DE60118593D1 - Verfahren zur herstellung von kristallinem n-formimidoylthienamycin-monohydrat (imipenem-monohydrat) - Google Patents
Verfahren zur herstellung von kristallinem n-formimidoylthienamycin-monohydrat (imipenem-monohydrat)Info
- Publication number
- DE60118593D1 DE60118593D1 DE60118593T DE60118593T DE60118593D1 DE 60118593 D1 DE60118593 D1 DE 60118593D1 DE 60118593 T DE60118593 T DE 60118593T DE 60118593 T DE60118593 T DE 60118593T DE 60118593 D1 DE60118593 D1 DE 60118593D1
- Authority
- DE
- Germany
- Prior art keywords
- monohydrate
- formimidoylthienamycin
- imipenem
- preparing crystalline
- crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 N-FORMIMIDOYLTHIENAMYCIN MONOHYDRATE Chemical class 0.000 title abstract 2
- GSOSVVULSKVSLQ-JJVRHELESA-N imipenem hydrate Chemical compound O.C1C(SCCNC=N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 GSOSVVULSKVSLQ-JJVRHELESA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN983DE2000 IN191798B (de) | 2000-11-03 | 2000-11-03 | |
PCT/IB2001/002069 WO2002036594A1 (en) | 2000-11-03 | 2001-11-05 | Process for the preparation of crystalline n-formimidoyl thienamycin monohydrate (imipenem monohydrate) |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60118593D1 true DE60118593D1 (de) | 2006-05-18 |
Family
ID=11097114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60118593T Expired - Lifetime DE60118593D1 (de) | 2000-11-03 | 2001-11-05 | Verfahren zur herstellung von kristallinem n-formimidoylthienamycin-monohydrat (imipenem-monohydrat) |
Country Status (19)
Country | Link |
---|---|
US (1) | US7078534B2 (de) |
EP (1) | EP1334105B1 (de) |
JP (1) | JP2004525084A (de) |
KR (1) | KR20030059812A (de) |
CN (1) | CN100445284C (de) |
AT (1) | ATE322495T1 (de) |
AU (1) | AU2002212591A1 (de) |
BG (1) | BG107852A (de) |
CA (1) | CA2427762C (de) |
DE (1) | DE60118593D1 (de) |
DK (1) | DK1334105T3 (de) |
EA (1) | EA006442B1 (de) |
EE (1) | EE200300206A (de) |
ES (1) | ES2261494T3 (de) |
IN (1) | IN191798B (de) |
MX (1) | MXPA03003916A (de) |
PT (1) | PT1334105E (de) |
WO (1) | WO2002036594A1 (de) |
ZA (1) | ZA200303338B (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE437879T1 (de) | 2001-05-18 | 2009-08-15 | Ranbaxy Lab Ltd | Verfahren zur herstellung von imipenem |
MXPA03010548A (es) | 2001-05-18 | 2004-05-27 | Ranbaxy Lab Ltd | Proceso para el aislamiento de imipenem cristalino. |
BR0209843A (pt) * | 2001-05-18 | 2004-08-24 | Ranbaxy Lab Ltd | Processo para a preparação de cilastatina sódica amorfa |
WO2003016312A1 (fr) * | 2001-08-13 | 2003-02-27 | Eisai Co., Ltd. | Procede de preparation d'antibiotiques a base de carbapenem |
WO2003042215A1 (en) | 2001-11-16 | 2003-05-22 | Ranbaxy Laboratories Limited | Process for the preparation of crystalline imipenem |
US6537985B1 (en) | 2001-11-30 | 2003-03-25 | Phoenix Scientific, Inc. | Antibiotic formulation and a method of making this formulation |
MXPA06001115A (es) * | 2003-12-09 | 2006-04-11 | Choongwae Pharm Co | Un proceso nuevo para la preparacion de imipenem. |
KR100848752B1 (ko) * | 2006-11-10 | 2008-07-25 | 제일약품주식회사 | 티에나마이신 용매화합물 및 그의 제조방법 |
KR100848751B1 (ko) * | 2006-11-10 | 2008-07-25 | 제일약품주식회사 | 이미페넴의 제조방법 |
WO2009047604A1 (en) * | 2007-10-08 | 2009-04-16 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of carbapenem antibiotic |
CN108623598A (zh) * | 2018-05-21 | 2018-10-09 | 重庆天地药业有限责任公司 | 一种亚胺培南中间体及亚胺培南的制备方法 |
CN111413427A (zh) * | 2020-04-08 | 2020-07-14 | 苏州和合医学检验有限公司 | 超滤前处理高效液相色谱测定血浆中亚胺培南含量的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4194047A (en) | 1975-11-21 | 1980-03-18 | Merck & Co., Inc. | Substituted N-methylene derivatives of thienamycin |
US4260543A (en) * | 1978-07-03 | 1981-04-07 | Merck & Co., Inc. | Crystalline N-formimidoyl thienamycin |
JP3048196B2 (ja) | 1991-06-20 | 2000-06-05 | 第一製薬株式会社 | カルバペネム誘導体 |
ES2101119T3 (es) | 1991-10-01 | 1997-07-01 | Procter & Gamble Pharma | Procedimiento para preparar quinolonil-lactamas antimicrobianas. |
HUT65301A (en) | 1992-09-09 | 1994-05-02 | Sankyo Co | New method for preparing of carbapenem- and penem-carbonacid-derivatives with antibacterial activity |
US5245069A (en) * | 1992-10-27 | 1993-09-14 | Merck & Co., Inc. | Process for the preparation of bis(aryl)-phosphorohalidates |
US5872250A (en) * | 1997-07-30 | 1999-02-16 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
-
2000
- 2000-11-03 IN IN983DE2000 patent/IN191798B/en unknown
-
2001
- 2001-11-05 CN CNB018207154A patent/CN100445284C/zh not_active Expired - Fee Related
- 2001-11-05 EE EEP200300206A patent/EE200300206A/xx unknown
- 2001-11-05 EP EP01980805A patent/EP1334105B1/de not_active Expired - Lifetime
- 2001-11-05 JP JP2002539352A patent/JP2004525084A/ja not_active Withdrawn
- 2001-11-05 MX MXPA03003916A patent/MXPA03003916A/es active IP Right Grant
- 2001-11-05 ES ES01980805T patent/ES2261494T3/es not_active Expired - Lifetime
- 2001-11-05 KR KR10-2003-7006118A patent/KR20030059812A/ko not_active Application Discontinuation
- 2001-11-05 AT AT01980805T patent/ATE322495T1/de active
- 2001-11-05 US US10/415,633 patent/US7078534B2/en not_active Expired - Fee Related
- 2001-11-05 DK DK01980805T patent/DK1334105T3/da active
- 2001-11-05 EA EA200300520A patent/EA006442B1/ru not_active IP Right Cessation
- 2001-11-05 PT PT01980805T patent/PT1334105E/pt unknown
- 2001-11-05 CA CA002427762A patent/CA2427762C/en not_active Expired - Fee Related
- 2001-11-05 DE DE60118593T patent/DE60118593D1/de not_active Expired - Lifetime
- 2001-11-05 AU AU2002212591A patent/AU2002212591A1/en not_active Abandoned
- 2001-11-05 WO PCT/IB2001/002069 patent/WO2002036594A1/en active IP Right Grant
-
2003
- 2003-04-30 ZA ZA200303338A patent/ZA200303338B/en unknown
- 2003-05-27 BG BG107852A patent/BG107852A/bg unknown
Also Published As
Publication number | Publication date |
---|---|
US20040054167A1 (en) | 2004-03-18 |
EE200300206A (et) | 2003-10-15 |
CN100445284C (zh) | 2008-12-24 |
PT1334105E (pt) | 2006-08-31 |
DK1334105T3 (da) | 2006-08-14 |
US7078534B2 (en) | 2006-07-18 |
CA2427762C (en) | 2009-10-20 |
MXPA03003916A (es) | 2004-01-29 |
EP1334105B1 (de) | 2006-04-05 |
CN1481384A (zh) | 2004-03-10 |
ATE322495T1 (de) | 2006-04-15 |
AU2002212591A1 (en) | 2002-05-15 |
ZA200303338B (en) | 2004-03-09 |
CA2427762A1 (en) | 2002-05-10 |
EA006442B1 (ru) | 2005-12-29 |
KR20030059812A (ko) | 2003-07-10 |
WO2002036594A1 (en) | 2002-05-10 |
EA200300520A1 (ru) | 2003-10-30 |
EP1334105A1 (de) | 2003-08-13 |
BG107852A (bg) | 2004-01-30 |
ES2261494T3 (es) | 2006-11-16 |
JP2004525084A (ja) | 2004-08-19 |
IN191798B (de) | 2004-01-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |