MXPA02011530A - Nuevo proceso para la preparacion de derivados de vinil-pirrolidinon,cefalosporina. - Google Patents

Nuevo proceso para la preparacion de derivados de vinil-pirrolidinon,cefalosporina.

Info

Publication number
MXPA02011530A
MXPA02011530A MXPA02011530A MXPA02011530A MXPA02011530A MX PA02011530 A MXPA02011530 A MX PA02011530A MX PA02011530 A MXPA02011530 A MX PA02011530A MX PA02011530 A MXPA02011530 A MX PA02011530A MX PA02011530 A MXPA02011530 A MX PA02011530A
Authority
MX
Mexico
Prior art keywords
preparation
new process
vinyl pyrrolidinone
pyrrolidinone cephalosporine
cephalosporine derivatives
Prior art date
Application number
MXPA02011530A
Other languages
English (en)
Inventor
Paul Hebeisen
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of MXPA02011530A publication Critical patent/MXPA02011530A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Abstract

La invencion se refiere a un nuevo proceso para la preparacion de un derivado de vinil-pirrolidinon- cefalosporina de la formula (I). El compuesto de la formula (I), preparado de acuerdo a la invencion, puede ser utilizado para el tratamiento y profilaxis de enfermedades infecciosas, especialmente enfermedades infecciosas provocadas por patogenos bacterianos en particular Staphylococcus aureus resistentes a la meticilina (MRSA) y Pseudomonas aeruginosa.
MXPA02011530A 2000-05-24 2001-05-18 Nuevo proceso para la preparacion de derivados de vinil-pirrolidinon,cefalosporina. MXPA02011530A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00111164 2000-05-24
PCT/EP2001/005721 WO2001090111A1 (en) 2000-05-24 2001-05-18 New process for the preparation of vinyl-pyrrolidinone cephalosporine derivatives

Publications (1)

Publication Number Publication Date
MXPA02011530A true MXPA02011530A (es) 2003-04-25

Family

ID=8168825

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02011530A MXPA02011530A (es) 2000-05-24 2001-05-18 Nuevo proceso para la preparacion de derivados de vinil-pirrolidinon,cefalosporina.

Country Status (16)

Country Link
US (1) US6504025B2 (es)
EP (2) EP1435357B1 (es)
JP (1) JP3994011B2 (es)
KR (1) KR100528305B1 (es)
CN (4) CN100567314C (es)
AT (2) ATE461203T1 (es)
AU (1) AU2001262299A1 (es)
CA (2) CA2408941C (es)
CY (1) CY1110298T1 (es)
DE (2) DE60141609D1 (es)
DK (2) DK1435357T3 (es)
ES (2) ES2340273T3 (es)
HK (3) HK1074620A1 (es)
MX (1) MXPA02011530A (es)
PT (2) PT1289998E (es)
WO (1) WO2001090111A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1302456B1 (de) 2001-10-11 2004-01-02 Consortium für elektrochemische Industrie GmbH Verfahren zur Oxidation von Alkoholen unter Katalyse von Nitroxylverbindungen
ES2329244T3 (es) * 2003-03-27 2009-11-24 Basilea Pharmaceutica Ag Cefalosporina en forma cristalina.
EA201070504A1 (ru) * 2007-10-25 2010-12-30 Эйкеоджен, Инк. КАРБАЦЕФЕМ β-ЛАКТАМОВЫЕ АНТИБИОТИКИ
AR071318A1 (es) * 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
WO2010030810A1 (en) * 2008-09-10 2010-03-18 Achaogen, Inc. Carbacephem beta-lactam antibiotics
WO2010072672A1 (en) 2008-12-24 2010-07-01 Basilea Pharmaceutica Ag New crystal polymorphs of ceftobiprole
EP2435442B1 (de) * 2009-05-25 2016-01-13 Sandoz AG Verfahren zur herstellung von ceftobiprol medocaril
PT2569321E (pt) 2010-05-10 2015-05-25 Basilea Pharmaceutica Int Ltd Processo de oxidação para a preparação de derivados 3-formil cefeme
CN103275104B (zh) * 2013-05-15 2015-05-20 苏州明锐医药科技有限公司 头孢托罗及头孢托罗酯的制备方法
CN105601648A (zh) * 2016-03-09 2016-05-25 上海宁瑞生化技术有限公司 一锅法制备头孢吡普的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0620225B1 (en) * 1993-04-16 2002-11-13 Basilea Pharmaceutica AG Cephalosporin derivatives
US5466811A (en) 1994-07-18 1995-11-14 Merck & Co., Inc. Dioxolenylmethyl carbamates pro moieties for amine drugs
US5631366A (en) * 1995-01-12 1997-05-20 Hoffmann-La Roche Inc. Process for making 3-formylcephem derivatives
KR100197788B1 (ko) 1995-06-30 1999-06-15 김충환 세펨 유도체의 제조방법
US5883247A (en) 1996-06-10 1999-03-16 Hoffmann-La Roche Inc. Preparation of cephem and isooxacephem derivatives
TW415949B (en) 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents
PL200130B1 (pl) * 1997-04-01 2008-12-31 Nabriva Therapeutics Forschung Podstawione pochodne 7-acyloamino-3-(metylohydrazono)metylocefalosporyny, sposób ich wytwarzania, kompozycja farmaceutyczna zawierająca takie pochodne, zastosowania tych pochodnych oraz związki pośrednie służące do otrzymywania podstawionych 7-acyloamino-3-(metylohydrazono)metylocefalosporyn
BRPI9911178B8 (pt) 1998-06-15 2017-03-07 Basilea Pharmaceutica Ag derivados de 3-(2-oxo-[1,3']bipirrolidinil-3-ilidenometil)-cefems, bem como preparação farmacêutica e uso dos mesmos

Also Published As

Publication number Publication date
CN100567314C (zh) 2009-12-09
EP1435357A3 (en) 2006-05-03
US20020019381A1 (en) 2002-02-14
CA2583727C (en) 2010-03-30
KR100528305B1 (ko) 2005-11-15
WO2001090111A1 (en) 2001-11-29
CA2583727A1 (en) 2001-11-29
HK1096091A1 (en) 2007-05-25
PT1435357E (pt) 2010-04-20
CA2408941C (en) 2009-01-27
CN1301998C (zh) 2007-02-28
CY1110298T1 (el) 2015-04-29
JP3994011B2 (ja) 2007-10-17
CN1916006A (zh) 2007-02-21
HK1096101A1 (en) 2007-05-25
ES2340273T3 (es) 2010-06-01
JP2003535059A (ja) 2003-11-25
EP1289998A1 (en) 2003-03-12
EP1289998B1 (en) 2005-03-30
CN1915997A (zh) 2007-02-21
DK1289998T3 (da) 2005-08-08
CN1430621A (zh) 2003-07-16
AU2001262299A1 (en) 2001-12-03
CN1915997B (zh) 2010-06-16
CN1170831C (zh) 2004-10-13
DE60109771T2 (de) 2006-02-16
KR20030005386A (ko) 2003-01-17
ATE461203T1 (de) 2010-04-15
DK1435357T3 (da) 2010-05-03
DE60109771D1 (de) 2005-05-04
CN1603327A (zh) 2005-04-06
EP1435357A2 (en) 2004-07-07
CA2408941A1 (en) 2001-11-29
DE60141609D1 (de) 2010-04-29
EP1435357B1 (en) 2010-03-17
US6504025B2 (en) 2003-01-07
ATE292135T1 (de) 2005-04-15
ES2238441T3 (es) 2005-09-01
HK1074620A1 (en) 2005-11-18
PT1289998E (pt) 2005-06-30

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