ES8306377A1 - Un procedimiento para la preparacion de cefalosporina bis-tetrazolmetil sustituidas. - Google Patents
Un procedimiento para la preparacion de cefalosporina bis-tetrazolmetil sustituidas.Info
- Publication number
- ES8306377A1 ES8306377A1 ES505550A ES505550A ES8306377A1 ES 8306377 A1 ES8306377 A1 ES 8306377A1 ES 505550 A ES505550 A ES 505550A ES 505550 A ES505550 A ES 505550A ES 8306377 A1 ES8306377 A1 ES 8306377A1
- Authority
- ES
- Spain
- Prior art keywords
- bis
- preparation
- tetrazoylmethyl
- pharmaceutical formulations
- formulations containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE CEFALOSPORINAS BIS-TETRAZOLMETIL SUSTUITUIDAS DE FORMULA GENERAL (I), EN LA QUE R ES HIDROGENO, UN GRUPO ACILO O UN GRUPO AROILO; R ES HIDROGENO O UN GRUPO PROTECTOR DEL CARBOXILO FACILMENTE ELIMINABLE; R ES HIDROGENO O METOXILO; Y R ES UN RADICAL, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II), DONDE R , R Y R TIENEN LOS SIGNIFICADOS YA INDICADOS; Y R ES ACILOXILO DE C -C O HALO, CON UN COMPUESTO DE BIS-TETRAZOLMETIL TIOL DE FORMULA (III), DONDE R ES HIDROGENO O ALQUILO DE C -C , EN PRESENCIA DE UN DISOLVENTE ORGANICO INERTE. DE APLICACION COMO ANTIBIOTICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/187,859 US4346076A (en) | 1980-09-17 | 1980-09-17 | Bis-tetrazoylmethyl substituted cephalosporin antibiotics |
Publications (2)
Publication Number | Publication Date |
---|---|
ES505550A0 ES505550A0 (es) | 1983-05-16 |
ES8306377A1 true ES8306377A1 (es) | 1983-05-16 |
Family
ID=22690789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES505550A Expired ES8306377A1 (es) | 1980-09-17 | 1981-09-16 | Un procedimiento para la preparacion de cefalosporina bis-tetrazolmetil sustituidas. |
Country Status (22)
Country | Link |
---|---|
US (1) | US4346076A (es) |
EP (1) | EP0048169A3 (es) |
JP (1) | JPS5781492A (es) |
KR (1) | KR830007688A (es) |
AU (1) | AU7528481A (es) |
CA (1) | CA1174668A (es) |
CS (1) | CS686781A2 (es) |
DD (1) | DD201142A5 (es) |
DK (1) | DK412181A (es) |
ES (1) | ES8306377A1 (es) |
FI (1) | FI812782L (es) |
GB (1) | GB2084144B (es) |
GR (1) | GR74671B (es) |
HU (1) | HU185954B (es) |
IL (1) | IL63770A0 (es) |
PH (1) | PH16985A (es) |
PL (1) | PL132001B1 (es) |
PT (1) | PT73680B (es) |
RO (1) | RO82970B (es) |
SU (2) | SU1087076A3 (es) |
YU (1) | YU222681A (es) |
ZA (1) | ZA816224B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR850001206B1 (ko) * | 1984-04-27 | 1985-08-20 | 한국과학기술원 | 세펨 유도체의 제조 방법 |
IT1181672B (it) * | 1984-10-25 | 1987-09-30 | Upjohn Co | Cefalosporina alogenidrato cristallino |
US4868193A (en) * | 1986-09-24 | 1989-09-19 | Rorer Pharmaceutical Corporation | Styryl tetrazoles and anti-allergic use thereof |
EP0333082A3 (en) * | 1988-03-15 | 1991-05-02 | Takeda Chemical Industries, Ltd. | Cephem compounds, their production and use |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ176206A (en) * | 1973-12-25 | 1978-03-06 | Takeda Chemical Industries Ltd | Cephalosporins |
US4286089A (en) * | 1974-12-27 | 1981-08-25 | Smithkline Corporation | 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins |
JPS525787A (en) * | 1975-06-27 | 1977-01-17 | Bristol Myers Co | Antiibacterial agent |
US4109085A (en) * | 1976-02-17 | 1978-08-22 | Pfizer Inc. | 7-amino-3-substituted-cephem compounds |
US4113942A (en) * | 1976-02-17 | 1978-09-12 | Pfizer Inc. | 4-(Tetrazol-5-yl)-Δ3 -cephem compounds |
US4278670A (en) * | 1976-07-12 | 1981-07-14 | Smithkline Corporation | 7-Alpha-oxyiminoacylcephalosporins |
US4129732A (en) * | 1977-04-27 | 1978-12-12 | Pfizer Inc. | 4(Tetrazol-5-yl)-Δ3 -cephem compounds |
FR2387235A1 (fr) * | 1978-01-23 | 1978-11-10 | Fujisawa Pharmaceutical Co | Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne |
-
1980
- 1980-09-17 US US06/187,859 patent/US4346076A/en not_active Expired - Lifetime
-
1981
- 1981-09-08 FI FI812782A patent/FI812782L/fi not_active Application Discontinuation
- 1981-09-08 ZA ZA816224A patent/ZA816224B/xx unknown
- 1981-09-08 CA CA000385411A patent/CA1174668A/en not_active Expired
- 1981-09-08 IL IL63770A patent/IL63770A0/xx unknown
- 1981-09-09 HU HU812606A patent/HU185954B/hu unknown
- 1981-09-10 PH PH26186A patent/PH16985A/en unknown
- 1981-09-14 GR GR66041A patent/GR74671B/el unknown
- 1981-09-16 YU YU02226/81A patent/YU222681A/xx unknown
- 1981-09-16 PT PT73680A patent/PT73680B/pt unknown
- 1981-09-16 JP JP56147706A patent/JPS5781492A/ja active Pending
- 1981-09-16 EP EP81304242A patent/EP0048169A3/en not_active Withdrawn
- 1981-09-16 DK DK412181A patent/DK412181A/da not_active Application Discontinuation
- 1981-09-16 SU SU813336819A patent/SU1087076A3/ru active
- 1981-09-16 RO RO105322A patent/RO82970B/ro unknown
- 1981-09-16 GB GB8127951A patent/GB2084144B/en not_active Expired
- 1981-09-16 ES ES505550A patent/ES8306377A1/es not_active Expired
- 1981-09-16 AU AU75284/81A patent/AU7528481A/en not_active Abandoned
- 1981-09-17 CS CS816867A patent/CS686781A2/cs unknown
- 1981-09-17 DD DD81233364A patent/DD201142A5/de unknown
- 1981-09-17 PL PL1981233058A patent/PL132001B1/pl unknown
- 1981-09-17 KR KR1019810003492A patent/KR830007688A/ko unknown
-
1982
- 1982-08-20 SU SU823480177A patent/SU1119607A3/ru active
Also Published As
Publication number | Publication date |
---|---|
SU1119607A3 (ru) | 1984-10-15 |
PT73680A (en) | 1981-10-01 |
CS686781A2 (en) | 1985-06-13 |
KR830007688A (ko) | 1983-11-04 |
PL233058A1 (es) | 1982-10-11 |
AU7528481A (en) | 1982-03-25 |
US4346076A (en) | 1982-08-24 |
DD201142A5 (de) | 1983-07-06 |
GB2084144B (en) | 1985-02-06 |
CA1174668A (en) | 1984-09-18 |
EP0048169A2 (en) | 1982-03-24 |
SU1087076A3 (ru) | 1984-04-15 |
YU222681A (en) | 1983-10-31 |
GR74671B (es) | 1984-07-02 |
EP0048169A3 (en) | 1983-01-19 |
DK412181A (da) | 1982-04-21 |
HU185954B (en) | 1985-04-28 |
ES505550A0 (es) | 1983-05-16 |
PT73680B (en) | 1982-11-26 |
FI812782L (fi) | 1982-03-18 |
RO82970B (ro) | 1984-01-30 |
PH16985A (en) | 1984-05-04 |
IL63770A0 (en) | 1981-12-31 |
GB2084144A (en) | 1982-04-07 |
RO82970A (ro) | 1984-01-14 |
PL132001B1 (en) | 1985-01-31 |
ZA816224B (en) | 1983-04-27 |
JPS5781492A (en) | 1982-05-21 |
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