BRPI0712312A2 - Composto, processo para a produção do mesmo, composição farmacêutica, agente antimicrobiano, agente anti-mrsa, método para a prevenção ou o tratamento de uma doença infecciosa, e, uso do composto - Google Patents

Composto, processo para a produção do mesmo, composição farmacêutica, agente antimicrobiano, agente anti-mrsa, método para a prevenção ou o tratamento de uma doença infecciosa, e, uso do composto Download PDF

Info

Publication number
BRPI0712312A2
BRPI0712312A2 BRPI0712312-4A BRPI0712312A BRPI0712312A2 BR PI0712312 A2 BRPI0712312 A2 BR PI0712312A2 BR PI0712312 A BRPI0712312 A BR PI0712312A BR PI0712312 A2 BRPI0712312 A2 BR PI0712312A2
Authority
BR
Brazil
Prior art keywords
compound
agent
mrsa
prevention
pharmaceutical composition
Prior art date
Application number
BRPI0712312-4A
Other languages
English (en)
Inventor
Kobayashi Yoshihiko
Akiyama Yoshihisa
Murakami Takeshi
Minowa Nobuto
Tsushima Masaki
Hiraiwa Yukiko
Murakami Shoichi
Abe Mitsuhiro
Sasaki Kazushige
Hoshiko Shigeru
Miyake Toshiaki
Takahashi Yoshiaki
Ikeda Daishiro
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Publication of BRPI0712312A2 publication Critical patent/BRPI0712312A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

COMPOSTO, PROCESSO PARA A PRODUÇçO DO MESMO, COMPOSIÇçO FARMACÊUTICA, AGENTE ANTIMICROBIANO, AGENTE ANTI-MRSA, MÉTODO PARA A PREVENÇçO OU O TRATAMENTO DE UMA DOENÇA INFECCIOSA, E, USO DO COMPOSTO São expostos: um novo antibiótico de aminoglicosídeo, que possui uma excelente atividade antibacteriana contra bactérias, que induzem doenças infecciosas, em particular MRSA, e também que apresenta uma baixa toxicidade renal; e um processo para a produção do antibiótico. De um modo mais específico, são expostos: um composto representado pela fórmula (Ia) ou um sal farmacologicamente aceitável ou solvato do mesmo, ou uma mistura diastereomérica do composto, o sal ou o solvato; um agente antibacteriano, que compreende o composto, o sal, o solvato ou a mistura diastomérica; e um processo para a produção do composto.
BRPI0712312-4A 2006-06-02 2007-06-01 Composto, processo para a produção do mesmo, composição farmacêutica, agente antimicrobiano, agente anti-mrsa, método para a prevenção ou o tratamento de uma doença infecciosa, e, uso do composto BRPI0712312A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006155062 2006-06-02
JP2006-155062 2006-06-02
PCT/JP2007/061209 WO2007142150A1 (ja) 2006-06-02 2007-06-01 新規アミノグリコシド系抗生物質

Publications (1)

Publication Number Publication Date
BRPI0712312A2 true BRPI0712312A2 (pt) 2012-03-06

Family

ID=38801405

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0712312-4A BRPI0712312A2 (pt) 2006-06-02 2007-06-01 Composto, processo para a produção do mesmo, composição farmacêutica, agente antimicrobiano, agente anti-mrsa, método para a prevenção ou o tratamento de uma doença infecciosa, e, uso do composto

Country Status (14)

Country Link
US (4) US8148504B2 (pt)
EP (1) EP2036917B1 (pt)
JP (1) JP5160419B2 (pt)
KR (1) KR101458223B1 (pt)
CN (2) CN101495493B (pt)
AU (1) AU2007255856B2 (pt)
BR (1) BRPI0712312A2 (pt)
CA (1) CA2654561A1 (pt)
ES (1) ES2557992T3 (pt)
MX (1) MX2008015280A (pt)
RU (1) RU2458931C2 (pt)
UA (1) UA97245C2 (pt)
WO (1) WO2007142150A1 (pt)
ZA (1) ZA200810676B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103003293A (zh) * 2010-05-12 2013-03-27 莱姆派克斯制药公司 氨基糖苷衍生物
ES2682931T3 (es) * 2013-05-30 2018-09-24 Meiji Seika Pharma Co., Ltd. Derivado de arbekacina y producción y uso del mismo
RU2751634C2 (ru) * 2015-07-30 2021-07-15 Майкробиал Кемистри Рисерч Фаундейшн Новый эффективный аминогликозидный антибиотик против бактерий с множественной лекарственной резистентностью
JP2019001717A (ja) * 2015-11-02 2019-01-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 アミノグリコシド系抗生物質の製造方法
JP2019001716A (ja) * 2015-11-02 2019-01-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 アミノグリコシド系抗生物質の製造方法
JP2019001718A (ja) * 2015-11-02 2019-01-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 アミノグリコシド系抗生物質の製造方法
BR112021009988A2 (pt) * 2018-11-25 2021-08-17 Tnt Medical Corporation composto de fórmula (i), ou um n-óxido deste, ou um sal, solvato, polimorfo, tautômero, estereoisômero farmaceuticamente aceitável, uma forma isotópica, ou um pró-fármaco do dito composto de fórmula (i) ou n-óxido deste, composição farmacêutica, e método de tratamento de uma doença neoplásica

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1349302A (en) * 1970-07-29 1974-04-03 Microbial Chem Res Found 3,-4,-dideoxykanamycin b active against resistant bacteria and its synthesis
US4107424A (en) * 1972-10-06 1978-08-15 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl] derivatives of 3',4'-dideoxykanamycin B and 3'-deoxykanamycin B antibiotics
US4001208A (en) 1972-10-06 1977-01-04 Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl]
JPS5233629B2 (pt) 1972-10-19 1977-08-30
JPS5148634A (en) * 1974-10-08 1976-04-26 Microbial Chem Res Found Taiseikinnyukona 11nn * arufua hidorokishi omega aminoashiru * 6**nn mechiru 3* *hh jideokishikanamaishin b no seizoho
US4396609A (en) * 1975-02-18 1983-08-02 Sterling Drug Inc. Aminocyclitol antibiotics, pharmaceutical compositions and method of using same
GB1529376A (en) 1975-02-18 1978-10-18 Sterling Drug Inc Aminocyclitol antibiotics and processes therefor
US3982996A (en) 1975-09-22 1976-09-28 Sterling Drug Inc. Process for preparing aminocyclitol antibiotics
US4147861A (en) 1975-09-24 1979-04-03 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1N-(α-Hydroxy-ω-aminoalkanoyl)-6'N-methyl-3',4'-dideoxykanamycin B and the production thereof
JPS55164696A (en) 1979-06-12 1980-12-22 Microbial Chem Res Found Preparation of protected derivative of aminoglycoside antibiotic substance wherein amino groups other than 1-position are selectively protected, and preparation of 1-n- alpha-hydroxy-omega-aminoalkanoyl -aminoglycoside antibiotic substance
JPS55151597A (en) 1979-05-11 1980-11-26 Kyowa Hakko Kogyo Co Ltd New material 2-hydroxysagamicin and its preparation
JPS5753496A (en) 1980-08-12 1982-03-30 Microbial Chem Res Found 1-n-acyl derivative of 5,3',4'-trideoxykanamycin b or 5,3',4',6'- tetradeoxykanamycin b, and their preparation
US4410516A (en) 1981-07-21 1983-10-18 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1-N(αHydroxy-ω-aminoalkanoyl) derivatives of 5,3',4'-trideoxy- or 5,3', 4'-trideoxy-6'-N- methyl- or 5, 3', 4',6"-tetradeoxykannamyci B and production thereof
JPS5815994A (ja) * 1981-07-22 1983-01-29 Microbial Chem Res Found ２′位修飾カナマイシン誘導体およびその製造法
JPH07121859B2 (ja) 1986-03-18 1995-12-25 第一製薬株式会社 徐放性カプセル剤
CN1197869C (zh) * 2002-12-09 2005-04-20 北京大学 具有抗病毒活性的氨基糖苷类化合物及其制备方法
JPWO2005070945A1 (ja) * 2004-01-21 2007-09-06 明治製菓株式会社 メチシリン耐性黄色ブドウ球菌（ｍｒｓａ）に有効な新規アミノグリコシド系抗生物質
JP2006155062A (ja) 2004-11-26 2006-06-15 Pfu Ltd ネットワーク検疫システム

Also Published As

Publication number Publication date
US9260465B2 (en) 2016-02-16
EP2036917B1 (en) 2015-10-07
US8148504B2 (en) 2012-04-03
US20090186841A1 (en) 2009-07-23
CN101495493A (zh) 2009-07-29
EP2036917A4 (en) 2014-09-03
UA97245C2 (en) 2012-01-25
US20160152653A1 (en) 2016-06-02
JP5160419B2 (ja) 2013-03-13
AU2007255856A1 (en) 2007-12-13
CN102942603A (zh) 2013-02-27
US8541394B2 (en) 2013-09-24
CN101495493B (zh) 2012-11-14
AU2007255856B2 (en) 2012-08-16
US20120165283A1 (en) 2012-06-28
RU2008152358A (ru) 2010-07-20
ZA200810676B (en) 2010-03-31
EP2036917A1 (en) 2009-03-18
MX2008015280A (es) 2009-01-28
KR101458223B1 (ko) 2014-11-04
KR20090014309A (ko) 2009-02-09
RU2458931C2 (ru) 2012-08-20
CA2654561A1 (en) 2007-12-13
ES2557992T3 (es) 2016-02-01
CN102942603B (zh) 2016-01-20
JPWO2007142150A1 (ja) 2009-10-22
US20130345411A1 (en) 2013-12-26
WO2007142150A1 (ja) 2007-12-13

Similar Documents

Publication Publication Date Title
CY1109970T1 (el) Παραγωγα 6-11 δικυκλικου κετολιδιου
BRPI0712312A2 (pt) Composto, processo para a produção do mesmo, composição farmacêutica, agente antimicrobiano, agente anti-mrsa, método para a prevenção ou o tratamento de uma doença infecciosa, e, uso do composto
BRPI0712631B8 (pt) compostos, processos para a preparação de um composto, composição farmacêutica, uso de um composto e combinações
MX2010005632A (es) Analogos de aminoglucosidos antibacterianos.
WO2008154642A3 (en) Antibacterial agents
BRPI0809977A8 (pt) Uso de um composto, compostos e composição farmacêutica que o contém
WO2004062601A3 (en) Antibacterial agents
WO2007128480A3 (en) Thioglycosides as pharmaceutically active agents
BRPI0922220A8 (pt) Uso de compostos antibacterianos, composição farmacêutica e combinação compreendendo os mesmos
MX2007010072A (es) Derivados de piperidina antibacterianos.
UA96964C2 (ru) Соединения полициклической мочевины с антибактериальными свойствами
TW200634021A (en) 3,6-bicyclolides
BR112013025275A2 (pt) derivados de cefalosporina e suas composições farmacêuticas
WO2005070113A3 (en) 9n-substituted 6-11 bicyclic erythromycin derivatives
WO2005000863A3 (en) 6, 11-4c-bicyclic 9a-azalide derivatives
NZ596628A (en) Ketolide compounds having antimicrobial activity
WO2006039263A3 (en) NOVEL BICYCLIC 9a-AZALIDE DERIVATIVES
MX2010002932A (es) Macrolidos de biarilo con puente en 6, 11.
MX2009006325A (es) Compuestos de heteroaril-heteroarilo como inhibidores de cdk para el tratamiento de cancer, inflamacion e infecciones virales.
WO2006065721A3 (en) 11, 12-lactone bicyclolides
CR9991A (es) Nuevo derivado de pleuromutilina y su uso
UA95630C2 (ru) Лизобактинамиды, способ их получения (варианты) и применение их как антибактериального средства
TW200635600A (en) Tetracyclic bicyclolides
WO2007044927A3 (en) 6, 11-bridged tricyclic macrolides
MX2009005912A (es) Derivados de etilamina-fenilo heterociclilo sustituidos, su preparacion y uso como medicamentos.

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: MICROBIAL CHEMISTRY RESEARCH FOUNDATION (JP) , MEI

Free format text: NOME ALTERADO DE: MEIJI SEIKA KAISHA, LTD.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2310 DE 14-04-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.