DE60317045T2 - Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen - Google Patents

Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen Download PDF

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Publication number
DE60317045T2
DE60317045T2 DE60317045T DE60317045T DE60317045T2 DE 60317045 T2 DE60317045 T2 DE 60317045T2 DE 60317045 T DE60317045 T DE 60317045T DE 60317045 T DE60317045 T DE 60317045T DE 60317045 T2 DE60317045 T2 DE 60317045T2
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Germany
Prior art keywords
seq
dna
methylation
sequence
eya4
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Expired - Lifetime
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DE60317045T
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German (de)
English (en)
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DE60317045D1 (de
Inventor
Peter Adorjan
Matthias Burger
Sabine Maier
Ralf Lesche
Susan Seattle COTTRELL
Theo Seattle DE VOS
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Epigenomics AG
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Epigenomics AG
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Publication of DE60317045D1 publication Critical patent/DE60317045D1/de
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Publication of DE60317045T2 publication Critical patent/DE60317045T2/de
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE60317045T 2002-02-27 2003-02-13 Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen Expired - Lifetime DE60317045T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02004551 2002-02-27
EP02004551A EP1340818A1 (en) 2002-02-27 2002-02-27 Method and nucleic acids for the analysis of a colon cell proliferative disorder
PCT/EP2003/001457 WO2003072812A2 (en) 2002-02-27 2003-02-13 Method and nucleic acids for the analysis of colorectal cell proliferative disorders

Publications (2)

Publication Number Publication Date
DE60317045D1 DE60317045D1 (de) 2007-12-06
DE60317045T2 true DE60317045T2 (de) 2008-08-07

Family

ID=27675653

Family Applications (3)

Application Number Title Priority Date Filing Date
DE60317045T Expired - Lifetime DE60317045T2 (de) 2002-02-27 2003-02-13 Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen
DE60327600T Expired - Lifetime DE60327600D1 (de) 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebszellen
DE60335245T Expired - Lifetime DE60335245D1 (de) 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebs

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE60327600T Expired - Lifetime DE60327600D1 (de) 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebszellen
DE60335245T Expired - Lifetime DE60335245D1 (de) 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebs

Country Status (9)

Country Link
US (6) US8691503B2 (enExample)
EP (4) EP1340818A1 (enExample)
JP (3) JP2005518218A (enExample)
AT (3) ATE376596T1 (enExample)
AU (3) AU2003210265A1 (enExample)
CA (1) CA2451982A1 (enExample)
DE (3) DE60317045T2 (enExample)
ES (2) ES2295607T3 (enExample)
WO (3) WO2003072812A2 (enExample)

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US7943308B2 (en) * 2004-06-23 2011-05-17 Epigenomics Ag Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders
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EP3342877B1 (en) * 2004-09-30 2020-01-29 Epigenomics AG Method for providing dna fragments derived from an archived sample
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PT1871912E (pt) 2005-04-15 2012-05-25 Epigenomics Ag Método para determinar metilação de adn em amostras de sangue ou urina
US20100143899A1 (en) * 2005-05-17 2010-06-10 University Of Vermont And State Agricultural College Methods and products for diagnosing cancer
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US8445442B2 (en) * 2007-04-26 2013-05-21 University Of Vermont And State Agricultural College CCL18 and CCL3 methods and compositions for detecting and treating cancer
WO2009045370A2 (en) * 2007-09-28 2009-04-09 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
MY188455A (en) * 2007-10-19 2021-12-09 Genentech Inc Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
CN102099485A (zh) * 2007-10-23 2011-06-15 临床基因组学有限公司 诊断新生物的方法-ⅱ
KR100969692B1 (ko) * 2008-01-18 2010-07-14 한국생명공학연구원 대장암 과발현 유전자를 이용한 대장암 진단 마커
US20100112713A1 (en) * 2008-11-05 2010-05-06 The Texas A&M University System Methods For Detecting Colorectal Diseases And Disorders
US20120053071A1 (en) * 2008-12-18 2012-03-01 Koninklijke Philips Electronics N.V. Method for the detection of dna methylation patterns
WO2012106525A2 (en) 2011-02-02 2012-08-09 Exact Sciences Corporation Digital sequence analysis of dna methylation
AU2012324545A1 (en) * 2011-10-17 2014-06-05 King Abdullah University Of Science And Technology Composite biomarker for non-invasive screening, diagnosis and prognosis of colorectal cancer
US9598735B2 (en) * 2012-11-14 2017-03-21 JBS Science Inc. Detection of a panel of urine DNA markers for HCC screening and disease management
EP2886659A1 (en) 2013-12-20 2015-06-24 AIT Austrian Institute of Technology GmbH Gene methylation based colorectal cancer diagnosis

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Also Published As

Publication number Publication date
AU2003248349B2 (en) 2008-05-01
AU2003248349A1 (en) 2003-09-09
EP1481095B1 (en) 2010-12-08
WO2003072820A3 (en) 2004-04-08
EP1481095A2 (en) 2004-12-01
DE60317045D1 (de) 2007-12-06
AU2003210265A1 (en) 2003-09-09
EP1478778B1 (en) 2009-05-13
US8691503B2 (en) 2014-04-08
EP1478778A2 (en) 2004-11-24
EP1478784B1 (en) 2007-10-24
AU2003219002A1 (en) 2003-09-09
US20050003463A1 (en) 2005-01-06
JP2005518218A (ja) 2005-06-23
US20150275312A1 (en) 2015-10-01
US20110046005A1 (en) 2011-02-24
ES2325363T3 (es) 2009-09-02
ATE491038T1 (de) 2010-12-15
JP2005518220A (ja) 2005-06-23
AU2003219002B2 (en) 2008-04-24
ATE376596T1 (de) 2007-11-15
ES2295607T3 (es) 2008-04-16
WO2003072821A3 (en) 2004-04-01
ATE431429T1 (de) 2009-05-15
DE60327600D1 (de) 2009-06-25
EP1478784A2 (en) 2004-11-24
WO2003072820A2 (en) 2003-09-04
EP1340818A1 (en) 2003-09-03
US20060234224A1 (en) 2006-10-19
WO2003072812A3 (en) 2003-10-23
US20140179563A1 (en) 2014-06-26
US20060246433A1 (en) 2006-11-02
US9988683B2 (en) 2018-06-05
DE60335245D1 (de) 2011-01-20
WO2003072812A2 (en) 2003-09-04
WO2003072821A2 (en) 2003-09-04
JP2005518219A (ja) 2005-06-23
CA2451982A1 (en) 2003-09-04

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