DE60208018T2 - Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-bisphosphonsäure - Google Patents

Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-bisphosphonsäure Download PDF

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Publication number
DE60208018T2
DE60208018T2 DE60208018T DE60208018T DE60208018T2 DE 60208018 T2 DE60208018 T2 DE 60208018T2 DE 60208018 T DE60208018 T DE 60208018T DE 60208018 T DE60208018 T DE 60208018T DE 60208018 T2 DE60208018 T2 DE 60208018T2
Authority
DE
Germany
Prior art keywords
amino
hydroxybutylidene
reaction
acid
diphosphonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60208018T
Other languages
German (de)
English (en)
Other versions
DE60208018D1 (de
Inventor
Kadir Dabak
Evren A. OZARSLAN
Filiz Sahbaz
Tuncer Aslan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zentiva Kinyasal Urunleri Sanayi ve Ticaret AS
Original Assignee
EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi ve Ticaret AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi ve Ticaret AS filed Critical EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi ve Ticaret AS
Application granted granted Critical
Publication of DE60208018D1 publication Critical patent/DE60208018D1/de
Publication of DE60208018T2 publication Critical patent/DE60208018T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
DE60208018T 2001-05-10 2002-05-08 Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-bisphosphonsäure Expired - Lifetime DE60208018T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
TR2001/01250A TR200101250A2 (tr) 2001-05-10 2001-05-10 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
TR200101250 2001-05-10
PCT/TR2002/000018 WO2002090367A1 (en) 2001-05-10 2002-05-08 Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid

Publications (2)

Publication Number Publication Date
DE60208018D1 DE60208018D1 (de) 2006-01-19
DE60208018T2 true DE60208018T2 (de) 2006-07-13

Family

ID=21623110

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60208018T Expired - Lifetime DE60208018T2 (de) 2001-05-10 2002-05-08 Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-bisphosphonsäure

Country Status (9)

Country Link
US (1) US7009071B2 (enExample)
EP (1) EP1390373B9 (enExample)
JP (1) JP3911287B2 (enExample)
AT (1) ATE312836T1 (enExample)
CA (1) CA2445428C (enExample)
DE (1) DE60208018T2 (enExample)
ES (1) ES2254691T3 (enExample)
TR (1) TR200101250A2 (enExample)
WO (1) WO2002090367A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA006053B1 (ru) * 2001-12-24 2005-08-25 Тева Фармасьютикал Индастриес Лтд. Твёрдая лекарственная форма, способ её изготовления и устройство
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
ATE461205T1 (de) * 2002-05-17 2010-04-15 Teva Pharma Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
ES2337063T3 (es) 2003-08-21 2010-04-20 Sun Pharmaceuticals Industries Ltd. Proceso para la preparacion de acido bisfosfonico.
US8003820B2 (en) 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
EP1798236A1 (en) * 2005-12-13 2007-06-20 EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. Process for the preparation of 3-pyridyl-1-hydroxyethylidene-1,1- biphosphonic acid and hydrated forms thereof
DE602006005597D1 (de) 2005-12-27 2009-04-23 Ipca Lab Ltd Verbesserter Herstellungsprozess von 4-Amino-Hydroxybutyliden-1,1-bisphosphonischer Säure und ihrer Salze
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
WO2007096896A1 (en) * 2006-02-20 2007-08-30 Alembic Limited An improved process for the preparation of biphosphonic derivatives
CN101443341A (zh) * 2006-03-21 2009-05-27 雅宝公司 制造二膦酸的方法
WO2008157050A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
CN102124016A (zh) 2008-07-11 2011-07-13 斯索恩有限公司 制备1-羟基亚烷基-1，1-双膦酸的方法
WO2011023280A1 (en) 2009-08-28 2011-03-03 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
TW198039B (enExample) * 1988-11-28 1993-01-11 Ciba Geigy Ag
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
YU59401A (sh) * 1999-02-17 2004-05-12 Teva Pharmaceutical Industries Ltd. Postupak za proizvodnju alendronske kiseline

Also Published As

Publication number Publication date
CA2445428A1 (en) 2002-11-14
US7009071B2 (en) 2006-03-07
EP1390373B1 (en) 2005-12-14
ES2254691T3 (es) 2006-06-16
ATE312836T1 (de) 2005-12-15
CA2445428C (en) 2006-05-02
US20040152916A1 (en) 2004-08-05
JP2004528382A (ja) 2004-09-16
WO2002090367A1 (en) 2002-11-14
DE60208018D1 (de) 2006-01-19
JP3911287B2 (ja) 2007-05-09
TR200101250A2 (tr) 2003-04-21
EP1390373A1 (en) 2004-02-25
EP1390373B9 (en) 2006-08-16

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8380 Miscellaneous part iii

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Owner name: ECZACIBASI-ZENTIVA KIMYASAL URUNLER SANAYI VE , TR

8327 Change in the person/name/address of the patent owner

Owner name: ZENTIVA KIMYASAL URUNLER SANAYI VE TICARET A.S, TR