DE60130256T2 - Naphthalinderivate, die sich an den ep4?rezeptor binden - Google Patents
Naphthalinderivate, die sich an den ep4?rezeptor binden Download PDFInfo
- Publication number
- DE60130256T2 DE60130256T2 DE60130256T DE60130256T DE60130256T2 DE 60130256 T2 DE60130256 T2 DE 60130256T2 DE 60130256 T DE60130256 T DE 60130256T DE 60130256 T DE60130256 T DE 60130256T DE 60130256 T2 DE60130256 T2 DE 60130256T2
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- formula
- phenyl
- compounds
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 0 *C(c(c(*)c1*)c(*)c(*)c1N=C)S(N)(=O)=O Chemical compound *C(c(c(*)c1*)c(*)c(*)c1N=C)S(N)(=O)=O 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0031302.3A GB0031302D0 (en) | 2000-12-21 | 2000-12-21 | Napthalene derivatives |
| GB0031302 | 2000-12-21 | ||
| PCT/GB2001/005676 WO2002050032A1 (en) | 2000-12-21 | 2001-12-20 | Naphthalene derivatives which bind to the ep4 receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60130256D1 DE60130256D1 (de) | 2007-10-11 |
| DE60130256T2 true DE60130256T2 (de) | 2008-05-21 |
Family
ID=9905630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60130256T Expired - Lifetime DE60130256T2 (de) | 2000-12-21 | 2001-12-20 | Naphthalinderivate, die sich an den ep4?rezeptor binden |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6924297B2 (OSRAM) |
| EP (1) | EP1351934B1 (OSRAM) |
| JP (1) | JP4397586B2 (OSRAM) |
| AT (1) | ATE371645T1 (OSRAM) |
| AU (1) | AU2002216218A1 (OSRAM) |
| DE (1) | DE60130256T2 (OSRAM) |
| ES (1) | ES2290093T3 (OSRAM) |
| GB (1) | GB0031302D0 (OSRAM) |
| WO (1) | WO2002050032A1 (OSRAM) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN2001000224A (es) | 2000-10-19 | 2002-06-13 | Pfizer | Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos. |
| GB0031295D0 (en) * | 2000-12-21 | 2001-01-31 | Glaxo Group Ltd | Naphthalene derivatives |
| WO2005102389A2 (en) * | 2004-04-20 | 2005-11-03 | Pfizer Products Inc. | Combinations comprising alpha-2-delta ligands and ep4 receptor antagonists |
| AU2006246930C1 (en) | 2005-05-19 | 2012-01-19 | Merck Canada Inc. | Quinoline derivatives as EP4 antagonists |
| UY30121A1 (es) | 2006-02-03 | 2007-08-31 | Glaxo Group Ltd | Nuevos compuestos |
| GB0615111D0 (en) * | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel compounds |
| GB0615105D0 (en) | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel compounds |
| JP5069752B2 (ja) | 2006-12-15 | 2012-11-07 | グラクソ グループ リミテッド | Ep4受容体アゴニストとしてのベンズアミド誘導体 |
| CA2681146A1 (en) * | 2007-03-26 | 2008-10-02 | Merck Frosst Canada Ltd. | Naphthalene and quinoline sulfonylurea derivatives as ep4 receptor antagonists |
| GB0721611D0 (en) | 2007-11-02 | 2007-12-12 | Glaxo Group Ltd | Novel compounds |
| EP2149554A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma Aktiengesellschaft | Indolylamide als Modulatoren des EP2-Rezeptors |
| EP2149551A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | N-(Indol-3-ylalkyl)-(hetero)arylamidderivate als Modulatoren des EP2-Rezeptors |
| EP2149552A1 (de) | 2008-07-30 | 2010-02-03 | Bayer Schering Pharma AG | 5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors |
| WO2010087425A1 (ja) | 2009-01-30 | 2010-08-05 | 国立大学法人京都大学 | 前立腺癌の進行抑制剤および進行抑制方法 |
| DE102009049662A1 (de) | 2009-10-13 | 2011-04-14 | Bayer Schering Pharma Aktiengesellschaft | 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten |
| KR20120093955A (ko) | 2009-10-14 | 2012-08-23 | 젬머스 파마 인코포레이티드 | 바이러스 감염에 대한 병용 요법 치료 |
| CN114404588A (zh) | 2013-08-09 | 2022-04-29 | 阿德利克斯公司 | 用于抑制磷酸盐转运的化合物和方法 |
| TWI712595B (zh) * | 2015-01-09 | 2020-12-11 | 日商小野藥品工業股份有限公司 | 三環性螺化合物 |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| JP6269888B1 (ja) * | 2016-07-07 | 2018-01-31 | 小野薬品工業株式会社 | 医薬用途 |
| TW201900180A (zh) | 2017-05-18 | 2019-01-01 | 瑞士商愛杜西亞製藥有限公司 | 嘧啶衍生物 |
| LT3625224T (lt) | 2017-05-18 | 2021-10-25 | Idorsia Pharmaceuticals Ltd | N-pakeistieji indolo dariniai |
| LT3625222T (lt) | 2017-05-18 | 2021-11-10 | Idorsia Pharmaceuticals Ltd | Fenilo dariniai, kaip pge2 receptoriaus moduliatoriai |
| CN110621671A (zh) | 2017-05-18 | 2019-12-27 | 爱杜西亚药品有限公司 | 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物 |
| PT3625228T (pt) | 2017-05-18 | 2021-09-16 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores dos recetores de pge2 |
| US12168653B2 (en) | 2018-03-02 | 2024-12-17 | Inflazome Limited | Sulfonamide derivates as NLRP3 inhibitors |
| EP3759102A1 (en) | 2018-03-02 | 2021-01-06 | Inflazome Limited | Novel compounds |
| US12030879B2 (en) | 2018-03-02 | 2024-07-09 | Inflazome Limited | Sulfonyl acetamides as NLRP3 inhibitors |
| WO2019166632A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
| WO2019166628A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
| EP3972599B1 (en) | 2019-05-21 | 2025-10-22 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| JPWO2022102731A1 (OSRAM) | 2020-11-13 | 2022-05-19 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4014899A (en) | 1973-10-29 | 1977-03-29 | Ciba-Geigy Corporation | 5,6-Benzoisoindolines |
| US4395417A (en) | 1980-04-22 | 1983-07-26 | Research Corporation | Antihyperlipidemic compositions |
| ID18046A (id) * | 1996-08-20 | 1998-02-19 | Takeda Chemical Industries Ltd | Senyawa siklik campuran, pembuatan dan penngunaannya. |
| DE19650975A1 (de) * | 1996-12-09 | 1998-06-10 | Basf Ag | Neue heterocyclisch substituierte Benzamide und deren Anwendung |
| YU86801A (sh) * | 1999-06-10 | 2004-07-15 | Warner-Lambert Company | Izoindol derivati korisni u inhibiciji agregacije amiloidnih proteina i snimanju amiloidnih naslaga |
-
2000
- 2000-12-21 GB GBGB0031302.3A patent/GB0031302D0/en not_active Ceased
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- 2001-12-20 US US10/450,891 patent/US6924297B2/en not_active Expired - Fee Related
- 2001-12-20 EP EP01271355A patent/EP1351934B1/en not_active Expired - Lifetime
- 2001-12-20 AU AU2002216218A patent/AU2002216218A1/en not_active Abandoned
- 2001-12-20 AT AT01271355T patent/ATE371645T1/de not_active IP Right Cessation
- 2001-12-20 JP JP2002551529A patent/JP4397586B2/ja not_active Expired - Fee Related
- 2001-12-20 DE DE60130256T patent/DE60130256T2/de not_active Expired - Lifetime
- 2001-12-20 WO PCT/GB2001/005676 patent/WO2002050032A1/en not_active Ceased
- 2001-12-20 ES ES01271355T patent/ES2290093T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1351934B1 (en) | 2007-08-29 |
| DE60130256D1 (de) | 2007-10-11 |
| ATE371645T1 (de) | 2007-09-15 |
| JP2004517099A (ja) | 2004-06-10 |
| WO2002050032A1 (en) | 2002-06-27 |
| ES2290093T3 (es) | 2008-02-16 |
| AU2002216218A1 (en) | 2002-07-01 |
| US20040102508A1 (en) | 2004-05-27 |
| US6924297B2 (en) | 2005-08-02 |
| JP4397586B2 (ja) | 2010-01-13 |
| GB0031302D0 (en) | 2001-01-31 |
| EP1351934A1 (en) | 2003-10-15 |
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