DE60236952D1 - Beschichtete teilchenförmige cefuroximeaxetil-zusammensetzungen - Google Patents

Beschichtete teilchenförmige cefuroximeaxetil-zusammensetzungen

Info

Publication number
DE60236952D1
DE60236952D1 DE60236952T DE60236952T DE60236952D1 DE 60236952 D1 DE60236952 D1 DE 60236952D1 DE 60236952 T DE60236952 T DE 60236952T DE 60236952 T DE60236952 T DE 60236952T DE 60236952 D1 DE60236952 D1 DE 60236952D1
Authority
DE
Germany
Prior art keywords
cefuroximeaxetile
compositions
coated particulate
masked
decomposing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60236952T
Other languages
English (en)
Inventor
Matilde Ibanez Fernandez
Emilio Sanz Garriz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DE60236952D1 publication Critical patent/DE60236952D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
DE60236952T 2001-11-23 2002-11-21 Beschichtete teilchenförmige cefuroximeaxetil-zusammensetzungen Expired - Lifetime DE60236952D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01500277 2001-11-23
PCT/EP2002/013150 WO2003043638A1 (en) 2001-11-23 2002-11-21 Coated particulate cefuroxime axetil compositions

Publications (1)

Publication Number Publication Date
DE60236952D1 true DE60236952D1 (de) 2010-08-19

Family

ID=8183502

Family Applications (3)

Application Number Title Priority Date Filing Date
DE10254412A Withdrawn DE10254412A1 (de) 2001-11-23 2002-11-21 Arzneimittel
DE20218068U Expired - Lifetime DE20218068U1 (de) 2001-11-23 2002-11-21 Arzneimittel
DE60236952T Expired - Lifetime DE60236952D1 (de) 2001-11-23 2002-11-21 Beschichtete teilchenförmige cefuroximeaxetil-zusammensetzungen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE10254412A Withdrawn DE10254412A1 (de) 2001-11-23 2002-11-21 Arzneimittel
DE20218068U Expired - Lifetime DE20218068U1 (de) 2001-11-23 2002-11-21 Arzneimittel

Country Status (34)

Country Link
US (1) US20030161888A1 (de)
EP (1) EP1446126B1 (de)
JP (1) JP3497503B2 (de)
KR (1) KR100979328B1 (de)
CN (1) CN1297274C (de)
AT (1) ATE473006T1 (de)
AU (2) AU2002302147B2 (de)
BE (2) BE1015217A5 (de)
BR (1) BR0204767A (de)
CA (1) CA2408198C (de)
CH (1) CH693982A5 (de)
CO (1) CO5580783A2 (de)
CY (1) CY1110778T1 (de)
CZ (1) CZ12993U1 (de)
DE (3) DE10254412A1 (de)
DK (1) DK1446126T3 (de)
ES (2) ES2201932B2 (de)
FR (1) FR2832635B1 (de)
GB (1) GB2383536B (de)
GR (1) GR1004522B (de)
HR (2) HRP20020923A2 (de)
HU (1) HUP0204026A3 (de)
IL (2) IL161972A0 (de)
IT (1) ITMI20022470A1 (de)
MX (1) MXPA02011561A (de)
NO (1) NO335273B1 (de)
NZ (1) NZ533092A (de)
PL (1) PL205325B1 (de)
PT (1) PT1446126E (de)
RU (1) RU2241460C2 (de)
SI (1) SI1446126T1 (de)
TR (1) TR200202559A2 (de)
WO (1) WO2003043638A1 (de)
ZA (1) ZA200209473B (de)

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US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
ATE516019T1 (de) 2004-05-11 2011-07-15 Egalet Ltd Quellbare dosierform mit gellan-gummit
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
NZ589750A (en) 2004-10-21 2012-07-27 Aptalis Pharmatech Inc Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
JP4972311B2 (ja) * 2004-12-15 2012-07-11 あすか製薬株式会社 イソソルビドの苦味が軽減された経口製剤及びその製造方法
JP2012107060A (ja) * 2004-12-15 2012-06-07 Aska Pharmaceutical Co Ltd イソソルビドの苦味が軽減された経口製剤及びその製造方法
DE102005019458A1 (de) 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
CN100402035C (zh) * 2005-07-07 2008-07-16 石药集团中奇制药技术（石家庄）有限公司 一种微囊化头孢呋辛酯的药物组合物
US8637076B2 (en) * 2006-06-01 2014-01-28 Cima Labs Inc. Prednisolone salt formulations
US20070281014A1 (en) * 2006-06-01 2007-12-06 Cima Labs, Inc. Prednisolone salt formulations
CN101756906B (zh) * 2009-11-02 2011-11-16 严洁 盐酸头孢卡品酯颗粒的药物组合物及其制备方法
JP5309262B2 (ja) 2009-12-02 2013-10-09 アプタリス ファーマ リミテッド フェキソフェナジン・マイクロカプセル及びそれを含む組成物
TW201127375A (en) * 2010-01-08 2011-08-16 Eurand Inc Taste masked topiramate composition and an orally disintegrating tablet comprising the same
EP2566458B1 (de) 2010-05-04 2015-08-05 Mahmut Bilgic Pharmazeutische formulierungen mit cefuroxim-axetil
JP5853461B2 (ja) * 2010-07-30 2016-02-09 大正製薬株式会社 内服液剤
EP2741750A1 (de) * 2011-08-12 2014-06-18 Dhanuka Laboratories Ltd. Pharmazeutische zusammensetzung mit cefuroxim
CN102440960A (zh) * 2011-09-01 2012-05-09 山东鲁抗医药股份有限公司 一种头孢呋辛酯干混悬剂药物组合物及其制备方法
IN2014CN02850A (de) 2011-10-31 2015-07-03 Glaxosmithkline Intellectual Property Ltd
CN108338936A (zh) * 2017-01-23 2018-07-31 刘全忠 敏感皮肤防护露的制备及使用

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GB1323161A (en) * 1970-02-16 1973-07-11 Wyeth John & Brother Ltd Penicillin composition
GB1571683A (en) * 1976-02-16 1980-07-16 Glaxo Operations Ltd Ester derivatives of cefuroxime
CA1094545A (en) * 1976-02-16 1981-01-27 Michael Gregson Cephalosporin antibiotics
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
GB8320520D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
GB8524001D0 (en) * 1985-09-30 1985-11-06 Glaxo Group Ltd Pharmaceutical composition
NL193682C (nl) * 1987-05-14 2000-07-04 Glaxo Group Ltd Beklede cefuroximaxetilsamenstelling.
US4992276A (en) * 1988-12-14 1991-02-12 Warner-Lambert Company Antiseptic compositions containing hexahydro-5-pyrimidinamine compounds and thymol and methods for preparing same
KR950703935A (ko) * 1992-11-30 1995-11-17 밋첼 아이, 커시너 맛을 차단하는 약제학적 조성물
IT1277426B1 (it) * 1995-08-03 1997-11-10 Acs Dobfar Spa Forma cristallina biodisponibile del cefuroxima axetil
NZ299077A (en) * 1996-07-26 1998-06-26 Apotex Inc Preparation of amorphous cefuroxime axetil (a cephalosporin derivative) by dissolving crystalline cefuroxim axetil in a highly polar solvent, typically dmso and/or dmf
CA2269806C (en) * 1996-10-28 2006-01-24 Bernhard H. Van Lengerich Embedding and encapsulation of controlled release particles
CA2209868C (en) * 1997-08-15 2001-08-14 Bernard Charles Sherman Pharmaceutical compositions comprising cefuroxime axetil
GB9726781D0 (en) * 1997-12-19 1998-02-18 Glaxo Group Ltd Pharmaceutical composition
AT413647B (de) * 1998-11-26 2006-04-15 Sandoz Ag Verwendung eines copolymerisats aus 1-vinyl-2-pyrrolidon und vinylacetat zur herstellung von cefuroximaxetil-hältigen tabletten

Also Published As

Publication number Publication date
GR20020100506A (el) 2003-07-16
CO5580783A2 (es) 2005-11-30
AU2002302147B2 (en) 2005-01-20
GR1004522B (el) 2004-04-06
HRP20020924A2 (en) 2003-10-31
ES2201932A1 (es) 2004-03-16
FR2832635B1 (fr) 2006-04-21
JP2003160493A (ja) 2003-06-03
BE1015217A5 (de) 2004-11-09
ATE473006T1 (de) 2010-07-15
US20030161888A1 (en) 2003-08-28
DE10254412A1 (de) 2003-06-12
CN1297274C (zh) 2007-01-31
AU2002338950A1 (en) 2003-06-10
EP1446126A1 (de) 2004-08-18
DE20218068U1 (de) 2003-03-27
TR200202559A2 (tr) 2003-06-23
GB2383536A (en) 2003-07-02
BR0204767A (pt) 2003-09-16
FR2832635A1 (fr) 2003-05-30
HU0204026D0 (en) 2003-01-28
CA2408198A1 (en) 2003-02-02
IL161972A0 (en) 2005-11-20
NO20042620L (no) 2004-06-22
BE1014078A6 (fr) 2003-03-04
KR20050044590A (ko) 2005-05-12
WO2003043638A1 (en) 2003-05-30
ES2201932B2 (es) 2005-03-16
CH693982A5 (de) 2004-05-28
KR100979328B1 (ko) 2010-08-31
GB2383536B (en) 2003-11-19
DK1446126T3 (da) 2010-10-11
PL205325B1 (pl) 2010-04-30
RU2241460C2 (ru) 2004-12-10
EP1446126B1 (de) 2010-07-07
SI1446126T1 (sl) 2010-10-29
PT1446126E (pt) 2010-09-24
PL357259A1 (en) 2003-06-02
CY1110778T1 (el) 2015-06-10
GB0227215D0 (en) 2002-12-24
HRP20020923A2 (en) 2003-10-31
IL161972A (en) 2009-06-15
CZ12993U1 (cs) 2003-02-10
ITMI20022470A1 (it) 2003-05-24
HUP0204026A3 (en) 2004-09-28
NO335273B1 (no) 2014-11-03
ZA200209473B (en) 2003-06-10
CA2408198C (en) 2004-03-09
CN1421206A (zh) 2003-06-04
MXPA02011561A (es) 2005-07-13
NZ533092A (en) 2006-02-24
HUP0204026A2 (hu) 2003-08-28
ES2347536T3 (es) 2010-11-02
JP3497503B2 (ja) 2004-02-16

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