DE60227517D1 - Verfahren zur herstellung von 10,11 dihydro 10 hydroxy 5h-dibenz/b,f/azepin-5-carbonsäureamid und 10,11 dihydro 10 oxo-5h-dibenz/b,f/azepin-5 carbonsäureamid - Google Patents

Verfahren zur herstellung von 10,11 dihydro 10 hydroxy 5h-dibenz/b,f/azepin-5-carbonsäureamid und 10,11 dihydro 10 oxo-5h-dibenz/b,f/azepin-5 carbonsäureamid

Info

Publication number
DE60227517D1
DE60227517D1 DE60227517T DE60227517T DE60227517D1 DE 60227517 D1 DE60227517 D1 DE 60227517D1 DE 60227517 T DE60227517 T DE 60227517T DE 60227517 T DE60227517 T DE 60227517T DE 60227517 D1 DE60227517 D1 DE 60227517D1
Authority
DE
Germany
Prior art keywords
dibenz
amid
dihydro
carboxylic
azepin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60227517T
Other languages
German (de)
English (en)
Inventor
David Alexander Learmonth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bial Portela and Cia SA
Original Assignee
Bial Portela and Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bial Portela and Cia SA filed Critical Bial Portela and Cia SA
Application granted granted Critical
Publication of DE60227517D1 publication Critical patent/DE60227517D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
DE60227517T 2001-05-25 2002-05-22 Verfahren zur herstellung von 10,11 dihydro 10 hydroxy 5h-dibenz/b,f/azepin-5-carbonsäureamid und 10,11 dihydro 10 oxo-5h-dibenz/b,f/azepin-5 carbonsäureamid Expired - Lifetime DE60227517D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0112812.3A GB0112812D0 (en) 2001-05-25 2001-05-25 Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom
PCT/GB2002/002356 WO2002096881A1 (en) 2001-05-25 2002-05-22 Method for preparation of 10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide and 10,11-dihydro-10-0x0-5h-dibenz/b,f/azepine-5-carboxamide

Publications (1)

Publication Number Publication Date
DE60227517D1 true DE60227517D1 (de) 2008-08-21

Family

ID=9915332

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60227517T Expired - Lifetime DE60227517D1 (de) 2001-05-25 2002-05-22 Verfahren zur herstellung von 10,11 dihydro 10 hydroxy 5h-dibenz/b,f/azepin-5-carbonsäureamid und 10,11 dihydro 10 oxo-5h-dibenz/b,f/azepin-5 carbonsäureamid
DE60239842T Expired - Lifetime DE60239842D1 (de) 2001-05-25 2002-05-22 Verfahren zur Herstellung von 10,11-dihydro-10-oxo-5h-dibenzoÄb,fÜazepin-5-carboxamid

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60239842T Expired - Lifetime DE60239842D1 (de) 2001-05-25 2002-05-22 Verfahren zur Herstellung von 10,11-dihydro-10-oxo-5h-dibenzoÄb,fÜazepin-5-carboxamid

Country Status (23)

Country Link
US (1) US7241886B2 (cs)
EP (2) EP1958938B1 (cs)
JP (3) JP4323309B2 (cs)
KR (1) KR100931916B1 (cs)
CN (2) CN1511141B (cs)
AR (1) AR035460A1 (cs)
AT (2) ATE506351T1 (cs)
AU (2) AU2002307863B8 (cs)
BR (1) BR0210019A (cs)
CA (2) CA2750876C (cs)
CY (3) CY1108345T1 (cs)
CZ (1) CZ303130B6 (cs)
DE (2) DE60227517D1 (cs)
DK (2) DK1958938T3 (cs)
ES (2) ES2362688T3 (cs)
GB (1) GB0112812D0 (cs)
HU (1) HU230019B1 (cs)
LU (1) LU91603I2 (cs)
MX (1) MXPA03010793A (cs)
PL (1) PL215305B1 (cs)
RU (2) RU2311411C2 (cs)
SI (1) SI1399424T1 (cs)
WO (1) WO2002096881A1 (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0303615D0 (en) * 2003-02-17 2003-03-19 Novartis Ag Use of organic compounds
ITMI20042230A1 (it) 2004-11-19 2005-02-19 Farchemia Srl Procedimento per la preparazione della 10,11-diidro-10 idrossi-5h-dibenz-b,f-azepin-5carbossiammide
ITMI20042291A1 (it) 2004-11-26 2005-02-26 Farchema S R L Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide
GB2422149A (en) * 2005-01-14 2006-07-19 Portela & Ca Sa Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
US20060252745A1 (en) * 2005-05-06 2006-11-09 Almeida Jose L D Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use
GB0515690D0 (en) 2005-07-29 2005-09-07 Portela & Ca Sa Asymmetric catalytic reduction
GB0517740D0 (en) * 2005-08-31 2005-10-12 Novartis Ag Organic compounds
GB0700773D0 (en) 2007-01-15 2007-02-21 Portela & Ca Sa Drug therapies
US8372431B2 (en) 2007-10-26 2013-02-12 Bial-Portela & C.A., S.A. Pharmaceutical composition comprising licarbazepine acetate
UA106384C2 (ru) 2009-07-27 2014-08-26 БИАЛ-ПОРТЕЛА энд КА., С.А. ПРИМЕНЕНИЕ ПРОИЗВОДНЫХ 5H-ДИБЕНЗ/б,ф/АЗЕПИН-5-КАРБОКСАМИДА ДЛЯ ЛЕЧЕНИЯ ФИБРОМИАЛГИИ
WO2013008194A2 (en) 2011-07-13 2013-01-17 Ranbaxy Laboratories Limited Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
EP2900640A1 (en) 2012-09-26 2015-08-05 Ranbaxy Laboratories Limited Process for the preparation of oxcarbazepine and its use as intermediate in the preparation of eslicarbazepine acetate
CA2998886C (en) 2015-09-16 2023-05-16 PetaOmics, Inc. Methods and compositions for genomic target enrichment and selective dna sequencing
CN111943347B (zh) * 2020-07-16 2022-08-30 同济大学 一种铜离子活化过氧乙酸去除废水中卡马西平的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5439390B2 (cs) * 1971-09-30 1979-11-27
BE789320A (fr) * 1971-09-30 1973-03-27 Takeda Chemical Industries Ltd Derives de dibenzoxirenazepine
CH633271A5 (en) 1978-04-18 1982-11-30 Ciba Geigy Ag Process for the rearrangement of 10,11-epoxy-10,11-dihydro-5H-dibenz[b,f]azepines to give 10-oxo-10,11-dihydro-5H-dibenz(b,f)azepines
CH642950A5 (en) * 1979-10-30 1984-05-15 Ciba Geigy Ag Process for the preparation of 10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
IT1272897B (it) * 1995-01-13 1997-07-01 I F C Iniziative Finanziaarie Processo per la produzione di 10-oxo-10,11-diidro-sh- -dibenz(b,f) azepin-5-carbossiammide
PT101732B (pt) * 1995-06-30 1997-12-31 Portela & Ca Sa Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso
PT101876B (pt) * 1996-05-27 1999-09-30 Portela & Ca Sa Novos derivados de 10,11-di-hidro-10-oxo-5h-dibenzo(b,f)azepina-5-carboxamida
AT408224B (de) 1999-03-15 2001-09-25 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von oxcarbazepin

Also Published As

Publication number Publication date
SI1399424T1 (sl) 2008-10-31
EP1958938A3 (en) 2008-09-03
CA2448094C (en) 2011-11-01
US7241886B2 (en) 2007-07-10
AU2007221834B2 (en) 2009-02-05
GB0112812D0 (en) 2001-07-18
JP2009057376A (ja) 2009-03-19
ATE506351T1 (de) 2011-05-15
JP2004532263A (ja) 2004-10-21
EP1399424A1 (en) 2004-03-24
BR0210019A (pt) 2004-08-10
CY2009017I2 (el) 2012-01-25
CN1511141B (zh) 2011-06-08
KR20040030626A (ko) 2004-04-09
CY1111492T1 (el) 2015-08-05
HU230019B1 (hu) 2015-05-28
ES2305299T3 (es) 2008-11-01
LU91603I2 (fr) 2009-10-28
RU2003137224A (ru) 2005-05-27
AU2007221834A1 (en) 2007-10-25
ES2362688T3 (es) 2011-07-11
JP4323309B2 (ja) 2009-09-02
PL215305B1 (pl) 2013-11-29
RU2311411C2 (ru) 2007-11-27
AR035460A1 (es) 2004-05-26
EP1958938A2 (en) 2008-08-20
WO2002096881A8 (en) 2003-02-27
EP1399424B1 (en) 2008-07-09
WO2002096881A1 (en) 2002-12-05
CN1511141A (zh) 2004-07-07
HUP0400296A3 (en) 2008-03-28
EP1958938B1 (en) 2011-04-20
HUP0400296A2 (hu) 2004-08-30
CN101172967A (zh) 2008-05-07
PL366993A1 (en) 2005-02-07
DK1958938T3 (da) 2011-07-25
CA2750876C (en) 2014-10-28
CA2750876A1 (en) 2002-12-05
AU2002307863B8 (en) 2007-10-18
JP5280252B2 (ja) 2013-09-04
JP2009167194A (ja) 2009-07-30
RU2007120532A (ru) 2008-12-10
ATE400560T1 (de) 2008-07-15
US20040158060A1 (en) 2004-08-12
DE60239842D1 (de) 2011-06-01
CZ20033203A3 (cs) 2004-06-16
MXPA03010793A (es) 2004-07-01
KR100931916B1 (ko) 2009-12-15
AU2002307863B2 (en) 2007-09-27
CA2448094A1 (en) 2002-12-05
EP1399424B8 (en) 2008-10-01
DK1399424T3 (da) 2008-09-08
CY1108345T1 (el) 2012-01-25
CY2009017I1 (el) 2012-01-25
CZ303130B6 (cs) 2012-04-18
RU2449992C2 (ru) 2012-05-10

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: BIAL - PORTELA & CA., S.A., S. MAMEDE DO CORON, PT

8364 No opposition during term of opposition