DE69417560T2 - Gefässverengende subtituierte dihydropyranopyridine - Google Patents

Gefässverengende subtituierte dihydropyranopyridine

Info

Publication number
DE69417560T2
DE69417560T2 DE69417560T DE69417560T DE69417560T2 DE 69417560 T2 DE69417560 T2 DE 69417560T2 DE 69417560 T DE69417560 T DE 69417560T DE 69417560 T DE69417560 T DE 69417560T DE 69417560 T2 DE69417560 T2 DE 69417560T2
Authority
DE
Germany
Prior art keywords
6alkyl
hydrogen
pct
formula
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69417560T
Other languages
English (en)
Other versions
DE69417560D1 (de
Inventor
Lommen Guy Van
Francisco Javi Fernandez-Gadea
Jose Ignacio Vesubi Andres-Gil
Maria Enc Matesanz-Ballesteros
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE69417560D1 publication Critical patent/DE69417560D1/de
Application granted granted Critical
Publication of DE69417560T2 publication Critical patent/DE69417560T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
DE69417560T 1993-08-19 1994-08-12 Gefässverengende subtituierte dihydropyranopyridine Expired - Lifetime DE69417560T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93202440 1993-08-19
PCT/EP1994/002700 WO1995005381A1 (en) 1993-08-19 1994-08-12 Vasoconstrictive substituted dihydropyranopyridines

Publications (2)

Publication Number Publication Date
DE69417560D1 DE69417560D1 (de) 1999-05-06
DE69417560T2 true DE69417560T2 (de) 1999-11-11

Family

ID=8214053

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69417560T Expired - Lifetime DE69417560T2 (de) 1993-08-19 1994-08-12 Gefässverengende subtituierte dihydropyranopyridine

Country Status (27)

Country Link
US (1) US5691344A (de)
EP (1) EP0714395B1 (de)
JP (1) JP3650398B2 (de)
KR (1) KR100330697B1 (de)
CN (1) CN1051085C (de)
AT (1) ATE178330T1 (de)
AU (1) AU684819B2 (de)
BR (1) BR9407298A (de)
CA (1) CA2168022C (de)
CZ (1) CZ286645B6 (de)
DE (1) DE69417560T2 (de)
DK (1) DK0714395T3 (de)
ES (1) ES2132424T3 (de)
FI (1) FI113773B (de)
GR (1) GR3029924T3 (de)
HU (1) HU228673B1 (de)
IL (1) IL110688A (de)
MY (1) MY111419A (de)
NO (1) NO315001B1 (de)
NZ (1) NZ271383A (de)
PL (1) PL177516B1 (de)
RO (1) RO116729B1 (de)
RU (1) RU2135501C1 (de)
SI (1) SI0714395T1 (de)
SK (1) SK282108B6 (de)
WO (1) WO1995005381A1 (de)
ZA (1) ZA946268B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818659B2 (en) 2001-11-06 2004-11-16 Bristol-Myers Squibb Pharma, Inc. (2S)-2-amino-4-(2-amino-(3,4,5,6-tetrahydropyrimidin-4-yl) butanoyl and its use in cyclic and acyclic peptides
JP7171444B2 (ja) * 2016-07-01 2022-11-15 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー ウイルス感染治療用のジヒドロピラノピリミジン

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU576868B2 (en) * 1984-06-11 1988-09-08 E.I. Du Pont De Nemours And Company Thiophene and pyridine sulfonamides
FR2615191B1 (fr) * 1987-05-16 1991-01-11 Sandoz Sa Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments
DE3901814A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
US5140031A (en) * 1989-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Pyranyl cyanoguanidine derivatives
US5250450A (en) * 1991-04-08 1993-10-05 Micron Technology, Inc. Insulated-gate vertical field-effect transistor with high current drive and minimum overlap capacitance
DE4120322A1 (de) * 1991-06-20 1992-12-24 Bayer Ag Aminomethyl-substituierte 2,3-dihydropyrano(2,3-b)pyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
SI9300097B (en) * 1992-02-27 2001-12-31 Janssen Pharmaceutica Nv (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines

Also Published As

Publication number Publication date
IL110688A (en) 1998-10-30
SK19496A3 (en) 1997-02-05
KR100330697B1 (ko) 2002-10-04
CN1051085C (zh) 2000-04-05
AU7499594A (en) 1995-03-14
CA2168022C (en) 2006-11-21
CZ37396A3 (en) 1996-05-15
SI0714395T1 (en) 1999-08-31
RU2135501C1 (ru) 1999-08-27
EP0714395A1 (de) 1996-06-05
HU228673B1 (en) 2013-05-28
CZ286645B6 (cs) 2000-05-17
JP3650398B2 (ja) 2005-05-18
FI113773B (fi) 2004-06-15
HU9600374D0 (en) 1996-04-29
HUT74676A (en) 1997-01-28
DE69417560D1 (de) 1999-05-06
ES2132424T3 (es) 1999-08-16
FI960721A0 (fi) 1996-02-16
ATE178330T1 (de) 1999-04-15
CN1129943A (zh) 1996-08-28
PL177516B1 (pl) 1999-12-31
SK282108B6 (sk) 2001-11-06
BR9407298A (pt) 1996-10-01
DK0714395T3 (da) 1999-10-11
NZ271383A (en) 1997-05-26
ZA946268B (en) 1996-02-19
IL110688A0 (en) 1994-11-11
NO960647D0 (no) 1996-02-19
FI960721A (fi) 1996-02-16
WO1995005381A1 (en) 1995-02-23
NO315001B1 (no) 2003-06-23
MY111419A (en) 2000-04-29
NO960647L (no) 1996-02-19
CA2168022A1 (en) 1995-02-23
JPH09501669A (ja) 1997-02-18
US5691344A (en) 1997-11-25
EP0714395B1 (de) 1999-03-31
GR3029924T3 (en) 1999-07-30
PL313080A1 (en) 1996-05-27
RO116729B1 (ro) 2001-05-30
AU684819B2 (en) 1998-01-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition