DE60130023T2 - Behandlung der nebenwirkungen von statinen - Google Patents

Behandlung der nebenwirkungen von statinen Download PDF

Info

Publication number
DE60130023T2
DE60130023T2 DE60130023T DE60130023T DE60130023T2 DE 60130023 T2 DE60130023 T2 DE 60130023T2 DE 60130023 T DE60130023 T DE 60130023T DE 60130023 T DE60130023 T DE 60130023T DE 60130023 T2 DE60130023 T2 DE 60130023T2
Authority
DE
Germany
Prior art keywords
uridine
salt
statin
alkyl
tautomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60130023T
Other languages
German (de)
English (en)
Other versions
DE60130023D1 (de
Inventor
Anthony William Canterbury LINNANE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Magral Ltd
Original Assignee
Magral Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magral Ltd filed Critical Magral Ltd
Application granted granted Critical
Publication of DE60130023D1 publication Critical patent/DE60130023D1/de
Publication of DE60130023T2 publication Critical patent/DE60130023T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60130023T 2000-11-29 2001-11-29 Behandlung der nebenwirkungen von statinen Expired - Lifetime DE60130023T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPR177300 2000-11-29
AUPR1773A AUPR177300A0 (en) 2000-11-29 2000-11-29 Therapeutic methods
PCT/AU2001/001545 WO2002043721A1 (en) 2000-11-29 2001-11-29 Treatment of statin side effects

Publications (2)

Publication Number Publication Date
DE60130023D1 DE60130023D1 (de) 2007-09-27
DE60130023T2 true DE60130023T2 (de) 2008-05-08

Family

ID=3825810

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60130023T Expired - Lifetime DE60130023T2 (de) 2000-11-29 2001-11-29 Behandlung der nebenwirkungen von statinen

Country Status (10)

Country Link
US (3) US20040063661A1 (enExample)
EP (1) EP1343488B1 (enExample)
JP (2) JP4596734B2 (enExample)
AT (1) ATE369845T1 (enExample)
AU (3) AUPR177300A0 (enExample)
CA (1) CA2429979C (enExample)
DE (1) DE60130023T2 (enExample)
ES (1) ES2292643T3 (enExample)
NZ (1) NZ526069A (enExample)
WO (1) WO2002043721A1 (enExample)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR951101A0 (en) * 2001-12-13 2002-01-24 Centre For Molecular Biology And Medicine Method of treatment
ES2574918T3 (es) * 2003-06-02 2016-06-23 Isis Innovation Limited Tratamiento de la fatiga muscular
DK1648952T3 (en) 2003-06-03 2018-05-28 The Us Gov As Represented By The Department Of Health And Human Services Dietary supplements and therapeutic compositions comprising (R) -3-hydroxybutyrate derivatives
HRP20130459T1 (en) * 2004-01-22 2013-06-30 University Of Miami Topical co-enzyme q10 formulations and methods of use
US20050288379A1 (en) * 2004-06-21 2005-12-29 Xiaoqiang Yan Benzoquinone compounds as anti-cancer agents
JP2008503579A (ja) * 2004-06-21 2008-02-07 ハッチソン メディファーマ エンタープライジズ リミテッド 癌の化学療法
JP4896501B2 (ja) * 2004-11-26 2012-03-14 第一三共株式会社 血中遊離脂肪酸低下作用を有する医薬組成物
WO2006057209A1 (ja) * 2004-11-26 2006-06-01 Sankyo Company, Limited 血中遊離脂肪酸低下作用を有する医薬組成物
US20060252830A1 (en) * 2005-05-06 2006-11-09 Brandon Stephen F Method for the treatment of magnesium and potassium deficiencies
US20060252831A1 (en) * 2005-05-06 2006-11-09 Christopher Offen Method for the treatment of magnesium and potassium deficiencies
EA035619B1 (ru) 2005-06-01 2020-07-16 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Композиции для использования в способе лечения митохондриальных нарушений
WO2007061798A2 (en) * 2005-11-18 2007-05-31 Cornell Research Foundation, Inc. Nicotinoyl riboside compositions and methods of use
WO2007095716A1 (en) * 2006-02-23 2007-08-30 Iomedix Sleep International Srl Compositions and methods for the induction and maintenance of quality sleep
US20070286906A1 (en) * 2006-04-28 2007-12-13 Hutchison Medipharma Enterprises Limited Dihydrobenzoquinone compounds
JP2009536215A (ja) * 2006-05-02 2009-10-08 ユニバーシティ オブ マイアミ 局所コエンザイムq10製剤、及び疼痛、疲労、並びに創傷の治療
WO2009089144A1 (en) 2008-01-04 2009-07-16 Isis Innovation Limited Ketone bodies and ketone body esters as blood lipid lowering agents
US20110052556A1 (en) 2008-02-29 2011-03-03 Biolab Sanus Farmaceutical Ltda Pharmaceutical composition comprising racetam and carnitine and process for its preparation
JP6058263B2 (ja) 2008-04-11 2017-01-11 バーグ リミテッド ライアビリティ カンパニー 癌細胞においてアポトーシスを誘導する方法および使用
US8642654B2 (en) 2009-04-16 2014-02-04 Isis Innovation Limited Hydroxybutyrate ester and medical use thereof
EP2344142B1 (en) 2008-09-10 2024-06-26 PTC Therapeutics, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
JP5426918B2 (ja) * 2009-04-20 2014-02-26 株式会社 伊藤園 ウリジンを含有する抗疲労剤又は体力向上剤
CN102481269B (zh) 2009-05-11 2015-10-07 博格有限责任公司 包含辅酶q10的药物组合物及其制备方法
US8557236B2 (en) * 2010-02-09 2013-10-15 Vascure Natural LLC Cardiovascular support supplement and compositions and methods thereof
GB201002983D0 (en) 2010-02-22 2010-04-07 Tdeltas Ltd Nutritinal composition
JP6092844B2 (ja) 2011-04-04 2017-03-08 バーグ エルエルシー 中枢神経系腫瘍の治療方法
MX2014001823A (es) * 2011-08-15 2014-08-21 Technion Res & Dev Foundation Combinaciones de corroles y estatinas.
TWI489982B (zh) * 2012-09-18 2015-07-01 Univ China Medical 苯醌類化合物應用於抑制動脈粥狀血管硬化之用途
TWI504390B (zh) * 2012-09-18 2015-10-21 Univ China Medical 苯醌類化合物應用於抑制黑色素瘤細胞之Wnt/β-catenin訊息途徑之用途
WO2014071389A1 (en) 2012-11-05 2014-05-08 Veech Richard L Ketone bodies to protect tissues from damage by ionizing radiation
GB201304467D0 (en) 2013-03-12 2013-04-24 Tdeltas Ltd Compound for use in protecting skin
GB2515603B (en) 2013-03-14 2015-10-14 Isis Innovation Process for producing (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate
BR112015025424A2 (pt) 2013-04-08 2017-07-18 Berg Llc tratamento de câncer usando terapias de combinação de coenzima q10
WO2015003246A1 (en) * 2013-07-09 2015-01-15 Mcmaster University Combination of a statin with an inflammasome inhibitor
MX381399B (es) 2013-09-04 2025-03-12 Berg Llc Formulaciones de coenzima q10 y métodos de uso.
WO2017087576A1 (en) 2015-11-16 2017-05-26 Berg Llc Methods of treatment of temozolomide-resistant glioma using coenzyme q10
EP3389646A1 (en) 2015-12-17 2018-10-24 BioElectron Technology Corporation Flouroalkyl, flouroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
CA3063916A1 (en) 2017-05-17 2018-11-22 Berg Llc Use of coenzyme q10 formulations in the treatment and prevention of epidermolysis bullosa
WO2018218287A1 (en) * 2017-05-29 2018-12-06 Woodlinda Pty Ltd Treatment and/or prevention of neuropathic symptoms associated with diabetes mellitus type ii
US20220088040A1 (en) * 2017-10-13 2022-03-24 Exerkine Corporation Use of System XC-Inhibitor for Treating Statin-Induced Myalgia
KR102060722B1 (ko) * 2017-11-06 2020-02-11 연세대학교 산학협력단 스타틴에 의한 약물유해반응용 동물 모델 및 이의 제조방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2462312A1 (de) * 1974-03-04 1976-10-14 Nadrol Chemie Pharma Keizer Kg Arzneimittel zur behandlung von migraene-erkrankungen
SU988814A1 (ru) * 1979-11-20 1983-01-15 Филиал Всесоюзного научно-исследовательского химико-фармацевтического института им.Серго Орджоникидзе Соли оротовой кислоты и @ -аминокислот, предупреждающие развитие утомлени при физических нагрузках
DE3110560A1 (de) * 1981-03-18 1982-10-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen "angiotropine der leukozyten und des entzuendungsgewebes: eine neue klasse natuerlicher chemotropischer mitogene fuer das richtungswachstum von blutgefaessen und zur neovaskularisierung von geweben"
US4911917A (en) * 1988-06-28 1990-03-27 Hauser-Kuhrts, Inc. Cholesterol-lowering combination comopsitions of magnesium salt and niacin
CA2007983C (en) * 1989-01-18 1996-12-10 Michael S. Brown Coenzyme q10 with hmg-coa reductase inhibitors
US4929437A (en) * 1989-02-02 1990-05-29 Merck & Co., Inc. Coenzyme Q10 with HMG-CoA reductase inhibitors
US5316765A (en) * 1989-09-07 1994-05-31 Karl Folkers Foundation For Biomedical And Clinical Research Use of coenzyme Q10 in combination with HMG-CoA reductase inhibitor therapies
JPH07504198A (ja) * 1992-02-24 1995-05-11 イースト カロライナ ユニバーシティ デヒドロエピアンドロステロンおよびその類縁体を用いる処置によって発癌を抑制する方法
BE1005939A6 (fr) * 1992-05-14 1994-03-15 Pirmez Thierry Dr Utilisation des sels de l'acide orotique comme tranporteurs preferentiels d'oligo-elements.
WO1993024650A1 (en) * 1992-05-28 1993-12-09 Monash University Therapeutic compositions
AT405477B (de) * 1996-04-03 1999-08-25 Norbert Mag Fuchs Kombinationspräparat
US6472378B2 (en) * 1998-08-31 2002-10-29 Pro-Neuron, Inc. Compositions and methods for treatment of mitochondrial diseases
US6245800B1 (en) * 1999-06-08 2001-06-12 Sigma-Tau Method of preventing or treating statin-induced toxic effects using L-carnitine or an alkanoyl L-carnitine
IT1317008B1 (it) * 2000-04-04 2003-05-26 Sigma Tau Healthscience Spa Integratore alimentare energizzante sulla muscolatura scheletrica eprotettivo sull'apparato cardiovascolare.
US6420342B1 (en) * 2000-05-08 2002-07-16 N.V. Nutricia Nutritional preparation comprising ribose and medical use thereof

Also Published As

Publication number Publication date
AUPR177300A0 (en) 2000-12-21
CA2429979C (en) 2011-11-15
JP2004531468A (ja) 2004-10-14
EP1343488B1 (en) 2007-08-15
US20100144665A1 (en) 2010-06-10
US20040063661A1 (en) 2004-04-01
ATE369845T1 (de) 2007-09-15
NZ526069A (en) 2006-11-30
EP1343488A1 (en) 2003-09-17
JP4596734B2 (ja) 2010-12-15
EP1343488A4 (en) 2005-05-04
JP2010248230A (ja) 2010-11-04
US20100323981A1 (en) 2010-12-23
AU2002223302B2 (en) 2006-08-31
ES2292643T3 (es) 2008-03-16
WO2002043721A1 (en) 2002-06-06
HK1059044A1 (en) 2004-06-18
DE60130023D1 (de) 2007-09-27
CA2429979A1 (en) 2002-06-06
AU2330202A (en) 2002-06-11

Similar Documents

Publication Publication Date Title
EP1343488B1 (en) Treatment of statin side effects
DE68912331T2 (de) Erniedrigung der zellvermehrung und steigerung der killerzellenaktivität.
AU2002223302A1 (en) Treatment of statin side effects
DE69834658T2 (de) Verwendung von aminothiolverbindungen zur behandlung von nerven- und nieren-erkrankungen und der arzneimitteltoxizität
DE60223670T2 (de) Fettsäuren als Faktoren für das Überleben und die Aktivierung von Neutrophilen.
DE69434416T2 (de) Präparate auf purinbasis
DE60202278T2 (de) Aktivierung natürlicher killerzellen durch adenosin-a3-rezeptoragonisten
EP2611439B1 (de) Die parenterale applikation von fischöl/dha +epa vor bzw. mit beginn der chemotherapie
EP0241809A1 (de) Synergistische Kombination von Amantadin und Selegilin
DE69528992T2 (de) Verwendung von aromatischen halogenverbindungen zur behandlung der zellproliferation in säugetieren
DE60107272T2 (de) Eisenverbindungen
DE102020116980A1 (de) Verwendung von Co-Enzym-Antagonisten zur Stoffwechselverlangsamung
DE69413090T2 (de) Verwendung von 5-Amino-Phthaloylhydrazid als antihypoxisches und defensives Mittel
DE69029693T2 (de) Hydantoin- oder Imidazolidintrionderivate zur Vorbeugung oder Behandlung von Niereninsuffizienz
EP1135146A1 (de) Pharmazeutische zusammensetzung enthaltend fischöl, vitamin e und c und acetylsalicylsaüre gegen arteriosklerose
EP0374096B1 (de) 2',3'-Dideoxypurinnucleosid/Purinnucleosid-Phosphorylase-Inhibitor Kombinationstherapie und Zusammensetzungen dafür
LU84892A1 (fr) Komposition zur reduktion der sebumsekretion
CH670952A5 (enExample)
DE69121551T2 (de) Antineoplastisch wirkender und den antineoplastischen effekt verstärkender wirkstoff
DE69330638T2 (de) Verwendung von 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine zur herstrllung eines medikaments zur behandlung von bestimmten schmerzen und ödem
DE69907387T2 (de) Verwendung von Hydantoin-Derivaten zur Herstellung eines Medikaments zur Behandlung von refraktärer Vasculitis.
DE60124516T2 (de) Kombination des lezithins mit ascorbinsäure
DE69630073T2 (de) (-)Hydroxycitrat enthaltende Verbindungen mit neuen therapeutischen Wirkungen
DE60213237T2 (de) Verwendung von l-acetylcarnitin in kombination mit biotin zur behandlung von patienten mit insulinresistentem diabetes mellitus typ ii
DE69808270T2 (de) Verbesserte darreichung von antikrebsmittel an feste tumore mittels primer-verbindungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition