyurethane coatings and films |
NO134790C (no) * | 1968-07-09 | 1984-03-22 | Smith & Nephew | Klebende,; trykkfoelsomt, vanndamp-permeabelt produkt for bruk paa hud hos mennesker. |
US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
US3699963A (en) * | 1969-10-31 | 1972-10-24 | Alza Corp | Therapeutic adhesive patch |
US3685734A (en) * | 1971-02-19 | 1972-08-22 | Minnesota Mining & Mfg | Controlled fragrance release device |
US3849238A (en) * | 1972-04-07 | 1974-11-19 | S Ronel | Artificial skin |
US4438139A (en) * | 1979-08-14 | 1984-03-20 | Key Pharmaceuticals, Inc. | Polymeric diffusion matrix containing estrogens |
US4286592A (en) * | 1980-02-04 | 1981-09-01 | Alza Corporation | Therapeutic system for administering drugs to the skin |
IE51473B1 (en) * | 1980-08-13 | 1986-12-24 | Smith & Nephew Ass | Polymer blend films,their preparation and use |
DK147035C (da) * | 1980-12-05 | 1984-09-03 | Coloplast As | Hudplade |
US4460372A (en) * | 1981-02-17 | 1984-07-17 | Alza Corporation | Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer |
US4379454A (en) * | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
JPS57139011A (en) * | 1981-02-20 | 1982-08-27 | Nitto Electric Ind Co Ltd | Material for releasing physiologically active substance |
US4453007A (en) * | 1981-11-23 | 1984-06-05 | Usv Pharmaceutical Corporation | Method for increasing the purity of amphoteric compound compositions |
US4460371A (en) * | 1981-11-24 | 1984-07-17 | Dennison Manufacturing Company | Silicone pressure sensitive adhesive and uses |
JPS5896016A (ja) * | 1981-12-03 | 1983-06-07 | Nitto Electric Ind Co Ltd | 医薬製剤 |
US4510197A (en) * | 1983-04-01 | 1985-04-09 | The Kendall Company | Water vapor permeable pressure sensitive adhesives incorporating modified acrylate copolymers |
US4588580B2 (en) * | 1984-07-23 | 1999-02-16 | Alaz Corp | Transdermal administration of fentanyl and device therefor |
EP0190262B1 (en) * | 1984-07-24 | 1990-12-27 | Key Pharmaceuticals, Inc. | Adhesive transdermal dosage layer |
US4649075A (en) * | 1984-08-09 | 1987-03-10 | Leonora Jost | Transdermal and transmucosal vortexed foam devices and the method of making |
US4559054A (en) * | 1984-08-09 | 1985-12-17 | Research Corporation | Rate-controlled drug release system |
US4600001A (en) * | 1984-08-15 | 1986-07-15 | The Kendall Company | Combined wound dressing and delivery means composite |
US4568343A (en) * | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
US4573995A (en) * | 1984-10-09 | 1986-03-04 | Alza Corporation | Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine |
DE3685895T2 (de) * | 1985-02-25 | 1992-12-24 | Univ Rutgers | Dosierungssystem fuer transdermale absorption von arzneimittelwirkstoffen. |
US4818540A (en) * | 1985-02-25 | 1989-04-04 | Rutgers, The State University Of New Jersey | Transdermal fertility control system and process |
US4645502A (en) * | 1985-05-03 | 1987-02-24 | Alza Corporation | Transdermal delivery of highly ionized fat insoluble drugs |
US4638797A (en) * | 1986-04-23 | 1987-01-27 | Acme United Corporation | Reinforced moisture vapor permeable, pressure-sensitive adhesive wound dressings |
AU601528B2 (en) * | 1986-12-22 | 1990-09-13 | Ortho-Mcneil Pharmaceutical, Inc. | Resilient transdermal drug-delivery device and compositions and devices employing fatty acid esters/ethers of alkanediols and percutaneous absorption enhancers |
-
1987
- 1987-12-14 AU AU82499/87A patent/AU607172B2/en not_active Ceased
- 1987-12-22 ES ES87311308T patent/ES2041238T3/es not_active Expired - Lifetime
- 1987-12-22 JP JP62325100A patent/JPH07112972B2/ja not_active Expired - Lifetime
- 1987-12-22 CA CA000555142A patent/CA1308655C/en not_active Expired - Fee Related
- 1987-12-22 DE DE8787311308T patent/DE3780432T2/de not_active Expired - Fee Related
- 1987-12-22 EP EP87311308A patent/EP0272918B1/en not_active Expired - Lifetime
- 1987-12-22 AT AT87311308T patent/ATE78183T1/de not_active IP Right Cessation
-
1988
- 1988-04-08 US US07/179,561 patent/US4911916A/en not_active Expired - Lifetime
-
1992
- 1992-08-06 GR GR920401702T patent/GR3005368T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0272918A3 (en) | 1988-08-24 |
EP0272918B1 (en) | 1992-07-15 |
GR3005368T3 (es) | 1993-05-24 |
ES2041238T1 (es) | 1993-11-16 |
JPS63190823A (ja) | 1988-08-08 |
EP0272918A2 (en) | 1988-06-29 |
DE3780432T2 (de) | 1992-12-10 |
ATE78183T1 (de) | 1992-08-15 |
AU607172B2 (en) | 1991-02-28 |
US4911916A (en) | 1990-03-27 |
JPH07112972B2 (ja) | 1995-12-06 |
DE3780432D1 (de) | 1992-08-20 |
AU8249987A (en) | 1988-06-23 |
CA1308655C (en) | 1992-10-13 |
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FG2A | Definitive protection |
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