JP2004528382A5 - - Google Patents
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- Publication number
- JP2004528382A5 JP2004528382A5 JP2002587445A JP2002587445A JP2004528382A5 JP 2004528382 A5 JP2004528382 A5 JP 2004528382A5 JP 2002587445 A JP2002587445 A JP 2002587445A JP 2002587445 A JP2002587445 A JP 2002587445A JP 2004528382 A5 JP2004528382 A5 JP 2004528382A5
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- amino
- ethoxylate
- carried out
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 8
- 238000006243 chemical reaction Methods 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 2
- 150000003626 triacylglycerols Chemical class 0.000 claims 2
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 claims 1
- 240000007817 Olea europaea Species 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 235000019486 Sunflower oil Nutrition 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 239000010775 animal oil Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000002285 corn oil Substances 0.000 claims 1
- 235000005687 corn oil Nutrition 0.000 claims 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 239000002600 sunflower oil Chemical class 0.000 claims 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2001/01250A TR200101250A2 (tr) | 2001-05-10 | 2001-05-10 | 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses |
| PCT/TR2002/000018 WO2002090367A1 (en) | 2001-05-10 | 2002-05-08 | Process for the preparation of 4-amino-1-hydroxybutylidene-1, 1-biphosphonic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004528382A JP2004528382A (ja) | 2004-09-16 |
| JP2004528382A5 true JP2004528382A5 (enExample) | 2005-12-22 |
| JP3911287B2 JP3911287B2 (ja) | 2007-05-09 |
Family
ID=21623110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002587445A Expired - Fee Related JP3911287B2 (ja) | 2001-05-10 | 2002-05-08 | ４−アミノ−１−ヒドロキシブチリデン−１，１−ビホスホン酸（４−Ａｍｉｎｏ−１−ｈｙｄｒｏｘｂｕｔｙｌｉｄｅｎ−１，１−ｂｉｐｈｏｓｐｈｏｎｉｃａｃｉｄ）の調整方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7009071B2 (enExample) |
| EP (1) | EP1390373B9 (enExample) |
| JP (1) | JP3911287B2 (enExample) |
| AT (1) | ATE312836T1 (enExample) |
| CA (1) | CA2445428C (enExample) |
| DE (1) | DE60208018T2 (enExample) |
| ES (1) | ES2254691T3 (enExample) |
| TR (1) | TR200101250A2 (enExample) |
| WO (1) | WO2002090367A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA006053B1 (ru) * | 2001-12-24 | 2005-08-25 | Тева Фармасьютикал Индастриес Лтд. | Твёрдая лекарственная форма, способ её изготовления и устройство |
| US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
| ATE461205T1 (de) * | 2002-05-17 | 2010-04-15 | Teva Pharma | Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren |
| HUP0300227A2 (hu) * | 2003-01-28 | 2004-09-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására |
| ES2337063T3 (es) | 2003-08-21 | 2010-04-20 | Sun Pharmaceuticals Industries Ltd. | Proceso para la preparacion de acido bisfosfonico. |
| US8003820B2 (en) | 2005-10-20 | 2011-08-23 | Dr. Reddy's Laboratories Limited | Process for preparing bisphosphonic acids |
| EP1798236A1 (en) * | 2005-12-13 | 2007-06-20 | EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. | Process for the preparation of 3-pyridyl-1-hydroxyethylidene-1,1- biphosphonic acid and hydrated forms thereof |
| DE602006005597D1 (de) | 2005-12-27 | 2009-04-23 | Ipca Lab Ltd | Verbesserter Herstellungsprozess von 4-Amino-Hydroxybutyliden-1,1-bisphosphonischer Säure und ihrer Salze |
| WO2007083240A2 (en) | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of bisphosphonic acids |
| WO2007096896A1 (en) * | 2006-02-20 | 2007-08-30 | Alembic Limited | An improved process for the preparation of biphosphonic derivatives |
| CN101443341A (zh) * | 2006-03-21 | 2009-05-27 | 雅宝公司 | 制造二膦酸的方法 |
| WO2008157050A1 (en) * | 2007-06-19 | 2008-12-24 | Albemarle Corporation | Processes for manufacturing bisphosphonic acids |
| CN102124016A (zh) | 2008-07-11 | 2011-07-13 | 斯索恩有限公司 | 制备1-羟基亚烷基-1，1-双膦酸的方法 |
| WO2011023280A1 (en) | 2009-08-28 | 2011-03-03 | Synthon B.V. | Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| DE3434667A1 (de) * | 1984-09-21 | 1986-04-03 | Henkel KGaA, 4000 Düsseldorf | 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung |
| IT1196315B (it) * | 1984-10-29 | 1988-11-16 | Gentili Ist Spa | Procedimento per la preparazione di acidi difosfonici |
| TW198039B (enExample) * | 1988-11-28 | 1993-01-11 | Ciba Geigy Ag | |
| US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| CA2197267C (en) * | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| YU59401A (sh) * | 1999-02-17 | 2004-05-12 | Teva Pharmaceutical Industries Ltd. | Postupak za proizvodnju alendronske kiseline |
-
2001
- 2001-05-10 TR TR2001/01250A patent/TR200101250A2/xx unknown
-
2002
- 2002-05-08 AT AT02736468T patent/ATE312836T1/de not_active IP Right Cessation
- 2002-05-08 WO PCT/TR2002/000018 patent/WO2002090367A1/en not_active Ceased
- 2002-05-08 EP EP02736468A patent/EP1390373B9/en not_active Expired - Lifetime
- 2002-05-08 ES ES02736468T patent/ES2254691T3/es not_active Expired - Lifetime
- 2002-05-08 CA CA002445428A patent/CA2445428C/en not_active Expired - Fee Related
- 2002-05-08 DE DE60208018T patent/DE60208018T2/de not_active Expired - Lifetime
- 2002-05-08 US US10/473,600 patent/US7009071B2/en not_active Expired - Fee Related
- 2002-05-08 JP JP2002587445A patent/JP3911287B2/ja not_active Expired - Fee Related
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