DE60215544T2 - Zwischenprodukte für die synthese von lhrh-antagonisten, verfahren zu deren herstellung und verfahren zur herstellung von lhrh-antagonisten - Google Patents

Zwischenprodukte für die synthese von lhrh-antagonisten, verfahren zu deren herstellung und verfahren zur herstellung von lhrh-antagonisten Download PDF

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Publication number
DE60215544T2
DE60215544T2 DE60215544T DE60215544T DE60215544T2 DE 60215544 T2 DE60215544 T2 DE 60215544T2 DE 60215544 T DE60215544 T DE 60215544T DE 60215544 T DE60215544 T DE 60215544T DE 60215544 T2 DE60215544 T2 DE 60215544T2
Authority
DE
Germany
Prior art keywords
boc
4clphe
3pal
2nal
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60215544T
Other languages
German (de)
English (en)
Other versions
DE60215544D1 (de
Inventor
H. Jon RASMUSSEN
H. Palle RASMUSSEN
O. Wolfgang WACHS
Stefan Hansen
Jens Fomsgaard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CARLBIOTECH Ltd AS
Polypeptide Laboratories AS
Original Assignee
CARLBIOTECH Ltd AS
Polypeptide Laboratories AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CARLBIOTECH Ltd AS, Polypeptide Laboratories AS filed Critical CARLBIOTECH Ltd AS
Publication of DE60215544D1 publication Critical patent/DE60215544D1/de
Application granted granted Critical
Publication of DE60215544T2 publication Critical patent/DE60215544T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60215544T 2001-12-29 2002-12-23 Zwischenprodukte für die synthese von lhrh-antagonisten, verfahren zu deren herstellung und verfahren zur herstellung von lhrh-antagonisten Expired - Lifetime DE60215544T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0104463A SE0104463D0 (sv) 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
SE0104463 2001-12-29
PCT/IB2002/005583 WO2003055902A1 (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production

Publications (2)

Publication Number Publication Date
DE60215544D1 DE60215544D1 (de) 2006-11-30
DE60215544T2 true DE60215544T2 (de) 2007-08-30

Family

ID=20286557

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60215544T Expired - Lifetime DE60215544T2 (de) 2001-12-29 2002-12-23 Zwischenprodukte für die synthese von lhrh-antagonisten, verfahren zu deren herstellung und verfahren zur herstellung von lhrh-antagonisten
DE60222189T Expired - Lifetime DE60222189T2 (de) 2001-12-29 2002-12-23 Zwischenprodukte für die Synthese von LHRH-Antagonisten, Verfahren zu deren Herstellung und Verfahren zur Herstellung von LHRH-Antagonisten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60222189T Expired - Lifetime DE60222189T2 (de) 2001-12-29 2002-12-23 Zwischenprodukte für die Synthese von LHRH-Antagonisten, Verfahren zu deren Herstellung und Verfahren zur Herstellung von LHRH-Antagonisten

Country Status (21)

Country Link
US (2) US20050124788A1 (https=)
EP (2) EP1630169B1 (https=)
JP (1) JP4272529B2 (https=)
KR (1) KR100844520B1 (https=)
CN (1) CN1304417C (https=)
AT (2) ATE371666T1 (https=)
AU (1) AU2002348749B2 (https=)
CA (1) CA2471723C (https=)
CY (2) CY1107580T1 (https=)
DE (2) DE60215544T2 (https=)
DK (2) DK1465917T3 (https=)
ES (2) ES2296050T3 (https=)
IL (2) IL162788A0 (https=)
NO (1) NO330129B1 (https=)
NZ (1) NZ534245A (https=)
PT (2) PT1465917E (https=)
RU (1) RU2307125C2 (https=)
SE (1) SE0104463D0 (https=)
SI (1) SI1630169T1 (https=)
WO (1) WO2003055902A1 (https=)
ZA (1) ZA200405136B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4407322B2 (ja) * 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
TWI442932B (zh) 2008-02-11 2014-07-01 Ferring Int Ct Sa 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法
PT2632934T (pt) * 2010-10-27 2017-01-06 Ferring Bv Processo para o fabrico de degarelix e seus intermediários
EP2447276A1 (en) * 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
SG11201407679PA (en) 2012-06-01 2014-12-30 Ferring Bv Manufacture of degarelix

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098777A (en) * 1977-03-14 1978-07-04 Merck & Co., Inc. Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
SU1623166A1 (ru) * 1989-04-03 1994-02-15 Институт биоорганической химии АН БССР Нейтропептиды, обладающие поведенческой активностью
US5225598A (en) * 1990-03-30 1993-07-06 Union Carbide Chemicals & Plastics Technology Corporation Selective production of linear pentaethylenehexamine and hydroxyethyldiethylenetriamine
EP0540626A1 (en) * 1990-07-24 1993-05-12 Eastman Chemical Company Process for synthesizing peptides
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
WO1998018798A1 (en) * 1996-10-30 1998-05-07 Pfizer Inc. Pyridone-fused azabicyclic- or cytisine derivatives, their preparation and their use in addiction therapy
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE19941248A1 (de) 1998-09-01 2000-03-02 Asta Medica Ag Peptide mit N-substituierten Glycingruppen sowie diese enthaltende Arzneimittel zur Behandlung hormonabhängiger Tumore

Also Published As

Publication number Publication date
DE60215544D1 (de) 2006-11-30
HK1075052A1 (en) 2005-12-02
KR100844520B1 (ko) 2008-07-08
ATE371666T1 (de) 2007-09-15
CY1107025T1 (el) 2012-09-26
CY1107580T1 (el) 2013-03-13
NO20043047L (no) 2004-08-30
PT1465917E (pt) 2007-01-31
DE60222189T2 (de) 2008-06-19
DK1465917T3 (da) 2007-02-19
CN1622954A (zh) 2005-06-01
NZ534245A (en) 2007-05-31
ATE342913T1 (de) 2006-11-15
KR20040090965A (ko) 2004-10-27
CN1304417C (zh) 2007-03-14
DK1630169T3 (da) 2008-01-02
CA2471723C (en) 2011-02-15
EP1465917A1 (en) 2004-10-13
ES2275012T3 (es) 2007-06-01
JP4272529B2 (ja) 2009-06-03
EP1630169A2 (en) 2006-03-01
US20050124788A1 (en) 2005-06-09
RU2004119964A (ru) 2006-01-10
SE0104463D0 (sv) 2001-12-29
IL162788A (en) 2010-12-30
CA2471723A1 (en) 2003-07-10
AU2002348749A1 (en) 2003-07-15
SI1630169T1 (sl) 2008-04-30
US20080306242A1 (en) 2008-12-11
US8173770B2 (en) 2012-05-08
ES2296050T3 (es) 2008-04-16
ZA200405136B (en) 2005-07-27
JP2005516962A (ja) 2005-06-09
PT1630169E (pt) 2007-12-06
EP1465917B1 (en) 2006-10-18
IL162788A0 (en) 2005-11-20
WO2003055902A1 (en) 2003-07-10
AU2002348749B2 (en) 2008-09-04
EP1630169A3 (en) 2006-03-15
NO330129B1 (no) 2011-02-21
EP1630169B1 (en) 2007-08-29
RU2307125C2 (ru) 2007-09-27
DE60222189D1 (de) 2007-10-11

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