DE60141609D1 - Neues Verfahren zur Herstellung von Vinyl-Pyrrolidin Cephalosporin Derivaten - Google Patents

Neues Verfahren zur Herstellung von Vinyl-Pyrrolidin Cephalosporin Derivaten

Info

Publication number
DE60141609D1
DE60141609D1 DE60141609T DE60141609T DE60141609D1 DE 60141609 D1 DE60141609 D1 DE 60141609D1 DE 60141609 T DE60141609 T DE 60141609T DE 60141609 T DE60141609 T DE 60141609T DE 60141609 D1 DE60141609 D1 DE 60141609D1
Authority
DE
Germany
Prior art keywords
vinyl
preparation
new process
pyrrolidine
cephalosporin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60141609T
Other languages
English (en)
Inventor
Paul Hebeisen
Hans Hilpert
Roland Humm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Basilea Pharmaceutica AG
Original Assignee
Basilea Pharmaceutica AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica AG filed Critical Basilea Pharmaceutica AG
Application granted granted Critical
Publication of DE60141609D1 publication Critical patent/DE60141609D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
DE60141609T 2000-05-24 2001-05-18 Neues Verfahren zur Herstellung von Vinyl-Pyrrolidin Cephalosporin Derivaten Expired - Lifetime DE60141609D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00111164 2000-05-24

Publications (1)

Publication Number Publication Date
DE60141609D1 true DE60141609D1 (de) 2010-04-29

Family

ID=8168825

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60141609T Expired - Lifetime DE60141609D1 (de) 2000-05-24 2001-05-18 Neues Verfahren zur Herstellung von Vinyl-Pyrrolidin Cephalosporin Derivaten
DE60109771T Expired - Lifetime DE60109771T2 (de) 2000-05-24 2001-05-18 Neues verfahren zur herstellung von vinyl-pyrrolidinon cephalosporin derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60109771T Expired - Lifetime DE60109771T2 (de) 2000-05-24 2001-05-18 Neues verfahren zur herstellung von vinyl-pyrrolidinon cephalosporin derivate

Country Status (16)

Country Link
US (1) US6504025B2 (de)
EP (2) EP1435357B1 (de)
JP (1) JP3994011B2 (de)
KR (1) KR100528305B1 (de)
CN (4) CN100567314C (de)
AT (2) ATE461203T1 (de)
AU (1) AU2001262299A1 (de)
CA (2) CA2408941C (de)
CY (1) CY1110298T1 (de)
DE (2) DE60141609D1 (de)
DK (2) DK1435357T3 (de)
ES (2) ES2238441T3 (de)
HK (3) HK1074620A1 (de)
MX (1) MXPA02011530A (de)
PT (2) PT1289998E (de)
WO (1) WO2001090111A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2211848T3 (es) 2001-10-11 2004-07-16 Consortium Fur Elektrochemische Industrie Gmbh Proceso para la oxidacion de alcoholes bajo catalisis con compuestos de nitroxilo.
AU2004224181B2 (en) * 2003-03-27 2011-06-02 Basilea Pharmaceutica Ag Cephalosporin in crystalline form
CN101835777A (zh) * 2007-10-25 2010-09-15 尔察祯有限公司 碳头孢烯β-内酰胺抗生素
AR071318A1 (es) * 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
WO2010030810A1 (en) * 2008-09-10 2010-03-18 Achaogen, Inc. Carbacephem beta-lactam antibiotics
WO2010072672A1 (en) 2008-12-24 2010-07-01 Basilea Pharmaceutica Ag New crystal polymorphs of ceftobiprole
CN102448966A (zh) * 2009-05-25 2012-05-09 桑多斯股份公司 生产头孢托罗酯的方法
PT2569321E (pt) * 2010-05-10 2015-05-25 Basilea Pharmaceutica Int Ltd Processo de oxidação para a preparação de derivados 3-formil cefeme
CN103275104B (zh) * 2013-05-15 2015-05-20 苏州明锐医药科技有限公司 头孢托罗及头孢托罗酯的制备方法
CN105601648A (zh) * 2016-03-09 2016-05-25 上海宁瑞生化技术有限公司 一锅法制备头孢吡普的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT620225E (pt) * 1993-04-16 2003-03-31 Basilea Pharmaceutica Ag Derivados de cefalosporina
US5466811A (en) 1994-07-18 1995-11-14 Merck & Co., Inc. Dioxolenylmethyl carbamates pro moieties for amine drugs
US5631366A (en) * 1995-01-12 1997-05-20 Hoffmann-La Roche Inc. Process for making 3-formylcephem derivatives
KR100197788B1 (ko) 1995-06-30 1999-06-15 김충환 세펨 유도체의 제조방법
US5883247A (en) 1996-06-10 1999-03-16 Hoffmann-La Roche Inc. Preparation of cephem and isooxacephem derivatives
TW415949B (en) 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents
ES2203955T3 (es) * 1997-04-01 2004-04-16 Biochemie Gesellschaft M.B.H. 7-acilamino-3-(metilhidrazono)metil-cefalosporinas sustituidas antibacterianas y productos intermedios.
DK1087980T3 (da) 1998-06-15 2003-05-26 Basilea Pharmaceutica Ag 3-[2-oxo-(1,3')bipyrrolidinyl-3-yliden-methyl]-cephemderivater

Also Published As

Publication number Publication date
ATE292135T1 (de) 2005-04-15
CA2408941C (en) 2009-01-27
CN1915997A (zh) 2007-02-21
HK1074620A1 (en) 2005-11-18
EP1435357A3 (de) 2006-05-03
JP3994011B2 (ja) 2007-10-17
ES2238441T3 (es) 2005-09-01
CN1430621A (zh) 2003-07-16
JP2003535059A (ja) 2003-11-25
CN1301998C (zh) 2007-02-28
ATE461203T1 (de) 2010-04-15
EP1435357B1 (de) 2010-03-17
CN1915997B (zh) 2010-06-16
DE60109771T2 (de) 2006-02-16
CA2583727A1 (en) 2001-11-29
CA2583727C (en) 2010-03-30
EP1289998B1 (de) 2005-03-30
CY1110298T1 (el) 2015-04-29
US6504025B2 (en) 2003-01-07
DK1435357T3 (da) 2010-05-03
CA2408941A1 (en) 2001-11-29
AU2001262299A1 (en) 2001-12-03
KR100528305B1 (ko) 2005-11-15
CN1603327A (zh) 2005-04-06
PT1289998E (pt) 2005-06-30
ES2340273T3 (es) 2010-06-01
CN100567314C (zh) 2009-12-09
CN1170831C (zh) 2004-10-13
PT1435357E (pt) 2010-04-20
MXPA02011530A (es) 2003-04-25
EP1435357A2 (de) 2004-07-07
HK1096101A1 (en) 2007-05-25
EP1289998A1 (de) 2003-03-12
HK1096091A1 (en) 2007-05-25
DK1289998T3 (da) 2005-08-08
US20020019381A1 (en) 2002-02-14
DE60109771D1 (de) 2005-05-04
WO2001090111A1 (en) 2001-11-29
KR20030005386A (ko) 2003-01-17
CN1916006A (zh) 2007-02-21

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Legal Events

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