WO2003090679A3 - 11-deoxy azalide antibacterials - Google Patents

11-deoxy azalide antibacterials Download PDF

Info

Publication number
WO2003090679A3
WO2003090679A3 PCT/US2003/012590 US0312590W WO03090679A3 WO 2003090679 A3 WO2003090679 A3 WO 2003090679A3 US 0312590 W US0312590 W US 0312590W WO 03090679 A3 WO03090679 A3 WO 03090679A3
Authority
WO
WIPO (PCT)
Prior art keywords
azalide
antibacterials
deoxy
compounds
prodrugs
Prior art date
Application number
PCT/US2003/012590
Other languages
French (fr)
Other versions
WO2003090679A2 (en
Inventor
Richard Clark
Stevan Djuric
Zhenkun Ma
Sanyi Wang
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to JP2003587318A priority Critical patent/JP2005529884A/en
Priority to EP03733878A priority patent/EP1501847A2/en
Priority to CA002483281A priority patent/CA2483281A1/en
Priority to MXPA04010557A priority patent/MXPA04010557A/en
Publication of WO2003090679A2 publication Critical patent/WO2003090679A2/en
Publication of WO2003090679A3 publication Critical patent/WO2003090679A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Antibacterial compounds having formula (I) and formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.
PCT/US2003/012590 2002-04-25 2003-04-24 11-deoxy azalide antibacterials WO2003090679A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2003587318A JP2005529884A (en) 2002-04-25 2003-04-24 11-deoxyazalide antibacterial drug
EP03733878A EP1501847A2 (en) 2002-04-25 2003-04-24 11-deoxy azalide antibacterials
CA002483281A CA2483281A1 (en) 2002-04-25 2003-04-24 11-deoxy azalide antibacterials
MXPA04010557A MXPA04010557A (en) 2002-04-25 2003-04-24 11-deoxy azalide antibacterials.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13203602A 2002-04-25 2002-04-25
US10/132,036 2002-04-25
US42109103A 2003-04-23 2003-04-23
US10/421,091 2003-04-23

Publications (2)

Publication Number Publication Date
WO2003090679A2 WO2003090679A2 (en) 2003-11-06
WO2003090679A3 true WO2003090679A3 (en) 2004-03-11

Family

ID=29272618

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/012590 WO2003090679A2 (en) 2002-04-25 2003-04-24 11-deoxy azalide antibacterials

Country Status (5)

Country Link
EP (1) EP1501847A2 (en)
JP (1) JP2005529884A (en)
CA (1) CA2483281A1 (en)
MX (1) MXPA04010557A (en)
WO (1) WO2003090679A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7407941B2 (en) 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A.BRIAN JONES ET AL.: "Assessment of the biological value of the 11-hydroxy group of the azalides.", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 3, no. 10, 1993, pages 1999 - 2004, XP008023252 *

Also Published As

Publication number Publication date
WO2003090679A2 (en) 2003-11-06
MXPA04010557A (en) 2005-02-17
JP2005529884A (en) 2005-10-06
EP1501847A2 (en) 2005-02-02
CA2483281A1 (en) 2003-11-06

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