MXPA04004604A - Proceso para la preparacion de imipenem cristalino. - Google Patents
Proceso para la preparacion de imipenem cristalino.Info
- Publication number
- MXPA04004604A MXPA04004604A MXPA04004604A MXPA04004604A MXPA04004604A MX PA04004604 A MXPA04004604 A MX PA04004604A MX PA04004604 A MXPA04004604 A MX PA04004604A MX PA04004604 A MXPA04004604 A MX PA04004604A MX PA04004604 A MXPA04004604 A MX PA04004604A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- imipenem
- crystalline imipenem
- crystalline
- high purity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invencion se relaciona a un proceso para la preparacion de imipenem de alta pureza efectivo en costos e industrialmente ventajoso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1152DE2001 | 2001-11-16 | ||
PCT/IB2002/004804 WO2003042215A1 (en) | 2001-11-16 | 2002-11-18 | Process for the preparation of crystalline imipenem |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04004604A true MXPA04004604A (es) | 2004-09-10 |
Family
ID=11097136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04004604A MXPA04004604A (es) | 2001-11-16 | 2002-11-18 | Proceso para la preparacion de imipenem cristalino. |
Country Status (15)
Country | Link |
---|---|
US (1) | US7332600B2 (es) |
EP (1) | EP1448563A1 (es) |
JP (1) | JP2005509037A (es) |
KR (1) | KR20050044506A (es) |
CN (1) | CN1608066A (es) |
AR (1) | AR037551A1 (es) |
BR (1) | BR0214209A (es) |
CA (1) | CA2467427A1 (es) |
EA (1) | EA200400682A1 (es) |
HR (1) | HRP20040552A2 (es) |
HU (1) | HUP0402112A2 (es) |
MX (1) | MXPA04004604A (es) |
PL (1) | PL368984A1 (es) |
WO (1) | WO2003042215A1 (es) |
ZA (1) | ZA200403961B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2447673A1 (en) * | 2001-05-18 | 2002-11-28 | Ranbaxy Laboratories Limited | Process for the isolation of crystalline imipenem |
JP2005023081A (ja) * | 2003-06-11 | 2005-01-27 | Api Corporation | アルブチン結晶及びその製造方法 |
US7640048B2 (en) | 2004-07-13 | 2009-12-29 | Dexcom, Inc. | Analyte sensor |
EP1991110B1 (en) | 2006-03-09 | 2018-11-07 | DexCom, Inc. | Systems and methods for processing analyte sensor data |
EP4218548A1 (en) | 2006-03-09 | 2023-08-02 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
JP5220026B2 (ja) * | 2006-12-15 | 2013-06-26 | メルク・シャープ・アンド・ドーム・コーポレーション | アルファ−ケトアミドの亜硫酸水素塩精製 |
US8621008B2 (en) | 2007-04-26 | 2013-12-31 | Mcafee, Inc. | System, method and computer program product for performing an action based on an aspect of an electronic mail message thread |
US8199965B1 (en) | 2007-08-17 | 2012-06-12 | Mcafee, Inc. | System, method, and computer program product for preventing image-related data loss |
US20130276061A1 (en) | 2007-09-05 | 2013-10-17 | Gopi Krishna Chebiyyam | System, method, and computer program product for preventing access to data with respect to a data access attempt associated with a remote data sharing session |
US8293924B2 (en) | 2007-10-08 | 2012-10-23 | Orchid Chemicals & Pharmaceuticals Limited | Process for the preparation of carbapenem antibiotic |
US8893285B2 (en) | 2008-03-14 | 2014-11-18 | Mcafee, Inc. | Securing data using integrated host-based data loss agent with encryption detection |
US9077684B1 (en) | 2008-08-06 | 2015-07-07 | Mcafee, Inc. | System, method, and computer program product for determining whether an electronic mail message is compliant with an etiquette policy |
CN101891745B (zh) * | 2010-07-20 | 2012-06-13 | 深圳市海滨制药有限公司 | 亚胺培南一水合物晶体的制备方法 |
CN101891744B (zh) * | 2010-07-20 | 2012-06-13 | 深圳市海滨制药有限公司 | 亚胺培南一水合物结晶的制备方法 |
WO2012081033A2 (en) * | 2010-12-06 | 2012-06-21 | Sequent Scientific Limited | A process for preparation of imipenem |
CN103524508B (zh) * | 2013-09-02 | 2016-03-30 | 上海龙翔生物医药开发有限公司 | 一种亚胺培南一水合物的结晶方法 |
CN113135916A (zh) * | 2020-01-20 | 2021-07-20 | 鲁南制药集团股份有限公司 | 一种亚胺培南制备工艺的除钯方法 |
CN111747959B (zh) * | 2020-05-15 | 2022-02-11 | 深圳市海滨制药有限公司 | 一种亚胺培南原料药的制备方法 |
CN114671877B (zh) * | 2022-02-18 | 2023-05-16 | 珠海联邦制药股份有限公司 | 亚胺培南的精制方法 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE268240C (es) | ||||
JPS606957B2 (ja) * | 1973-04-10 | 1985-02-21 | ブリストル マイヤ−ズ カンパニ− | 抗生物質誘導体の製造方法 |
US4194047A (en) * | 1975-11-21 | 1980-03-18 | Merck & Co., Inc. | Substituted N-methylene derivatives of thienamycin |
DK153486C (da) * | 1978-07-03 | 1988-11-28 | Merck & Co Inc | Analogifremgangsmaade til fremstilling af krystallinsk n-formimidoyl-thienamycin-monohydrat |
US4260543A (en) * | 1978-07-03 | 1981-04-07 | Merck & Co., Inc. | Crystalline N-formimidoyl thienamycin |
US4292436A (en) * | 1980-06-25 | 1981-09-29 | Merck & Co., Inc. | Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol |
US5061730A (en) * | 1987-01-26 | 1991-10-29 | Fujisawa Pharmaceutical Co., Ltd. | Carboxylic acid derivatives |
DD268240A1 (de) * | 1987-12-05 | 1989-05-24 | Univ Schiller Jena | Verfahren zur erzeugung von fuer die applikation in optiken aus polymeren werkstoffen geeigneten hochreinen 2-hydroxy-4-alkoxybenzophenonen |
US5321020A (en) * | 1989-03-28 | 1994-06-14 | Pfizer Inc. | Antibacterial 2-carbapenem derivatives |
CA2023144A1 (en) * | 1989-08-21 | 1991-02-22 | Frank P. Dininno | 2-(quinoliniumalkyl and isoquinoliniumalkyl)-phenyl carbapenem antibacterial agents |
JPH03256262A (ja) | 1990-03-07 | 1991-11-14 | Nec Corp | 磁気ディスク装置 |
US5240920A (en) * | 1990-10-11 | 1993-08-31 | Merck & Co., Inc. | 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents |
JPH06256262A (ja) * | 1993-03-08 | 1994-09-13 | Sekiyu Sangyo Kasseika Center | 2,6−ナフタレンジカルボン酸ジメチルエステルの精製法 |
US5621084A (en) * | 1994-04-05 | 1997-04-15 | Pfizer Inc. | Process for removal of allyl group or allyloxycarbonyl group |
ATE187437T1 (de) * | 1995-09-08 | 1999-12-15 | Bracco Int Bv | Verfahren zur kristallisierung aus wasser von (s)-n,n'-bis(2-hydroxy-1-(hydroxymethiel)ethyl> 5-((2-hydroxy-1-oxopropyl)amino>-2,4,6-triiodo- ,3- benzoldicarboxamide |
DE69734779T2 (de) * | 1996-03-14 | 2006-07-27 | Novozymes A/S | Erhöhte ausbeuten an einem kristallisierten protein unter verwenden eines festen adsorptionsmaterials |
CN1109688C (zh) | 1999-01-12 | 2003-05-28 | 中国药品生物制品检定所 | 他唑巴坦半水合物的制备与应用 |
JP2002540090A (ja) * | 1999-03-22 | 2002-11-26 | ピユラク・バイオケム・ベー・ブイ | 乳酸を産業規模で精製する方法 |
GB9925215D0 (en) * | 1999-10-26 | 1999-12-22 | Cerestar Holding Bv | Process for the manufacture of citric acid |
CA2404703C (en) * | 2000-03-31 | 2007-06-05 | Shionogi & Co., Ltd. | Novel crystal form of pyrrolidylthiocarbapenem derivative |
IN191798B (es) | 2000-11-03 | 2004-01-03 | Ranbaxy Lab Ltd | |
AR035728A1 (es) * | 2001-01-16 | 2004-07-07 | Merck & Co Inc | Proceso perfeccionado para la sintesis de carbapenem |
CA2447673A1 (en) * | 2001-05-18 | 2002-11-28 | Ranbaxy Laboratories Limited | Process for the isolation of crystalline imipenem |
ES2368997T3 (es) * | 2001-09-26 | 2011-11-24 | Merck Sharp & Dohme Corp. | Procedimiento de fabricación de compuestos de carbapenem. |
USRE40794E1 (en) * | 2001-09-26 | 2009-06-23 | Merck & Co., Inc. | Crystalline forms of carbapenem antibiotics and methods of preparation |
-
2002
- 2002-11-18 CN CNA028260082A patent/CN1608066A/zh active Pending
- 2002-11-18 JP JP2003544051A patent/JP2005509037A/ja not_active Withdrawn
- 2002-11-18 EA EA200400682A patent/EA200400682A1/ru unknown
- 2002-11-18 BR BR0214209-0A patent/BR0214209A/pt not_active IP Right Cessation
- 2002-11-18 CA CA002467427A patent/CA2467427A1/en not_active Abandoned
- 2002-11-18 HU HU0402112A patent/HUP0402112A2/hu unknown
- 2002-11-18 KR KR1020047007508A patent/KR20050044506A/ko not_active Application Discontinuation
- 2002-11-18 MX MXPA04004604A patent/MXPA04004604A/es unknown
- 2002-11-18 PL PL02368984A patent/PL368984A1/xx not_active Application Discontinuation
- 2002-11-18 EP EP02783385A patent/EP1448563A1/en not_active Withdrawn
- 2002-11-18 US US10/495,681 patent/US7332600B2/en not_active Expired - Fee Related
- 2002-11-18 WO PCT/IB2002/004804 patent/WO2003042215A1/en active Application Filing
- 2002-11-19 AR ARP020104429A patent/AR037551A1/es not_active Application Discontinuation
-
2004
- 2004-05-21 ZA ZA200403961A patent/ZA200403961B/en unknown
- 2004-06-16 HR HR20040552A patent/HRP20040552A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BR0214209A (pt) | 2004-10-26 |
CN1608066A (zh) | 2005-04-20 |
EA200400682A1 (ru) | 2004-10-28 |
CA2467427A1 (en) | 2003-05-22 |
KR20050044506A (ko) | 2005-05-12 |
US20050004359A1 (en) | 2005-01-06 |
US7332600B2 (en) | 2008-02-19 |
HRP20040552A2 (en) | 2004-10-31 |
ZA200403961B (en) | 2005-09-19 |
HUP0402112A2 (hu) | 2005-02-28 |
PL368984A1 (en) | 2005-04-04 |
AR037551A1 (es) | 2004-11-17 |
EP1448563A1 (en) | 2004-08-25 |
JP2005509037A (ja) | 2005-04-07 |
WO2003042215A1 (en) | 2003-05-22 |
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