DE60304188T8 - [1,4]diazocino[7,8,1-hi]indolderivate als antipsychotische mittel und mittel gegen obesität - Google Patents
[1,4]diazocino[7,8,1-hi]indolderivate als antipsychotische mittel und mittel gegen obesität Download PDFInfo
- Publication number
- DE60304188T8 DE60304188T8 DE60304188T DE60304188T DE60304188T8 DE 60304188 T8 DE60304188 T8 DE 60304188T8 DE 60304188 T DE60304188 T DE 60304188T DE 60304188 T DE60304188 T DE 60304188T DE 60304188 T8 DE60304188 T8 DE 60304188T8
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- Prior art keywords
- agents
- diazocino
- indole derivatives
- against obesity
- antipsychotic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37534902P | 2002-04-25 | 2002-04-25 | |
US375349P | 2002-04-25 | ||
PCT/US2003/012691 WO2003091257A1 (en) | 2002-04-25 | 2003-04-23 | [1,4]DIAZOCINO [7,8,1-hi]INDOLE DERIVATIVES AS ANTIPSYCHOTIC AND ANTIOBESITY AGENTS |
Publications (3)
Publication Number | Publication Date |
---|---|
DE60304188D1 DE60304188D1 (de) | 2006-05-11 |
DE60304188T2 DE60304188T2 (de) | 2006-12-28 |
DE60304188T8 true DE60304188T8 (de) | 2007-04-19 |
Family
ID=29270634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60304188T Active DE60304188T8 (de) | 2002-04-25 | 2003-04-23 | [1,4]diazocino[7,8,1-hi]indolderivate als antipsychotische mittel und mittel gegen obesität |
Country Status (15)
Country | Link |
---|---|
US (1) | US7012089B2 (de) |
EP (1) | EP1497296B1 (de) |
JP (1) | JP4537076B2 (de) |
CN (2) | CN100376581C (de) |
AR (1) | AR039668A1 (de) |
AT (1) | ATE321050T1 (de) |
AU (1) | AU2003263119B2 (de) |
BR (1) | BR0309499A (de) |
CA (1) | CA2481324A1 (de) |
DE (1) | DE60304188T8 (de) |
DK (1) | DK1497296T3 (de) |
ES (1) | ES2260631T3 (de) |
MX (1) | MXPA04010373A (de) |
TW (1) | TW200307540A (de) |
WO (1) | WO2003091257A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI312781B (en) * | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
TW200307682A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
EP2400300A1 (de) | 2004-08-25 | 2011-12-28 | Takeda Pharmaceutical Company Limited | Screeningverfahren von Mitteln zur Prävention/Behandlung von stressbedingter Harninkontinenz |
GT200500317A (es) * | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
TW200635926A (en) * | 2004-11-05 | 2006-10-16 | Wyeth Corp | Metabolites of ceratin [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof |
AR051946A1 (es) * | 2004-11-05 | 2007-02-21 | Wyeth Corp | Formulaciones de derivados de [1,4] diazepina [6,7,1-ij] quinolina |
AR054849A1 (es) * | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
US20090203750A1 (en) * | 2005-08-24 | 2009-08-13 | Alan Kozikowski | 5-HT2C Receptor Agonists as Anorectic Agents |
TW200734334A (en) * | 2006-01-13 | 2007-09-16 | Wyeth Corp | Treatment of substance abuse |
EP1998780A2 (de) * | 2006-03-24 | 2008-12-10 | Wyeth a Corporation of the State of Delaware | Neue therapeutische kombinationen zur behandlung oder prävention psychotischer störungen |
CA2644662A1 (en) * | 2006-03-24 | 2007-10-04 | Wyeth | New therapeutic combinations for the treatment of depression |
AR060088A1 (es) * | 2006-03-24 | 2008-05-21 | Wyeth Corp | Metodos para tratar trastornos cognitivos y otros afines |
WO2007112000A2 (en) * | 2006-03-24 | 2007-10-04 | Wyeth | Treatment of pain |
EP2727585A1 (de) | 2006-05-16 | 2014-05-07 | Takeda Pharmaceutical Company Limited | In-vivo Screening-Methode |
CL2008002777A1 (es) * | 2007-09-21 | 2010-01-22 | Wyeth Corp | Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario. |
US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
JPWO2011071136A1 (ja) | 2009-12-11 | 2013-04-22 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
AU2011212930B2 (en) | 2010-02-04 | 2016-02-11 | The Board Of Trustees Of The University Of Illinois | Highly selective 5-HT(2C) receptor agonists having antagonist activity at the 5-HT(2B) receptor |
WO2012030953A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
WO2013133325A1 (ja) * | 2012-03-06 | 2013-09-12 | 武田薬品工業株式会社 | 三環性化合物 |
WO2013177241A1 (en) | 2012-05-22 | 2013-11-28 | Trustees Of Dartmouth College | Method for synthesizing cycloalkanyl(b}indoles, cycloalkanyl(b) benzofurans, cycloalkanyl(b)benzothiophenes, compounds and methods of use |
WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
EP3250549B1 (de) | 2015-01-29 | 2021-06-23 | The Board of Trustees of the University of Illinois | Cyclopropylmethanamine als selektive 5-ht (2c) rezeptoragonisten |
EP3733204A4 (de) | 2017-12-27 | 2021-09-15 | Takeda Pharmaceutical Company Limited | Therapeutikum für belastungsinkontinenz und stuhlinkontinenz |
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US3158619A (en) | 1962-06-14 | 1964-11-24 | Searle & Co | Certain sulfur-containing ortho-fused polycyclic pyrazole derivatives |
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US3335134A (en) | 1964-04-02 | 1967-08-08 | Sandoz Ag | Certain 3, 4-dihydrofluoreno[1, 9a, 9-e, f]1, 4-diazepin-3(2h)-ones |
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JPH0240379A (ja) | 1988-07-28 | 1990-02-09 | Wakunaga Pharmaceut Co Ltd | 新規キノロン誘導体 |
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US6759405B2 (en) | 2000-11-03 | 2004-07-06 | Wyeth | Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
US6503900B2 (en) | 2000-11-03 | 2003-01-07 | Wyeth | [1,4]diazepino [6,7,1-jk ]carbazoles and derivatives |
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AR031198A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Procedimiento para la preparacion de derivados de ciclopenta(b)diazepino(6,7,1)indol |
US6777407B2 (en) * | 2000-11-03 | 2004-08-17 | Wyeth | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
US6784172B2 (en) | 2000-11-03 | 2004-08-31 | Wyeth | Processes for preparation of cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
WO2002059129A2 (en) | 2000-12-20 | 2002-08-01 | Bristol-Myers Squibb Company | Substituted tetracyclic pyridoindoles as serotonin agonists and antagonists |
HUP0303530A3 (en) | 2000-12-20 | 2012-10-29 | Bristol Myers Squibb Co | Stituted pyrroloquinolines and pyridoquinolines as serotonin agonists and antagonists and pharmaceutical compositions containing them |
JP2005501092A (ja) | 2001-08-06 | 2005-01-13 | ファルマシア・アンド・アップジョン・カンパニー | 治療上有用な四環リガンド |
TWI312781B (en) | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
TW200307682A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
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2003
- 2003-04-22 TW TW092109350A patent/TW200307540A/zh unknown
- 2003-04-23 CA CA002481324A patent/CA2481324A1/en not_active Abandoned
- 2003-04-23 BR BR0309499-5A patent/BR0309499A/pt not_active IP Right Cessation
- 2003-04-23 MX MXPA04010373A patent/MXPA04010373A/es active IP Right Grant
- 2003-04-23 ES ES03741766T patent/ES2260631T3/es not_active Expired - Lifetime
- 2003-04-23 CN CNB038143496A patent/CN100376581C/zh not_active Expired - Fee Related
- 2003-04-23 EP EP03741766A patent/EP1497296B1/de not_active Expired - Lifetime
- 2003-04-23 WO PCT/US2003/012691 patent/WO2003091257A1/en active IP Right Grant
- 2003-04-23 DE DE60304188T patent/DE60304188T8/de active Active
- 2003-04-23 AU AU2003263119A patent/AU2003263119B2/en not_active Ceased
- 2003-04-23 AT AT03741766T patent/ATE321050T1/de not_active IP Right Cessation
- 2003-04-23 CN CNA2006101464687A patent/CN101003538A/zh not_active Withdrawn
- 2003-04-23 JP JP2003587815A patent/JP4537076B2/ja not_active Expired - Fee Related
- 2003-04-23 DK DK03741766T patent/DK1497296T3/da active
- 2003-04-24 US US10/422,657 patent/US7012089B2/en not_active Expired - Fee Related
- 2003-04-24 AR ARP030101429A patent/AR039668A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US7012089B2 (en) | 2006-03-14 |
JP2005531538A (ja) | 2005-10-20 |
DE60304188T2 (de) | 2006-12-28 |
BR0309499A (pt) | 2005-02-15 |
ES2260631T3 (es) | 2006-11-01 |
AU2003263119B2 (en) | 2009-05-07 |
CA2481324A1 (en) | 2003-11-06 |
DE60304188D1 (de) | 2006-05-11 |
JP4537076B2 (ja) | 2010-09-01 |
CN100376581C (zh) | 2008-03-26 |
DK1497296T3 (da) | 2006-06-06 |
ATE321050T1 (de) | 2006-04-15 |
AU2003263119A1 (en) | 2003-11-10 |
EP1497296B1 (de) | 2006-03-22 |
CN1662539A (zh) | 2005-08-31 |
TW200307540A (en) | 2003-12-16 |
US20040034005A1 (en) | 2004-02-19 |
MXPA04010373A (es) | 2005-02-03 |
WO2003091257A1 (en) | 2003-11-06 |
EP1497296A1 (de) | 2005-01-19 |
CN101003538A (zh) | 2007-07-25 |
AR039668A1 (es) | 2005-03-02 |
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