DE60235089D1 - Verfahren zur stabilisierung von reduziertem coenzym q10 und verfahren zur sauren kristallisation - Google Patents

Verfahren zur stabilisierung von reduziertem coenzym q10 und verfahren zur sauren kristallisation

Info

Publication number
DE60235089D1
DE60235089D1 DE60235089T DE60235089T DE60235089D1 DE 60235089 D1 DE60235089 D1 DE 60235089D1 DE 60235089 T DE60235089 T DE 60235089T DE 60235089 T DE60235089 T DE 60235089T DE 60235089 D1 DE60235089 D1 DE 60235089D1
Authority
DE
Germany
Prior art keywords
reduced coenzyme
acid crystallization
stabilizing reduced
stabilizing
strong acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60235089T
Other languages
English (en)
Inventor
Takahiro Ueda
Shiro Kitamura
Yasuyoshi Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Application granted granted Critical
Publication of DE60235089D1 publication Critical patent/DE60235089D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/40—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/46—Use of additives, e.g. for stabilisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DE60235089T 2001-07-16 2002-07-15 Verfahren zur stabilisierung von reduziertem coenzym q10 und verfahren zur sauren kristallisation Expired - Lifetime DE60235089D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001215804 2001-07-16
JP2002114878 2002-04-17
PCT/JP2002/007148 WO2003008363A1 (en) 2001-07-16 2002-07-15 Method of stabilizing reduced coenzyme q10 and method of acidic crystallization

Publications (1)

Publication Number Publication Date
DE60235089D1 true DE60235089D1 (de) 2010-03-04

Family

ID=26618815

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60235089T Expired - Lifetime DE60235089D1 (de) 2001-07-16 2002-07-15 Verfahren zur stabilisierung von reduziertem coenzym q10 und verfahren zur sauren kristallisation

Country Status (11)

Country Link
US (1) US7169590B2 (de)
EP (1) EP1415973B1 (de)
JP (1) JP4149917B2 (de)
KR (1) KR20040018464A (de)
CN (1) CN1254462C (de)
AT (1) ATE455086T1 (de)
AU (1) AU2002318516B2 (de)
CA (1) CA2453135A1 (de)
DE (1) DE60235089D1 (de)
TW (1) TWI235146B (de)
WO (1) WO2003008363A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI349039B (en) 2001-12-27 2011-09-21 Kaneka Corp Processes for producing coenzyme q10
TW200302056A (en) * 2002-01-18 2003-08-01 Kaneka Corp Method for stabilizing reduced coenzyme Q10 and composition therefor
US7358402B2 (en) * 2003-09-10 2008-04-15 Kaneka Corporation Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal
ME01881B (me) 2004-01-22 2014-12-20 Univ Miami Topijske formulacije koenzima q10 i postupci upotrebe
US20060147542A1 (en) * 2004-12-24 2006-07-06 Tadao Ono Solid preparation containing reduced coenzyme Q10 and method for producing the same
US8067217B2 (en) * 2004-12-28 2011-11-29 Kaneka Corporation Method for preserving reduced coenzyme Q10
US20070258967A1 (en) * 2006-04-28 2007-11-08 Kaneka Corporation Purification method of reduced coenzyme q10
EP2136787B1 (de) 2007-03-22 2019-08-21 Berg LLC Topische formulierungen mit erhöhter bioverfügbarkeit
EP3015104A1 (de) 2008-04-11 2016-05-04 Berg LLC Verfahren und verwendung zur einleitung von apoptose bei krebszellen
CN101307338B (zh) * 2008-07-17 2012-04-25 任雷 还原型辅酶q10的制备方法
EA034552B1 (ru) 2009-05-11 2020-02-19 БЕРГ ЭлЭлСи Способ лечения или предотвращения прогрессирования онкологических заболеваний
PE20130045A1 (es) 2010-03-12 2013-01-28 Berg Pharma Llc FORMULACIONES INTRAVENOSAS DE COENZIMA Q10 (CoQ10) Y METODOS DE USO DE LAS MISMAS
KR101038916B1 (ko) * 2011-03-17 2011-06-07 노새미 콘크리트 저수조의 짜임공법식 내벽 마감구조
ES2762451T3 (es) 2011-04-04 2020-05-25 Berg Llc Tratamiento de tumores del sistema nervioso central con coenzima Q10
KR102058256B1 (ko) 2011-06-17 2020-01-22 버그 엘엘씨 흡입성 약제학적 조성물들
ES2668675T3 (es) * 2011-06-24 2018-05-21 Kaneka Corporation Cristal de coenzima Q10 reducida que tiene una excelente estabilidad
JP6731336B2 (ja) 2013-04-08 2020-07-29 バーグ エルエルシー コエンザイムｑ１０併用療法を用いた癌の処置方法
WO2015035094A1 (en) 2013-09-04 2015-03-12 Berg Llc Methods of treatment of cancer by continuous infusion of coenzyme q10
CN105833793B (zh) * 2015-12-21 2019-04-02 神舟生物科技有限责任公司 一种工业生产辅酶q10的工艺方法
CN113166017B (zh) * 2018-09-28 2024-03-29 株式会社钟化 稳定性优异的还原型辅酶q10结晶的制造方法
CN113024362B (zh) * 2021-03-10 2022-02-15 中国科学院上海药物研究所 一种辅酶qh与烟酰胺的共晶及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1200646A (en) * 1966-09-17 1970-07-29 Takeda Chemical Industries Ltd A method for the production of coenzyme q
JPS5915894B2 (ja) 1975-12-15 1984-04-12 ニツシンセイフン カブシキガイシヤ ホコウソｑノセイゾウホウホウ
JPS609796B2 (ja) * 1977-04-21 1985-03-13 日清製粉株式会社 補酵素ｑの製造法
JPS56140947A (en) * 1980-04-03 1981-11-04 Sekisui Chem Co Ltd Production of coenzyme q
EP0796108A2 (de) 1994-12-06 1997-09-24 Ryan Pharmaceuticals, Inc. Wasser-lösliche ubiquinone-zusammensetzungen, prodroge, und verfahren dembezüglich
JP3889481B2 (ja) * 1996-08-16 2007-03-07 株式会社カネカ 医薬組成物
US8753675B1 (en) 2000-01-20 2014-06-17 Raj K. Chopra Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications

Also Published As

Publication number Publication date
AU2002318516B2 (en) 2007-12-06
EP1415973A1 (de) 2004-05-06
JP4149917B2 (ja) 2008-09-17
WO2003008363A1 (en) 2003-01-30
JPWO2003008363A1 (ja) 2004-11-04
US7169590B2 (en) 2007-01-30
CA2453135A1 (en) 2003-01-30
EP1415973A4 (de) 2006-02-01
EP1415973B1 (de) 2010-01-13
KR20040018464A (ko) 2004-03-03
AU2002318516A2 (en) 2003-03-03
US20040197418A1 (en) 2004-10-07
CN1254462C (zh) 2006-05-03
TWI235146B (en) 2005-07-01
CN1525951A (zh) 2004-09-01
ATE455086T1 (de) 2010-01-15

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