ATE376596T1 - Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen - Google Patents
Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellenInfo
- Publication number
- ATE376596T1 ATE376596T1 AT03742934T AT03742934T ATE376596T1 AT E376596 T1 ATE376596 T1 AT E376596T1 AT 03742934 T AT03742934 T AT 03742934T AT 03742934 T AT03742934 T AT 03742934T AT E376596 T1 ATE376596 T1 AT E376596T1
- Authority
- AT
- Austria
- Prior art keywords
- disorders
- analyzing
- nucleic acids
- cell proliferation
- colorectal cell
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000004663 cell proliferation Effects 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 210000001072 colon Anatomy 0.000 abstract 2
- 230000002062 proliferating effect Effects 0.000 abstract 2
- 230000030933 DNA methylation on cytosine Effects 0.000 abstract 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000001973 epigenetic effect Effects 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02004551A EP1340818A1 (en) | 2002-02-27 | 2002-02-27 | Method and nucleic acids for the analysis of a colon cell proliferative disorder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE376596T1 true ATE376596T1 (de) | 2007-11-15 |
Family
ID=27675653
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03742934T ATE376596T1 (de) | 2002-02-27 | 2003-02-13 | Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen |
| AT03742964T ATE491038T1 (de) | 2002-02-27 | 2003-02-27 | Verfahren und nukleinsäuren zur analyse von kolonkrebs |
| AT03714760T ATE431429T1 (de) | 2002-02-27 | 2003-02-27 | Verfahren und nukleinsäuren zur analyse von kolonkrebszellen |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03742964T ATE491038T1 (de) | 2002-02-27 | 2003-02-27 | Verfahren und nukleinsäuren zur analyse von kolonkrebs |
| AT03714760T ATE431429T1 (de) | 2002-02-27 | 2003-02-27 | Verfahren und nukleinsäuren zur analyse von kolonkrebszellen |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US8691503B2 (enExample) |
| EP (4) | EP1340818A1 (enExample) |
| JP (3) | JP2005518218A (enExample) |
| AT (3) | ATE376596T1 (enExample) |
| AU (3) | AU2003210265A1 (enExample) |
| CA (1) | CA2451982A1 (enExample) |
| DE (3) | DE60317045T2 (enExample) |
| ES (2) | ES2295607T3 (enExample) |
| WO (3) | WO2003072812A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9201067B2 (en) * | 2003-03-05 | 2015-12-01 | Posco | Size-controlled macromolecule |
| EP1340818A1 (en) | 2002-02-27 | 2003-09-03 | Epigenomics AG | Method and nucleic acids for the analysis of a colon cell proliferative disorder |
| US20040029128A1 (en) * | 2002-08-08 | 2004-02-12 | Epigenomics, Inc. | Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene |
| EP1709204A1 (en) * | 2004-01-23 | 2006-10-11 | Lingvitae AS | Improving polynucleotide ligation reactions |
| WO2005089414A2 (en) * | 2004-03-17 | 2005-09-29 | The Johns Hopkins University | Neoplasia diagnostic compositions and methods of use |
| US7943308B2 (en) * | 2004-06-23 | 2011-05-17 | Epigenomics Ag | Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders |
| KR100617649B1 (ko) | 2004-09-24 | 2006-09-04 | (주)지노믹트리 | 대장암 특이적 발현감소 유전자의 메틸화된 프로모터를 함유하는 암 진단용 조성물 및 그 용도 |
| EP3342877B1 (en) * | 2004-09-30 | 2020-01-29 | Epigenomics AG | Method for providing dna fragments derived from an archived sample |
| US7932027B2 (en) | 2005-02-16 | 2011-04-26 | Epigenomics Ag | Method for determining the methylation pattern of a polynucleic acid |
| EP1693468A1 (en) | 2005-02-16 | 2006-08-23 | Epigenomics AG | Method for determining the methylation pattern of a polynucleic acid |
| PT1871912E (pt) | 2005-04-15 | 2012-05-25 | Epigenomics Ag | Método para determinar metilação de adn em amostras de sangue ou urina |
| US20100143899A1 (en) * | 2005-05-17 | 2010-06-10 | University Of Vermont And State Agricultural College | Methods and products for diagnosing cancer |
| DK2081950T3 (da) * | 2006-09-21 | 2013-06-03 | Nuclea Biomarkers Llc | Med irinotecanbehandling forbundne ekspressionsprofiler |
| US8445442B2 (en) * | 2007-04-26 | 2013-05-21 | University Of Vermont And State Agricultural College | CCL18 and CCL3 methods and compositions for detecting and treating cancer |
| WO2009045370A2 (en) * | 2007-09-28 | 2009-04-09 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
| MY188455A (en) * | 2007-10-19 | 2021-12-09 | Genentech Inc | Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates |
| CN102099485A (zh) * | 2007-10-23 | 2011-06-15 | 临床基因组学有限公司 | 诊断新生物的方法-ⅱ |
| KR100969692B1 (ko) * | 2008-01-18 | 2010-07-14 | 한국생명공학연구원 | 대장암 과발현 유전자를 이용한 대장암 진단 마커 |
| US20100112713A1 (en) * | 2008-11-05 | 2010-05-06 | The Texas A&M University System | Methods For Detecting Colorectal Diseases And Disorders |
| US20120053071A1 (en) * | 2008-12-18 | 2012-03-01 | Koninklijke Philips Electronics N.V. | Method for the detection of dna methylation patterns |
| WO2012106525A2 (en) | 2011-02-02 | 2012-08-09 | Exact Sciences Corporation | Digital sequence analysis of dna methylation |
| AU2012324545A1 (en) * | 2011-10-17 | 2014-06-05 | King Abdullah University Of Science And Technology | Composite biomarker for non-invasive screening, diagnosis and prognosis of colorectal cancer |
| US9598735B2 (en) * | 2012-11-14 | 2017-03-21 | JBS Science Inc. | Detection of a panel of urine DNA markers for HCC screening and disease management |
| EP2886659A1 (en) | 2013-12-20 | 2015-06-24 | AIT Austrian Institute of Technology GmbH | Gene methylation based colorectal cancer diagnosis |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5585481A (en) * | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| US5023090A (en) * | 1989-08-16 | 1991-06-11 | Levin Robert H | Topical compositions containing LYCD and other topically active medicinal ingredients for the treatment of ACNE |
| US5457183A (en) * | 1989-03-06 | 1995-10-10 | Board Of Regents, The University Of Texas System | Hydroxylated texaphyrins |
| US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5580722A (en) * | 1989-07-18 | 1996-12-03 | Oncogene Science, Inc. | Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease |
| US5180808A (en) * | 1989-11-27 | 1993-01-19 | La Jolla Cancer Research Foundation | Versican core protein, nucleic acid sequences encoding the same, nucleic acid probes, anti-versican antibodies, and methods of detecting the same |
| US5245022A (en) * | 1990-08-03 | 1993-09-14 | Sterling Drug, Inc. | Exonuclease resistant terminally substituted oligonucleotides |
| US5210015A (en) * | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5565552A (en) * | 1992-01-21 | 1996-10-15 | Pharmacyclics, Inc. | Method of expanded porphyrin-oligonucleotide conjugate synthesis |
| US5574142A (en) * | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
| SE501439C2 (sv) | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Sätt och anordning för analys av polynukleotidsekvenser |
| US5837832A (en) * | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| DE69417918T2 (de) | 1993-11-30 | 2000-01-05 | Mcgill University, Montreal | Dna methyltransferase inhibierung |
| US5597696A (en) * | 1994-07-18 | 1997-01-28 | Becton Dickinson And Company | Covalent cyanine dye oligonucleotide conjugates |
| US6017704A (en) * | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US5786146A (en) * | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| WO1998032849A2 (en) | 1997-01-29 | 1998-07-30 | Institut Pasteur | Polynucleotide associated with the bo or bor syndrome, its corresponding polypeptide and diagnostic and therapeutic applications |
| DE19754482A1 (de) | 1997-11-27 | 1999-07-01 | Epigenomics Gmbh | Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke |
| CA2330929A1 (en) * | 1998-06-06 | 1999-12-16 | Genostic Pharma Limited | Probes used for genetic profiling |
| US7700324B1 (en) * | 1998-11-03 | 2010-04-20 | The Johns Hopkins University School Of Medicine | Methylated CpG island amplification (MCA) |
| US5958773A (en) * | 1998-12-17 | 1999-09-28 | Isis Pharmaceuticals Inc. | Antisense modulation of AKT-1 expression |
| US6335170B1 (en) | 1999-02-22 | 2002-01-01 | Torben F. Orntoft | Gene expression in bladder tumors |
| US6331393B1 (en) * | 1999-05-14 | 2001-12-18 | University Of Southern California | Process for high-throughput DNA methylation analysis |
| DE19935772C2 (de) * | 1999-07-26 | 2002-11-07 | Epigenomics Ag | Verfahren zur relativen Quantifizierung der Methylierung von Cytosin Basen in DNA-Proben |
| ATE373710T1 (de) * | 1999-07-30 | 2007-10-15 | Epidauros Ag Biotechnologie Ag | Polymorphismus im humanen mdr-1 gen und dessen verwendung |
| US20040029123A1 (en) * | 2000-03-15 | 2004-02-12 | Alexander Olek | Diagnosis of diseases associated with the cell cycle |
| DE10019058A1 (de) | 2000-04-06 | 2001-12-20 | Epigenomics Ag | Detektion von Variationen des DNA-Methylierungsprofils |
| AU2001287269A1 (en) | 2000-03-28 | 2001-10-08 | Chiron Corporation | Human genes and expression products |
| DE10029915B4 (de) * | 2000-06-19 | 2005-06-16 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungen |
| AU2001277521A1 (en) * | 2000-06-30 | 2002-01-14 | Epigenomics Ag | Diagnosis of diseases associated with cell signalling |
| MXPA03001834A (es) * | 2000-09-01 | 2003-08-01 | Epigenomics Ag | Metodo para determinar el grado de metilacion de determinadas citocinas en adn genomico en el contexto de secuencia 5'-cpg-3'. |
| AU2002305051A1 (en) * | 2001-03-15 | 2002-10-03 | Clemson University | Polynucleotide encoding a gene conferring resistance to bacillus thuringiensis toxins |
| DE10120798B4 (de) * | 2001-04-27 | 2005-12-29 | Genovoxx Gmbh | Verfahren zur Bestimmung der Genexpression |
| US20030138793A1 (en) | 2001-06-10 | 2003-07-24 | Irm Llc, A Delaware Limited Liability Company | Molecular signatures of commonly fatal carcinomas |
| US20030215842A1 (en) * | 2002-01-30 | 2003-11-20 | Epigenomics Ag | Method for the analysis of cytosine methylation patterns |
| EP1340818A1 (en) | 2002-02-27 | 2003-09-03 | Epigenomics AG | Method and nucleic acids for the analysis of a colon cell proliferative disorder |
| WO2007123892A2 (en) * | 2006-04-17 | 2007-11-01 | Arqule Inc. | Raf inhibitors and their uses |
-
2002
- 2002-02-27 EP EP02004551A patent/EP1340818A1/en not_active Withdrawn
-
2003
- 2003-02-13 EP EP03742934A patent/EP1478784B1/en not_active Expired - Lifetime
- 2003-02-13 ES ES03742934T patent/ES2295607T3/es not_active Expired - Lifetime
- 2003-02-13 JP JP2003571492A patent/JP2005518218A/ja active Pending
- 2003-02-13 AT AT03742934T patent/ATE376596T1/de not_active IP Right Cessation
- 2003-02-13 DE DE60317045T patent/DE60317045T2/de not_active Expired - Lifetime
- 2003-02-13 WO PCT/EP2003/001457 patent/WO2003072812A2/en not_active Ceased
- 2003-02-13 US US10/482,823 patent/US8691503B2/en not_active Expired - Fee Related
- 2003-02-13 CA CA002451982A patent/CA2451982A1/en not_active Abandoned
- 2003-02-13 AU AU2003210265A patent/AU2003210265A1/en not_active Abandoned
- 2003-02-27 DE DE60327600T patent/DE60327600D1/de not_active Expired - Lifetime
- 2003-02-27 AU AU2003219002A patent/AU2003219002B2/en not_active Ceased
- 2003-02-27 AT AT03742964T patent/ATE491038T1/de not_active IP Right Cessation
- 2003-02-27 WO PCT/EP2003/002035 patent/WO2003072821A2/en not_active Ceased
- 2003-02-27 EP EP03714760A patent/EP1478778B1/en not_active Expired - Lifetime
- 2003-02-27 EP EP03742964A patent/EP1481095B1/en not_active Expired - Lifetime
- 2003-02-27 DE DE60335245T patent/DE60335245D1/de not_active Expired - Lifetime
- 2003-02-27 AU AU2003248349A patent/AU2003248349B2/en not_active Ceased
- 2003-02-27 US US10/506,111 patent/US20060246433A1/en not_active Abandoned
- 2003-02-27 JP JP2003571501A patent/JP2005518220A/ja active Pending
- 2003-02-27 JP JP2003571500A patent/JP2005518219A/ja active Pending
- 2003-02-27 AT AT03714760T patent/ATE431429T1/de not_active IP Right Cessation
- 2003-02-27 WO PCT/EP2003/002034 patent/WO2003072820A2/en not_active Ceased
- 2003-02-27 US US10/506,089 patent/US20060234224A1/en not_active Abandoned
- 2003-02-27 ES ES03714760T patent/ES2325363T3/es not_active Expired - Lifetime
-
2010
- 2010-06-04 US US12/794,449 patent/US9988683B2/en not_active Expired - Lifetime
-
2014
- 2014-02-21 US US14/186,984 patent/US20140179563A1/en not_active Abandoned
- 2014-11-25 US US14/553,566 patent/US20150275312A1/en not_active Abandoned
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