ES2103394T3 - Nuevos derivados de diclavulanato de alquilendiamonio, procedimientos para su preparacion y para su utilizacion. - Google Patents

Nuevos derivados de diclavulanato de alquilendiamonio, procedimientos para su preparacion y para su utilizacion.

Info

Publication number
ES2103394T3
ES2103394T3 ES93104890T ES93104890T ES2103394T3 ES 2103394 T3 ES2103394 T3 ES 2103394T3 ES 93104890 T ES93104890 T ES 93104890T ES 93104890 T ES93104890 T ES 93104890T ES 2103394 T3 ES2103394 T3 ES 2103394T3
Authority
ES
Spain
Prior art keywords
acids
salts
clavulanic
gram
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93104890T
Other languages
English (en)
Inventor
Anton Dr Ing Copar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Original Assignee
Lek Pharmaceuticals and Chemical Co dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals and Chemical Co dd filed Critical Lek Pharmaceuticals and Chemical Co dd
Application granted granted Critical
Publication of ES2103394T3 publication Critical patent/ES2103394T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA OBTENCION DE ACIDO CLAVULANICO Y SUS SALES FARMACEUTICAMENTE UTILIZABLES. SEGUN ESTE, LOS ACIDOS CLAVULANICOS EN BRUTO, QUE SE PRESENTAN EN FORMA DE EXTRACTO EN DISOLVENTES ORGANICOS COMO EL ACETATO DE ETILO, CUYO EXTRACTO FUE OBTENIDO EN LA FORMA YA CONOCIDA, TRAS LA FERMENTACION CON UNOS MICROORGANISMOS PRODUCTORES DE ACIDO CLAVULANICO, CON DIAMINAS DE ALQUILENO SUSTITUIDAS, DE FORMULA II DONDE LOS SUSTITUYENTES R1, R2, R3, R4 Y R5, ASI COMO N, POSEEN LOS SIGNIFICADOS CITADOS EN LA SOLICITUD 1, P. EJ. CON N ENDIAMONIO R1, R2, R3, R4 Y R5, ASI COMO N, POSEEN LOS SIGNIFICADOS CITADOS EN LA SOLICITUD 1, P. EJ. SE TRANSFORMAN EN N PROPILETILENDIAMONIO DE FORMULA I SON, DADO EL CASO, AISLADOS Y CON SALES ALCALI DE ACIDOS ALCANICOS, P. EJ. CON POTASIO ISOPROPANOL, SE TRANSFORMAN EN POTASIO CLAVUNALATO. POR EL EFECTO INHIBIDOR SOBRE LAS (BETA) ETICA SIGNIFICATIVA, EN COMBINACION CON ANTIBIOTICOS DE (BETA) LACTAMA, DE LA SERIE DE PENICILINAS Y CEFALOSPORINAS, LOS ACIDOS CLAVULANICOS Y SUS SALES UTILIZABLES EN FARMACIA, SON COMPUESTOS VALIOSOS PARA LA OBTENCION DE PREPARADOS MEDICINALES, QUE SON ACTIVOS CONTRA LAS ENFERMEDADES INFECCIOSAS, CAUSADAS POR GRAN NUMERO DE MICROORGANISMOS GRAM-POSITIVOS Y GRAM-NEGATIVOS.
ES93104890T 1992-03-26 1993-03-24 Nuevos derivados de diclavulanato de alquilendiamonio, procedimientos para su preparacion y para su utilizacion. Expired - Lifetime ES2103394T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0061992A AT399155B (de) 1992-03-26 1992-03-26 Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung

Publications (1)

Publication Number Publication Date
ES2103394T3 true ES2103394T3 (es) 1997-09-16

Family

ID=3495387

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93104890T Expired - Lifetime ES2103394T3 (es) 1992-03-26 1993-03-24 Nuevos derivados de diclavulanato de alquilendiamonio, procedimientos para su preparacion y para su utilizacion.

Country Status (15)

Country Link
US (2) US5310898A (es)
EP (1) EP0562583B1 (es)
JP (1) JP2873143B2 (es)
KR (1) KR950014004B1 (es)
AT (1) AT399155B (es)
AU (1) AU655718B2 (es)
CA (1) CA2092330C (es)
DE (1) DE59306148D1 (es)
DK (1) DK0562583T3 (es)
ES (1) ES2103394T3 (es)
FI (1) FI98067C (es)
HU (1) HU212578B (es)
LV (1) LV11896B (es)
SG (1) SG44638A1 (es)
SI (1) SI9200392A (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
GB2282810B (en) * 1992-06-11 1997-02-26 Smithkline Beecham Plc Preparation or purification of clavulanic acid
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
US5741903A (en) * 1993-03-26 1998-04-21 Gist-Brocades N.V. Diamine salts for purification of clavulanic acid
US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
US5760218A (en) * 1993-03-26 1998-06-02 Gist-Brocades N.V. Diamine salts of clavulanic acid
SK279918B6 (sk) * 1993-03-26 1999-05-07 Gist-Brocades N.V. Soli kyseliny klavulánovej s diamínmi, spôsob ich
KR100187333B1 (ko) * 1993-03-26 1999-05-01 한스 발터 라벤 클라불란산의 디아민염
DE4318916A1 (de) * 1993-06-07 1994-12-08 Bayer Ag Cyclobutylazole
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
SI9500265A1 (en) * 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
CA2337072A1 (en) * 1998-07-16 2000-01-27 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1290132A (fr) * 1960-03-31 1962-04-13 Ministerul Ind Petrolului Procédé de valorisation des liqueurs mères de la préparation de la pénicilline
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
IE41110B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Esters of clavulanic acid
GB1508978A (en) * 1975-04-11 1978-04-26 Beecham Group Ltd Esters of clavulanic acid
GB1561395A (en) * 1976-02-26 1980-02-20 Beecham Group Ltd -lactam antibiotic
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
EP0002312B1 (en) * 1977-11-26 1982-02-03 Beecham Group Plc Derivatives of clavulanic acid and pharmaceutical compositions containing them
JPS55162993A (en) * 1979-06-07 1980-12-18 Sanraku Inc Preparation of culavulanic acid
US4454069A (en) * 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
SK279918B6 (sk) * 1993-03-26 1999-05-07 Gist-Brocades N.V. Soli kyseliny klavulánovej s diamínmi, spôsob ich

Also Published As

Publication number Publication date
FI931332A (fi) 1993-09-27
AT399155B (de) 1995-03-27
HU9300880D0 (en) 1993-06-28
HUT64347A (en) 1993-12-28
EP0562583B1 (de) 1997-04-16
KR950014004B1 (ko) 1995-11-20
FI98067C (fi) 1997-04-10
AU655718B2 (en) 1995-01-05
HU212578B (en) 1996-08-29
SI9200392A (en) 1993-09-30
JPH0656844A (ja) 1994-03-01
DK0562583T3 (da) 1997-09-29
US5859238A (en) 1999-01-12
FI931332A0 (fi) 1993-03-25
ATA61992A (de) 1994-08-15
EP0562583A1 (de) 1993-09-29
LV11896A (lv) 1997-12-20
JP2873143B2 (ja) 1999-03-24
AU3548993A (en) 1993-09-30
CA2092330C (en) 2002-01-29
DE59306148D1 (de) 1997-05-22
FI98067B (fi) 1996-12-31
SG44638A1 (en) 1997-12-19
LV11896B (en) 1998-03-20
CA2092330A1 (en) 1993-09-27
US5310898A (en) 1994-05-10
KR930019681A (ko) 1993-10-18

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