AU2002314040B2 - Self-containing lactococcus strain - Google Patents

Self-containing lactococcus strain Download PDF

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Publication number
AU2002314040B2
AU2002314040B2 AU2002314040A AU2002314040A AU2002314040B2 AU 2002314040 B2 AU2002314040 B2 AU 2002314040B2 AU 2002314040 A AU2002314040 A AU 2002314040A AU 2002314040 A AU2002314040 A AU 2002314040A AU 2002314040 B2 AU2002314040 B2 AU 2002314040B2
Authority
AU
Australia
Prior art keywords
lactococcus
gene
strain
thya
lactis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002314040A
Other languages
English (en)
Other versions
AU2002314040A1 (en
Inventor
Lothar Steidler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intrexon Actobiotics NV
Original Assignee
Intrexon Actobiotics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Actobiotics NV filed Critical Intrexon Actobiotics NV
Publication of AU2002314040A1 publication Critical patent/AU2002314040A1/en
Assigned to ACTOGENIX N.V. reassignment ACTOGENIX N.V. Request for Assignment Assignors: VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW
Application granted granted Critical
Publication of AU2002314040B2 publication Critical patent/AU2002314040B2/en
Assigned to INTREXON ACTOBIOTICS NV reassignment INTREXON ACTOBIOTICS NV Request to Amend Deed and Register Assignors: ACTOGENIX N.V.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01045—Thymidylate synthase (2.1.1.45)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
AU2002314040A 2001-05-03 2002-05-03 Self-containing lactococcus strain Ceased AU2002314040B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP01201631.7 2001-05-03
EP01201631 2001-05-03
EP01204785 2001-12-07
EP01204785.8 2001-12-07
PCT/EP2002/004942 WO2002090551A2 (en) 2001-05-03 2002-05-03 Self-containing lactococcus strain

Publications (2)

Publication Number Publication Date
AU2002314040A1 AU2002314040A1 (en) 2003-05-01
AU2002314040B2 true AU2002314040B2 (en) 2007-06-28

Family

ID=26076897

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002314040A Ceased AU2002314040B2 (en) 2001-05-03 2002-05-03 Self-containing lactococcus strain

Country Status (9)

Country Link
EP (1) EP1383897B1 (https=)
JP (2) JP4347575B2 (https=)
AT (1) ATE331789T1 (https=)
AU (1) AU2002314040B2 (https=)
CA (1) CA2446776C (https=)
DE (1) DE60212825T2 (https=)
DK (1) DK1383897T3 (https=)
ES (1) ES2266515T3 (https=)
WO (1) WO2002090551A2 (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7780961B2 (en) 2001-05-03 2010-08-24 Actogenix N.V. Self-containing Lactococcus strain
DE60319822T2 (de) 2002-06-19 2009-06-04 Actogenix Nv Verfahren und mittel zur erhöhung der darmabsorption
WO2004056850A2 (en) * 2002-12-19 2004-07-08 Vib Vzw Mutant proteins showing increased secretion
JP4589618B2 (ja) * 2003-11-28 2010-12-01 独立行政法人農業生物資源研究所 免疫調節性機能を誘導する乳酸菌類とその成分
ES2439698T3 (es) 2004-08-20 2014-01-24 Actogenix N.V. Procedimiento para mejorar la conservación de lactococos
AU2006319216B2 (en) * 2005-11-29 2012-09-13 Intrexon Actobiotics Nv Induction of mucosal tolerance to antigens
JP2010513245A (ja) * 2006-12-14 2010-04-30 アクトジェニックス・エヌブイ 免疫調節を誘起するための結合分子の送達
EP2115146B1 (en) * 2007-01-12 2016-07-06 Intrexon Actobiotics NV Lactococcus promoters and uses thereof
CN103933563B (zh) 2007-01-25 2016-09-28 英特瑞克斯顿阿克图比奥帝克斯有限公司 使用遗传修饰的乳杆菌通过抗原的粘膜递送治疗免疫疾病
DK3181682T3 (da) * 2008-09-29 2021-07-05 Intrexon Actobiotics Nv Reduceret kolonisering af mikrober på slimhinden
WO2012164083A1 (en) 2011-06-01 2012-12-06 Actogenix N.V. Polycistronic expression system for bacteria
WO2013041672A1 (en) 2011-09-23 2013-03-28 Actogenix Nv Modified gram positive bacteria and uses thereof
EP3382006B1 (en) 2011-09-23 2021-02-17 Intrexon Actobiotics NV Modified gram positive bacteria and uses thereof
US9688967B2 (en) 2014-12-05 2017-06-27 Synlogic, Inc. Bacteria engineered to treat diseases associated with hyperammonemia
US10610546B2 (en) 2015-05-13 2020-04-07 Synlogic Operating Company Inc. Bacteria engineered to reduce hyperphenylalaninemia
US20160206666A1 (en) 2014-12-22 2016-07-21 Synlogic, Inc. Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier
BR112017018656B1 (pt) * 2015-03-02 2021-11-30 Synlogic, Inc Bactéria geneticamente modificada, composição farmaceuticamente aceitável compreendendo a dita bactéria e uso da dita composição para tratar ou prevenir uma doença ou condição associada à inflamação intestinal e/ou função da barreira intestinal comprometida
CN106148254B (zh) * 2015-03-26 2019-11-12 南京华贞生物医药科技有限公司 一种用于减肥降脂的转化体及其构建方法与应用
US11685925B2 (en) 2015-10-30 2023-06-27 Synlogic Operating Company, Inc. Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier
WO2017087580A1 (en) 2015-11-16 2017-05-26 Synlogic, Inc. Bacteria engineered to reduce hyperphenylalaninemia
CA3011331C (en) 2016-01-14 2025-05-13 Intrexon Actobiotics N.V. Compositions and methods for the treatment of type 1 diabetes
JP7016865B2 (ja) 2016-09-02 2022-03-03 イントレクソン・アクトバイオテイクス・エヌブイ Ｉｌ－１０およびインスリンを安定的に発現する遺伝子改変された細菌
CN109983028B (zh) 2016-09-13 2023-10-20 英特瑞克斯顿阿克图比奥帝克斯有限公司 黏膜黏附性微生物
CN111655841A (zh) 2017-06-21 2020-09-11 同生运营公司 用于治疗紊乱的细菌
US20210393711A1 (en) 2018-10-11 2021-12-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Bacteria expressing single chain antibodies against toll-like receptors
CA3156035A1 (en) 2019-09-27 2021-04-01 Intrexon Actobiotics Nv D/B/A Precigen Actobio Treatment of celiac disease
CN115298308A (zh) 2020-03-20 2022-11-04 同生运营公司 经工程化以减轻高苯丙氨酸血症的微生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4231764A1 (de) * 1992-09-23 1994-03-24 Inst Pflanzengenetik & Kultur Verfahren zur chromosomalen Integration eines Produkt-Gens

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ross et al., 1990, Applied and Environmental Microbiology (56) p2164-2169. *

Also Published As

Publication number Publication date
WO2002090551A2 (en) 2002-11-14
ATE331789T1 (de) 2006-07-15
CA2446776C (en) 2011-07-12
ES2266515T3 (es) 2007-03-01
JP2009060913A (ja) 2009-03-26
JP4347575B2 (ja) 2009-10-21
DK1383897T3 (da) 2006-10-30
EP1383897A2 (en) 2004-01-28
WO2002090551A3 (en) 2003-03-27
JP2004533246A (ja) 2004-11-04
DE60212825D1 (de) 2006-08-10
CA2446776A1 (en) 2002-11-14
DE60212825T2 (de) 2007-01-11
EP1383897B1 (en) 2006-06-28

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: ACTOGENIX N.V.

Free format text: FORMER APPLICANT(S): VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired
NA Applications received for extensions of time, section 223

Free format text: AN APPLICATION TO EXTEND THE TIME FROM 03 MAY 2008 TO 03 DEC 2008 IN WHICH TO PAY A RENEWAL FEE HAS BEEN FILED .

NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO PAY A RENEWAL FEE HAS BEEN EXTENDED TO 03 DEC 2008.

HB Alteration of name in register

Owner name: INTREXON ACTOBIOTICS NV

Free format text: FORMER NAME(S): ACTOGENIX N.V.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired