DE60208178T2 - Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten - Google Patents

Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten Download PDF

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Publication number
DE60208178T2
DE60208178T2 DE60208178T DE60208178T DE60208178T2 DE 60208178 T2 DE60208178 T2 DE 60208178T2 DE 60208178 T DE60208178 T DE 60208178T DE 60208178 T DE60208178 T DE 60208178T DE 60208178 T2 DE60208178 T2 DE 60208178T2
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Germany
Prior art keywords
cyclohexylethyl
carboxylic acid
amide
phenylquinoline
ylmethyl
Prior art date
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Expired - Fee Related
Application number
DE60208178T
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German (de)
English (en)
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DE60208178D1 (de
Inventor
Carlo Farina
Stefania Gagliardi
Giuseppe A. M. Giardina
Marisa Martinelli
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GlaxoSmithKline SpA
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GlaxoSmithKline SpA
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Publication date
Priority claimed from GBGB0109123.0A external-priority patent/GB0109123D0/en
Priority claimed from GB0205649A external-priority patent/GB0205649D0/en
Application filed by GlaxoSmithKline SpA filed Critical GlaxoSmithKline SpA
Publication of DE60208178D1 publication Critical patent/DE60208178D1/de
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Publication of DE60208178T2 publication Critical patent/DE60208178T2/de
Anticipated expiration legal-status Critical
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D487/04—Ortho-condensed systems

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DE60208178T 2001-04-11 2002-04-11 Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten Expired - Fee Related DE60208178T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0109123 2001-04-11
GBGB0109123.0A GB0109123D0 (en) 2001-04-11 2001-04-11 Novel compounds
GB0205649A GB0205649D0 (en) 2002-03-11 2002-03-11 Novel compounds
GB0205649 2002-03-11
PCT/EP2002/004066 WO2002083663A1 (en) 2001-04-11 2002-04-11 Quinoline-4-carboxamide derivatives as nk-3 and nk-2 receptor antagonists

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DE60208178D1 DE60208178D1 (de) 2006-01-26
DE60208178T2 true DE60208178T2 (de) 2006-08-24

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DE60208178T Expired - Fee Related DE60208178T2 (de) 2001-04-11 2002-04-11 Chinolin-4-carboxamidderivate als nk-3 und nk-2 rezeptor antagonisten
DE60209362T Expired - Fee Related DE60209362T2 (de) 2001-04-11 2002-04-11 3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten

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DE60209362T Expired - Fee Related DE60209362T2 (de) 2001-04-11 2002-04-11 3-substituierte chinolin-4-carbonsäureamidderivate als nk-3- und nk-2-rezeptorantagonisten

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US (5) US20040152726A1 (enExample)
EP (3) EP1385839B1 (enExample)
JP (2) JP2004525183A (enExample)
AT (2) ATE313539T1 (enExample)
DE (2) DE60208178T2 (enExample)
ES (2) ES2254688T3 (enExample)
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DE60208178D1 (de) 2006-01-26
ES2259096T3 (es) 2006-09-16
US20070161647A1 (en) 2007-07-12
EP1377567A1 (en) 2004-01-07
DE60209362T2 (de) 2006-10-26
WO2002083664A1 (en) 2002-10-24
US20060229315A1 (en) 2006-10-12
EP1659120A1 (en) 2006-05-24
JP2004525183A (ja) 2004-08-19
ATE313539T1 (de) 2006-01-15
US20040152726A1 (en) 2004-08-05
US20070259882A1 (en) 2007-11-08
US20050176762A1 (en) 2005-08-11
EP1385839B1 (en) 2006-02-22
EP1385839A1 (en) 2004-02-04
ES2254688T3 (es) 2006-06-16
EP1377567B1 (en) 2005-12-21
DE60209362D1 (de) 2006-04-27
WO2002083663A1 (en) 2002-10-24
ATE318266T1 (de) 2006-03-15

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