ATE455086T1 - Verfahren zur stabilisierung von reduziertem coenzym q10 und verfahren zur sauren kristallisation - Google Patents

Verfahren zur stabilisierung von reduziertem coenzym q10 und verfahren zur sauren kristallisation

Info

Publication number
ATE455086T1
ATE455086T1 AT02746041T AT02746041T ATE455086T1 AT E455086 T1 ATE455086 T1 AT E455086T1 AT 02746041 T AT02746041 T AT 02746041T AT 02746041 T AT02746041 T AT 02746041T AT E455086 T1 ATE455086 T1 AT E455086T1
Authority
AT
Austria
Prior art keywords
reduced coenzyme
acid
crystalization
stabilizing reduced
stabilizing
Prior art date
Application number
AT02746041T
Other languages
English (en)
Inventor
Takahiro Ueda
Shiro Kitamura
Yasuyoshi Ueda
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Application granted granted Critical
Publication of ATE455086T1 publication Critical patent/ATE455086T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/40—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/46—Use of additives, e.g. for stabilisation
AT02746041T 2001-07-16 2002-07-15 Verfahren zur stabilisierung von reduziertem coenzym q10 und verfahren zur sauren kristallisation ATE455086T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001215804 2001-07-16
JP2002114878 2002-04-17
PCT/JP2002/007148 WO2003008363A1 (en) 2001-07-16 2002-07-15 Method of stabilizing reduced coenzyme q10 and method of acidic crystallization

Publications (1)

Publication Number Publication Date
ATE455086T1 true ATE455086T1 (de) 2010-01-15

Family

ID=26618815

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02746041T ATE455086T1 (de) 2001-07-16 2002-07-15 Verfahren zur stabilisierung von reduziertem coenzym q10 und verfahren zur sauren kristallisation

Country Status (11)

Country Link
US (1) US7169590B2 (de)
EP (1) EP1415973B1 (de)
JP (1) JP4149917B2 (de)
KR (1) KR20040018464A (de)
CN (1) CN1254462C (de)
AT (1) ATE455086T1 (de)
AU (1) AU2002318516B2 (de)
CA (1) CA2453135A1 (de)
DE (1) DE60235089D1 (de)
TW (1) TWI235146B (de)
WO (1) WO2003008363A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI349039B (en) * 2001-12-27 2011-09-21 Kaneka Corp Processes for producing coenzyme q10
TW200302056A (en) * 2002-01-18 2003-08-01 Kaneka Corp Method for stabilizing reduced coenzyme Q10 and composition therefor
US7358402B2 (en) * 2003-09-10 2008-04-15 Kaneka Corporation Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal
KR101535395B1 (ko) 2004-01-22 2015-07-08 유니버시티 오브 마이애미 국소용 코-엔자임 큐10 제형 및 그의 사용 방법
US20060147542A1 (en) * 2004-12-24 2006-07-06 Tadao Ono Solid preparation containing reduced coenzyme Q10 and method for producing the same
US8067217B2 (en) * 2004-12-28 2011-11-29 Kaneka Corporation Method for preserving reduced coenzyme Q10
JPWO2007126086A1 (ja) * 2006-04-28 2009-09-10 株式会社カネカ 還元型補酵素ｑ１０の精製方法
CA2680825C (en) 2007-03-22 2013-10-29 Cytotech Labs, Llc Topical formulations having enhanced bioavailability
EP2271325A4 (de) 2008-04-11 2011-11-09 Cytotech Labs Llc Verfahren und verfwendung zur einleitung von apoptose bei krebszellen
CN101307338B (zh) * 2008-07-17 2012-04-25 任雷 还原型辅酶q10的制备方法
KR20120034649A (ko) 2009-05-11 2012-04-12 버그 바이오시스템즈, 엘엘씨 환경대사적 전환인자（조효소 ｑ１０）를 사용한 질환의 치료 방법
NZ602057A (en) 2010-03-12 2015-06-26 Berg Pharma Llc Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof
KR101038916B1 (ko) * 2011-03-17 2011-06-07 노새미 콘크리트 저수조의 짜임공법식 내벽 마감구조
ES2762451T3 (es) 2011-04-04 2020-05-25 Berg Llc Tratamiento de tumores del sistema nervioso central con coenzima Q10
SG10201605008TA (en) 2011-06-17 2016-07-28 Berg Llc Inhalable pharmaceutical compositions
KR101991143B1 (ko) * 2011-06-24 2019-06-19 가부시키가이샤 가네카 안정성이 우수한 환원형 보효소 q10 결정
EA032775B1 (ru) 2013-04-08 2019-07-31 Берг Ллк Способы лечения злокачественной опухоли с использованием комбинированной терапии с коферментом q10
JP6595478B2 (ja) 2013-09-04 2019-10-23 バーグ エルエルシー コエンザイムｑ１０の連続注入によるがんの治療方法
CN105833793B (zh) * 2015-12-21 2019-04-02 神舟生物科技有限责任公司 一种工业生产辅酶q10的工艺方法
WO2020067275A1 (ja) * 2018-09-28 2020-04-02 株式会社カネカ 安定性に優れた還元型補酵素ｑ１０結晶の製造方法
CN113024362B (zh) * 2021-03-10 2022-02-15 中国科学院上海药物研究所 一种辅酶qh与烟酰胺的共晶及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6712642A (de) * 1966-09-17 1968-03-18
JPS5915894B2 (ja) 1975-12-15 1984-04-12 ニツシンセイフン カブシキガイシヤ ホコウソｑノセイゾウホウホウ
JPS609796B2 (ja) * 1977-04-21 1985-03-13 日清製粉株式会社 補酵素ｑの製造法
JPS56140947A (en) * 1980-04-03 1981-11-04 Sekisui Chem Co Ltd Production of coenzyme q
AU4510596A (en) * 1994-12-06 1996-06-26 National Research Council Of Canada Water soluble ubiquinone compositions, prodrugs, and methods relating thereto
JP3889481B2 (ja) * 1996-08-16 2007-03-07 株式会社カネカ 医薬組成物
US8753675B1 (en) 2000-01-20 2014-06-17 Raj K. Chopra Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications

Also Published As

Publication number Publication date
TWI235146B (en) 2005-07-01
JPWO2003008363A1 (ja) 2004-11-04
CA2453135A1 (en) 2003-01-30
JP4149917B2 (ja) 2008-09-17
CN1525951A (zh) 2004-09-01
EP1415973A4 (de) 2006-02-01
WO2003008363A1 (en) 2003-01-30
AU2002318516B2 (en) 2007-12-06
KR20040018464A (ko) 2004-03-03
EP1415973A1 (de) 2004-05-06
DE60235089D1 (de) 2010-03-04
US20040197418A1 (en) 2004-10-07
CN1254462C (zh) 2006-05-03
US7169590B2 (en) 2007-01-30
AU2002318516A2 (en) 2003-03-03
EP1415973B1 (de) 2010-01-13

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