TR200101250A2 - 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses - Google Patents

4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses

Info

Publication number
TR200101250A2
TR200101250A2 TR2001/01250A TR200101250A TR200101250A2 TR 200101250 A2 TR200101250 A2 TR 200101250A2 TR 2001/01250 A TR2001/01250 A TR 2001/01250A TR 200101250 A TR200101250 A TR 200101250A TR 200101250 A2 TR200101250 A2 TR 200101250A2
Authority
TR
Turkey
Prior art keywords
hydroxybutylidene
salts
amino
preparation
acid
Prior art date
Application number
TR2001/01250A
Other languages
English (en)
Turkish (tr)
Inventor
Dabak Kad�R
A. �Zarslan Evren
�Ahbaz F�L�Z
Aslan Tuncer
Original Assignee
E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. filed Critical E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�.
Priority to TR2001/01250A priority Critical patent/TR200101250A2/xx
Priority to PCT/TR2002/000018 priority patent/WO2002090367A1/en
Priority to US10/473,600 priority patent/US7009071B2/en
Priority to DE60208018T priority patent/DE60208018T2/de
Priority to JP2002587445A priority patent/JP3911287B2/ja
Priority to EP02736468A priority patent/EP1390373B9/en
Priority to CA002445428A priority patent/CA2445428C/en
Priority to ES02736468T priority patent/ES2254691T3/es
Priority to AT02736468T priority patent/ATE312836T1/de
Publication of TR200101250A2 publication Critical patent/TR200101250A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
TR2001/01250A 2001-05-10 2001-05-10 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses TR200101250A2 (tr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
TR2001/01250A TR200101250A2 (tr) 2001-05-10 2001-05-10 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
PCT/TR2002/000018 WO2002090367A1 (en) 2001-05-10 2002-05-08 Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid
US10/473,600 US7009071B2 (en) 2001-05-10 2002-05-08 Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid
DE60208018T DE60208018T2 (de) 2001-05-10 2002-05-08 Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-bisphosphonsäure
JP2002587445A JP3911287B2 (ja) 2001-05-10 2002-05-08 ４−アミノ−１−ヒドロキシブチリデン−１，１−ビホスホン酸（４−Ａｍｉｎｏ−１−ｈｙｄｒｏｘｂｕｔｙｌｉｄｅｎ−１，１−ｂｉｐｈｏｓｐｈｏｎｉｃａｃｉｄ）の調整方法
EP02736468A EP1390373B9 (en) 2001-05-10 2002-05-08 Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid
CA002445428A CA2445428C (en) 2001-05-10 2002-05-08 Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid
ES02736468T ES2254691T3 (es) 2001-05-10 2002-05-08 Procedimiento para la preparacion de acido 4-amino-1-hidroxibutilideno-1,1-biofosfonico.
AT02736468T ATE312836T1 (de) 2001-05-10 2002-05-08 Verfahren zur herstellung von 4-amino-1- hydroxybutyliden-1,1-bisphosphonsäure

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TR2001/01250A TR200101250A2 (tr) 2001-05-10 2001-05-10 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses

Publications (1)

Publication Number Publication Date
TR200101250A2 true TR200101250A2 (tr) 2003-04-21

Family

ID=21623110

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01250A TR200101250A2 (tr) 2001-05-10 2001-05-10 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses

Country Status (9)

Country Link
US (1) US7009071B2 (enExample)
EP (1) EP1390373B9 (enExample)
JP (1) JP3911287B2 (enExample)
AT (1) ATE312836T1 (enExample)
CA (1) CA2445428C (enExample)
DE (1) DE60208018T2 (enExample)
ES (1) ES2254691T3 (enExample)
TR (1) TR200101250A2 (enExample)
WO (1) WO2002090367A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
EP2172192A1 (en) * 2001-12-24 2010-04-07 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder of granular material, and process and tooling for producing it
DE60331724D1 (de) * 2002-05-17 2010-04-29 Teva Pharma Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
PL1656386T3 (pl) 2003-08-21 2010-05-31 Sun Pharmaceuticals Ind Ltd Proces wytwarzania związków kwasu difosfonowego
US8003820B2 (en) 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
EP1798236A1 (en) * 2005-12-13 2007-06-20 EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. Process for the preparation of 3-pyridyl-1-hydroxyethylidene-1,1- biphosphonic acid and hydrated forms thereof
ES2323728T3 (es) 2005-12-27 2009-07-23 Ipca Laboratories Limited Proceso mejorado para la fabricacion de 4-amino-hidroxibutilideno-1,1-bisfosfonico y sus sales.
WO2007083240A2 (en) * 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
EP1987046A1 (en) * 2006-02-20 2008-11-05 Alembic Limited An improved process for the preparation of biphosphonic derivatives
CA2646418A1 (en) * 2006-03-21 2007-09-27 Albemarle Corporation Process for manufacturing bisphosphonic acids
CA2689504A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
CN102124016A (zh) 2008-07-11 2011-07-13 斯索恩有限公司 制备1-羟基亚烷基-1，1-双膦酸的方法
WO2011023280A1 (en) 2009-08-28 2011-03-03 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
TW198039B (enExample) * 1988-11-28 1993-01-11 Ciba Geigy Ag
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
EP1169326B1 (en) * 1999-02-17 2004-07-14 Teva Pharmaceutical Industries Ltd. Process for preparing alendronic acid

Also Published As

Publication number Publication date
CA2445428A1 (en) 2002-11-14
WO2002090367A1 (en) 2002-11-14
DE60208018T2 (de) 2006-07-13
EP1390373B1 (en) 2005-12-14
US7009071B2 (en) 2006-03-07
EP1390373B9 (en) 2006-08-16
EP1390373A1 (en) 2004-02-25
CA2445428C (en) 2006-05-02
JP2004528382A (ja) 2004-09-16
ES2254691T3 (es) 2006-06-16
JP3911287B2 (ja) 2007-05-09
DE60208018D1 (de) 2006-01-19
US20040152916A1 (en) 2004-08-05
ATE312836T1 (de) 2005-12-15

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