ES8206532A1 - Procedimiento para la obtencion de compuestos de b-lactama. - Google Patents

Procedimiento para la obtencion de compuestos de b-lactama.

Info

Publication number
ES8206532A1
ES8206532A1 ES506115A ES506115A ES8206532A1 ES 8206532 A1 ES8206532 A1 ES 8206532A1 ES 506115 A ES506115 A ES 506115A ES 506115 A ES506115 A ES 506115A ES 8206532 A1 ES8206532 A1 ES 8206532A1
Authority
ES
Spain
Prior art keywords
beta
lactam antibiotics
preparation
compositions containing
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506115A
Other languages
English (en)
Other versions
ES506115A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8206532A1 publication Critical patent/ES8206532A1/es
Publication of ES506115A0 publication Critical patent/ES506115A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE B-LACTAMA DE FORMULA (I), EN LA QUE Z ES HIDROGENO O ALCOXI INFERIO Y A E Y PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE ENLA REACCION DE AMIDIFICACION DE UN DERIVADO REACTIVO EN EL GRUPO CARBOXILICO DEL COMPUESTO DE FORMULA (II), CUYO GRUPO AMINO ESTA PROTEGIDO O SIN PROTEGER, CON UN COMPUESTO DE FORMULA (III), EVENTUALMENTE EN FORMA DE MONO-ODISILILO O DE ESTERES, FORMULAS ENLAS QUE Z, A E Y TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE A UNA TEMPERATURA ENTRE -10 Y 5C. ESTOS COMPUESTOS TIENEN APLICACIONES COMO ANTIBACTERIALES, PARA FOMENTAR EL CRECIMIENTO, PARA MEJORAR EL APROVECHAMIENTO DE LOS ALIMENTOS Y COMO ANTIOXIDANTES.
ES506115A 1980-10-08 1981-10-08 Procedimiento para la obtencion de compuestos de b-lactama. Granted ES506115A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803037997 DE3037997A1 (de) 1980-10-08 1980-10-08 (beta) -lactamantibiotika, verfahren zu deren herstellung sowie sie enthaltende mittel

Publications (2)

Publication Number Publication Date
ES8206532A1 true ES8206532A1 (es) 1982-08-16
ES506115A0 ES506115A0 (es) 1982-08-16

Family

ID=6113915

Family Applications (1)

Application Number Title Priority Date Filing Date
ES506115A Granted ES506115A0 (es) 1980-10-08 1981-10-08 Procedimiento para la obtencion de compuestos de b-lactama.

Country Status (15)

Country Link
US (1) US4416880A (es)
EP (1) EP0049448B1 (es)
JP (4) JPS5793982A (es)
AT (1) ATE36714T1 (es)
AU (1) AU554294B2 (es)
CA (1) CA1178946A (es)
DE (2) DE3037997A1 (es)
DK (1) DK165924C (es)
ES (1) ES506115A0 (es)
FI (1) FI75825C (es)
GR (1) GR75073B (es)
HK (1) HK6191A (es)
HU (1) HU186429B (es)
IL (1) IL63959A (es)
ZA (1) ZA816932B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3145727A1 (de) * 1981-11-19 1983-05-26 Bayer Ag, 5090 Leverkusen Zwischenprodukte, verfahren zu deren herstellung und verfahren zur herstellung von cephalosporinen
CA1201431A (en) * 1981-12-17 1986-03-04 Daiei Tunemoto .beta.-LACTAM COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND INTERMEDIATE PRODUCTS FOR THE PREPARATION THEREOF
DE3224866A1 (de) * 1982-07-02 1984-01-05 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zu deren herstellung sowie sie enthaltende mittel
DE3239365A1 (de) * 1982-10-23 1984-04-26 Bayer Ag, 5090 Leverkusen Neue cephalosporine und verfahren zu ihrer herstellung
DE3300593A1 (de) * 1983-01-11 1984-07-12 Bayer Ag, 5090 Leverkusen Neue cephalosporine und verfahren zu ihrer herstellung
JPS6034957A (ja) * 1983-08-05 1985-02-22 Meiji Seika Kaisha Ltd ２−置換メチレン−２−（２−アミノチアゾ−ル−４−イル）酢酸誘導体及びその製造方法
DE3329427A1 (de) * 1983-08-13 1985-02-21 Bayer Ag, 5090 Leverkusen 7-amino-3(1-pyridiniomethyl)-8-oxo-5-oxa-1-azabicyclo(4.2.0)oct-2-en-2-carboxylate, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte zur synthese von ss-lactam-antibiotika
AU575854B2 (en) * 1983-10-04 1988-08-11 Shionogi & Co., Ltd. 7beta-(carboxyalkenamido) cephalosporins
DE3343208A1 (de) * 1983-11-30 1985-06-05 Bayer Ag, 5090 Leverkusen Neue cephalosporine und verfahren zu ihrer herstellung
DE3418376A1 (de) * 1984-05-17 1985-11-21 Bayer Ag, 5090 Leverkusen Zwischenprodukte sowie verfahren zur herstellung von zwischenprodukten fuer die synthese von cephalosporinen
DE3419012A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien
JP2501785B2 (ja) * 1984-07-09 1996-05-29 明治製菓株式会社 新規セフアロスポリン系化合物
JPS6153272A (ja) * 1984-08-24 1986-03-17 Shionogi & Co Ltd グルタル酸誘導体の製法
JPS61205282A (ja) * 1985-03-08 1986-09-11 Sagami Chem Res Center β−ラクタム化合物類
AT397963B (de) * 1985-03-29 1994-08-25 Shionogi & Co Verfahren zur herstellung von neuen 7 beta-(2-(2- amino-4-thiazolyl)-alkenoylamimo)-3-cephem-4- carbonsäureestern
AU580855B2 (en) * 1985-03-29 1989-02-02 Shionogi & Co., Ltd. Alkeneamidocephalosporin esters
US4731362A (en) * 1985-08-05 1988-03-15 Shionogi & Co., Ltd. Alkylcarbamoyloxymethylcephem compounds
DE3541095A1 (de) * 1985-11-21 1987-05-27 Bayer Ag Neue cephalosporine, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel
US5017380A (en) * 1986-07-02 1991-05-21 Shionogi & Co., Ltd. Gelatin hard capsule containing crystalline hydrate of oral cephalosporin
NZ220764A (en) * 1986-07-02 1989-09-27 Shionogi & Co Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions
WO1993013108A1 (en) * 1987-03-11 1993-07-08 Susumu Nakanishi Substituted 3-cephem compounds as antibacterial agents
MA21530A1 (fr) * 1988-04-06 1989-12-31 Beecham Group Plc Nouveaux composes contenant le cycle betalactame, et leur procede de preparation .
GB8906592D0 (en) * 1989-03-22 1989-05-04 Beecham Group Plc Novel compounds
GB8922410D0 (en) * 1989-10-05 1989-11-22 Beecham Group Plc Novel compounds
MA21969A1 (fr) * 1989-10-05 1991-07-01 Beecham Group Plc Procede de preparation de nouveaux composes contenant un cycle beta - lactame .
GB9117783D0 (en) * 1991-08-17 1991-10-09 Smithkline Beecham Plc Novel compounds
JP3217191B2 (ja) * 1992-07-16 2001-10-09 ビーエーエスエフ アクチェンゲゼルシャフト ヘテロ芳香族化合物およびこれを含有する植物保護剤
CA2287663C (en) * 1998-11-02 2008-04-08 Isao Kurimoto Process for producing 2-alkylidene-4-bromoacetoacetic acid ester
DE69911348T2 (de) 1998-11-12 2004-07-15 Shionogi & Co., Ltd. Herstellung von Derivaten von 2-Aminothiazol Hydrobromid Z-Isomeren
CN102827188B (zh) * 2012-08-25 2014-09-10 河北农业大学 一种青霉素类药物通用半抗原、人工抗原、广谱单克隆抗体及其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS435888B1 (es) * 1964-03-14 1968-03-04
US3622569A (en) * 1969-08-05 1971-11-23 R & L Molecular Research Ltd 6-(2-aryl-3-azido-and-3-amino-methyl-isocrotonamido)penicillanic acids
GB1497039A (en) * 1973-12-05 1978-01-05 Glaxo Lab Ltd Penicillins and cephalosporins
US4182868A (en) * 1974-10-29 1980-01-08 Takeda Chemical Industries, Ltd. 7-Methoxycephalosporin derivatives
US4298606A (en) * 1974-12-19 1981-11-03 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
FR2340093A1 (fr) * 1976-02-05 1977-09-02 Roussel Uclaf Derives de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2758000A1 (de) * 1977-12-24 1979-07-05 Hoechst Ag Verfahren zur herstellung von penicillinen und cephalosporinen
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
US4310459A (en) * 1978-04-03 1982-01-12 Bristol-Myers Company Process for producing carbamoyl substituted penams and carbamoyl substituted cephams from penicillin sulfoxide esters
DE2818263A1 (de) * 1978-04-26 1979-11-08 Bayer Ag Beta-lactamantibiotika
US4275062A (en) * 1979-09-19 1981-06-23 E. R. Squibb & Sons, Inc. Aminothiazolyl ureido sulfoxide cephalosporins
GB2076801A (en) * 1980-04-14 1981-12-09 Erba Farmitalia alpha , beta -Disubstituted Acrylamido Cephalosporins
CA1178947A (en) * 1980-09-26 1984-12-04 Sagami Chemical Research Center .beta.-LACTAM COMPOUNDS AND PROCESS FOR THEIR PREPARATION

Also Published As

Publication number Publication date
CA1178946A (en) 1984-12-04
IL63959A (en) 1985-07-31
AU554294B2 (en) 1986-08-14
GR75073B (es) 1984-07-13
JPS5793982A (en) 1982-06-11
FI75825C (fi) 1988-08-08
EP0049448A2 (de) 1982-04-14
ES506115A0 (es) 1982-08-16
DK165924C (da) 1993-06-28
EP0049448B1 (de) 1988-08-24
HU186429B (en) 1985-07-29
FI75825B (fi) 1988-04-29
DE3037997A1 (de) 1982-05-13
ATE36714T1 (de) 1988-09-15
ZA816932B (en) 1982-09-29
JPS61106579A (ja) 1986-05-24
EP0049448A3 (en) 1983-05-11
DE3176851D1 (en) 1988-09-29
HK6191A (en) 1991-01-25
IL63959A0 (en) 1981-12-31
US4416880A (en) 1983-11-22
FI813089L (fi) 1982-04-09
AU7613381A (en) 1982-04-22
JPH02209877A (ja) 1990-08-21
DK165924B (da) 1993-02-08
JPS6337107B2 (es) 1988-07-22
JPS6193173A (ja) 1986-05-12
DK444581A (da) 1982-04-09
JPH0662631B2 (ja) 1994-08-17

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