DE602004009962T2 - Verfahren zur herstellung von substituierten 5-aminopyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidinen - Google Patents

Verfahren zur herstellung von substituierten 5-aminopyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidinen Download PDF

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Publication number
DE602004009962T2
DE602004009962T2 DE602004009962T DE602004009962T DE602004009962T2 DE 602004009962 T2 DE602004009962 T2 DE 602004009962T2 DE 602004009962 T DE602004009962 T DE 602004009962T DE 602004009962 T DE602004009962 T DE 602004009962T DE 602004009962 T2 DE602004009962 T2 DE 602004009962T2
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DE
Germany
Prior art keywords
formula
compound
alkyl
hydrogen
dehydrating agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE602004009962T
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German (de)
English (en)
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DE602004009962D1 (de
Inventor
Shen-Chun Union KUO
Loc Thanh Piscataway TRAN
Pengyi Durham ZHANG
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Merck Sharp and Dohme LLC
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Schering Corp
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Publication of DE602004009962T2 publication Critical patent/DE602004009962T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE602004009962T 2003-12-01 2004-11-29 Verfahren zur herstellung von substituierten 5-aminopyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidinen Expired - Lifetime DE602004009962T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52592503P 2003-12-01 2003-12-01
US525925P 2003-12-01
PCT/US2004/039847 WO2005054245A2 (en) 2003-12-01 2004-11-29 Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines

Publications (2)

Publication Number Publication Date
DE602004009962D1 DE602004009962D1 (de) 2007-12-20
DE602004009962T2 true DE602004009962T2 (de) 2008-08-28

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Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004009962T Expired - Lifetime DE602004009962T2 (de) 2003-12-01 2004-11-29 Verfahren zur herstellung von substituierten 5-aminopyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidinen

Country Status (8)

Country Link
US (3) US7235659B2 (https=)
EP (1) EP1689749B1 (https=)
JP (1) JP2007513091A (https=)
AT (1) ATE377599T1 (https=)
CA (1) CA2547248A1 (https=)
DE (1) DE602004009962T2 (https=)
ES (1) ES2293380T3 (https=)
WO (1) WO2005054245A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1283839T1 (https=) * 2000-05-26 2005-08-31 Schering Corp
CN1898246B (zh) * 2003-10-28 2010-10-27 先灵公司 制备取代的5-氨基-吡唑并[4，3-e]-1，2，4-三唑并[1，5-c]嘧啶的方法
EP1902716A4 (en) * 2005-06-07 2009-05-13 Kyowa Hakko Kirin Co Ltd PROPHYLACTIC AND / OR THERAPEUTIC AGENT FOR MOTOR TROUBLESHOOTING
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
US8188098B2 (en) 2008-05-19 2012-05-29 Hoffmann-La Roche Inc. GPR119 receptor agonists
TW201100427A (en) 2009-03-31 2011-01-01 Arqule Inc Substituted heterocyclic compounds
EP3284494A1 (en) 2009-07-30 2018-02-21 Tandem Diabetes Care, Inc. Portable infusion pump system
WO2012127472A1 (en) * 2011-03-22 2012-09-27 Mapi Pharma Ltd. Process and intermediates for the preparation of preladenant and related compounds
WO2012129381A1 (en) 2011-03-22 2012-09-27 Concert Pharmaceuticals Inc. Deuterated preladenant
WO2013024474A1 (en) * 2011-08-18 2013-02-21 Mapi Phrarma Ltd. Polymorphs of preladenant
TW202039496A (zh) 2018-11-30 2020-11-01 美商默沙東藥廠 做為腺苷受體拮抗劑之9-經取代胺基三唑喹唑啉衍生物、醫藥組合物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264901B1 (it) * 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
SI1283839T1 (https=) * 2000-05-26 2005-08-31 Schering Corp

Also Published As

Publication number Publication date
EP1689749B1 (en) 2007-11-07
US20070238874A1 (en) 2007-10-11
CA2547248A1 (en) 2005-06-16
US7507822B2 (en) 2009-03-24
ATE377599T1 (de) 2007-11-15
JP2007513091A (ja) 2007-05-24
US20060149060A1 (en) 2006-07-06
DE602004009962D1 (de) 2007-12-20
ES2293380T3 (es) 2008-03-16
US7235659B2 (en) 2007-06-26
WO2005054245A2 (en) 2005-06-16
US20090131663A1 (en) 2009-05-21
WO2005054245A3 (en) 2005-08-11
EP1689749A2 (en) 2006-08-16

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