DE60318035T2 - Polymermikroemulsionen - Google Patents
Polymermikroemulsionen Download PDFInfo
- Publication number
- DE60318035T2 DE60318035T2 DE60318035T DE60318035T DE60318035T2 DE 60318035 T2 DE60318035 T2 DE 60318035T2 DE 60318035 T DE60318035 T DE 60318035T DE 60318035 T DE60318035 T DE 60318035T DE 60318035 T2 DE60318035 T2 DE 60318035T2
- Authority
- DE
- Germany
- Prior art keywords
- polymer
- diblock copolymer
- valerolactone
- copolymers
- polymer block
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920000642 polymer Polymers 0.000 title claims description 110
- 239000004530 micro-emulsion Substances 0.000 title description 14
- 229920000359 diblock copolymer Polymers 0.000 claims description 87
- 239000000243 solution Substances 0.000 claims description 85
- 239000000203 mixture Substances 0.000 claims description 78
- 229920001577 copolymer Polymers 0.000 claims description 69
- -1 e-lactone Chemical compound 0.000 claims description 69
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 68
- 239000000178 monomer Substances 0.000 claims description 48
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 claims description 45
- OZJPLYNZGCXSJM-UHFFFAOYSA-N 5-valerolactone Chemical compound O=C1CCCCO1 OZJPLYNZGCXSJM-UHFFFAOYSA-N 0.000 claims description 37
- 239000007788 liquid Substances 0.000 claims description 36
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims description 31
- 239000002552 dosage form Substances 0.000 claims description 29
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims description 29
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 26
- 239000007864 aqueous solution Substances 0.000 claims description 26
- GAEKPEKOJKCEMS-UHFFFAOYSA-N gamma-valerolactone Chemical compound CC1CCC(=O)O1 GAEKPEKOJKCEMS-UHFFFAOYSA-N 0.000 claims description 26
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 claims description 25
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 claims description 23
- 229920001223 polyethylene glycol Polymers 0.000 claims description 23
- 229960000380 propiolactone Drugs 0.000 claims description 23
- VKSWWACDZPRJAP-UHFFFAOYSA-N 1,3-dioxepan-2-one Chemical compound O=C1OCCCCO1 VKSWWACDZPRJAP-UHFFFAOYSA-N 0.000 claims description 21
- 238000002360 preparation method Methods 0.000 claims description 21
- AOLNDUQWRUPYGE-UHFFFAOYSA-N 1,4-dioxepan-5-one Chemical compound O=C1CCOCCO1 AOLNDUQWRUPYGE-UHFFFAOYSA-N 0.000 claims description 20
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 19
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- 125000002947 alkylene group Chemical group 0.000 claims description 7
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 6
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
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- UCBHICFFJKDMMR-AWEZNQCLSA-N n-[[(5s)-3-[3-fluoro-4-(2-methyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CC2=NN(C)C=C2C1 UCBHICFFJKDMMR-AWEZNQCLSA-N 0.000 description 8
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 7
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- ILAYIAGXTHKHNT-UHFFFAOYSA-N 4-[4-(2,4,6-trimethyl-phenylamino)-pyrimidin-2-ylamino]-benzonitrile Chemical compound CC1=CC(C)=CC(C)=C1NC1=CC=NC(NC=2C=CC(=CC=2)C#N)=N1 ILAYIAGXTHKHNT-UHFFFAOYSA-N 0.000 description 5
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- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
- Polymerisation Methods In General (AREA)
- Polyesters Or Polycarbonates (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyethers (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Centrifugal Separators (AREA)
- Paper (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37790102P | 2002-05-03 | 2002-05-03 | |
| US377901P | 2002-05-03 | ||
| PCT/EP2003/004368 WO2003093344A1 (en) | 2002-05-03 | 2003-04-24 | Polymeric microemulsions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60318035D1 DE60318035D1 (de) | 2008-01-24 |
| DE60318035T2 true DE60318035T2 (de) | 2008-12-11 |
Family
ID=29401581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60318035T Expired - Lifetime DE60318035T2 (de) | 2002-05-03 | 2003-04-24 | Polymermikroemulsionen |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US20060034797A1 (https=) |
| EP (1) | EP1504047B1 (https=) |
| JP (1) | JP4300184B2 (https=) |
| KR (1) | KR20040111466A (https=) |
| CN (1) | CN1290893C (https=) |
| AR (1) | AR039522A1 (https=) |
| AT (1) | ATE380834T1 (https=) |
| AU (1) | AU2003222310B2 (https=) |
| BR (1) | BR0309688A (https=) |
| CA (1) | CA2483282C (https=) |
| DE (1) | DE60318035T2 (https=) |
| EA (1) | EA008244B1 (https=) |
| ES (1) | ES2298510T3 (https=) |
| IL (1) | IL164977A (https=) |
| MX (1) | MXPA04010778A (https=) |
| MY (1) | MY139066A (https=) |
| NO (1) | NO20045283L (https=) |
| NZ (1) | NZ536294A (https=) |
| PL (1) | PL220850B1 (https=) |
| TW (1) | TWI310388B (https=) |
| WO (1) | WO2003093344A1 (https=) |
| ZA (1) | ZA200408854B (https=) |
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| US8101629B2 (en) * | 2001-08-13 | 2012-01-24 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile |
| US7638522B2 (en) * | 2001-08-13 | 2009-12-29 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| KR101140785B1 (ko) * | 2002-08-09 | 2012-05-03 | 얀센 파마슈티카 엔.브이. | 4-〔〔4-〔〔4-（2-시아노에테닐）-2,6-디메틸페닐〕아미노〕-2-피리미디닐〕아미노〕벤조니트릴의 제조방법 |
| WO2004035013A2 (en) * | 2002-10-21 | 2004-04-29 | L'oreal | Process for dissolving lipophilic compounds, and cosmetic composition |
| US7968115B2 (en) | 2004-03-05 | 2011-06-28 | Board Of Regents, The University Of Texas System | Liposomal curcumin for treatment of cancer |
| US8784881B2 (en) | 2004-03-05 | 2014-07-22 | Board Of Regents, The University Of Texas System | Liposomal curcumin for treatment of diseases |
| JP4929567B2 (ja) * | 2004-08-05 | 2012-05-09 | コニカミノルタエムジー株式会社 | ポリマーミセル含有製剤の製造方法 |
| KR101381454B1 (ko) * | 2004-09-29 | 2014-04-04 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 열역학적으로 안정한 형태의 ｂａｙ 43-9006 토실레이트 |
| WO2006042215A1 (en) * | 2004-10-08 | 2006-04-20 | Janssen Pharmaceutica, N.V. | 1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives |
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| CA2668748A1 (en) * | 2006-11-09 | 2008-05-15 | Bayer Schering Pharma Aktiengesellschaft | Polymorph iii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide |
| US20100113533A1 (en) * | 2006-11-14 | 2010-05-06 | Bayer Schering Pharma Aktiengesellschaft | Polymorph II of 4-[4-(Amino)-3- Fluorophenoxy]-N-Methylpyridine-2-Carboxamide |
| EP2078010B1 (en) | 2006-12-29 | 2014-01-29 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| WO2008083353A1 (en) | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| EP2114955B1 (en) | 2006-12-29 | 2013-02-13 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| ES2672172T3 (es) | 2006-12-29 | 2018-06-12 | Rigel Pharmaceuticals, Inc. | Triazoles N3-heteroarilsustituidos y triazoles N5-heteroarilsustituidos útiles como inhibidores de Axl |
| EP2079736B1 (en) | 2006-12-29 | 2017-10-18 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as axl inhibitors |
| CN101687044B (zh) * | 2007-05-25 | 2014-10-29 | 不列颠哥伦比亚大学 | 用于口服给药的治疗剂的制剂和相关方法 |
| FR2919296A1 (fr) * | 2007-07-25 | 2009-01-30 | Rhodia Operations Sas | Ouverture de cycles epoxy par des carbenes. |
| WO2009054864A1 (en) | 2007-10-26 | 2009-04-30 | Rigel Pharmaceuticals, Inc. | Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| CA2730231C (en) | 2008-07-09 | 2016-10-18 | Rigel Pharmaceuticals, Inc. | Polycyclic heteroaryl substituted triazoles useful as axl inhibitors |
| US8431594B2 (en) | 2008-07-09 | 2013-04-30 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic heteroaryl substituted triazoles useful as AXL inhibitors |
| WO2010072844A1 (en) | 2008-12-24 | 2010-07-01 | Tibotec Pharmaceuticals | Implantable devices for treating hiv |
| EP2201935B1 (en) * | 2008-12-26 | 2020-07-08 | Samyang Biopharmaceuticals Corporation | Polymeric micelle composition containing a poorly soluble drug and preparation method of the same |
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| SG172997A1 (en) | 2009-01-16 | 2011-08-29 | Rigel Pharmaceuticals Inc | Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
| CN101531756B (zh) * | 2009-04-16 | 2011-06-15 | 山东大学 | 一种水溶性聚乙二醇/聚乳酸多嵌段聚碳酸酯的制备方法 |
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| WO2011050457A1 (en) | 2009-10-26 | 2011-05-05 | The University Of British Columbia | Stabilized formulation for oral administration of therapeutic agents and related methods |
| ES2647614T3 (es) * | 2010-12-29 | 2017-12-22 | Medincell | Composiciones biodegradables de liberación de fármaco |
| EP2634179A1 (en) * | 2012-02-28 | 2013-09-04 | Sanofi | Functional PLA-PEG copolymers, the nanoparticles thereof, their preparation and use for targeted drug delivery and imaging |
| ITTO20130431A1 (it) * | 2013-05-28 | 2014-11-29 | Fond Istituto Italiano Di Tecnologia | Copolimero e nanoparticelle da esso ottenute per la veicolazione di un farmaco |
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| CN104523592B (zh) * | 2015-01-26 | 2017-03-15 | 湖北工业大学 | 甲泼尼龙醋酸酯注射用自微乳制剂及其制备方法 |
| EP4374861A3 (en) | 2015-11-16 | 2024-08-07 | MedinCell S.A. | A method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
| TWI728172B (zh) | 2016-08-18 | 2021-05-21 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
| EP4137323A1 (en) | 2021-08-18 | 2023-02-22 | Imertech | Hydraulic binder with low carbon footprint and high early strength |
| CN117064767A (zh) * | 2023-09-05 | 2023-11-17 | 深圳市护家科技有限公司 | 一种肤感优异的水包油组合物、外用皮肤制剂及其制备方法 |
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| ES2058081T3 (es) * | 1986-09-05 | 1994-11-01 | American Cyanamid Co | Poliesteres que contienen bloques de oxido de alquileno como sistemas de administracion de medicamentos. |
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| US5510418A (en) * | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
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| WO1998035631A1 (en) * | 1997-02-14 | 1998-08-20 | Pathak Chandrashekar | Biocompatible polymers and methods for their use |
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| KR100288103B1 (ko) * | 1998-12-26 | 2001-05-02 | 윤덕용 | 폴리에테르가 그라프트된 생분해성 지방족 폴리에스테르 및 그의 제조방법 |
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| US6617995B2 (en) * | 2001-09-24 | 2003-09-09 | Microline Co., Ltd. | Radar detector |
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-
2003
- 2003-04-24 CN CNB038095793A patent/CN1290893C/zh not_active Expired - Fee Related
- 2003-04-24 NZ NZ536294A patent/NZ536294A/en unknown
- 2003-04-24 AT AT03717321T patent/ATE380834T1/de not_active IP Right Cessation
- 2003-04-24 WO PCT/EP2003/004368 patent/WO2003093344A1/en not_active Ceased
- 2003-04-24 EP EP03717321A patent/EP1504047B1/en not_active Expired - Lifetime
- 2003-04-24 CA CA2483282A patent/CA2483282C/en not_active Expired - Fee Related
- 2003-04-24 AU AU2003222310A patent/AU2003222310B2/en not_active Ceased
- 2003-04-24 BR BR0309688-2A patent/BR0309688A/pt not_active IP Right Cessation
- 2003-04-24 DE DE60318035T patent/DE60318035T2/de not_active Expired - Lifetime
- 2003-04-24 PL PL371934A patent/PL220850B1/pl unknown
- 2003-04-24 EA EA200401465A patent/EA008244B1/ru not_active IP Right Cessation
- 2003-04-24 KR KR10-2004-7015633A patent/KR20040111466A/ko not_active Ceased
- 2003-04-24 ES ES03717321T patent/ES2298510T3/es not_active Expired - Lifetime
- 2003-04-24 US US10/522,456 patent/US20060034797A1/en not_active Abandoned
- 2003-04-24 JP JP2004501483A patent/JP4300184B2/ja not_active Expired - Fee Related
- 2003-04-24 MX MXPA04010778A patent/MXPA04010778A/es active IP Right Grant
- 2003-04-30 MY MYPI20031645A patent/MY139066A/en unknown
- 2003-05-02 AR ARP030101540A patent/AR039522A1/es unknown
- 2003-05-02 TW TW092112064A patent/TWI310388B/zh active
-
2004
- 2004-11-02 ZA ZA200408854A patent/ZA200408854B/en unknown
- 2004-11-02 IL IL164977A patent/IL164977A/en active IP Right Grant
- 2004-12-02 NO NO20045283A patent/NO20045283L/no not_active Application Discontinuation
-
2011
- 2011-01-06 US US12/985,608 patent/US20110112115A1/en not_active Abandoned
-
2014
- 2014-12-01 US US14/557,058 patent/US20150086504A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE380834T1 (de) | 2007-12-15 |
| ES2298510T3 (es) | 2008-05-16 |
| EA008244B1 (ru) | 2007-04-27 |
| US20150086504A1 (en) | 2015-03-26 |
| BR0309688A (pt) | 2005-02-22 |
| AU2003222310A1 (en) | 2003-11-17 |
| JP4300184B2 (ja) | 2009-07-22 |
| NZ536294A (en) | 2005-05-27 |
| CA2483282C (en) | 2012-05-29 |
| JP2005524730A (ja) | 2005-08-18 |
| IL164977A0 (en) | 2005-12-18 |
| ZA200408854B (en) | 2005-11-02 |
| EP1504047A1 (en) | 2005-02-09 |
| IL164977A (en) | 2007-12-03 |
| MXPA04010778A (es) | 2005-03-07 |
| WO2003093344A1 (en) | 2003-11-13 |
| KR20040111466A (ko) | 2004-12-31 |
| AU2003222310B2 (en) | 2009-04-09 |
| AR039522A1 (es) | 2005-02-23 |
| PL371934A1 (en) | 2005-07-11 |
| NO20045283L (no) | 2005-01-07 |
| CA2483282A1 (en) | 2003-11-13 |
| CN1649932A (zh) | 2005-08-03 |
| TWI310388B (en) | 2009-06-01 |
| CN1290893C (zh) | 2006-12-20 |
| DE60318035D1 (de) | 2008-01-24 |
| EP1504047B1 (en) | 2007-12-12 |
| MY139066A (en) | 2009-08-28 |
| US20060034797A1 (en) | 2006-02-16 |
| US20110112115A1 (en) | 2011-05-12 |
| TW200413434A (en) | 2004-08-01 |
| PL220850B1 (pl) | 2016-01-29 |
| EA200401465A1 (ru) | 2005-04-28 |
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