ES2292643T3 - Tratamiento de los efectos colaterales de la estatina. - Google Patents
Tratamiento de los efectos colaterales de la estatina. Download PDFInfo
- Publication number
- ES2292643T3 ES2292643T3 ES01998341T ES01998341T ES2292643T3 ES 2292643 T3 ES2292643 T3 ES 2292643T3 ES 01998341 T ES01998341 T ES 01998341T ES 01998341 T ES01998341 T ES 01998341T ES 2292643 T3 ES2292643 T3 ES 2292643T3
- Authority
- ES
- Spain
- Prior art keywords
- uridine
- statin
- salt
- alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Landscapes
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| ES2574918T3 (es) * | 2003-06-02 | 2016-06-23 | Isis Innovation Limited | Tratamiento de la fatiga muscular |
| AU2004245567B2 (en) | 2003-06-03 | 2011-06-23 | Oxford University Innovation Limited | Nutritional supplements and therapeutic compositions comprising (R)-3-hydroxybutyrate derivatives |
| ES2410587T3 (es) | 2004-01-22 | 2013-07-02 | University Of Miami | Formulaciones tópicas de coenzima Q10 y métodos de uso |
| KR20070032795A (ko) * | 2004-06-21 | 2007-03-22 | 허치슨 메디파르마 엔터프라이즈 리미티드 | 항암 화학요법 |
| US20050288379A1 (en) * | 2004-06-21 | 2005-12-29 | Xiaoqiang Yan | Benzoquinone compounds as anti-cancer agents |
| JP4896501B2 (ja) * | 2004-11-26 | 2012-03-14 | 第一三共株式会社 | 血中遊離脂肪酸低下作用を有する医薬組成物 |
| WO2006057209A1 (ja) * | 2004-11-26 | 2006-06-01 | Sankyo Company, Limited | 血中遊離脂肪酸低下作用を有する医薬組成物 |
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| US20060252830A1 (en) * | 2005-05-06 | 2006-11-09 | Brandon Stephen F | Method for the treatment of magnesium and potassium deficiencies |
| CA2610152C (en) | 2005-06-01 | 2018-04-10 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| DK1957086T3 (en) * | 2005-11-18 | 2018-06-06 | Cornell Res Foundation Inc | NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE |
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| EP2240017B1 (en) | 2008-01-04 | 2019-03-13 | Oxford University Innovation Limited | Ketone bodies and ketone body esters as blood lipid lowering agents |
| MX2010009290A (es) | 2008-02-29 | 2010-09-14 | Biolab Sanus Farmaceutica Ltda | Composicion farmaceutica. |
| WO2009126764A1 (en) | 2008-04-11 | 2009-10-15 | Cytotech Labs, Llc | Methods and use of inducing apoptosis in cancer cells |
| US8642654B2 (en) | 2009-04-16 | 2014-02-04 | Isis Innovation Limited | Hydroxybutyrate ester and medical use thereof |
| BRPI0918139B1 (pt) | 2008-09-10 | 2024-04-30 | Ptc Therapeutics, Inc | Composição, alimento medicinal ou funcional, suplemento alimentar ou dietético para tratamento de distúrbios de desenvolvimento pervasivos com terapêuticos redox-ativos |
| JP5426918B2 (ja) * | 2009-04-20 | 2014-02-26 | 株式会社 伊藤園 | ウリジンを含有する抗疲労剤又は体力向上剤 |
| EA023913B1 (ru) | 2009-05-11 | 2016-07-29 | БЕРГ ФАРМА ЭлЭлСи | Способы лечения метаболических нарушений, использующие эпиметаболические переключатели, многоаспектные внутриклеточные молекулы или факторы влияния |
| US8557236B2 (en) * | 2010-02-09 | 2013-10-15 | Vascure Natural LLC | Cardiovascular support supplement and compositions and methods thereof |
| GB201002983D0 (en) | 2010-02-22 | 2010-04-07 | Tdeltas Ltd | Nutritinal composition |
| CN103608323B (zh) | 2011-04-04 | 2016-08-17 | 博格有限责任公司 | 治疗中枢神经系统肿瘤的方法 |
| US9642860B2 (en) | 2011-08-15 | 2017-05-09 | Technion Research & Development Foundation Limited | Combinations of corroles and statins |
| TWI489982B (zh) * | 2012-09-18 | 2015-07-01 | Univ China Medical | 苯醌類化合物應用於抑制動脈粥狀血管硬化之用途 |
| TWI504390B (zh) * | 2012-09-18 | 2015-10-21 | Univ China Medical | 苯醌類化合物應用於抑制黑色素瘤細胞之Ｗｎｔ／β－ｃａｔｅｎｉｎ訊息途徑之用途 |
| JP6883384B2 (ja) | 2012-11-05 | 2021-06-09 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 電離放射線による傷害から組織を防護するためのケトン体 |
| GB201304467D0 (en) | 2013-03-12 | 2013-04-24 | Tdeltas Ltd | Compound for use in protecting skin |
| SG11201507685UA (en) | 2013-03-14 | 2015-10-29 | Isis Innovation | Process for producing (r)-3-hydroxybutyl (r)-3-hydroxybutyrate |
| EP2983654B1 (en) | 2013-04-08 | 2025-11-12 | BPGbio, Inc. | Treatment of cancer using coenzyme q10 combination therapies |
| WO2015003246A1 (en) * | 2013-07-09 | 2015-01-15 | Mcmaster University | Combination of a statin with an inflammasome inhibitor |
| WO2015035094A1 (en) | 2013-09-04 | 2015-03-12 | Berg Llc | Methods of treatment of cancer by continuous infusion of coenzyme q10 |
| US20170189350A1 (en) | 2015-11-16 | 2017-07-06 | Berg Llc | Methods of treatment of temozolomide-resistant glioma using coenzyme q10 |
| CN113024369A (zh) | 2015-12-17 | 2021-06-25 | Ptc医疗公司 | 用于治疗氧化应急障碍的化合物 |
| JP7173992B2 (ja) | 2017-05-17 | 2022-11-17 | バーグ エルエルシー | 表皮水疱症の治療および防止におけるコエンザイムｑ１０製剤の使用 |
| WO2018218287A1 (en) * | 2017-05-29 | 2018-12-06 | Woodlinda Pty Ltd | Treatment and/or prevention of neuropathic symptoms associated with diabetes mellitus type ii |
| WO2019071353A1 (en) * | 2017-10-13 | 2019-04-18 | Exerkine Corporation | USE OF XC-SYSTEM INHIBITOR FOR THE TREATMENT OF STATIN-INDUCED MYALGIA |
| KR102060722B1 (ko) * | 2017-11-06 | 2020-02-11 | 연세대학교 산학협력단 | 스타틴에 의한 약물유해반응용 동물 모델 및 이의 제조방법 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2462312A1 (de) * | 1974-03-04 | 1976-10-14 | Nadrol Chemie Pharma Keizer Kg | Arzneimittel zur behandlung von migraene-erkrankungen |
| SU988814A1 (ru) * | 1979-11-20 | 1983-01-15 | Филиал Всесоюзного научно-исследовательского химико-фармацевтического института им.Серго Орджоникидзе | Соли оротовой кислоты и @ -аминокислот, предупреждающие развитие утомлени при физических нагрузках |
| DE3110560A1 (de) * | 1981-03-18 | 1982-10-14 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | "angiotropine der leukozyten und des entzuendungsgewebes: eine neue klasse natuerlicher chemotropischer mitogene fuer das richtungswachstum von blutgefaessen und zur neovaskularisierung von geweben" |
| US4911917A (en) * | 1988-06-28 | 1990-03-27 | Hauser-Kuhrts, Inc. | Cholesterol-lowering combination comopsitions of magnesium salt and niacin |
| CA2007983C (en) * | 1989-01-18 | 1996-12-10 | Michael S. Brown | Coenzyme q10 with hmg-coa reductase inhibitors |
| US4929437A (en) * | 1989-02-02 | 1990-05-29 | Merck & Co., Inc. | Coenzyme Q10 with HMG-CoA reductase inhibitors |
| US5316765A (en) * | 1989-09-07 | 1994-05-31 | Karl Folkers Foundation For Biomedical And Clinical Research | Use of coenzyme Q10 in combination with HMG-CoA reductase inhibitor therapies |
| JPH07504198A (ja) * | 1992-02-24 | 1995-05-11 | イースト カロライナ ユニバーシティ | デヒドロエピアンドロステロンおよびその類縁体を用いる処置によって発癌を抑制する方法 |
| BE1005939A6 (fr) * | 1992-05-14 | 1994-03-15 | Pirmez Thierry Dr | Utilisation des sels de l'acide orotique comme tranporteurs preferentiels d'oligo-elements. |
| DE69333575T2 (de) * | 1992-05-28 | 2005-08-25 | Centre For Molecular Biology And Medicine, Richmond | Quinone-derivate zur verbesserung der zellulare bioenergie |
| AT405477B (de) * | 1996-04-03 | 1999-08-25 | Norbert Mag Fuchs | Kombinationspräparat |
| US6472378B2 (en) * | 1998-08-31 | 2002-10-29 | Pro-Neuron, Inc. | Compositions and methods for treatment of mitochondrial diseases |
| US6245800B1 (en) * | 1999-06-08 | 2001-06-12 | Sigma-Tau | Method of preventing or treating statin-induced toxic effects using L-carnitine or an alkanoyl L-carnitine |
| IT1317008B1 (it) * | 2000-04-04 | 2003-05-26 | Sigma Tau Healthscience Spa | Integratore alimentare energizzante sulla muscolatura scheletrica eprotettivo sull'apparato cardiovascolare. |
| US6420342B1 (en) * | 2000-05-08 | 2002-07-16 | N.V. Nutricia | Nutritional preparation comprising ribose and medical use thereof |
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2000
- 2000-11-29 AU AUPR1773A patent/AUPR177300A0/en not_active Abandoned
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2001
- 2001-11-29 DE DE60130023T patent/DE60130023T2/de not_active Expired - Lifetime
- 2001-11-29 CA CA2429979A patent/CA2429979C/en not_active Expired - Fee Related
- 2001-11-29 NZ NZ526069A patent/NZ526069A/en not_active IP Right Cessation
- 2001-11-29 AU AU2002223302A patent/AU2002223302B2/en not_active Ceased
- 2001-11-29 WO PCT/AU2001/001545 patent/WO2002043721A1/en not_active Ceased
- 2001-11-29 AT AT01998341T patent/ATE369845T1/de not_active IP Right Cessation
- 2001-11-29 US US10/433,074 patent/US20040063661A1/en not_active Abandoned
- 2001-11-29 EP EP01998341A patent/EP1343488B1/en not_active Expired - Lifetime
- 2001-11-29 JP JP2002545692A patent/JP4596734B2/ja not_active Expired - Fee Related
- 2001-11-29 AU AU2330202A patent/AU2330202A/xx active Pending
- 2001-11-29 ES ES01998341T patent/ES2292643T3/es not_active Expired - Lifetime
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2010
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- 2010-07-02 JP JP2010151665A patent/JP2010248230A/ja active Pending
- 2010-08-04 US US12/849,943 patent/US20100323981A1/en not_active Abandoned
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| ATE369845T1 (de) | 2007-09-15 |
| EP1343488A4 (en) | 2005-05-04 |
| AUPR177300A0 (en) | 2000-12-21 |
| EP1343488A1 (en) | 2003-09-17 |
| EP1343488B1 (en) | 2007-08-15 |
| US20040063661A1 (en) | 2004-04-01 |
| CA2429979C (en) | 2011-11-15 |
| AU2002223302B2 (en) | 2006-08-31 |
| DE60130023D1 (de) | 2007-09-27 |
| NZ526069A (en) | 2006-11-30 |
| JP2004531468A (ja) | 2004-10-14 |
| WO2002043721A1 (en) | 2002-06-06 |
| US20100323981A1 (en) | 2010-12-23 |
| US20100144665A1 (en) | 2010-06-10 |
| DE60130023T2 (de) | 2008-05-08 |
| JP4596734B2 (ja) | 2010-12-15 |
| CA2429979A1 (en) | 2002-06-06 |
| HK1059044A1 (en) | 2004-06-18 |
| AU2330202A (en) | 2002-06-11 |
| JP2010248230A (ja) | 2010-11-04 |
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