DE60124637D1 - Neues Reagens zur Markierung von Nukleinsäuren - Google Patents

Neues Reagens zur Markierung von Nukleinsäuren

Info

Publication number
DE60124637D1
DE60124637D1 DE60124637T DE60124637T DE60124637D1 DE 60124637 D1 DE60124637 D1 DE 60124637D1 DE 60124637 T DE60124637 T DE 60124637T DE 60124637 T DE60124637 T DE 60124637T DE 60124637 D1 DE60124637 D1 DE 60124637D1
Authority
DE
Germany
Prior art keywords
nucleic acids
new reagent
labeling nucleic
label
amide bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60124637T
Other languages
English (en)
Other versions
DE60124637T2 (de
Inventor
Dieter Dr Heindl
Gregor Dr Sagner
Heribert Maerz
Der Eltz Herbert Dr Von
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Roche Diagnostics GmbH filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE60124637D1 publication Critical patent/DE60124637D1/de
Publication of DE60124637T2 publication Critical patent/DE60124637T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2996—Glass particles or spheres

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyamides (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE60124637T 2000-09-08 2001-09-04 Neues Reagens zur Markierung von Nukleinsäuren Expired - Lifetime DE60124637T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10044373 2000-09-08
DE10044373A DE10044373A1 (de) 2000-09-08 2000-09-08 Neues Reagenz zur Markierung von Nukleinsäuren

Publications (2)

Publication Number Publication Date
DE60124637D1 true DE60124637D1 (de) 2007-01-04
DE60124637T2 DE60124637T2 (de) 2007-09-13

Family

ID=7655459

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10044373A Withdrawn DE10044373A1 (de) 2000-09-08 2000-09-08 Neues Reagenz zur Markierung von Nukleinsäuren
DE60124637T Expired - Lifetime DE60124637T2 (de) 2000-09-08 2001-09-04 Neues Reagens zur Markierung von Nukleinsäuren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10044373A Withdrawn DE10044373A1 (de) 2000-09-08 2000-09-08 Neues Reagenz zur Markierung von Nukleinsäuren

Country Status (7)

Country Link
US (1) US6875850B2 (de)
EP (1) EP1186613B8 (de)
JP (1) JP3684182B2 (de)
AT (1) ATE346079T1 (de)
CA (1) CA2356552C (de)
DE (2) DE10044373A1 (de)
ES (1) ES2276733T3 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7205106B1 (en) 2001-07-20 2007-04-17 Roche Molecular Systems, Inc. Association of polymorphisms in IL4-related genes with autoimmune disease
US7122189B2 (en) 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
US7087229B2 (en) * 2003-05-30 2006-08-08 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
EP1431297A1 (de) * 2002-12-20 2004-06-23 Boehringer Mannheim Gmbh Mannitol- und Glucitolderivate
ATE319699T1 (de) * 2002-12-20 2006-03-15 Hoffmann La Roche Mannitol- und glucitolderivate
US7560231B2 (en) 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
EP2370450A1 (de) 2008-11-27 2011-10-05 Roche Diagnostics GmbH Gezielte synthese von oligophosphoramidatstereoisomeren
AU2010296018B2 (en) 2009-09-16 2016-05-05 Genentech, Inc. Coiled coil and/or tether containing protein complexes and uses thereof
US8394948B2 (en) * 2009-09-30 2013-03-12 Glen Research Corporation Reagents utilizing a serinol scaffold for labeling synthetic oligonucleotides
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
ES2605493T3 (es) 2010-12-23 2017-03-14 F. Hoffmann-La Roche Ag Detección de un polipéptido modificado post-traduccionalmente mediante un agente ligante bivalente
EP2655413B1 (de) 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Polypeptid-polynukleotid-komplex und verwendung bei der gezielten effektorrest-bereitstellung
JP6162044B2 (ja) 2010-12-23 2017-07-12 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 結合剤
US9428809B2 (en) * 2011-08-12 2016-08-30 National Institute Of Advanced Industrial Science And Technology Solid-phase carrier for aminated oligonucleotide
BR112014019579A2 (pt) 2012-02-10 2019-10-15 Genentech, Inc Anticorpo de cadeia única, polinucleotídeo, vetor, célula hospedeira, método de produção de um anticorpo de cadeia única, heteromultímero e método de produção do heteromultímero
WO2014001324A1 (en) 2012-06-27 2014-01-03 Hoffmann-La Roche Ag Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof
EP2867254B1 (de) 2012-06-27 2017-10-25 F. Hoffmann-La Roche AG Verfahren zum herstellen von antikörper-fc-region-konjugaten mit mindestens einer bindungsstelle, die spezifisch an ein target bindet, und verwendungen davon
WO2016087416A1 (en) 2014-12-03 2016-06-09 F. Hoffmann-La Roche Ag Multispecific antibodies
WO2017124016A2 (en) * 2016-01-15 2017-07-20 Isi Life Sciences, Inc. Compositions and methods for internalizing pro-labeled molecules into targeted cells and transforming them in situ into labeled molecules
WO2018026538A1 (en) * 2016-08-02 2018-02-08 ISI Life Sciences Inc. Novel scaffolds for intracellular compound delivery for the detection of cancer cells
EP3493855A4 (de) 2016-08-02 2020-04-01 ISI Life Sciences, Inc. Zusammensetzungen und verfahren zur detektion von krebszellen in einer gewebeprobe
US10753942B2 (en) 2017-05-15 2020-08-25 Indicator Systems International, Inc. Methods to detect remnant cancer cells
US11384376B2 (en) 2018-05-31 2022-07-12 Roche Molecular Systems, Inc. Reagents and methods for post-synthetic modification of nucleic acids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5451463A (en) * 1989-08-28 1995-09-19 Clontech Laboratories, Inc. Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides
US5141837A (en) * 1990-02-23 1992-08-25 Eastman Kodak Company Method for preparing coating compositions containing photoconductive perylene pigments
US5290925A (en) 1990-12-20 1994-03-01 Abbott Laboratories Methods, kits, and reactive supports for 3' labeling of oligonucleotides
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5736626A (en) 1996-01-29 1998-04-07 The Perkin-Elmer Corporation Solid support reagents for the direct synthesis of 3'-labeled polynucleotides
ES2304573T3 (es) 1996-06-04 2008-10-16 University Of Utah Research Foundation Recipiente para llevar a cabo y controlar procesos biologicos.

Also Published As

Publication number Publication date
EP1186613A1 (de) 2002-03-13
EP1186613B1 (de) 2006-11-22
JP2003012951A (ja) 2003-01-15
DE10044373A1 (de) 2002-03-21
DE60124637T2 (de) 2007-09-13
US20020110691A1 (en) 2002-08-15
CA2356552A1 (en) 2002-03-08
ATE346079T1 (de) 2006-12-15
CA2356552C (en) 2009-07-28
US6875850B2 (en) 2005-04-05
EP1186613B8 (de) 2007-02-07
JP3684182B2 (ja) 2005-08-17
ES2276733T3 (es) 2007-07-01

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ROCHE DIAGNOSTICS GMBH, 68305 MANNHEIM, DE

8364 No opposition during term of opposition