ATE437879T1 - Verfahren zur herstellung von imipenem - Google Patents

Verfahren zur herstellung von imipenem

Info

Publication number
ATE437879T1
ATE437879T1 AT02730567T AT02730567T ATE437879T1 AT E437879 T1 ATE437879 T1 AT E437879T1 AT 02730567 T AT02730567 T AT 02730567T AT 02730567 T AT02730567 T AT 02730567T AT E437879 T1 ATE437879 T1 AT E437879T1
Authority
AT
Austria
Prior art keywords
imipenem
producing
producing imipenem
Prior art date
Application number
AT02730567T
Other languages
English (en)
Inventor
Yatendra Kumar
Neera Tewari
Bishwa Rai
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Application granted granted Critical
Publication of ATE437879T1 publication Critical patent/ATE437879T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
AT02730567T 2001-05-18 2002-05-15 Verfahren zur herstellung von imipenem ATE437879T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN594DE2001 2001-05-18
PCT/IB2002/001670 WO2002094828A1 (en) 2001-05-18 2002-05-15 Process for the preparation of imipenem

Publications (1)

Publication Number Publication Date
ATE437879T1 true ATE437879T1 (de) 2009-08-15

Family

ID=11097061

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02730567T ATE437879T1 (de) 2001-05-18 2002-05-15 Verfahren zur herstellung von imipenem

Country Status (19)

Country Link
US (1) US7462712B2 (de)
EP (1) EP1395587B1 (de)
JP (1) JP2005508860A (de)
KR (1) KR20040002973A (de)
CN (1) CN1694885A (de)
AR (1) AR035978A1 (de)
AT (1) ATE437879T1 (de)
BR (1) BR0209842A (de)
CA (1) CA2447227A1 (de)
DE (1) DE60233130D1 (de)
DK (1) DK1395587T3 (de)
EA (1) EA007252B1 (de)
ES (1) ES2328117T3 (de)
MX (1) MXPA03010498A (de)
NO (1) NO20035136D0 (de)
PL (1) PL370705A1 (de)
PT (1) PT1395587E (de)
WO (1) WO2002094828A1 (de)
ZA (1) ZA200308958B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2328117T3 (es) * 2001-05-18 2009-11-10 Ranbaxy Laboratories Limited Proceso para la preparacion de imipenem.
WO2005056553A1 (en) 2003-12-09 2005-06-23 Choongwae Pharm.Co. A new process for preparation of imipenem
WO2006035300A2 (en) * 2004-09-30 2006-04-06 Ranbaxy Laboratories Limited A process for the preparation of meropenem
WO2010146449A1 (en) * 2009-06-18 2010-12-23 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of imipenam
CN101921274B (zh) * 2010-07-16 2012-09-26 深圳市海滨制药有限公司 一种制备亚胺培南的方法
CN101921273B (zh) * 2010-07-16 2012-09-26 深圳市海滨制药有限公司 一种制备亚胺培南的方法
CN101921275B (zh) * 2010-07-16 2012-09-26 深圳市海滨制药有限公司 一种制备亚胺培南的方法
CN105051180B (zh) 2013-01-18 2020-06-12 科德克希思公司 用于碳青霉烯类合成的工程化的生物催化剂
CN110790765B (zh) * 2018-08-02 2022-08-05 江苏瑞科医药科技有限公司 一种亚胺培南的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194047A (en) 1975-11-21 1980-03-18 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin
US4292436A (en) 1980-06-25 1981-09-29 Merck & Co., Inc. Process for the preparation of N-protected N-formimidoyl 2-aminoethanethiol
US4745188A (en) * 1980-11-21 1988-05-17 Merck & Co., Inc. Process for preparing 3-substituted-6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
US4374772A (en) 1981-03-19 1983-02-22 Merck & Co., Inc. Process for the preparation of N-formimidoyl thienamycin and reagents therefor
US4640915A (en) * 1982-03-29 1987-02-03 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives
US4644061A (en) * 1982-09-28 1987-02-17 Bristol-Myers Company Carbapenem antibiotics
US4782051A (en) * 1985-06-10 1988-11-01 Merck & Co., Inc. 2-aza-substituted 1-carbadethiapen-2-em-3 carboxylic acids
US4894450A (en) * 1987-05-11 1990-01-16 Merck & Co., Inc. Process for 2-(aminoalkylthio) carbapenems
US5672701A (en) * 1990-01-16 1997-09-30 Bristol-Myers Squibb Company 4-substituted alkyl carbapenem antibiotics
JP3367104B2 (ja) * 1992-04-13 2003-01-14 藤沢薬品工業株式会社 抗菌剤としての置換された３−ピロリジニルチオ−カルバペネム化合物
US5245069A (en) * 1992-10-27 1993-09-14 Merck & Co., Inc. Process for the preparation of bis(aryl)-phosphorohalidates
IN191798B (de) * 2000-11-03 2004-01-03 Ranbaxy Lab Ltd
CN1522255A (zh) * 2001-05-18 2004-08-18 ʵ 结晶亚胺培南的分离方法
ES2328117T3 (es) * 2001-05-18 2009-11-10 Ranbaxy Laboratories Limited Proceso para la preparacion de imipenem.
WO2005056553A1 (en) * 2003-12-09 2005-06-23 Choongwae Pharm.Co. A new process for preparation of imipenem

Also Published As

Publication number Publication date
US7462712B2 (en) 2008-12-09
JP2005508860A (ja) 2005-04-07
ES2328117T3 (es) 2009-11-10
DE60233130D1 (de) 2009-09-10
KR20040002973A (ko) 2004-01-07
DK1395587T3 (da) 2009-10-12
BR0209842A (pt) 2005-01-04
US20040220168A1 (en) 2004-11-04
NO20035136D0 (no) 2003-11-18
PL370705A1 (en) 2005-05-30
EP1395587B1 (de) 2009-07-29
EA200301224A1 (ru) 2004-12-30
EP1395587A4 (de) 2004-09-15
MXPA03010498A (es) 2004-05-27
ZA200308958B (en) 2004-07-19
EP1395587A1 (de) 2004-03-10
CN1694885A (zh) 2005-11-09
AR035978A1 (es) 2004-07-28
EA007252B1 (ru) 2006-08-25
CA2447227A1 (en) 2002-11-28
WO2002094828A1 (en) 2002-11-28
PT1395587E (pt) 2009-09-03

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