DE602006016103D1 - Polymer-derivat von cytidin metabolit antagonist - Google Patents
Polymer-derivat von cytidin metabolit antagonistInfo
- Publication number
- DE602006016103D1 DE602006016103D1 DE602006016103T DE602006016103T DE602006016103D1 DE 602006016103 D1 DE602006016103 D1 DE 602006016103D1 DE 602006016103 T DE602006016103 T DE 602006016103T DE 602006016103 T DE602006016103 T DE 602006016103T DE 602006016103 D1 DE602006016103 D1 DE 602006016103D1
- Authority
- DE
- Germany
- Prior art keywords
- cytidine
- polymer derivative
- metabolite
- antagonist
- metabolite antagonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000005557 antagonist Substances 0.000 title 1
- UHDGCWIWMRVCDJ-XVFCMESISA-N cytidine Chemical class O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-XVFCMESISA-N 0.000 title 1
- 229920000642 polymer Polymers 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/48—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
- C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/3332—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing carboxamide group
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
- C08G73/028—Polyamidoamines
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyethers (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005138249 | 2005-05-11 | ||
PCT/JP2006/308826 WO2006120914A1 (ja) | 2005-05-11 | 2006-04-27 | シチジン系代謝拮抗剤の高分子誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006016103D1 true DE602006016103D1 (de) | 2010-09-23 |
Family
ID=37396423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006016103T Active DE602006016103D1 (de) | 2005-05-11 | 2006-04-27 | Polymer-derivat von cytidin metabolit antagonist |
Country Status (13)
Country | Link |
---|---|
US (1) | US7700709B2 (de) |
EP (1) | EP1881020B1 (de) |
JP (1) | JP5000512B2 (de) |
KR (1) | KR101312417B1 (de) |
CN (1) | CN101218280B (de) |
AU (1) | AU2006245107B2 (de) |
BR (1) | BRPI0609095A2 (de) |
CA (1) | CA2606939C (de) |
DE (1) | DE602006016103D1 (de) |
ES (1) | ES2350258T3 (de) |
RU (1) | RU2404980C2 (de) |
TW (1) | TW200716151A (de) |
WO (1) | WO2006120914A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7495099B2 (en) * | 2002-10-31 | 2009-02-24 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight derivatives of camptothecins |
CA2518964C (en) * | 2003-03-20 | 2011-09-13 | Nippon Kayaku Kabushiki Kaisha | Micellar preparation containing sparingly water-soluble anticancer agent and novel block copolymer |
CA2581125C (en) | 2004-09-22 | 2013-04-23 | Nippon Kayaku Kabushiki Kaisha | Modified poly(ethylene oxide-amino acid) copolymer, micelle preparation, and anticancer agent containing the same |
US8323669B2 (en) | 2006-03-28 | 2012-12-04 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of taxane |
CN101448875A (zh) | 2006-05-18 | 2009-06-03 | 日本化药株式会社 | 鬼臼毒素类的高分子量结合体 |
KR20090031597A (ko) * | 2006-07-19 | 2009-03-26 | 니폰 가야꾸 가부시끼가이샤 | 콤브레타스타틴류의 고분자 결합체 |
CA2664852A1 (en) * | 2006-10-03 | 2008-04-10 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of resorcinol derivatives |
WO2008056596A1 (en) * | 2006-11-06 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
CA2668478C (en) * | 2006-11-07 | 2015-05-26 | Dsm Ip Assets B.V. | Carbamate, thiocarbamate or carbamide comprising a biomolecular moiety |
EP2090607B1 (de) * | 2006-11-08 | 2015-05-20 | Nippon Kayaku Kabushiki Kaisha | Polymerderivat eines nukleinsäuremetabolismus-antagonisten |
EP2206502B1 (de) * | 2007-09-28 | 2018-09-12 | Nippon Kayaku Kabushiki Kaisha | Polymer-konjugat eines steroids |
EP2258397B1 (de) * | 2008-03-18 | 2017-10-11 | Nippon Kayaku Kabushiki Kaisha | Polymerkonjugat aus einem physiologisch aktiven stoff |
EP2284209B1 (de) | 2008-05-08 | 2016-08-31 | Nippon Kayaku Kabushiki Kaisha | Polymerkonjugat aus folsäure oder einem folsäurederivat |
WO2010131675A1 (ja) | 2009-05-15 | 2010-11-18 | 日本化薬株式会社 | 水酸基を有する生理活性物質の高分子結合体 |
IT1401360B1 (it) * | 2010-05-19 | 2013-07-18 | Lembo | Agenti anti-virali e relative composizioni |
US8840875B2 (en) | 2010-05-19 | 2014-09-23 | Paolo Ferruti | Anti-viral agents and compositions thereof |
CA2816997A1 (en) | 2010-11-17 | 2012-05-24 | Nippon Kayaku Kabushiki Kaisha | Novel polymer derivative of cytidine metabolic antagonist |
WO2012098557A1 (en) * | 2011-01-20 | 2012-07-26 | Institute Of Life Sciences | Pegylated gemcitabine derivative and process for preparing the same |
KR101849142B1 (ko) | 2011-09-11 | 2018-04-16 | 니폰 가야꾸 가부시끼가이샤 | 블록 공중합체의 제조방법 |
WO2014073447A1 (ja) | 2012-11-08 | 2014-05-15 | 日本化薬株式会社 | カンプトテシン類と抗癌効果増強剤の結合した高分子化合物及びその用途 |
JP2017160125A (ja) * | 2014-08-04 | 2017-09-14 | 日本化薬株式会社 | 核酸代謝拮抗剤が結合したポリアミノ酸誘導体。 |
EP3263107B1 (de) * | 2015-02-23 | 2020-11-11 | Nippon Kayaku Kabushiki Kaisha | Blockcopolymerkonjugat von einem physiologisch aktiven stoff |
EP3378494A4 (de) * | 2015-11-18 | 2019-07-31 | Nippon Kayaku Kabushiki Kaisha | Polymerisches derivat von macrolid-immunosuppressiva |
JP6830907B2 (ja) * | 2016-01-08 | 2021-02-17 | 日本化薬株式会社 | マクロライド系免疫抑制剤の高分子誘導体 |
CN106117561B (zh) * | 2016-06-27 | 2020-03-13 | 中国科学院长春应用化学研究所 | 一种吉西他滨衍生物及其制备方法 |
CN109475498B (zh) * | 2016-07-06 | 2021-04-02 | 株式会社三养生物制药 | 包含水难溶性药物的聚合物胶束制剂的体外释放试验及评价方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0097307A3 (de) * | 1982-06-21 | 1985-01-09 | American Hoechst Corporation | Thermo-chemisch vernetztes Poly(p-methylstyrol) und Verfahren zu seiner Herstellung |
JP2517760B2 (ja) * | 1989-05-11 | 1996-07-24 | 新技術事業団 | 水溶性高分子化医薬製剤 |
JP3310000B2 (ja) * | 1990-11-07 | 2002-07-29 | 靖久 桜井 | 水溶性高分子抗癌剤及び薬物担持用担体 |
JP3268913B2 (ja) * | 1992-10-27 | 2002-03-25 | 日本化薬株式会社 | 高分子担体 |
JPH0848766A (ja) | 1994-05-30 | 1996-02-20 | Mitsui Toatsu Chem Inc | 重合体及びその製造方法 |
US5571889A (en) * | 1994-05-30 | 1996-11-05 | Mitsui Toatsu Chemicals, Inc. | Polymer containing monomer units of chemically modified polyaspartic acids or their salts and process for preparing the same |
JP2694923B2 (ja) | 1995-08-21 | 1997-12-24 | 科学技術振興事業団 | 水溶性高分子化医薬製剤 |
JPH11279083A (ja) | 1998-03-30 | 1999-10-12 | Nippon Kayaku Co Ltd | 可溶化剤 |
US6376470B1 (en) * | 1999-09-23 | 2002-04-23 | Enzon, Inc. | Polymer conjugates of ara-C and ara-C derivatives |
DE60223499T2 (de) * | 2001-02-20 | 2008-10-16 | Enzon, Inc. | Terminal verzweigte, polymere linker und diese enthaltende polymere konjugate |
EP1594482A1 (de) * | 2003-03-26 | 2005-11-16 | LTT Bio-Pharma Co., Ltd. | Intravenöse nanoteilchen für die gezielte arzneimittelabgabe und verzögerte freisetzung von arzneimitteln |
EP2626083A1 (de) * | 2003-09-17 | 2013-08-14 | Nektar Therapeutics | Multi-Arm Polymerprodrogen |
WO2005030835A1 (ja) * | 2003-09-25 | 2005-04-07 | Terumo Kabushiki Kaisha | ポリエチレングリコール誘導体及びこれを膜構成成分とする薬物担体 |
ATE458022T1 (de) * | 2003-12-10 | 2010-03-15 | Toudai Tlo Ltd | Koordinationskomplex von diaminocyclohexanplatin(ii) mit einem blockcopolymer mit einem poly(carbonsäure)segment und diesen enthaltendes antitumormittel |
-
2006
- 2006-04-27 KR KR1020077025493A patent/KR101312417B1/ko not_active IP Right Cessation
- 2006-04-27 BR BRPI0609095-8A patent/BRPI0609095A2/pt not_active IP Right Cessation
- 2006-04-27 EP EP06745754A patent/EP1881020B1/de active Active
- 2006-04-27 CN CN2006800161666A patent/CN101218280B/zh not_active Expired - Fee Related
- 2006-04-27 DE DE602006016103T patent/DE602006016103D1/de active Active
- 2006-04-27 ES ES06745754T patent/ES2350258T3/es active Active
- 2006-04-27 AU AU2006245107A patent/AU2006245107B2/en not_active Ceased
- 2006-04-27 US US11/919,912 patent/US7700709B2/en not_active Expired - Fee Related
- 2006-04-27 JP JP2007528226A patent/JP5000512B2/ja not_active Expired - Fee Related
- 2006-04-27 RU RU2007145718/04A patent/RU2404980C2/ru not_active IP Right Cessation
- 2006-04-27 WO PCT/JP2006/308826 patent/WO2006120914A1/ja active Application Filing
- 2006-04-27 CA CA2606939A patent/CA2606939C/en not_active Expired - Fee Related
- 2006-05-09 TW TW095116441A patent/TW200716151A/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP5000512B2 (ja) | 2012-08-15 |
AU2006245107B2 (en) | 2011-02-10 |
RU2007145718A (ru) | 2009-06-20 |
US20090012252A1 (en) | 2009-01-08 |
BRPI0609095A2 (pt) | 2010-02-17 |
EP1881020A4 (de) | 2009-09-02 |
RU2404980C2 (ru) | 2010-11-27 |
CA2606939A1 (en) | 2006-11-16 |
KR20080013883A (ko) | 2008-02-13 |
EP1881020B1 (de) | 2010-08-11 |
KR101312417B1 (ko) | 2013-09-27 |
TWI371284B (de) | 2012-09-01 |
WO2006120914A1 (ja) | 2006-11-16 |
AU2006245107A1 (en) | 2006-11-16 |
CN101218280B (zh) | 2012-06-27 |
CN101218280A (zh) | 2008-07-09 |
ES2350258T3 (es) | 2011-01-20 |
US7700709B2 (en) | 2010-04-20 |
EP1881020A1 (de) | 2008-01-23 |
CA2606939C (en) | 2013-09-03 |
JPWO2006120914A1 (ja) | 2008-12-18 |
TW200716151A (en) | 2007-05-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE602006016103D1 (de) | Polymer-derivat von cytidin metabolit antagonist | |
FR20C1027I2 (fr) | Derives de tiglien-3-one | |
DE602006007563D1 (de) | Agonisten | |
DE602006016566D1 (de) | Als antikoagulanzien verwendbare phenylglycinamid-derivate | |
DE112006002542A5 (de) | Elektroakustisches Bauelement | |
DE602006016573D1 (de) | Substituierte piperidine | |
BRPI0714764A2 (pt) | Derivados substituídos de sulfonamida | |
BRPI0716193A2 (pt) | Replicon derivado de potexvírus | |
DE602006010581D1 (de) | 4-phenyl-6-substituierte pyrimidin-2-carbonitrilderivate | |
ATE485294T1 (de) | Azaindol-2-carboxamid-derivate | |
DK1856051T3 (da) | Amorft lercanidipinhydrochlorid | |
ATE527255T1 (de) | Aryl-isoxazol-4-yl-imidazol-derivate | |
DK1911769T3 (da) | Cellulosederivat | |
DE602007012260D1 (de) | Nitratester von piperidinen | |
DK2228656T3 (da) | Kvantificering af allergener | |
DE602006019103D1 (de) | Fluorsubstituierte 2-oxo-azepan-derivate | |
DE602006007885D1 (de) | Kleiderbügel | |
ATE524972T1 (de) | Poly-tlr-antagonist | |
DE602006009702D1 (de) | Dämpfer | |
ATE541837T1 (de) | Oxaphenanthren-derivate | |
DE502006002822D1 (de) | Ges | |
ATE477292T1 (de) | Polymer-derivat von cytidin metabolit antagonist | |
FI20065036L (fi) | Modifioitu trampoliinin pidinrakenne | |
FR2889236B1 (fr) | Charniere reglable | |
DE602006019209D1 (de) | Fluoroalkylpyrrolidin-derivate |