AR037551A1 - Proceso para la preparacion de imipenem monohidratado cristalino y compuesto - Google Patents

Proceso para la preparacion de imipenem monohidratado cristalino y compuesto

Info

Publication number
AR037551A1
AR037551A1 ARP020104429A ARP020104429A AR037551A1 AR 037551 A1 AR037551 A1 AR 037551A1 AR P020104429 A ARP020104429 A AR P020104429A AR P020104429 A ARP020104429 A AR P020104429A AR 037551 A1 AR037551 A1 AR 037551A1
Authority
AR
Argentina
Prior art keywords
imipenem
preparation
crystalline
monohydrate
monohidratado
Prior art date
Application number
ARP020104429A
Other languages
English (en)
Inventor
Bishwa Prakash Rai
Neera Tewari
Velayudhan Nair Gopa Kumar
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of AR037551A1 publication Critical patent/AR037551A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un proceso rentable y ventajoso para uso industrial para la preparación de imipenem monohidratado cristalino a partir de imipenem crudo con impurezas que incluyen impurezas poliméricas y coloreadas, y el compuesto preparado para aplicación en antibióticos tipo B-lactama, que posee el sistema de anillo carbapenem, frente a especies aeróbicas y anaerobias gram-positivas y gram-negativas. El imipenem monohidratado cristalino y puro presenta la fórmula(1): l proceso para su preparación comprende: (a) disolver imipenem crudo en agua para obtener una solución; (b) someter la solución resultante a un tratamiento con carbón activado; y(c) anadir un solvente orgánico para hacer que el imipenem monohidratado precipite como producto cristalino, imipenem monohidratado es el derivado N-formimidoílo de tienamacina.
ARP020104429A 2001-11-16 2002-11-19 Proceso para la preparacion de imipenem monohidratado cristalino y compuesto AR037551A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN1152DE2001 2001-11-16

Publications (1)

Publication Number Publication Date
AR037551A1 true AR037551A1 (es) 2004-11-17

Family

ID=11097136

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020104429A AR037551A1 (es) 2001-11-16 2002-11-19 Proceso para la preparacion de imipenem monohidratado cristalino y compuesto

Country Status (15)

Country Link
US (1) US7332600B2 (es)
EP (1) EP1448563A1 (es)
JP (1) JP2005509037A (es)
KR (1) KR20050044506A (es)
CN (1) CN1608066A (es)
AR (1) AR037551A1 (es)
BR (1) BR0214209A (es)
CA (1) CA2467427A1 (es)
EA (1) EA200400682A1 (es)
HR (1) HRP20040552A2 (es)
HU (1) HUP0402112A2 (es)
MX (1) MXPA04004604A (es)
PL (1) PL368984A1 (es)
WO (1) WO2003042215A1 (es)
ZA (1) ZA200403961B (es)

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WO2009047604A1 (en) * 2007-10-08 2009-04-16 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
US8893285B2 (en) 2008-03-14 2014-11-18 Mcafee, Inc. Securing data using integrated host-based data loss agent with encryption detection
US9077684B1 (en) 2008-08-06 2015-07-07 Mcafee, Inc. System, method, and computer program product for determining whether an electronic mail message is compliant with an etiquette policy
CN101891744B (zh) * 2010-07-20 2012-06-13 深圳市海滨制药有限公司 亚胺培南一水合物结晶的制备方法
CN101891745B (zh) * 2010-07-20 2012-06-13 深圳市海滨制药有限公司 亚胺培南一水合物晶体的制备方法
WO2012081033A2 (en) * 2010-12-06 2012-06-21 Sequent Scientific Limited A process for preparation of imipenem
CN103524508B (zh) * 2013-09-02 2016-03-30 上海龙翔生物医药开发有限公司 一种亚胺培南一水合物的结晶方法
CN113135916A (zh) * 2020-01-20 2021-07-20 鲁南制药集团股份有限公司 一种亚胺培南制备工艺的除钯方法
CN111747959B (zh) * 2020-05-15 2022-02-11 深圳市海滨制药有限公司 一种亚胺培南原料药的制备方法
CN114671877B (zh) * 2022-02-18 2023-05-16 珠海联邦制药股份有限公司 亚胺培南的精制方法

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Also Published As

Publication number Publication date
KR20050044506A (ko) 2005-05-12
WO2003042215A1 (en) 2003-05-22
HUP0402112A2 (hu) 2005-02-28
ZA200403961B (en) 2005-09-19
CN1608066A (zh) 2005-04-20
US20050004359A1 (en) 2005-01-06
MXPA04004604A (es) 2004-09-10
PL368984A1 (en) 2005-04-04
EA200400682A1 (ru) 2004-10-28
EP1448563A1 (en) 2004-08-25
HRP20040552A2 (en) 2004-10-31
BR0214209A (pt) 2004-10-26
US7332600B2 (en) 2008-02-19
JP2005509037A (ja) 2005-04-07
CA2467427A1 (en) 2003-05-22

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