DE68906965T2 - Analgetische Phenothiazinderivate. - Google Patents

Analgetische Phenothiazinderivate.

Info

Publication number
DE68906965T2
DE68906965T2 DE89401601T DE68906965T DE68906965T2 DE 68906965 T2 DE68906965 T2 DE 68906965T2 DE 89401601 T DE89401601 T DE 89401601T DE 68906965 T DE68906965 T DE 68906965T DE 68906965 T2 DE68906965 T2 DE 68906965T2
Authority
DE
Germany
Prior art keywords
analgesic
phenothiazine derivatives
branched
linear
mixtures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89401601T
Other languages
English (en)
Other versions
DE68906965D1 (de
Inventor
Claude Garret
Claude Guyon
Bernard Plau
Gerard Taurand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante SA filed Critical Rhone Poulenc Sante SA
Publication of DE68906965D1 publication Critical patent/DE68906965D1/de
Application granted granted Critical
Publication of DE68906965T2 publication Critical patent/DE68906965T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
    • C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE89401601T 1988-06-10 1989-06-09 Analgetische Phenothiazinderivate. Expired - Fee Related DE68906965T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8807770A FR2632520B1 (fr) 1988-06-10 1988-06-10 Derives de la phenothiazine analgesiques

Publications (2)

Publication Number Publication Date
DE68906965D1 DE68906965D1 (de) 1993-07-15
DE68906965T2 true DE68906965T2 (de) 1993-12-09

Family

ID=9367166

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89401601T Expired - Fee Related DE68906965T2 (de) 1988-06-10 1989-06-09 Analgetische Phenothiazinderivate.

Country Status (17)

Country Link
US (1) US5049669A (de)
EP (1) EP0346238B1 (de)
JP (1) JP2504830B2 (de)
KR (1) KR0125575B1 (de)
AT (1) ATE90346T1 (de)
AU (1) AU621120B2 (de)
CA (1) CA1325631C (de)
DE (1) DE68906965T2 (de)
DK (1) DK283089A (de)
ES (1) ES2058569T3 (de)
FR (1) FR2632520B1 (de)
HU (1) HU205752B (de)
IE (1) IE63300B1 (de)
IL (1) IL90559A (de)
MX (1) MX9203585A (de)
PT (1) PT90813B (de)
ZA (1) ZA894397B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2632521B1 (fr) * 1988-06-10 1990-09-14 Rhone Poulenc Sante Nouveaux derives de la phenothiazine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2632522B1 (fr) * 1988-06-10 1990-09-14 Rhone Poulenc Sante Nouveaux derives de la phenothiazine, leur preparation et les compositions qui les contiennent
FR2652084B1 (fr) * 1989-09-21 1991-10-31 Rhone Poulenc Sante Nouveaux derives de la phenothiazine, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689013B1 (fr) * 1992-03-30 1995-05-05 Rhone Poulenc Rorer Sa Nouvelle application thérapeutique des dérivés de la phénothiazine.
FR2720940A1 (fr) * 1994-06-13 1995-12-15 Rhone Poulenc Rorer Sa Application du (+)-N-propyl [(pyrrolidinyl-1)-1 propyl-2]-10 phénothiazinecarboxamide comme antidépresseur.
EP0946157B1 (de) * 1996-12-16 2002-03-13 Alcon Laboratories, Inc. Topische verwendung von kappa-opioidrezeptoragonisten zur behandlung von augenschmerz
US6174878B1 (en) 1999-08-31 2001-01-16 Alcon Laboratories, Inc. Topical use of kappa opioid agonists to treat otic pain
JP4371142B2 (ja) * 2004-12-28 2009-11-25 株式会社村田製作所 イオン発生ユニットおよびイオン発生装置
KR101646962B1 (ko) 2014-09-29 2016-08-10 한국과학기술연구원 CaM 저해활성을 가지는 페노싸이아진 유도체

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2956996A (en) * 1960-10-18 Alkylated phenotfflazenecarboxamede
NL222355A (de) * 1957-11-05
US3112310A (en) * 1962-01-15 1963-11-26 Searle & Co 10-alkylaminoalkylphenothiazine-2-carboxamides
FR180F (fr) * 1964-11-30 Bruneau & Cie Lab Médicament a base de dérivés d'acide phénothiazine carboxylique-3.
FR2632521B1 (fr) * 1988-06-10 1990-09-14 Rhone Poulenc Sante Nouveaux derives de la phenothiazine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2632522B1 (fr) * 1988-06-10 1990-09-14 Rhone Poulenc Sante Nouveaux derives de la phenothiazine, leur preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
JPH037269A (ja) 1991-01-14
HUT50464A (en) 1990-02-28
PT90813B (pt) 1994-10-31
FR2632520A1 (fr) 1989-12-15
DK283089D0 (da) 1989-06-09
KR0125575B1 (ko) 1998-07-01
IL90559A (en) 1994-08-26
PT90813A (pt) 1989-12-29
ZA894397B (en) 1990-02-28
IE891865L (en) 1989-12-10
MX9203585A (es) 1992-09-01
IL90559A0 (en) 1990-01-18
JP2504830B2 (ja) 1996-06-05
EP0346238B1 (de) 1993-06-09
DE68906965D1 (de) 1993-07-15
KR910000680A (ko) 1991-01-30
AU621120B2 (en) 1992-03-05
IE63300B1 (en) 1995-04-05
CA1325631C (fr) 1993-12-28
EP0346238A1 (de) 1989-12-13
FR2632520B1 (fr) 1990-09-14
HU205752B (en) 1992-06-29
DK283089A (da) 1989-12-11
US5049669A (en) 1991-09-17
ATE90346T1 (de) 1993-06-15
ES2058569T3 (es) 1994-11-01
AU3624089A (en) 1989-12-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee