DE60227343D1 - Verfahren zur herstellung eines biochips - Google Patents
Verfahren zur herstellung eines biochipsInfo
- Publication number
- DE60227343D1 DE60227343D1 DE60227343T DE60227343T DE60227343D1 DE 60227343 D1 DE60227343 D1 DE 60227343D1 DE 60227343 T DE60227343 T DE 60227343T DE 60227343 T DE60227343 T DE 60227343T DE 60227343 D1 DE60227343 D1 DE 60227343D1
- Authority
- DE
- Germany
- Prior art keywords
- biochip
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000018 DNA microarray Methods 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00378—Piezoelectric or ink jet dispensers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00387—Applications using probes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/00527—Sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medical Informatics (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001032829 | 2001-02-08 | ||
PCT/JP2002/001011 WO2002063310A1 (fr) | 2001-02-08 | 2002-02-07 | Puce biologique et procede de fabrication de cette puce |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60227343D1 true DE60227343D1 (de) | 2008-08-14 |
Family
ID=18896694
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60227343T Expired - Lifetime DE60227343D1 (de) | 2001-02-08 | 2002-02-07 | Verfahren zur herstellung eines biochips |
Country Status (5)
Country | Link |
---|---|
US (1) | US7407746B2 (de) |
EP (1) | EP1365249B1 (de) |
JP (1) | JP3922454B2 (de) |
DE (1) | DE60227343D1 (de) |
WO (1) | WO2002063310A1 (de) |
Families Citing this family (36)
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EP2290364A1 (de) | 1996-04-25 | 2011-03-02 | BioArray Solutions Ltd. | Lichtgesteuerte elektrokinetische Anordnung von Partikeln in der Nähe von Oberflächen |
US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
AU7299301A (en) | 2000-06-21 | 2002-01-02 | Bioarray Solutions Ltd | Multianalyte molecular analysis using application-specific random particle arrays |
US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
EP2722395B1 (de) | 2001-10-15 | 2018-12-19 | Bioarray Solutions Ltd | Gemultiplexte Analyse polymorphischer Stellen durch gleichzeitige Abfrage und enzymvermittelte Detektion |
AU2003258683A1 (en) * | 2002-09-03 | 2004-03-29 | Zeptosens Ag | Analytical platform and detection method with analytes which are to be detected in a sample in the form of immobilized specific binding partners |
US7526114B2 (en) | 2002-11-15 | 2009-04-28 | Bioarray Solutions Ltd. | Analysis, secure access to, and transmission of array images |
CN1217003C (zh) * | 2003-02-20 | 2005-08-31 | 北京博奥生物芯片有限责任公司 | 一种微阵列反应装置及其应用 |
JP3878567B2 (ja) * | 2003-03-20 | 2007-02-07 | 東洋鋼鈑株式会社 | 生体関連分子固定化担体用ブロッキング剤、それを用いたブロッキング方法およびそれからなる生体関連分子検出用キット |
US20040241667A1 (en) * | 2003-05-30 | 2004-12-02 | Chesk William G. | Pulse-jet ejection head diagnostic system |
JP4532854B2 (ja) * | 2003-06-25 | 2010-08-25 | キヤノン株式会社 | 検出素子および検出素子の製造方法 |
CN1289904C (zh) * | 2003-08-01 | 2006-12-13 | 博奥生物有限公司 | 一种微阵列反应装置及其应用 |
US7927796B2 (en) | 2003-09-18 | 2011-04-19 | Bioarray Solutions, Ltd. | Number coding for identification of subtypes of coded types of solid phase carriers |
WO2005031305A2 (en) | 2003-09-22 | 2005-04-07 | Bioarray Solutions, Ltd. | Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules |
JP2007521017A (ja) | 2003-10-28 | 2007-08-02 | バイオアレイ ソリューションズ リミテッド | 固定化捕捉プローブを用いる遺伝子発現分析法の最適化 |
AU2004287069B2 (en) | 2003-10-29 | 2009-07-16 | Bioarray Solutions, Ltd. | Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA |
JP3949118B2 (ja) * | 2004-03-12 | 2007-07-25 | ジーエルサイエンス株式会社 | マイクロチップ |
US20080248972A1 (en) | 2004-05-14 | 2008-10-09 | Matsuhiko Nishizawa | Method of Immobilizing Protein, Protein Chip, Method of Immobilizing Cell and Cell Chip |
US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
JP4424158B2 (ja) * | 2004-11-04 | 2010-03-03 | ソニー株式会社 | バイオアッセイ装置とバイオアッセイ方法 |
US8486629B2 (en) | 2005-06-01 | 2013-07-16 | Bioarray Solutions, Ltd. | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
GB0513910D0 (en) * | 2005-07-07 | 2005-08-10 | Univ Newcastle | Immobilisation of biological molecules |
EP1887355B1 (de) * | 2006-08-02 | 2017-09-27 | F. Hoffmann-La Roche AG | Beschichtungsverfahren für ein mikrofluidiksystem. |
JP5001019B2 (ja) * | 2007-02-02 | 2012-08-15 | 株式会社日立ハイテクノロジーズ | 生体分子検出素子、生体分子検出素子の製造方法及び生体分子検出方法 |
JP4582224B2 (ja) * | 2008-05-02 | 2010-11-17 | ソニー株式会社 | マイクロビーズ作製方法及びマイクロビーズ |
JP4999007B2 (ja) * | 2008-06-24 | 2012-08-15 | 独立行政法人産業技術総合研究所 | 抗原抗体反応を利用した標的物質検出用チップ |
JP4930544B2 (ja) * | 2009-04-24 | 2012-05-16 | 大日本印刷株式会社 | 細胞培養用担体の製造方法 |
US20150045249A1 (en) | 2012-02-27 | 2015-02-12 | Toray Industries, Inc. | Nucleic acid detection method |
KR102062565B1 (ko) | 2012-06-20 | 2020-01-06 | 도레이 카부시키가이샤 | 핵산의 검출 방법 및 핵산 검출 키트 |
KR102062418B1 (ko) | 2012-08-31 | 2020-01-03 | 도레이 카부시키가이샤 | 표적 핵산의 검출 방법 |
EP2903740A2 (de) * | 2012-10-08 | 2015-08-12 | Albert-Ludwigs-Universität Freiburg | Einstufiges verfahren zur biomolekularen immobilisierung und produkte daraus |
US20170136452A1 (en) * | 2015-11-13 | 2017-05-18 | SoluDot LLC | Method for high throughput dispensing of biological samples |
CN112513267B (zh) | 2018-07-31 | 2024-05-10 | 东丽株式会社 | 体液样本的品质评价方法 |
WO2020067120A1 (ja) | 2018-09-25 | 2020-04-02 | 東レ株式会社 | 脱リン酸化試薬の品質を評価する方法及び標的核酸を検出する方法 |
WO2020067121A1 (ja) | 2018-09-25 | 2020-04-02 | 東レ株式会社 | アルカリホスファターゼ組成物並びに脱リン酸化核酸及び標識化核酸の製造方法 |
CN112752842A (zh) | 2018-09-25 | 2021-05-04 | 东丽株式会社 | 碱性磷酸酶组合物以及去磷酸化核酸和标记化核酸的制造方法 |
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FR2787582B1 (fr) | 1998-12-16 | 2001-01-12 | Commissariat Energie Atomique | Procede de fabrication d'une biopuce et biopuce |
EP1026259B1 (de) | 1999-02-08 | 2002-11-27 | Fuji Photo Film Co., Ltd. | Verfahren zur herstellung eines dns chip |
CN1185492C (zh) | 1999-03-15 | 2005-01-19 | 清华大学 | 可单点选通式微电磁单元阵列芯片、电磁生物芯片及应用 |
KR100379411B1 (ko) * | 1999-06-28 | 2003-04-10 | 엘지전자 주식회사 | 바이오칩 및 그의 생체 물질 패터닝 및 측정 방법 |
JP2001186880A (ja) | 1999-10-22 | 2001-07-10 | Ngk Insulators Ltd | Dnaチップの製造方法 |
US6656432B1 (en) | 1999-10-22 | 2003-12-02 | Ngk Insulators, Ltd. | Micropipette and dividedly injectable apparatus |
CA2344946A1 (en) | 2000-05-10 | 2001-11-10 | Symyx Technologies, Inc. | Polymer libraries on a substrate, method of forming polymer libraries on a substrate and characterization methods with same |
US20020076832A1 (en) * | 2000-06-02 | 2002-06-20 | Pirrung Michael C. | Method of attaching a biopolymer to a solid support |
-
2002
- 2002-02-06 US US10/068,292 patent/US7407746B2/en not_active Expired - Fee Related
- 2002-02-07 WO PCT/JP2002/001011 patent/WO2002063310A1/ja active IP Right Grant
- 2002-02-07 EP EP02711366A patent/EP1365249B1/de not_active Expired - Lifetime
- 2002-02-07 JP JP2002563004A patent/JP3922454B2/ja not_active Expired - Fee Related
- 2002-02-07 DE DE60227343T patent/DE60227343D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20020155481A1 (en) | 2002-10-24 |
US7407746B2 (en) | 2008-08-05 |
EP1365249A4 (de) | 2006-04-19 |
JP3922454B2 (ja) | 2007-05-30 |
EP1365249A1 (de) | 2003-11-26 |
EP1365249B1 (de) | 2008-07-02 |
WO2002063310A1 (fr) | 2002-08-15 |
JPWO2002063310A1 (ja) | 2004-06-10 |
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