DE68912355T2 - Antibiotische Antitumor-Verbindung und Methode zu deren Herstellung. - Google Patents
Antibiotische Antitumor-Verbindung und Methode zu deren Herstellung.Info
- Publication number
- DE68912355T2 DE68912355T2 DE68912355T DE68912355T DE68912355T2 DE 68912355 T2 DE68912355 T2 DE 68912355T2 DE 68912355 T DE68912355 T DE 68912355T DE 68912355 T DE68912355 T DE 68912355T DE 68912355 T2 DE68912355 T2 DE 68912355T2
- Authority
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- Germany
- Prior art keywords
- substance
- agar
- microorganism
- strain
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- MFTJRTUKCOVIMD-KUWIHEQQSA-N kidamycin Chemical compound OC1=C2C(=O)C3=C4OC(C(\C)=C/C)=CC(=O)C4=C(C)C=C3C(=O)C2=C([C@@H]2O[C@H](C)[C@@H](O)[C@H](C2)N(C)C)C=C1[C@H]1C[C@](C)(N(C)C)[C@H](O)[C@@H](C)O1 MFTJRTUKCOVIMD-KUWIHEQQSA-N 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- YCTKRMVYSFHSKT-UHFFFAOYSA-N neopluramycin Natural products CC=C(C)/C1=CC(=O)c2c(C)cc3C(=O)c4c(cc(C5CC(C)(C(OC(=O)C)C(C)O5)N(C)C)c(O)c4C(=O)c3c2O1)C6OC(C)C(O)C(C6O)N(C)C YCTKRMVYSFHSKT-UHFFFAOYSA-N 0.000 description 1
- QMMRZOWCJAIUJA-UHFFFAOYSA-L nickel dichloride Chemical compound Cl[Ni]Cl QMMRZOWCJAIUJA-UHFFFAOYSA-L 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000013587 production medium Substances 0.000 description 1
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000028070 sporulation Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63015983A JPH01193265A (ja) | 1988-01-28 | 1988-01-28 | 新規抗腫瘍性抗生物質ｓｆ２５８７物質及びその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68912355D1 DE68912355D1 (de) | 1994-03-03 |
| DE68912355T2 true DE68912355T2 (de) | 1994-08-25 |
Family
ID=11903907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68912355T Expired - Fee Related DE68912355T2 (de) | 1988-01-28 | 1989-01-27 | Antibiotische Antitumor-Verbindung und Methode zu deren Herstellung. |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4954641A (enrdf_load_stackoverflow) |
| EP (1) | EP0326173B1 (enrdf_load_stackoverflow) |
| JP (1) | JPH01193265A (enrdf_load_stackoverflow) |
| DE (1) | DE68912355T2 (enrdf_load_stackoverflow) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1321788C (en) * | 1988-09-30 | 1993-08-31 | Masaji Sezaki | Antitumor substance, process for preparing the same and anticancer agent containing the same |
| JPH03148275A (ja) * | 1989-11-02 | 1991-06-25 | Meiji Seika Kaisha Ltd | Ｓｆ２５８７物質誘導体，その製造法および制癌剤 |
| JP2766351B2 (ja) * | 1989-11-13 | 1998-06-18 | 協和醗酵工業株式会社 | 新規物質ｄｃ１１４―ｃ |
| US5168100A (en) * | 1990-03-16 | 1992-12-01 | Sapporo Breweries Limited | Hp530 compounds and process for preparing the same |
| JPH05279374A (ja) * | 1992-03-31 | 1993-10-26 | Sawao Murao | スイダトレスチン及びその製造方法 |
| CN102644392A (zh) * | 2012-05-07 | 2012-08-22 | 张建忠 | 一种可运输的钢结构密闭单元模块以及制作该单元模块的制造方法 |
| KR101911767B1 (ko) * | 2017-08-10 | 2018-10-25 | 가톨릭대학교 산학협력단 | 키다마이신 유도체 l1-95-1 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 조성물 |
| CN115650913B (zh) * | 2022-10-12 | 2024-03-01 | 北京中医药大学 | 醌式喹啉类化合物及其制备方法和用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988000591A1 (en) * | 1986-07-21 | 1988-01-28 | Kyowa Hakko Kogyo Co., Ltd. | Novel substances dc-92b and dc-92d, and process for their preparation |
-
1988
- 1988-01-28 JP JP63015983A patent/JPH01193265A/ja active Granted
-
1989
- 1989-01-27 EP EP89101481A patent/EP0326173B1/en not_active Expired - Lifetime
- 1989-01-27 DE DE68912355T patent/DE68912355T2/de not_active Expired - Fee Related
- 1989-01-30 US US07/303,230 patent/US4954641A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0427237B2 (enrdf_load_stackoverflow) | 1992-05-11 |
| JPH01193265A (ja) | 1989-08-03 |
| EP0326173A3 (en) | 1990-11-07 |
| US4954641A (en) | 1990-09-04 |
| DE68912355D1 (de) | 1994-03-03 |
| EP0326173B1 (en) | 1994-01-19 |
| EP0326173A2 (en) | 1989-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |