ATE312836T1 - Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-bisphosphonsäure - Google Patents
Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-bisphosphonsäureInfo
- Publication number
- ATE312836T1 ATE312836T1 AT02736468T AT02736468T ATE312836T1 AT E312836 T1 ATE312836 T1 AT E312836T1 AT 02736468 T AT02736468 T AT 02736468T AT 02736468 T AT02736468 T AT 02736468T AT E312836 T1 ATE312836 T1 AT E312836T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxybutylidene
- amino
- acid
- producing
- bisphosphonic acid
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000010775 animal oil Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- 238000005954 phosphonylation reaction Methods 0.000 abstract 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1
- 239000010773 plant oil Substances 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2001/01250A TR200101250A2 (tr) | 2001-05-10 | 2001-05-10 | 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses |
| PCT/TR2002/000018 WO2002090367A1 (en) | 2001-05-10 | 2002-05-08 | Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE312836T1 true ATE312836T1 (de) | 2005-12-15 |
Family
ID=21623110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02736468T ATE312836T1 (de) | 2001-05-10 | 2002-05-08 | Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-bisphosphonsäure |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7009071B2 (enExample) |
| EP (1) | EP1390373B9 (enExample) |
| JP (1) | JP3911287B2 (enExample) |
| AT (1) | ATE312836T1 (enExample) |
| CA (1) | CA2445428C (enExample) |
| DE (1) | DE60208018T2 (enExample) |
| ES (1) | ES2254691T3 (enExample) |
| TR (1) | TR200101250A2 (enExample) |
| WO (1) | WO2002090367A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA006053B1 (ru) * | 2001-12-24 | 2005-08-25 | Тева Фармасьютикал Индастриес Лтд. | Твёрдая лекарственная форма, способ её изготовления и устройство |
| US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
| ATE461205T1 (de) * | 2002-05-17 | 2010-04-15 | Teva Pharma | Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren |
| HUP0300227A2 (hu) * | 2003-01-28 | 2004-09-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására |
| ES2337063T3 (es) | 2003-08-21 | 2010-04-20 | Sun Pharmaceuticals Industries Ltd. | Proceso para la preparacion de acido bisfosfonico. |
| US8003820B2 (en) | 2005-10-20 | 2011-08-23 | Dr. Reddy's Laboratories Limited | Process for preparing bisphosphonic acids |
| EP1798236A1 (en) * | 2005-12-13 | 2007-06-20 | EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. | Process for the preparation of 3-pyridyl-1-hydroxyethylidene-1,1- biphosphonic acid and hydrated forms thereof |
| DE602006005597D1 (de) | 2005-12-27 | 2009-04-23 | Ipca Lab Ltd | Verbesserter Herstellungsprozess von 4-Amino-Hydroxybutyliden-1,1-bisphosphonischer Säure und ihrer Salze |
| WO2007083240A2 (en) | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of bisphosphonic acids |
| WO2007096896A1 (en) * | 2006-02-20 | 2007-08-30 | Alembic Limited | An improved process for the preparation of biphosphonic derivatives |
| CN101443341A (zh) * | 2006-03-21 | 2009-05-27 | 雅宝公司 | 制造二膦酸的方法 |
| WO2008157050A1 (en) * | 2007-06-19 | 2008-12-24 | Albemarle Corporation | Processes for manufacturing bisphosphonic acids |
| CN102124016A (zh) | 2008-07-11 | 2011-07-13 | 斯索恩有限公司 | 制备1-羟基亚烷基-1，1-双膦酸的方法 |
| WO2011023280A1 (en) | 2009-08-28 | 2011-03-03 | Synthon B.V. | Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| DE3434667A1 (de) * | 1984-09-21 | 1986-04-03 | Henkel KGaA, 4000 Düsseldorf | 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung |
| IT1196315B (it) * | 1984-10-29 | 1988-11-16 | Gentili Ist Spa | Procedimento per la preparazione di acidi difosfonici |
| TW198039B (enExample) * | 1988-11-28 | 1993-01-11 | Ciba Geigy Ag | |
| US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| CA2197267C (en) * | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| YU59401A (sh) * | 1999-02-17 | 2004-05-12 | Teva Pharmaceutical Industries Ltd. | Postupak za proizvodnju alendronske kiseline |
-
2001
- 2001-05-10 TR TR2001/01250A patent/TR200101250A2/xx unknown
-
2002
- 2002-05-08 AT AT02736468T patent/ATE312836T1/de not_active IP Right Cessation
- 2002-05-08 WO PCT/TR2002/000018 patent/WO2002090367A1/en not_active Ceased
- 2002-05-08 EP EP02736468A patent/EP1390373B9/en not_active Expired - Lifetime
- 2002-05-08 ES ES02736468T patent/ES2254691T3/es not_active Expired - Lifetime
- 2002-05-08 CA CA002445428A patent/CA2445428C/en not_active Expired - Fee Related
- 2002-05-08 DE DE60208018T patent/DE60208018T2/de not_active Expired - Lifetime
- 2002-05-08 US US10/473,600 patent/US7009071B2/en not_active Expired - Fee Related
- 2002-05-08 JP JP2002587445A patent/JP3911287B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2445428A1 (en) | 2002-11-14 |
| US7009071B2 (en) | 2006-03-07 |
| EP1390373B1 (en) | 2005-12-14 |
| ES2254691T3 (es) | 2006-06-16 |
| CA2445428C (en) | 2006-05-02 |
| US20040152916A1 (en) | 2004-08-05 |
| JP2004528382A (ja) | 2004-09-16 |
| WO2002090367A1 (en) | 2002-11-14 |
| DE60208018T2 (de) | 2006-07-13 |
| DE60208018D1 (de) | 2006-01-19 |
| JP3911287B2 (ja) | 2007-05-09 |
| TR200101250A2 (tr) | 2003-04-21 |
| EP1390373A1 (en) | 2004-02-25 |
| EP1390373B9 (en) | 2006-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |