DE60212825T2 - Selbsterhaltender lactococcus stamm - Google Patents
Selbsterhaltender lactococcus stamm Download PDFInfo
- Publication number
- DE60212825T2 DE60212825T2 DE60212825T DE60212825T DE60212825T2 DE 60212825 T2 DE60212825 T2 DE 60212825T2 DE 60212825 T DE60212825 T DE 60212825T DE 60212825 T DE60212825 T DE 60212825T DE 60212825 T2 DE60212825 T2 DE 60212825T2
- Authority
- DE
- Germany
- Prior art keywords
- gene
- lactococcus
- strain
- thya
- lactis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000194036 Lactococcus Species 0.000 title abstract description 17
- 108090000623 proteins and genes Proteins 0.000 claims description 47
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- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 28
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- 101900156096 Lactococcus lactis subsp. lactis Thymidylate synthase Proteins 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1007—Methyltransferases (general) (2.1.1.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/01—Methyltransferases (2.1.1)
- C12Y201/01045—Thymidylate synthase (2.1.1.45)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01201631 | 2001-05-03 | ||
| EP01201631 | 2001-05-03 | ||
| EP01204785 | 2001-12-07 | ||
| EP01204785 | 2001-12-07 | ||
| PCT/EP2002/004942 WO2002090551A2 (en) | 2001-05-03 | 2002-05-03 | Self-containing lactococcus strain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60212825D1 DE60212825D1 (de) | 2006-08-10 |
| DE60212825T2 true DE60212825T2 (de) | 2007-01-11 |
Family
ID=26076897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60212825T Expired - Lifetime DE60212825T2 (de) | 2001-05-03 | 2002-05-03 | Selbsterhaltender lactococcus stamm |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1383897B1 (https=) |
| JP (2) | JP4347575B2 (https=) |
| AT (1) | ATE331789T1 (https=) |
| AU (1) | AU2002314040B2 (https=) |
| CA (1) | CA2446776C (https=) |
| DE (1) | DE60212825T2 (https=) |
| DK (1) | DK1383897T3 (https=) |
| ES (1) | ES2266515T3 (https=) |
| WO (1) | WO2002090551A2 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| DE60319822T2 (de) | 2002-06-19 | 2009-06-04 | Actogenix Nv | Verfahren und mittel zur erhöhung der darmabsorption |
| WO2004056850A2 (en) * | 2002-12-19 | 2004-07-08 | Vib Vzw | Mutant proteins showing increased secretion |
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| ES2439698T3 (es) | 2004-08-20 | 2014-01-24 | Actogenix N.V. | Procedimiento para mejorar la conservación de lactococos |
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| DK3181682T3 (da) * | 2008-09-29 | 2021-07-05 | Intrexon Actobiotics Nv | Reduceret kolonisering af mikrober på slimhinden |
| WO2012164083A1 (en) | 2011-06-01 | 2012-12-06 | Actogenix N.V. | Polycistronic expression system for bacteria |
| WO2013041672A1 (en) | 2011-09-23 | 2013-03-28 | Actogenix Nv | Modified gram positive bacteria and uses thereof |
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| BR112017018656B1 (pt) * | 2015-03-02 | 2021-11-30 | Synlogic, Inc | Bactéria geneticamente modificada, composição farmaceuticamente aceitável compreendendo a dita bactéria e uso da dita composição para tratar ou prevenir uma doença ou condição associada à inflamação intestinal e/ou função da barreira intestinal comprometida |
| CN106148254B (zh) * | 2015-03-26 | 2019-11-12 | 南京华贞生物医药科技有限公司 | 一种用于减肥降脂的转化体及其构建方法与应用 |
| US11685925B2 (en) | 2015-10-30 | 2023-06-27 | Synlogic Operating Company, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier |
| WO2017087580A1 (en) | 2015-11-16 | 2017-05-26 | Synlogic, Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| CA3011331C (en) | 2016-01-14 | 2025-05-13 | Intrexon Actobiotics N.V. | Compositions and methods for the treatment of type 1 diabetes |
| JP7016865B2 (ja) | 2016-09-02 | 2022-03-03 | イントレクソン・アクトバイオテイクス・エヌブイ | Ｉｌ－１０およびインスリンを安定的に発現する遺伝子改変された細菌 |
| CN109983028B (zh) | 2016-09-13 | 2023-10-20 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 黏膜黏附性微生物 |
| CN111655841A (zh) | 2017-06-21 | 2020-09-11 | 同生运营公司 | 用于治疗紊乱的细菌 |
| US20210393711A1 (en) | 2018-10-11 | 2021-12-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Bacteria expressing single chain antibodies against toll-like receptors |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE4231764A1 (de) * | 1992-09-23 | 1994-03-24 | Inst Pflanzengenetik & Kultur | Verfahren zur chromosomalen Integration eines Produkt-Gens |
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- 2002-05-03 JP JP2002587611A patent/JP4347575B2/ja not_active Expired - Fee Related
- 2002-05-03 CA CA2446776A patent/CA2446776C/en not_active Expired - Fee Related
- 2002-05-03 AU AU2002314040A patent/AU2002314040B2/en not_active Ceased
- 2002-05-03 EP EP02740565A patent/EP1383897B1/en not_active Expired - Lifetime
- 2002-05-03 AT AT02740565T patent/ATE331789T1/de active
- 2002-05-03 DK DK02740565T patent/DK1383897T3/da active
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- 2002-05-03 DE DE60212825T patent/DE60212825T2/de not_active Expired - Lifetime
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| WO2002090551A2 (en) | 2002-11-14 |
| ATE331789T1 (de) | 2006-07-15 |
| CA2446776C (en) | 2011-07-12 |
| ES2266515T3 (es) | 2007-03-01 |
| JP2009060913A (ja) | 2009-03-26 |
| JP4347575B2 (ja) | 2009-10-21 |
| AU2002314040B2 (en) | 2007-06-28 |
| DK1383897T3 (da) | 2006-10-30 |
| EP1383897A2 (en) | 2004-01-28 |
| WO2002090551A3 (en) | 2003-03-27 |
| JP2004533246A (ja) | 2004-11-04 |
| DE60212825D1 (de) | 2006-08-10 |
| CA2446776A1 (en) | 2002-11-14 |
| EP1383897B1 (en) | 2006-06-28 |
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