DE60212949T2 - Antivirale pyrazolopyridin verbindungen - Google Patents

Antivirale pyrazolopyridin verbindungen Download PDF

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Publication number
DE60212949T2
DE60212949T2 DE60212949T DE60212949T DE60212949T2 DE 60212949 T2 DE60212949 T2 DE 60212949T2 DE 60212949 T DE60212949 T DE 60212949T DE 60212949 T DE60212949 T DE 60212949T DE 60212949 T2 DE60212949 T2 DE 60212949T2
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DE
Germany
Prior art keywords
het
nhr
formula
compound
group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60212949T
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German (de)
English (en)
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DE60212949D1 (de
Inventor
Mui GlaxoSmithKline Research Triangle Park CHEUNG
Kristjan GlaxoSmithKline Research Triangle Park GUDMUNDSSON
A. GlaxoSmithKline Brian Research Triangle Park JOHNS
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SmithKline Beecham Corp
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SmithKline Beecham Corp
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Publication of DE60212949D1 publication Critical patent/DE60212949D1/de
Publication of DE60212949T2 publication Critical patent/DE60212949T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60212949T 2001-04-10 2002-03-21 Antivirale pyrazolopyridin verbindungen Expired - Fee Related DE60212949T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28274901P 2001-04-10 2001-04-10
US282749P 2001-04-10
PCT/US2002/008793 WO2002083672A1 (en) 2001-04-10 2002-03-21 Antiviral pyrazolopyridine compounds

Publications (2)

Publication Number Publication Date
DE60212949D1 DE60212949D1 (de) 2006-08-17
DE60212949T2 true DE60212949T2 (de) 2007-01-04

Family

ID=23082954

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60212949T Expired - Fee Related DE60212949T2 (de) 2001-04-10 2002-03-21 Antivirale pyrazolopyridin verbindungen

Country Status (7)

Country Link
US (2) US7141569B2 (enExample)
EP (1) EP1377575B1 (enExample)
JP (1) JP4219171B2 (enExample)
AT (1) ATE332301T1 (enExample)
DE (1) DE60212949T2 (enExample)
ES (1) ES2266487T3 (enExample)
WO (1) WO2002083672A1 (enExample)

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WO2017070089A1 (en) 2015-10-19 2017-04-27 Incyte Corporation Heterocyclic compounds as immunomodulators
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EP3390361B1 (en) 2015-12-17 2022-03-16 Incyte Corporation N-phenyl-pyridine-2-carboxamide derivatives and their use as pd-1/pd-l1 protein/protein interaction modulators
TWI767896B (zh) 2015-12-22 2022-06-21 美商英塞特公司 作為免疫調節劑之雜環化合物
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ES2905980T3 (es) 2016-05-26 2022-04-12 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
CN109890819B (zh) 2016-06-20 2022-11-22 因赛特公司 作为免疫调节剂的杂环化合物
EP3484866B1 (en) 2016-07-14 2022-09-07 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2018044783A1 (en) 2016-08-29 2018-03-08 Incyte Corporation Heterocyclic compounds as immunomodulators
SMT202200415T1 (it) 2016-12-22 2022-11-18 Incyte Corp Derivati di tetraidro imidazo[4,5-c]piridina come induttori di internalizzazione di pd-l1
WO2018119221A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Pyridine derivatives as immunomodulators
EP3558963B1 (en) 2016-12-22 2022-03-23 Incyte Corporation Bicyclic heteroaromatic compounds as immunomodulators
GEAP202215134A (en) 2016-12-22 2022-05-10 Incyte Corp Heterocyclic compounds as immunomodulators
US20180179201A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
PL4212529T3 (pl) 2018-03-30 2025-07-07 Incyte Corporation Związki heterocykliczne jako immunomodulatory
JOP20200288A1 (ar) 2018-05-11 2020-11-11 Incyte Corp مشتقات تترا هيدرو – إيميدازو[4، 5-c]بيريدين كمعدِّلات مناعية pd-l1
TW202115059A (zh) 2019-08-09 2021-04-16 美商英塞特公司 Ｐｄ—１／ｐｄ—ｌ１抑制劑之鹽
AR120109A1 (es) 2019-09-30 2022-02-02 Incyte Corp Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores
CR20220237A (es) 2019-11-11 2022-08-05 Incyte Corp Sales y formas cristalinas de un inhibidor de pd-1/pd-l1
WO2022099018A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Process of preparing a pd-1/pd-l1 inhibitor
IL302590A (en) 2020-11-06 2023-07-01 Incyte Corp Process for preparing PD-1/PD-L1 inhibitor and salts and crystalline forms thereof
TW202233615A (zh) 2020-11-06 2022-09-01 美商英塞特公司 Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式

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Also Published As

Publication number Publication date
US20060235043A1 (en) 2006-10-19
US7141569B2 (en) 2006-11-28
US20040167335A1 (en) 2004-08-26
JP2004529926A (ja) 2004-09-30
EP1377575A1 (en) 2004-01-07
DE60212949D1 (de) 2006-08-17
ES2266487T3 (es) 2007-03-01
ATE332301T1 (de) 2006-07-15
WO2002083672A1 (en) 2002-10-24
JP4219171B2 (ja) 2009-02-04
EP1377575B1 (en) 2006-07-05

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