WO2002018354A8 - Oxazolidinones and their use as antibacterial agents - Google Patents

Oxazolidinones and their use as antibacterial agents

Info

Publication number
WO2002018354A8
WO2002018354A8 PCT/US2001/026883 US0126883W WO0218354A8 WO 2002018354 A8 WO2002018354 A8 WO 2002018354A8 US 0126883 W US0126883 W US 0126883W WO 0218354 A8 WO0218354 A8 WO 0218354A8
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
oxazolidinones
antibacterial agents
forumula
prodrugs
Prior art date
Application number
PCT/US2001/026883
Other languages
French (fr)
Other versions
WO2002018354A1 (en
Inventor
Paul E Wiedeman
Stevan W Djuric
Marina Pliushchev
Richard J Sciotti
David J Madar
Hana Kopecka
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of WO2002018354A1 publication Critical patent/WO2002018354A1/en
Publication of WO2002018354A8 publication Critical patent/WO2002018354A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

Compounds of forumula (I) or therapeutically acceptable salts or prodrugs thereof, are useful for treating bacterial infections, psoriasis, arthritis, and toxicity due to chemotherapy. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
PCT/US2001/026883 2000-08-31 2001-08-29 Oxazolidinones and their use as antibacterial agents WO2002018354A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65233200A 2000-08-31 2000-08-31
US09/652,332 2000-08-31
US94180301A 2001-08-29 2001-08-29
US09/941,803 2001-08-29

Publications (2)

Publication Number Publication Date
WO2002018354A1 WO2002018354A1 (en) 2002-03-07
WO2002018354A8 true WO2002018354A8 (en) 2002-07-04

Family

ID=27096272

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/026883 WO2002018354A1 (en) 2000-08-31 2001-08-29 Oxazolidinones and their use as antibacterial agents

Country Status (1)

Country Link
WO (1) WO2002018354A1 (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
FR2500450A1 (en) * 1981-02-25 1982-08-27 Delalande Sa NOVEL AMINOMETHYL-5-OXAZOLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC USE THEREOF
US4705799A (en) * 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
ATE95176T1 (en) * 1987-10-21 1993-10-15 Du Pont Merck Pharma AMINOMETHYL-OXO-OXAZOLIDINYL-ETHENYLBENZENE DERIVATES, USEFUL AS AN ANTIBACTERIAL AGENT.
FR2653017B1 (en) * 1989-10-17 1995-05-05 Delalande Sa DERIVATIVES OF ARYL-3 OXAZOLIDINONE-2, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS.
DE4425612A1 (en) * 1994-07-20 1996-04-04 Bayer Ag 6-membered nitrogen-containing heteroaryl oxazolidinones
DE4425613A1 (en) * 1994-07-20 1996-01-25 Bayer Ag 5-membered heteroaryl oxazolidinones
US6277868B1 (en) * 2000-08-31 2001-08-21 Abbott Laboratories Oxazolidinone chemotherapeutic agents

Also Published As

Publication number Publication date
WO2002018354A1 (en) 2002-03-07

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