CA2547248A1 - Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines - Google Patents

Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines Download PDF

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Publication number
CA2547248A1
CA2547248A1 CA002547248A CA2547248A CA2547248A1 CA 2547248 A1 CA2547248 A1 CA 2547248A1 CA 002547248 A CA002547248 A CA 002547248A CA 2547248 A CA2547248 A CA 2547248A CA 2547248 A1 CA2547248 A1 CA 2547248A1
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CA
Canada
Prior art keywords
formula
compound
alkoxy
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002547248A
Other languages
English (en)
French (fr)
Inventor
Shen-Chun Kuo
Loc Thanh Tran
Pengyi Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2547248A1 publication Critical patent/CA2547248A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA002547248A 2003-12-01 2004-11-29 Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines Abandoned CA2547248A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52592503P 2003-12-01 2003-12-01
US60/525,925 2003-12-01
PCT/US2004/039847 WO2005054245A2 (en) 2003-12-01 2004-11-29 Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines

Publications (1)

Publication Number Publication Date
CA2547248A1 true CA2547248A1 (en) 2005-06-16

Family

ID=34652398

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002547248A Abandoned CA2547248A1 (en) 2003-12-01 2004-11-29 Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines

Country Status (8)

Country Link
US (3) US7235659B2 (https=)
EP (1) EP1689749B1 (https=)
JP (1) JP2007513091A (https=)
AT (1) ATE377599T1 (https=)
CA (1) CA2547248A1 (https=)
DE (1) DE602004009962T2 (https=)
ES (1) ES2293380T3 (https=)
WO (1) WO2005054245A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1283839T1 (https=) * 2000-05-26 2005-08-31 Schering Corp
CN1898246B (zh) * 2003-10-28 2010-10-27 先灵公司 制备取代的5-氨基-吡唑并[4，3-e]-1，2，4-三唑并[1，5-c]嘧啶的方法
EP1902716A4 (en) * 2005-06-07 2009-05-13 Kyowa Hakko Kirin Co Ltd PROPHYLACTIC AND / OR THERAPEUTIC AGENT FOR MOTOR TROUBLESHOOTING
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
US8188098B2 (en) 2008-05-19 2012-05-29 Hoffmann-La Roche Inc. GPR119 receptor agonists
TW201100427A (en) 2009-03-31 2011-01-01 Arqule Inc Substituted heterocyclic compounds
EP3284494A1 (en) 2009-07-30 2018-02-21 Tandem Diabetes Care, Inc. Portable infusion pump system
WO2012127472A1 (en) * 2011-03-22 2012-09-27 Mapi Pharma Ltd. Process and intermediates for the preparation of preladenant and related compounds
WO2012129381A1 (en) 2011-03-22 2012-09-27 Concert Pharmaceuticals Inc. Deuterated preladenant
WO2013024474A1 (en) * 2011-08-18 2013-02-21 Mapi Phrarma Ltd. Polymorphs of preladenant
TW202039496A (zh) 2018-11-30 2020-11-01 美商默沙東藥廠 做為腺苷受體拮抗劑之9-經取代胺基三唑喹唑啉衍生物、醫藥組合物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264901B1 (it) * 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
SI1283839T1 (https=) * 2000-05-26 2005-08-31 Schering Corp

Also Published As

Publication number Publication date
EP1689749B1 (en) 2007-11-07
US20070238874A1 (en) 2007-10-11
US7507822B2 (en) 2009-03-24
ATE377599T1 (de) 2007-11-15
JP2007513091A (ja) 2007-05-24
US20060149060A1 (en) 2006-07-06
DE602004009962D1 (de) 2007-12-20
ES2293380T3 (es) 2008-03-16
DE602004009962T2 (de) 2008-08-28
US7235659B2 (en) 2007-06-26
WO2005054245A2 (en) 2005-06-16
US20090131663A1 (en) 2009-05-21
WO2005054245A3 (en) 2005-08-11
EP1689749A2 (en) 2006-08-16

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued